Advanced glycation end products (AGEs) and their receptor (RAGE) induce apoptosis of periodontal ligament fibroblasts

Brazilian Journal of Medical and Biological Research

Volumn 47, Issue 12, 2014, Pages 1036-1043

  Li, D X ^a   Deng, T Z ^a   Lv, J ^a   Ke, J ^a  

^a AIR FORCE GENERAL HOSPITAL   (China)

Author keywords

Apoptosis; Diabetes mellitus; Periodontal diseases; RAGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; BOVINE SERUM ALBUMIN; CASPASE 3; ADVANCED GLYCATION END PRODUCTS-BOVINE SERUM ALBUMIN; IMMUNOGLOBULIN RECEPTOR;

APOPTOSIS; ARTICLE; CELL COUNT; CELL GROWTH; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE EXACERBATION; FIBROBLAST; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MTT ASSAY; NICK END LABELING; PERIODONTAL LIGAMENT; PERIODONTITIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; BOVINE; CELL SURVIVAL; COMPLICATION; CYTOLOGY; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; METABOLISM; PERIODONTAL DISEASE; PRIMARY CELL CULTURE; TUNEL ASSAY;

BOVINAE;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANIMALS; APOPTOSIS; CASPASE 3; CATTLE; CELL COUNT; CELL SURVIVAL; DIABETES COMPLICATIONS; FIBROBLASTS; FLOW CYTOMETRY; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; PERIODONTAL DISEASES; PERIODONTAL LIGAMENT; PRIMARY CELL CULTURE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, IMMUNOLOGIC; SERUM ALBUMIN, BOVINE;

EID: 84922888744     PISSN: None     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20143996     Document Type: Article

References (37)

