Unraveling tissue repair immune responses in flies

Seminars in Immunology

Volumn 26, Issue 4, 2014, Pages 310-314

  Stramer, Brian M ^a   Dionne, Marc S ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Drosophila; Wound repair

Indexed keywords

CELL ACTIVATION; CELLULAR IMMUNITY; CENTRAL NERVOUS SYSTEM; COMPLEX FORMATION; DROSOPHILA; EPIDERMIS; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFLAMMATION; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; TISSUE REPAIR; WOUND HEALING; ANIMAL; ANIMAL MODEL; DROSOPHILA MELANOGASTER; IMMUNOLOGY; PHYSIOLOGY;

ANIMALS; DROSOPHILA MELANOGASTER; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; INFLAMMATION; MODELS, ANIMAL; WOUND HEALING;

EID: 84922885848     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2014.04.004     Document Type: Review

References (53)

1. Schmalstieg F.C., Goldman A.S. Ilya Ilich Metchnikoff (1845-1915) and Paul Ehrlich (1854-1915): the centennial of the 1908 Nobel Prize in Physiology or Medicine. J Med Biogr 2008, 16:96-103.
2. Crozatier M., Meister M. Drosophila haematopoiesis. Cell Microbiol 2007, 9:1117-1126.
3. Tepass U., Fessler L.I., Aziz A., Hartenstein V. Embryonic origin of hemocytes and their relationship to cell death in Drosophila. Development 1994, 120:1829-1837.
4. Davis J., Huang C.Y., Zanet J., Harrison S., Rosten E., Cox S., et al. Emergence of embryonic pattern through contact inhibition of locomotion. Development 2012, 139:4555-4560.
5. Stramer B., Moreira S., Millard T., Evans I., Huang C.Y., Sabet O., et al. Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo. J Cell Biol 2010, 189:681-689.
6. Stramer B., Wood W., Galko M.J., Redd M.J., Jacinto A., Parkhurst S.M., et al. Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J Cell Biol 2005, 168:567-573.
7. Wood W., Faria C., Jacinto A. Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. J Cell Biol 2006, 173:405-416.
8. Moreira S., Stramer B., Evans I., Wood W., Martin P. Prioritization of competing damage and developmental signals by migrating macrophages in the Drosophila embryo. Curr Biol 2010, 20:464-470.
9. Razzell W., Evans I.R., Martin P., Wood W. Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release. Curr Biol 2013, 23:424-429.
10. Babcock D.T., Brock A.R., Fish G.S., Wang Y., Perrin L., Krasnow M.A., et al. Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae. Proc Natl Acad Sci U S A 2008, 105:10017-10022.
11. Pastor-Pareja J.C., Wu M., Xu T. An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis Model Mech 2008, 1:144-154. [discussion 153].
12. Moreira C.G., Jacinto A., Prag S. Drosophila integrin adhesion complexes are essential for hemocyte migration in vivo. Biol Open 2013, 2:795-801.
13. Moreira C.G., Regan J.C., Zaidman-Remy A., Jacinto A., Prag S. Drosophila hemocyte migration: an in vivo assay for directional cell migration. Methods Mol Biol 2011, 769:249-260.
14. Regan J.C., Brandao A.S., Leitao A.B., Mantas Dias A.R., Sucena E., Jacinto A., et al. Steroid hormone signaling is essential to regulate innate immune cells and fight bacterial infection in Drosophila. PLoS Pathog 2013, 9:e1003720.
15. Goulding N.J. The molecular complexity of glucocorticoid actions in inflammation - a four-ring circus. Curr Opin Pharmacol 2004, 4:629-636.
16. Routley C.E., Ashcroft G.S. Effect of estrogen and progesterone on macrophage activation during wound healing. Wound Repair Regen 2009, 17:42-50.
17. Martin P., D'Souza D., Martin J., Grose R., Cooper L., Maki R., et al. Wound healing in the PU.1 null mouse - tissue repair is not dependent on inflammatory cells. Curr Biol 2003, 13:1122-1128.
18. Katsuyama T., Paro R. Innate immune cells are dispensable for regenerative growth of imaginal discs. Mech Dev 2013, 130:112-121.
19. Chen G.Y., Nunez G. Sterile inflammation: sensing and reacting to damage. Nat Rev 2010, 10:826-837.
20. Matzinger P. The danger model: a renewed sense of self. Science 2002, 296:301-305.
21. Niethammer P., Grabher C., Look A.T., Mitchison T.J. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 2009, 459:996-999.
22. Rigutto S., Hoste C., Grasberger H., Milenkovic M., Communi D., Dumont J.E., et al. Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation. J Biol Chem 2009, 284:6725-6734.
23. Buckley C.D., Gilroy D.W., Serhan C.N., Stockinger B., Tak P.P. The resolution of inflammation. Nat Rev 2013, 13:59-66.
