Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration

Neurobiology of Aging

Volumn 35, Issue 11, 2014, Pages 2562-2573

  Biesemeier, Antje ^a   Taubitz, Tatjana ^a   Julien, Sylvie ^a   Yoeruek, Efdal ^a   Schraermeyer, Ulrich ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Age related macular degeneration; Choriocapillaris; Retinal pigment epithelium; Transition between healthy and atrophied areas; Whole section panorama images

Indexed keywords

AGE RELATED MACULAR DEGENERATION; AGED; ARTICLE; BRUCH MEMBRANE; CHOROID CAPILLARY LAYER; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN TISSUE; MALE; PHASE TRANSITION; PHOTORECEPTOR; PIGMENT EPITHELIUM; RETINAL THICKNESS; VERY ELDERLY; AGING; CAPILLARY; CHOROID; DISEASE COURSE; MACULAR DEGENERATION; MICROSCOPY; MIDDLE AGED; PATHOLOGY; SEVERITY OF ILLNESS INDEX; ULTRASTRUCTURE; VASCULARIZATION;

AGED; AGED, 80 AND OVER; AGING; CAPILLARIES; CHOROID; DISEASE PROGRESSION; FEMALE; HUMANS; MACULAR DEGENERATION; MALE; MICROSCOPY; MIDDLE AGED; RETINAL PIGMENT EPITHELIUM; SEVERITY OF ILLNESS INDEX;

EID: 84922948140     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.05.003     Document Type: Article

References (48)

