Structural insights for the optimization of dihydropyrimidin-2(1 H)-one based mPGES-1 inhibitors

ACS Medicinal Chemistry Letters

Volumn 6, Issue 2, 2015, Pages 187-191

  Terracciano, Stefania ^a   Lauro, Gianluigi ^a   Strocchia, Maria ^a   Fischer, Katrin ^b   Werz, Oliver ^b   Riccio, Raffaele ^a   Bruno, Ines ^a   Bifulco, Giuseppe ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Biginelli reaction; inflammation; Molecular docking; mPGES 1 inhibitors

Indexed keywords

2 [[2,6 BIS(CHLORANYL) 3 [(2,2 DIMETHYLPROPANOYLAMINO)METHYL]PHENYL]AMINO] 1 METHYL 6 (2 METHYL 2 OXIDANYL PROPOXY) N [2,2,2 TRIS(FLUORANYL)ETHYL]BENZIMIDAZOLE 5 CARBOXAMIDE; AMIDE; DIHYDROPYRIMIDIN 2(1H) ONE; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIGINELLI REACTION; BINDING SITE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; IN VITRO STUDY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84922936636     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500433j     Document Type: Article

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