SH2B1 CpG-SNP is associated with body weight reduction in obese subjects following a dietary restriction program

Annals of Nutrition and Metabolism

Volumn 66, Issue 1, 2014, Pages 1-9

  Mansego, Maria Luisa ^a,b   Milagro, Fermin Ignacio ^a,b   Zulet, Maria Angeles ^a,b   Martinez, José Alfredo ^a,b  

^a Instituto de Salud Carlos III   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

CpG SNP; Dietary response; DNA methylation; Energy restricted program; Obesity

Indexed keywords

BIOCHEMICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; SH2B1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; BODY MASS; CELL ISOLATION; CLINICAL ARTICLE; CPG ISLAND; DIET RESTRICTION; DNA ISOLATION; DNA METHYLATION; FAT MASS; FEMALE; GENE EXPRESSION; GENOTYPE; HUMAN; LEUKOCYTE; MACRONUTRIENT; MALE; MIDDLE AGED; OBESITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT CHANGE; WEIGHT REDUCTION; BODY WEIGHT; EPIGENETICS; GENETIC PREDISPOSITION; GENETICS; METABOLISM; PATHOPHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOSITY; ADULT; BODY MASS INDEX; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CPG ISLANDS; DNA METHYLATION; EPIGENOMICS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; WEIGHT LOSS;

EID: 84922965825     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000368425     Document Type: Article

References (35)

