메뉴 건너뛰기




Volumn 15, Issue 7, 2012, Pages 979-987

Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy

Author keywords

[No Author keywords available]

Indexed keywords

CRK MBC DCED 12 COMPLEX PROTEIN; DROSOPHILA PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAC1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84862839308     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3135     Document Type: Article
Times cited : (64)

References (45)
  • 1
    • 0031690332 scopus 로고    scopus 로고
    • The origin and differentiation of microglial cells during development
    • DOI 10.1016/S0301-0082(98)00035-5, PII S0301008298000355
    • Cuadros, M.A. & Navascues, J. The origin and differentiation of microglial cells during development. Prog. Neurobiol. 56, 173-189 (1998). (Pubitemid 28432564)
    • (1998) Progress in Neurobiology , vol.56 , Issue.2 , pp. 173-189
    • Cuadros, M.A.1    Navascues, J.2
  • 2
    • 0344172793 scopus 로고    scopus 로고
    • Naturally occurring cell death and migration of microglial precursors in the quail retina during normal development
    • DOI 10.1002/(SICI)1096-9861(19990920)412:2<255::AID-CNE6>3.0.CO;2-H
    • Marín-Teva, J.L., Cuadros, M.A., Calvente, R., Almendros, A. & Navascues, J. Naturally occurring cell death and migration of microglial precursors in the quail retina during normal development. J. Comp. Neurol. 412, 255-275 (1999). (Pubitemid 29395364)
    • (1999) Journal of Comparative Neurology , vol.412 , Issue.2 , pp. 255-275
    • Marin-Teva, J.L.1    Cuadros, M.A.2    Calvente, R.3    Almendros, A.4    Navascues, J.5
  • 3
    • 0034644114 scopus 로고    scopus 로고
    • Differences between the clearance of apoptotic cells by professional and non-professional phagocytes
    • DOI 10.1016/S0960-9822(00)00598-4
    • Parnaik, R., Raff, M.C. & Scholes, J. Differences between the clearance of apoptotic cells by professional and non-professional phagocytes. Curr. Biol. 10, 857-860 (2000). (Pubitemid 30597206)
    • (2000) Current Biology , vol.10 , Issue.14 , pp. 857-860
    • Parnaik, R.1    Raff, M.C.2    Scholes, J.3
  • 4
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • DOI 10.1038/nrn2038, PII NRN2038
    • Block, M.L., Zecca, L. & Hong, J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69 (2007). (Pubitemid 46011999)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.1 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.-S.3
  • 5
    • 70449678738 scopus 로고    scopus 로고
    • Molecular dissection of reactive astrogliosis and glial scar formation
    • Sofroniew, M.V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 32, 638-647 (2009).
    • (2009) Trends Neurosci. , vol.32 , pp. 638-647
    • Sofroniew, M.V.1
  • 6
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: Clearance of apoptotic cells regulates immune responses
    • DOI 10.1038/nri957
    • Savill, J., Dransfield, I., Gregory, C. & Haslett, C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat. Rev. Immunol. 2, 965-975 (2002). (Pubitemid 37323217)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.12 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 7
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: An essential link between degeneration and regeneration
    • Neumann, H., Kotter, M.R. & Franklin, R.J. Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132, 288-295 (2009).
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.3
  • 8
    • 33847785649 scopus 로고    scopus 로고
    • Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    • DOI 10.1523/JNEUROSCI.5360-06.2007
    • Lalancette-Hébert, M., Gowing, G., Simard, A., Weng, Y.C. & Kriz, J. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J. Neurosci. 27, 2596-2605 (2007). (Pubitemid 46393607)