1. Mealey BL, Rethman MP. Periodontal disease and diabetes mellitus. Bidirectional relationship. Dent Today 2003; 22: 107-113.
2. Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, et al. Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. J Periodontol 1996; 67: 1085-1093, doi: 10.1902/jop.1996.67.10s.1085.
3. Rahbar S. The discovery of glycated hemoglobin: a major event in the study of nonenzymatic chemistry in biological systems. Ann N Y Acad Sci 2005; 1043: 9-19, doi: 10.1196/ annals.1333.002.
4. Amir J, Waite M, Tobler J, Catalfamo DL, Koutouzis T, Katz J, et al. The role of hyperglycemia in mechanisms of exacerbated inflammatory responses within the oral cavity. Cell Immunol 2011; 272: 45-52, doi: 10.1016/j.cellimm. 2011.09.008.
5. Mealey B. Diabetes and periodontal diseases. J Periodontol 1999; 70: 935-949, doi: 10.1902/jop.1999.70.8.935.
6. Neeper M, Schmidt AM, Brett J, Yan SD, Wang F, Pan YC, et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 1992; 267: 14998-15004.
7. Katz J, Bhattacharyya I, Farkhondeh-Kish F, Perez FM, Caudle RM, Heft MW. Expression of the receptor of advanced glycation end products in gingival tissues of type 2 diabetes patients with chronic periodontal disease: a study utilizing immunohistochemistry and RT-PCR. J Clin Periodontol 2005; 32: 40-44, doi: 10.1111/j.1600-051X. 2004.00623.x.
8. Schmidt AM, Vianna M, Gerlach M, Brett J, Ryan J, Kao J, et al. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem 1992; 267: 14987-14997.
9. Schmidt AM, Yan SD, Yan SF, Stern DM. The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta 2000; 1498: 99-111, doi: 10.1016/S0167-4889(00)00087-2.
10. Chen J, Song M, Yu S, Gao P, Yu Y, Wang H, et al. Advanced glycation endproducts alter functions and promote apoptosis in endothelial progenitor cells through receptor for advanced glycation endproducts mediate overpression of cell oxidant stress. Mol Cell Biochem 2010; 335: 137-146, doi: 10.1007/s11010-009-0250-y.
11. Ding Q, Keller JN. Evaluation of rage isoforms, ligands, and signaling in the brain. Biochim Biophys Acta 2005; 1746: 18- 27, doi: 10.1016/j.bbamcr.2005.08.006.
12. Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, Schmidt AM. Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology 2005; 15: 16R-28R, doi: 10.1093/glycob/cwi053.
13. Alikhani M, Alikhani Z, Boyd C, MacLellan CM, Raptis M, Liu R, et al. Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways. Bone 2007; 40: 345-353, doi: 10.1016/ j.bone.2006.09.011.
14. Alikhani Z, Alikhani M, Boyd CM, Nagao K, Trackman PC, Graves DT. Advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways. J Biol Chem 2005; 280: 12087-12095, doi: 10.1074/jbc. M406313200.
15. Alikhani M, MacLellan CM, Raptis M, Vora S, Trackman PC, Graves DT. Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor. Am J Physiol Cell Physiol 2007; 292: C850-C856, doi: 10.1152/ajpcell. 00356.2006.
16. Ding Q, Keller JN. Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain. Neurosci Lett 2005; 373: 67-72, doi: 10.1016/j.neulet. 2004.09.059.
17. Yao D, Brownlee M. Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes 2010; 59: 249-255, doi: 10.2337/db09-0801.
18. Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005; 115: 2656-2664, doi: 10.1172/JCI26373.
19. Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 2004; 11: 381-389, doi: 10.1038/sj.cdd.4401373.
20. Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 2001; 33: 637-668, doi: 10.1016/S1357-2725(01)00046-2.
21. Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, et al. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 2000; 405: 354-360, doi: 10.1038/35012626.
22. Huttunen HJ, Fages C, Rauvala H. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem 1999; 274: 19919-19924, doi: 10.1074/jbc.274.28.19919.
23. Murillo J, Wang Y, Xu X, Klebe RJ, Chen Z, Zardeneta G, et al. Advanced glycation of type I collagen and fibronectin modifies periodontal cell behavior. J Periodontol 2008; 79: 2190-2199, doi: 10.1902/jop.2008.080210.
24. Denis U, Lecomte M, Paget C, Ruggiero D, Wiernsperger N, Lagarde M. Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction. Free Radic Biol Med 2002; 33: 236-247, doi: 10.1016/S0891-5849(02)00879-1.
25. Kim J, Kim CS, Sohn E, Lee YM, Jo K, Kim JS. KIOM-79 protects AGE-induced retinal pericyte apoptosis via inhibition of NF-kappaB activation in vitro and in vivo. PLoS One 2012; 7: e43591, doi: 10.1371/journal.pone.0043591.
26. Shi L, Yu X, Yang H, Wu X. Advanced glycation end products induce human corneal epithelial cells apoptosis through generation of reactive oxygen species and activation of JNK and p38 MAPK pathways. PLoS One 2013; 8: e66781, doi: 10.1371/journal.pone.0066781.
27. Lee JJ, Hsiao CC, Yang IH, Chou MH, Wu CL, Wei YC, et al. High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5. Mol Vis 2012; 18: 838-850.
28. Markopoulos AK, Poulopoulos AK, Kayavis I, Papanayotou P. Immunohistochemical detection of insulin-like growth factor-I in the labial salivary glands of patients with Sjogren's syndrome. Oral Dis 2000; 6: 31-34, doi: 10.1111/j.1601- 0825.2000.tb00318.x.
29. Gurgul E, Lortz S, Tiedge M, Jorns A, Lenzen S. Mitochondrial catalase overexpression protects insulinproducing cells against toxicity of reactive oxygen species and proinflammatory cytokines. Diabetes 2004; 53: 2271- 2280, doi: 10.2337/diabetes.53.9.2271.
30. Wang HQ, Quan T, He T, Franke TF, Voorhees JJ, Fisher GJ. Epidermal growth factor receptor-dependent, NFkappaB- independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes. J Biol Chem 2003; 278: 45737-45745, doi: 10.1074/jbc.M300574200.
31. Miyata T, Hori O, Zhang J, Yan SD, Ferran L, Iida Y, et al. The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis. J Clin Invest 1996; 98: 1088-1094, doi: 10.1172/JCI118889.
32. Sakaguchi T, Yan SF, Yan SD, Belov D, Rong LL, Sousa M, et al. Central role of RAGE-dependent neointimal expansion in arterial restenosis. J Clin Invest 2003; 111: 959-972, doi: 10.1172/JCI200317115.
33. Nordal RA, Wong CS. Molecular targets in radiation-induced blood-brain barrier disruption. Int J Radiat Oncol Biol Phys 2005; 62: 279-287, doi: 10.1016/j.ijrobp.2005.01.039.
34. Liang YJ, Jian JH, Liu YC, Juang SJ, Shyu KG, Lai LP, et al. Advanced glycation end products-induced apoptosis attenuated by PPARdelta activation and epigallocatechin gallate through NF-kappaB pathway in human embryonic kidney cells and human mesangial cells. Diabetes Metab Res Rev 2010; 26: 406-416, doi: 10.1002/dmrr.1100.
35. Liu R, Bal HS, Desta T, Krothapalli N, Alyassi M, Luan Q, et al. Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation. J Dent Res 2006; 85: 510-514, doi: 10.1177/154405910608500606.
36. Al-Mashat HA, Kandru S, Liu R, Behl Y, Desta T, Graves DT. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Diabetes 2006; 55: 487-495, doi: 10.2337/diabetes.55. 02.06.db05-1201.
37. Joe BH, Borke JL, Keskintepe M, Hanes PJ, Mailhot JM, Singh BB. Interleukin-1beta regulation of adhesion molecules on human gingival and periodontal ligament fibroblasts. J Periodontol 2001; 72: 865-870, doi: 10.1902/jop. 2001.72.7.865.