Early-life exposure to organophosphate pesticides and pediatric respiratory symptoms in the CHAMACOS cohort

Environmental Health Perspectives

Volumn 123, Issue 2, 2015, Pages 179-185

  Raanan, Rachel ^a   Harley, Kim G ^a   Balmes, John R ^b,c   Bradman, Asa ^a   Lipsett, Michael ^d   Eskenazi, Brenda ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CALIFORNIA DEPARTMENT OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANEDIOL DERIVATIVE; CHLORPYRIFOS; CREATININE; DIETHYL PHOSPHATE; DIMETHYL PHOSPHATE; DIMPYLATE; MALATHION; ORGANOPHOSPHATE PESTICIDE; UNCLASSIFIED DRUG; ORGANOPHOSPHATE; POLLUTANT;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CHILD; FEMALE; FOLLOW UP; HUMAN; INFANT; KIDNEY CONCENTRATING CAPACITY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MATERNAL WELFARE; MIDDLE AGED; OUTCOME ASSESSMENT; PREGNANCY; PREGNANT WOMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; QUESTIONNAIRE; RELATIVE DENSITY; RESPIRATORY TRACT DISEASE; SCHOOL CHILD; SENSITIVITY ANALYSIS; SYMPTOM ASSESSMENT; URINALYSIS; YOUNG ADULT; CHEMICALLY INDUCED; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; NEWBORN; POLLUTANT; PRESCHOOL CHILD; RESPIRATORY SYSTEM; TOXICITY; UNITED STATES; URINE;

BLATTARIA; NICOTIANA TABACUM;

ADULT; ASTHMA; CALIFORNIA; CHILD; CHILD, PRESCHOOL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MATERNAL EXPOSURE; ORGANOPHOSPHATES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RESPIRATORY SYSTEM;

EID: 84922976358     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1408235     Document Type: Article

References (47)

1. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, et al. 1995. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 8(3):483–491; doi:10.1183/09031936.95.08030483.
2. Barnes PJ. 1986. Neural control of human airways in health and disease. Am Rev Respir Dis 134(6):1289–1314.
3. Bradman A, Barr DB, Claus Henn BG, Drumheller T, Curry C, Eskenazi B. 2003. Measurement of pesti-cides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: a valida-tion study. Environ Health Perspect 111:1779–1782; doi:10.1289/ehp.6259.
4. Bradman A, Eskenazi B, Barr DB, Bravo R, Castorina R, Chevrier J, et al. 2005. Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community. Environ Health Perspect 113:1802–1807; doi:10.1289/ehp.7894.
5. Bradman A, Kogut K, Eisen EA, Jewell NP, Quirós- Alcalá L, Castorina R, et al. 2013. Variability of Organophosphorous Pesticide metabolite levels in spot and 24-hr urine samples collected from young children during 1 week. Environ Health Perspect 121:118–124; doi:10.1289/ehp.1104808.
6. Bravo R, Driskell WJ, Whitehead RD Jr, Needham LL, Barr DB. 2002. Quantitation of dialkyl phosphate metabolites of organophosphate pesticides in human urine using GC-MS-MS with isotopic internal standards. J Anal Toxicol 26:245–252; doi:10.1093/jat/26.5.245.
7. Cavari Y, Lifshitz M, Leibson T, Shorer Z, Rubinstein M, Sofer S. 2013. Severe and uncommon complica-tions of anticholinesterase intoxication in children [in Hebrew]. Harefuah 152(7):391–394.
8. CDC (Centers for Disease Control and Prevention). 2004. 2001–2002 National Health and Nutrition Examination Survey (NHANES). Atlanta, GA:Centers for Disease Control and Prevention, National Center for Health Statistics. Available: http://www.cdc.gov/nchs/about/major/nhanes/datalink.htm [accessed 4 February 2014].
9. CDC (Centers for Disease Control and Prevention). 2009. Organophosphorus insecticides: dialkyl phosphate metabolites. In: Fourth National Report on Human Exposure to Environmental Chemicals. Atlanta, GA:Centers for Disease Control and Prevention, National Center for Health, Division of Laboratory Sciences, 117–133. Available: http://www.cdc.gov/exposurereport/pdf/fourthreport.pdf [accessed 4 February 2014].
10. CDC (Centers for Disease Control and Prevention). 2014. Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, August, 2014. Atlanta, GA:Centers for Disease Control and Prevention. Available: http://www.cdc.gov/exposurereport/pdf/fourthreport_updatedtables_aug2014.pdf [accessed 18 September 2014].
11. CDPR (California Department of Pesticide Regulation). 2001. Summary of Pesticide Use Report Data for 2001. Available: http://calpip.cdpr.ca.gov/year.cfm [accessed 4 February 2014].
12. Chen L, Zhao T, Pan C, Ross JH, Krieger RI. 2012. Preformed biomarkers including dialkylphosphates (DAPs) in produce may confound biomonitoring in pesticide exposure and risk assessment. J Agric Food Chem 60(36):9342–9351; doi:10.1021/jf303116p.
13. De Luca G, Olivieri F, Melotti G, Aiello G, Lubrano L, Boner AL. 2010. Fetal and early postnatal life roots of asthma. J Matern Fetal Neonatal Med 23(suppl 3):80–83; doi:10.3109/14767058.2010.509931.
14. Duramad P, Harley K, Lipsett M, Bradman A, Eskenazi B, Holland N, et al. 2006. Early environmental exposures and intracellular Th1/ Th2 cytokine profiles in 24-month-old children living in an agricultural area. Environ Health Perspect 114:1916–1922; doi:10.1289/ehp.9306.
15. Eskenazi B, Marks AR, Bradman A, Harley K, Barr DB, Johnson C, et al. 2007. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect 115:792–798; doi:10.1289/ehp.9828.
16. Fryer AD, Lein PJ, Howard AS, Yost BL, Beckles RA, Jett DA. 2004. Mechanisms of organophosphate insecticide-induced airway hyperreactivity. Am J Physiol Lung Cell Mol Physiol 286:L963–L969; doi:10.1152/ajplung.00343.2003.
17. Grube A, Donaldson D, Kiely T, Wu L. 2011. Pesticides Industry Sales and Usage: 2006 and 2007 Market Estimates. Washington, DC: U.S. Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention. Available: http://www.epa.gov/opp00001/pestsales/07pestsales/market_estimates2007.pdf [accessed 4 February 2014].
18. Guha N, Ward MH, Gunier R, Colt JS, Lea CS, Buffler PA, et al. 2013. Characterization of residential pesticide use and chemical formula-tions through self-report and household inventory: the Northern California Childhood Leukemia Study. Environ Health Perspect 121:276–282; doi:10.1289/ehp.1204926.
19. Hameed A, Sherkheli MA, Hussain A, Ul-haq R. 2013. Molecular and physiological determinants of pulmonary developmental biology: a review. Am J Biomed Res 1(1):13–24; doi:10.12691/ajbr-1-1-3.
20. Harley KG, Macher JM, Lipsett M, Duramad P, Holland NT, Prager SS, et al. 2009. Fungi and pollen exposure in the first months of life and risk of early childhood wheezing. Thorax 64(4):353–358; doi:10.1136/thx.2007.090241.
21. Hernán MA, Hernández-Díaz S, Robins JM. 2004. A structural approach to selection bias. Epidemiology 15(5):615–625; doi:10.1097/01.ede.0000135174.63482.43.
22. Holguin F, Flores S, Ross Z, Cortez M, Molina M, Molina L. 2007. Traffic-related exposures, airway function, inflammation, and respiratory symptoms in children. Am J Respir Crit Care Med 176(12):1236–1242; doi:10.1164/rccm.200611-1616OC.