    • (2007) Journal of Neuroscience , vol.27 , Issue.10 , pp. 2596-2605
    • Lalancette-Hebert, M.1    Gowing, G.2    Simard, A.3    Yuan, C.W.4    Kriz, J.5
  • 9
    • 69349095671 scopus 로고    scopus 로고
    • Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris
    • Fuentes-Medel, Y. et al. Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris. PLoS Biol. 7, e1000184 (2009).
    • (2009) PLoS Biol. , vol.7
    • Fuentes-Medel, Y.1
  • 10
    • 34548314557 scopus 로고    scopus 로고
    • The scoop on the fly brain: Glial engulfment functions in Drosophila
    • DOI 10.1017/S1740925X0700049X, PII S1740925X0700049X
    • Logan, M.A. & Freeman, M.R. The scoop on the fly brain: glial engulfment functions in Drosophila. Neuron Glia Biol. 3, 63-74 (2007). (Pubitemid 47345536)
    • (2007) Neuron Glia Biology , vol.3 , Issue.1 , pp. 63-74
    • Logan, M.A.1    Freeman, M.R.2
  • 11
    • 23244436227 scopus 로고    scopus 로고
    • Axon retraction and degeneration in development and disease
    • DOI 10.1146/annurev.neuro.28.061604.135632
    • Luo, L. & O'Leary, D.D. Axon retraction and degeneration in development and disease. Annu. Rev. Neurosci. 28, 127-156 (2005). (Pubitemid 41098902)
    • (2005) Annual Review of Neuroscience , vol.28 , pp. 127-156
    • Luo, L.1    O'Leary, D.D.M.2
  • 12
    • 34447550617 scopus 로고    scopus 로고
    • Journey to the grave: Signaling events regulating removal of apoptotic cells
    • DOI 10.1242/jcs.03463
    • Kinchen, J.M. & Ravichandran, K.S. Journey to the grave: signaling events regulating removal of apoptotic cells. J. Cell Sci. 120, 2143-2149 (2007). (Pubitemid 47074120)
    • (2007) Journal of Cell Science , vol.120 , Issue.13 , pp. 2143-2149
    • Kinchen, J.M.1    Ravichandran, K.S.2
  • 13
    • 8444252166 scopus 로고    scopus 로고
    • The engulfment process of programmed cell death in Caenorhabditis elegans
    • DOI 10.1146/annurev.cellbio.20.022003.114619
    • Reddien, P.W. & Horvitz, H.R. The engulfment process of programmed cell death in Caenorhabditis elegans. Annu. Rev. Cell Dev. Biol. 20, 193-221 (2004). (Pubitemid 39488637)
    • (2004) Annual Review of Cell and Developmental Biology , vol.20 , pp. 193-221
    • Reddien, P.W.1    Horvitz, H.R.2
  • 15
    • 0035487646 scopus 로고    scopus 로고
    • The C. elegans PH Domain Protein CED-12 Regulates Cytoskeletal Reorganization via a Rho/Rac GTPase Signaling Pathway
    • DOI 10.1016/S1534-5807(01)00058-2, PII S1534580701000582
    • Zhou, Z., Caron, E., Hartwieg, E., Hall, A. & Horvitz, H.R. The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. Dev. Cell 1, 477-489 (2001). (Pubitemid 33586100)
    • (2001) Developmental Cell , vol.1 , Issue.4 , pp. 477-489
    • Zhou, Z.1    Caron, E.2    Hartwieg, E.3    Hall, A.4    Horvitz, H.R.5
  • 16
    • 0036045768 scopus 로고    scopus 로고
    • Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
    • Brugnera, E. et al. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat. Cell Biol. 4, 574-582 (2002).
    • (2002) Nat. Cell Biol. , vol.4 , pp. 574-582
    • Brugnera, E.1
  • 18
    • 0035846903 scopus 로고    scopus 로고
    • CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans
    • DOI 10.1016/S0092-8674(01)00190-8
    • Zhou, Z., Hartwieg, E. & Horvitz, H.R. CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans. Cell 104, 43-56 (2001). (Pubitemid 32144971)
    • (2001) Cell , vol.104 , Issue.1 , pp. 43-56
    • Zhou, Z.1    Hartwieg, E.2    Horvitz H.Robert3
  • 19
    • 41749109981 scopus 로고    scopus 로고
    • Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells
    • Yu, X., Lu, N. & Zhou, Z. Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells. PLoS Biol. 6, e61 (2008).
    • (2008) PLoS Biol. , vol.6
    • Yu, X.1    Lu, N.2    Zhou, Z.3
  • 20