1. Bhutto I., Lutty G. Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. Mol. Aspects Med. 2012, 33:295-317.
2. Brown N.H., Koreishi A.F., McCall M., Izatt J.A., Rickman C.B., Toth C.A. Developing SDOCT to assess donor human eyes prior to tissue sectioning for research. Graefes Arch. Clin. Exp. Ophthalmol. 2009, 247:1069-1080.
3. Brown W.R., Thore C.R. Review: cerebral microvascular pathology in ageing and neurodegeneration. Neuropathol. Appl. Neurobiol. 2010, 37:56-74.
4. Curcio C.A., Johnson M., Rudolf M., Huang J.D. The oil spill in ageing Bruch membrane. Br. J. Ophthalmol. 2011, 95:1638-1645.
5. Curcio C.A., Medeiros N.E., Millican C.L. The Alabama age-related macular degeneration grading system for donor eyes. Invest Ophthalmol. Vis. Sci. 1998, 39:1085-1096.
6. Curcio C.A., Messinger J.D., Sloan K.R., McGwin G., Medeiros N.E., Spaide R.F. Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model. Retina 2012, 33:265-276.
7. Curcio C.A., Millican C.L. Basal linear deposit and large drusen are specific for early age-related maculopathy. Arch. Ophthalmol. 1999, 117:329-339.
8. Curcio C.A., Saunders P.L., Younger P.W., Malek G. Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss. Ophthalmology 2000, 107:334-343.
9. Duke-Elder S. System of Ophthalmology 1966, 610. Kimpton, London.
10. Freund K.B., Zweifel S.A., Engelbert M. Do we need a new classification for choroidal neovascularization in age-related macular degeneration?. Retina 2010, 30:1333-1349.
11. Friedman E. Ahemodynamic model of the pathogenesis of age-related macular degeneration. Am. J. Ophthalmol. 1997, 124:677-682.
12. Green W.R., Enger C. Age-related macular degeneration histopathologic studies. The 1992 Lorenz E. Zimmerman Lecture. Ophthalmology 1993, 100:1519-1535.
13. Grossniklaus H.E., Green W.R. Choroidal neovascularization. Am. J. Ophthalmol. 2004, 137:496-503.
14. Grunwald J.E., Hariprasad S.M., DuPont J., Maguire M.G., Fine S.L., Brucker A.J., Maguire A.M., Ho A.C. Foveolar choroidal blood flow in age-related macular degeneration. Invest Ophthalmol. Vis. Sci. 1998, 39:385-390.
15. Herrmann P., Holz F.G., Charbel Issa P. Etiology and pathogenesis of age-related macular degeneration. Ophthalmologe 2013, 110:377-387. quiz 388-9.
16. Hogan M.J. Bruch's membrane and disease of the macula. Role of elastic tissue and collagen. Trans. Ophthalmol. Soc. U.K 1967, 87:113-161.
17. Hogan M.J. Role of the retinal pigment epithelium in macular disease. Trans. Am. Acad. Ophthalmol. Otolaryngol. 1972, 76:64-80.
18. Jonas J.B., Forster T.M., Steinmetz P., Schlichtenbrede F.C., Harder B.C. Choroidal thickness in age-related macular degeneration. Retina 2014, 34:1149-1155.
19. Kochounian H., Johnson L.V., Fong H.K. Accumulation of extracellular RGR-d in Bruch's membrane and close association with drusen at intercapillary regions. Exp. Eye Res. 2009, 88:1129-1136.
20. Kocur I., Resnikoff S. Visual impairment and blindness in Europe and their prevention. Br. J. Ophthalmol. 2002, 86:716-722.
21. Lengyel I., Flinn J.M., Peto T., Linkous D.H., Cano K., Bird A.C., Lanzirotti A., Frederickson C.J., van Kuijk F.J. High concentration of zinc in sub-retinal pigment epithelial deposits. Exp. Eye Res. 2007, 84:772-780.
22. Lengyel I., Tufail A., Hosaini H.A., Luthert P., Bird A.C., Jeffery G. Association of drusen deposition with choroidal intercapillary pillars in the aging human eye. Invest Ophthalmol. Vis. Sci. 2004, 45:2886-2892.
23. Liu M.M., Chan C.C., Tuo J. Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics. Hum. Genomics 2012, 6:13.
24. Loffler K.U., Lee W.R. Basal linear deposit in the human macula. Graefes Arch. Clin. Exp. Ophthalmol. 1986, 224:493-501.
25. Lutty G., Grunwald J., Majji A.B., Uyama M., Yoneya S. Changes in choriocapillaris and retinal pigment epithelium in age-related macular degeneration. Mol. Vis. 1999, 5:35.
26. Machalinska A., Safranow K., Sylwestrzak Z., Szmatloch K., Kuprjanowicz L., Karczewicz D. Elevated level of circulating endothelial cells as an exponent of chronic vascular dysfunction in the course of AMD. Klin Oczna 2011, 113:228-232.
27. Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration. Results of a randomized clinical trial. Arch. Ophthalmol. 1991, 109:1220-1231. Macular Photocoagulation Study Group.
28. Occult choroidal neovascularization. Influence on visual outcome in patients with age-related macular degeneration. Arch. Ophthalmol. 1996, 114:400-412. Macular Photocoagulation Study Group.
29. Margolis R., Spaide R.F. Apilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am. J. Ophthalmol. 2009, 147:811-815.
30. McLeod D.S., Grebe R., Bhutto I., Merges C., Baba T., Lutty G.A. Relationship between RPE and choriocapillaris in age-related macular degeneration. Invest Ophthalmol. Vis. Sci. 2009, 50:4982-4991.
31. McLeod D.S., Taomoto M., Otsuji T., Green W.R., Sunness J.S., Lutty G.A. Quantifying changes in RPE and choroidal vasculature in eyes with age-related macular degeneration. Invest Ophthalmol. Vis. Sci. 2002, 43:1986-1993.
32. Metelitsina T.I., Grunwald J.E., DuPont J.C., Ying G.S., Brucker A.J., Dunaief J.L. Foveolar choroidal circulation and choroidal neovascularization in age-related macular degeneration. Invest Ophthalmol. Vis. Sci. 2008, 49:358-363.
33. Mullins R.F., Johnson M.N., Faidley E.A., Skeie J.M., Huang J. Choriocapillaris vascular dropout related to density of drusen in human eyes with early age-related macular degeneration. Invest Ophthalmol. Vis. Sci. 2011, 52:1606-1612.
34. Prokofyeva E., Zrenner E. Epidemiology of major eye diseases leading to blindness in Europe: a literature review. Ophthalmic Res. 2011, 47:171-188.
35. Ramrattan R.S., van der Schaft T.L., Mooy C.M., de Bruijn W.C., Mulder P.G., deJong P.T. Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging. Invest Ophthalmol. Vis. Sci. 1994, 35:2857-2864.
36. Rudolf M., Vogt S.D., Curcio C.A., Huisingh C., McGwin G., Wagner A., Grisanti S., Read R.W. Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy. Ophthalmology 2013, 120:821-828.
37. Russell S.R., Mullins R.F., Schneider B.L., Hageman G.S. Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration. Am. J. Ophthalmol. 2000, 129:205-214.
38. Sarks S., Cherepanoff S., Killingsworth M., Sarks J. Relationship of Basallaminar deposit and membranous debris to the clinical presentation of early age-related macular degeneration. Invest Ophthalmol. Vis. Sci. 2007, 48:968-977.
39. Sarks S.H. Ageing and degeneration in the macular region: a clinico-pathological study. Br. J. Ophthalmol. 1976, 60:324-341.
40. Sarks S.H., A J.J., Killingsworth M.C., Sarks J.P. Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study. Br. J. Ophthalmol. 1999, 83:358-368.
41. Sierra C. Cerebral small vessel disease, cognitive impairment and vascular dementia. Panminerva Med. 2012, 54:179-188.
42. Spaide R.F., Curcio C.A. Drusen characterization with multimodal imaging. Retina 2010, 30:1441-1454.
43. Spraul C.W., Lang G.E., Grossniklaus H.E. Morphometric analysis of thechoroid, Bruch's membrane, and retinal pigment epithelium in eyes withage-related macular degeneration. Invest Ophthalmol. Vis. Sci. 1996, 37:2724-2735.
44. Spraul C.W., Lang G.E., Grossniklaus H.E., Lang G.K. Characteristics of drusen and changes in Bruch's membrane in eyes with age-related macular degeneration. Histological study. Ophthalmologe 1998, 95:73-79.
45. van der Schaft T.L., Mooy C.M., de Bruijn W.C., Oron F.G., Mulder P.G., de Jong P.T. Histologic features of the early stages of age-related macular degeneration. A statistical analysis. Ophthalmology 1992, 99:278-286.
46. Verhoeff F.H., Grossman H.P. The pathogenesis of disciform degeneration of the macula. Trans. Am. Ophthalmol. Soc. 1937, 35:262-294.
47. Vogt S.D., Curcio C.A., Wang L., Li C.M., McGwin G., Medeiros N.E., Philp N.J., Kimble J.A., Read R.W. Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy. Exp. Eye Res. 2011, 93:413-423.
48. Whitmore S.S., Braun T.A., Skeie J.M., Haas C.M., Sohn E.H., Stone E.M., Scheetz T.E., Mullins R.F. Altered gene expression in dry age-related macular degeneration suggests early loss of choroidal endothelial cells. Mol. Vis. 2013, 19:2274-2297.