24. Aldskogius H., Kozlova E.N. Central neuron-glial and glial-glial interactions following axon injury. Prog Neurobiol 1998, 55:1-26.
25. Sofroniew M.V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 2009, 32:638-647.
26. Perry V.H., Nicoll J.A., Holmes C. Microglia in neurodegenerative disease. Nat Rev 2010, 6:193-201.
27. Loane D.J., Byrnes K.R. Role of microglia in neurotrauma. Neurotherapeutics 2010, 7:366-377.
28. Freeman M.R., Doherty J. Glial cell biology in Drosophila and vertebrates. Trends Neurosci 2006, 29:82-90.
29. MacDonald J.M., Beach M.G., Porpiglia E., Sheehan A.E., Watts R.J., Freeman M.R. The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron 2006, 50:869-881.
30. Doherty J., Logan M.A., Tasdemir O.E., Freeman M.R. Ensheathing glia function as phagocytes in the adult Drosophila brain. J Neurosci 2009, 29:4768-4781.
31. Ziegenfuss J.S., Biswas R., Avery M.A., Hong K., Sheehan A.E., Yeung Y.G., et al. Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Nature 2008, 453:935-939.
32. Ziegenfuss J.S., Doherty J., Freeman M.R. Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. Nat Neurosci 2012, 15:979-987.
33. Underhill D.M., Goodridge H.S. The many faces of ITAMs. Trends Immunol 2007, 28:66-73.
34. Logan M.A., Hackett R., Doherty J., Sheehan A., Speese S.D., Freeman M.R. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. Nat Neurosci 2012, 15:722-730.
35. Macdonald J.M., Doherty J., Hackett R., Freeman M.R. The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function. Cell Death Differ 2013, 20:1140-1148.
36. Schafer M., Werner S. Transcriptional control of wound repair. Annu Rev Cell Dev Biol 2007, 23:69-92.
37. Martin P., Nobes C.D. An early molecular component of the wound healing response in rat embryos - induction of c-fos protein in cells at the epidermal wound margin. Mech Dev 1992, 38:209-215.
38. Schilmiller A.L., Howe G.A. Systemic signaling in the wound response. Curr Opin Plant Biol 2005, 8:369-377.
39. Lowry S.F., Calvano S.E. Challenges for modeling and interpreting the complex biology of severe injury and inflammation. J Leuk Biol 2008, 83:553-557.
40. Foex B.A. Systemic responses to trauma. Br Med Bull 1999, 55:726-743.
41. Markus R., Kurucz E., Rus F., Ando I. Sterile wounding is a minimal and sufficient trigger for a cellular immune response in Drosophila melanogaster. Immunol Lett 2005, 101:108-111.
42. Sinenko S.A., Shim J., Banerjee U. Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila. EMBO Rep 2012, 13:83-89.
43. Nam H.J., Jang I.H., You H., Lee K.A., Lee W.J. Genetic evidence of a redox-dependent systemic wound response via Hayan protease-phenoloxidase system in Drosophila. EMBO J 2012, 31:1253-1265.
44. Samakovlis C., Kimbrell D.A., Kylsten P., Engstrom A., Hultmark D. The immune response in Drosophila: pattern of cecropin expression and biological activity. EMBO J 1990, 9:2969-2976.
45. Tingvall T.O., Roos E., Engstrom Y. The GATA factor Serpent is required for the onset of the humoral immune response in Drosophila embryos. Proc Natl Acad Sci U S A 2001, 98:3884-3888.
46. Tzou P., Ohresser S., Ferrandon D., Capovilla M., Reichhart J.M., Lemaitre B., et al. Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 2000, 13:737-748.
47. Onfelt Tingvall T., Roos E., Engstrom Y. The imd gene is required for local Cecropin expression in Drosophila barrier epithelia. EMBO Rep 2001, 2:239-243.
48. Clark R.I., Woodcock K.J., Geissmann F., Trouillet C., Dionne M.S. Multiple TGF-beta superfamily signals modulate the adult Drosophila immune response. Curr Biol 2011, 21:1672-1677.
49. Lemaitre B., Reichhart J.M., Hoffmann J.A. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci U S A 1997, 94:14614-14619.
50. Stramer B., Winfield M., Shaw T., Millard T.H., Woolner S., Martin P. Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos. EMBO Rep 2008, 9:465-471.
51. Takeishi A., Kuranaga E., Tonoki A., Misaki K., Yonemura S., Kanuka H., et al. Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila. Cell Rep 2013, 3:919-930.
52. Kulkarni A.B., Huh C.G., Becker D., Geiser A., Lyght M., Flanders K.C., et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A 1993, 90:770-774.
53. Shull M.M., Ormsby I., Kier A.B., Pawlowski S., Diebold R.J., Yin M., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992, 359:693-699.