    • 0032511234 scopus 로고    scopus 로고
    • Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans
    • DOI 10.1016/S0092-8674(00)81202-7
    • Liu, Q.A. & Hengartner, M.O. Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans. Cell 93, 961-972 (1998). (Pubitemid 28280790)
    • (1998) Cell , vol.93 , Issue.6 , pp. 961-972
    • Liu, Q.A.1    Hengartner, M.O.2
  • 21
    • 0038012647 scopus 로고    scopus 로고
    • Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function
    • DOI 10.1016/S0896-6273(03)00289-7
    • Freeman, M.R., Delrow, J., Kim, J., Johnson, E. & Doe, C.Q. Unwrapping glial biology. Gcm target genes regulating glial development, diversification, and function. Neuron 38, 567-580 (2003). (Pubitemid 36645032)
    • (2003) Neuron , vol.38 , Issue.4 , pp. 567-580
    • Freeman, M.R.1    Delrow, J.2    Kim, J.3    Johnson, E.4    Doe, C.Q.5
  • 22
    • 33744947548 scopus 로고    scopus 로고
    • Essential Role of the Apoptotic Cell Engulfment Genes draper and ced-6 in Programmed Axon Pruning during Drosophila Metamorphosis
    • DOI 10.1016/j.neuron.2006.04.027, PII S0896627306003187
    • Awasaki, T. et al. Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis. Neuron 50, 855-867 (2006). (Pubitemid 43850685)
    • (2006) Neuron , vol.50 , Issue.6 , pp. 855-867
    • Awasaki, T.1    Tatsumi, R.2    Takahashi, K.3    Arai, K.4    Nakanishi, Y.5    Ueda, R.6    Ito, K.7
  • 23
    • 33744922406 scopus 로고    scopus 로고
    • s Protection Distinguishes Axon Degeneration following Injury from Naturally Occurring Developmental Pruning
    • DOI 10.1016/j.neuron.2006.05.013, PII S0896627306003801
    • Hoopfer, E.D. et al. Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron 50, 883-895 (2006). (Pubitemid 43850690)
    • (2006) Neuron , vol.50 , Issue.6 , pp. 883-895
    • Hoopfer, E.D.1    McLaughlin, T.2    Watts, R.J.3    Schuldiner, O.4    O'Leary, D.D.M.5    Luo, L.6
  • 24
    • 33749000311 scopus 로고    scopus 로고
    • Local caspase activity directs engulfment of dendrites during pruning
    • DOI 10.1038/nn1774, PII NN1774
    • Williams, D.W., Kondo, S., Krzyzanowska, A., Hiromi, Y. & Truman, J.W. Local caspase activity directs engulfment of dendrites during pruning. Nat. Neurosci. 9, 1234-1236 (2006). (Pubitemid 44454262)
    • (2006) Nature Neuroscience , vol.9 , Issue.10 , pp. 1234-1236
    • Williams, D.W.1    Kondo, S.2    Krzyzanowska, A.3    Hiromi, Y.4    Truman, J.W.5
  • 25
    • 33744926927 scopus 로고    scopus 로고
    • The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons
    • DOI 10.1016/j.neuron.2006.04.028, PII S0896627306003199
    • MacDonald, J.M. et al. The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron 50, 869-881 (2006). (Pubitemid 43850686)
    • (2006) Neuron , vol.50 , Issue.6 , pp. 869-881
    • MacDonald, J.M.1    Beach, M.G.2    Porpiglia, E.3    Sheehan, A.E.4    Watts, R.J.5    Freeman, M.R.6
  • 26
    • 65549154978 scopus 로고    scopus 로고
    • Ensheathing glia function as phagocytes in the adult Drosophila brain
    • Doherty, J., Logan, M.A., Tasdemir, O.E. & Freeman, M.R. Ensheathing glia function as phagocytes in the adult Drosophila brain. J. Neurosci. 29, 4768-4781 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 4768-4781
    • Doherty, J.1    Logan, M.A.2    Tasdemir, O.E.3    Freeman, M.R.4
  • 28
    • 70549113177 scopus 로고    scopus 로고
    • Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor
    • Wu, H.H. et al. Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Nat. Neurosci. 12, 1534-1541 (2009).
    • (2009) Nat. Neurosci. , vol.12 , pp. 1534-1541
    • Wu, H.H.1
  • 31
    • 0033771902 scopus 로고    scopus 로고
    • CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