23. Hoppin JA, Umbach DM, London SJ, Lynch CF, Alavanja MCR, Sandler DP. 2006. Pesticides associated with wheeze among commercial pesticide applicators in the Agricultural Health Study. Am J Epidemiol 163:1129–1137; doi:10.1093/aje/kwj138.
24. Hubbard AE, Ahern J, Fleischer NL, Van der Laan M, Lippman SA, Jewell N, et al. 2010. To GEE or not to GEE: comparing population average and mixed models for estimating the associations between neighborhood risk factors and health. Epidemiology 21(4):467–474; doi:10.1097/EDE.0b013e3181caeb90.
25. Kraai S, Verhagen LM, Valladares E, Goecke J, Rasquin L, Colmenares P. 2013. High prevalence of asthma symptoms in Warao Amerindian children in Venezuela is significantly associated with open-fire cooking: a cross-sectional observational study. Respir Res 14(1):76; doi:10.1186/1465-9921-14-76.
26. Kwak ES, Just A, Whyatt R, Miller RL. 2009. Phthalates, pesticides, and bisphenol-A exposure and the development of nonoccupational asthma and allergies: how valid are the links? Open Allergy J 2:45–50; doi:10.2174/1874838400902010045.
27. Lein PJ, Fryer AD. 2005. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicol Sci 83:166–176; doi:10.1093/toxsci/kfi001.
28. Lu C, Bravo R, Caltabiano LM, Irish RM, Weerasekera G, Barr DB. 2005. The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments. J Toxicol Environ Health A 68(3):209–227; doi:10.1080/15287390590890554.
29. Mellon M, Parasuraman B. 2004. Pediatric asthma: improving management to reduce cost of care. J Manag Care Pharm 10(2):130–141.
30. Ndlovu V, Dalvie MA, Jeebhay MF. 2011. Pesticides and the airways—a review of the literature. Curr Allergy Clin Immunol 24(4):212–217.
31. Pawankar R, Canonica GW, Holgate ST, Lockey RF, eds. 2011. WAO White Book on Allergy. Milwaukee, WI:World Allergy Organization, 1–216. Available: http://www.worldallergy.org/UserFiles/file/WAO-White-Book-on-Allergy_web.pdf [accessed 4 February 2014].
32. Pijnenburg MW. 2012. Pediatric asthma: where to go? Eur Respir Rev 21(125):173–174; doi:10.1183/09059180.00004012.
33. Proskocil BJ, Bruun DA, Jacoby DB, van Rooijen N, Lein PJ, Fryer AD. 2013. Macrophage TNFα mediates parathion-induced airway hyperreactivity in guinea pigs. Am J Physiol Lung Cell Mol Physiol 304(8):519–529; doi:10.1152/ajplung.00381.2012.
34. Rauh VA, Garfinkel R, Perera FP, Andrews HF, Hoepner L, Barr DB, et al. 2006. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 118:e1845–e1859; doi:10.1542/peds.2006-0338.
35. Salam MT, Li YF, Langholz B, Gilliland FD, Children’s Health Study. 2004. Early-life environmental risk factors for asthma: findings from the Children’s Health Study. Environ Health Perspect 112:760–765; doi:10.1289/ehp.6662.
36. Salameh P, Baldi I, Brochard P, Raherison C, Abi Saleh B, Salamon R. 2003. Respiratory symptoms in children and exposure to pesticides. Eur Respir J 22:507–512; doi:10.1183/09031936.03.00107403a.
37. Samoliński B, Fronczak A, Włodarczyk A, Bousquet J. 2012. Council of the European Union conclusions on chronic respiratory diseases in children. Lancet 379(9822):e45–e46; doi:10.1016/S0140-6736(12)60514-5.
38. Selgrade MK, Blain RB, Fedak KM, Cawley, MA. 2013. Potential risk of asthma associated with in utero exposure to xenobiotics. Birth Defects Res C Embryo Today 99(1):1–13; doi:10.1002/bdrc.21028.
39. Stellman SD, Thomas PA, Osahan S, Brackbill RM, Farfel MR. 2013. Respiratory health of 985 children exposed to the World Trade Center disaster: report on World Trade Center Health Registry wave 2 follow-up, 2007–2008. J Asthma 50(4):354–363; doi:10.3109/02770903.2013.776073.
40. Stocks J, Sonnappa S. 2013. Early life influences on the development of chronic obstructive pulmonary disease. Ther Adv Respir Dis 7(3):161–173; doi:10.1177/1753465813479428.
41. Sudakin DL, Stone DL. 2011. Dialkyl phosphates as biomarkers of organophosphates: the current divide between epidemiology and clinical toxicology. Clin Toxicol (Phila) 49(9):771–781; doi:10.3109/15563650.2011.624101.
42. U.S. EPA (U.S. Environmental Protection Agency). 2013. Pesticide Registration Status for Organophosphates. Available: http://www.epa.gov/pesticides/reregistration/status.htm [accessed 4 February 2014].
43. van der Laan MJ, Polley EC, Hubbard AE. 2007. Super Learner. U.C. Berkeley Division of Biostatistics Working Paper Series, 2007: Working Paper 222. Available: http://biostats.bepress.com/ucbbiostat/paper222 [accessed 4 February 2014].
44. WHO (World Health Organization). 2007. Global Surveillance, Prevention and Control of Chronic Respiratory Diseases: A Comprehensive Approach (Bousquet J, Khaltaev NG, eds). Available: http:// www.who.int/gard/publications/GARD_Manual/en/ [accessed 4 February 2014].
45. Whyatt RM, Garfinkel R, Hoepner LA, Andrews H, Holmes D, Williams MK, et al. 2009. A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy. Environ Health Perspect 117:559–567; doi:10.1289/ehp.0800041.
46. Wright SM, Hockey PM, Enhorning G, Strong P, Reid KB, Holgate ST, et al. 2000. Altered airway surfactant phospholipid composition and reduced lung function in asthma. J Appl Physiol (1985) 89(4):1283–1292.
47. Zeger SL, Liang KY. 1986. Longitudinal data analysis for discrete and continuous outcomes. Biometrics 42:121–130.