1. Martinez JA, Parra MD, Santos JL, Moreno-Aliaga MJ, Marti A, Martinez-Gonzalez MA: Genotype-dependent response to energy-restricted diets in obese subjects: towards personalized nutrition. Asia Pac J Clin Nutr 2008; 17(suppl 1):119-122
2. Willyard C: Heritability: the family roots of obesity. Nature 2014; 508:S58-S60
3. Wang K, Li WD, Zhang CK, Wang Z, Glessner JT, Grant SF, Zhao H, Hakonarson H, Price RA: A genome-wide association study on obesity and obesity-related traits. PLoS One 2011; 6:e18939
4. Nagai N, Sakane N, Kotani K, Hamada T, Tsuzaki K, Moritani T: Uncoupling protein 1 gene -3826 A/G polymorphism is associated with weight loss on a short-term, controlledenergy diet in young women. Nutr Res 2011; 31: 255-261
5. Ren D, Li M, Duan C, Rui L: Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab 2005; 2: 95-104
6. Heerwagen MJ, Miller MR, Barbour LA, Friedman JE: Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol 2010; 299:R711-R722
7. Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR: Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009; 462: 315-322
8. Bird A: Perceptions of epigenetics. Nature 2007; 447: 396-398
9. Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ: Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring. Nature 2010; 467: 963-966
10. Milagro FI, Campion J, Garcia-Diaz DF, Goyenechea E, Paternain L, Martinez JA: High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats. J Physiol Biochem 2009; 65: 1-9
11. Bouchard L, Rabasa-Lhoret R, Faraj M, Lavoie ME, Mill J, Perusse L, Vohl MC: Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction. Am J Clin Nutr 2010; 91: 309-320
12. Milagro FI, Campion J, Cordero P, Goyenechea E, Gomez-Uriz AM, Abete I, Zulet MA, Martinez JA: A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss. FASEB J 2011; 25: 1378-1389
13. Ling C, Poulsen P, Simonsson S, Ronn T, Holmkvist J, Almgren P, Hagert P, Nilsson E, Mabey AG, Nilsson P, Vaag A, Groop L: Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J Clin Invest 2007; 117: 3427-3435
14. Dayeh TA, Olsson AH, Volkov P, Almgren P, Ronn T, Ling C: Identification of CpGSNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. Diabetologia 2013; 56: 1036-1046
15. Fall T, Ingelsson E: Genome-wide association studies of obesity and metabolic syndrome. Mol Cell Endocrinol 2014; 382: 740-757
16. Zulet MA, Bondia-Pons I, Abete I, de la Iglesia R, Lopez-Legarrea P, Forga L, Navas-Carretero S, Martinez JA: The reduction of the metabolyc syndrome in Navarra-Spain (RESMENA-S) study: a multidisciplinary strategy based on chrononutrition and nutritional education, together with dietetic and psychological control. Nutr Hosp 2011; 26: 16-26
17. Whitworth JA: 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 2003; 21: 1983-1992
18. Lopez-Legarrea P, de la Iglesia R, Abete I, Bondia-Pons I, Navas-Carretero S, Forga L, Martinez JA, Zulet MA: Short-term role of the dietary total antioxidant capacity in two hypocaloric regimes on obese with metabolic syndrome symptoms: the RESMEMA randomized controlled trial. Nutr Metab (Lond) 2013; 10: 22
19. Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM, Sirotkin K: DbSNP: the NCBI database of genetic variation. Nucleic Acids Res 2001; 29: 308-311
20. Stefanska B, Bouzelmat A, Huang J, Suderman M, Hallett M, Han ZG, Al-Mahtab M, Akbar SM, Khan WA, Raqib R, Szyf M: Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes. PLoS One 2013; 8: e68439
21. Rozen S, Skaletsky H: Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000; 132: 365-386
22. Shi W, Oshlack A, Smyth GK: Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips. Nucleic Acids Res 2010; 38:e204
23. Rustici G, Kolesnikov N, Brandizi M, Burdett T, Dylag M, Emam I, Farne A, Hastings E, Ison J, Keays M, Kurbatova N, Malone J, Mani R, Mupo A, Pedro Pereira R, Pilicheva E, Rung J, Sharma A, Tang YA, Ternent T, Tikhonov A, Welter D, Williams E, Brazma A, Parkinson H, Sarkans U: ArrayExpress update - trends in database growth and links to data analysis tools. Nucleic Acids Res 2013; 41:D987-D990
24. Zhang FF, Santella RM, Wolff M, Kappil MA, Markowitz SB, Morabia A: White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population. Epigenetics 2012; 7: 606-614
25. Bani-Fatemi A, Goncalves VF, Zai C, de Souza R, Le Foll B, Kennedy JL, Wong AH, De Luca V: Analysis of CpG SNPs in 34 genes: association test with suicide attempt in schizophrenia. Schizophr Res 2013; 147: 262-268
26. Shoemaker R, Deng J, Wang W, Zhang K: Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res 2010; 20: 883-889
27. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS: Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activitydependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 2004; 24: 4401-4411
28. Ong CHJ, Hyde TM, Lipska BK, Mou Z, Tsao JW, Kleinman JE, Yanovski JA: Associations of single nucleotide polymorphisms (SNPS) in brain-derived neurotrophic factor (BDNF) with bdnf expression in human ventromedial hypothalamus (VMH) and with body mass index. Obesity 2010; 18:S61-S62
29. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gomez-Marin C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nobrega MA: Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 2014; 507: 371-375
30. Harris MJ, Arias IM: FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. Biochim Biophys Acta 2003; 1633: 127-131
31. Morris DL, Cho KW, Rui L: Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice. Endocrinology 2010; 151: 3643-3651
32. Harlid S, Ivarsson MI, Butt S, Hussain S, Grzybowska E, Eyfjord JE, Lenner P, Forsti A, Hemminki K, Manjer J, Dillner J, Carlson J: A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP. Int J Cancer 2011; 129: 1689-1698
33. Volckmar AL, Putter C, Song JY, Graniger J, Knoll N, Wolters B, Hebebrand J, Scherag A, Reinehr T, Hinney A: Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention. Exp Clin Endocrinol Diabetes 2013; 121: 334-337
34. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I, Jonsdottir T, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Jonsson F, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Lauritzen T, Aben KK, Verbeek AL, Roeleveld N, Kampman E, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Becker DM, Gulcher J, Kiemeney LA, Pedersen O, Kong A, Thorsteinsdottir U, Stefansson K: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009; 41: 18-24
35. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O,Rahilly S, Purmann C, Rees MG, Ridderstrale M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34