    • Reddien, P.W. & Horvitz, H.R. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat. Cell Biol. 2, 131-136 (2000).
    • (2000) Nat. Cell Biol. , vol.2 , pp. 131-136
    • Reddien, P.W.1    Horvitz, H.R.2
  • 32
    • 0035487807 scopus 로고    scopus 로고
    • C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment
    • Wu, Y.C., Tsai, M.C., Cheng, L.C., Chou, C.J. & Weng, N.Y. C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. Dev. Cell 1, 491-502 (2001).
    • (2001) Dev. Cell , vol.1 , pp. 491-502
    • Wu, Y.C.1    Tsai, M.C.2    Cheng, L.C.3    Chou, C.J.4    Weng, N.Y.5
  • 33
    • 84860312823 scopus 로고    scopus 로고
    • Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury
    • Logan, M.A. et al. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. Nat. Neurosci. 15, 722-730 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 722-730
    • Logan, M.A.1
  • 35
    • 77649151901 scopus 로고    scopus 로고
    • The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac
    • Cabello, J. et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 8, e1000297 (2010).
    • (2010) PLoS Biol. , vol.8
    • Cabello, J.1
  • 36
    • 0031172081 scopus 로고    scopus 로고
    • Astrocytes and microglial cells incorporate degenerating fibers following entorhinal lesion: A light, confocal, and electron microscopical study using a phagocytosis-dependent labeling technique
    • DOI 10.1002/(SICI)1098-1136(199706)20:2<145::AID-GLIA6>3.0.CO;2-8
    • Bechmann, I. & Nitsch, R. Astrocytes and microglial cells incorporate degenerating fibers following entorhinal lesion: a light, confocal, and electron microscopical study using a phagocytosis-dependent labeling technique. Glia 20, 145-154 (1997). (Pubitemid 27253207)
    • (1997) GLIA , vol.20 , Issue.2 , pp. 145-154
    • Bechmann, I.1    Nitsch, R.2
  • 37
    • 0023620656 scopus 로고
    • Deafferentation-induced alterations in the rat dorsal horn: I. Comparison of peripheral nerve injury vs. rhizotomy effects on presynaptic, postsynaptic and glial processes
    • Kapadia, S.E. & LaMotte, C.C. Deafferentation-induced alterations in the rat dorsal horn: I. Comparison of peripheral nerve injury vs. rhizotomy effects on presynaptic, postsynaptic, and glial processes. J. Comp. Neurol. 266, 183-197 (1987). (Pubitemid 18021934)
    • (1987) Journal of Comparative Neurology , vol.266 , Issue.2 , pp. 183-197
    • Kapadia, S.E.1    LaMotte, C.C.2
  • 38
    • 0023610946 scopus 로고
    • Deafferentation-induced alterations in the rat dorsal horn: II. Effects of selective poisoning by pronase of the central processes of a peripheral nerve
    • LaMotte, C.C. & Kapadia, S.E. Deafferentation-induced alterations in the rat dorsal horn: II. Effects of selective poisoning by pronase of the central processes of a peripheral nerve. J. Comp. Neurol. 266, 198-208 (1987). (Pubitemid 18021935)
    • (1987) Journal of Comparative Neurology , vol.266 , Issue.2 , pp. 198-208
    • LaMotte, C.C.1    Kapadia, S.E.2
  • 39
    • 2342647947 scopus 로고    scopus 로고
    • Diverse Microglial Motility Behaviors during Clearance of Dead Cells in Hippocampal Slices
    • DOI 10.1002/glia.10362
    • Petersen, M.A. & Dailey, M.E. Diverse microglial motility behaviors during clearance of dead cells in hippocampal slices. Glia 46, 195-206 (2004). (Pubitemid 38596184)
    • (2004) GLIA , vol.46 , Issue.2 , pp. 195-206
    • Petersen, M.A.1    Dailey, M.E.2
  • 40
    • 0031778574 scopus 로고    scopus 로고
    • Central neuron-glial and glial-glial interactions following axon injury
    • DOI 10.1016/S0301-0082(97)00093-2, PII S0301008297000932
    • Aldskogius, H. & Kozlova, E.N. Central neuron-glial and glial-glial interactions following axon injury. Prog. Neurobiol. 55, 1-26 (1998). (Pubitemid 28231100)
    • (1998) Progress in Neurobiology , vol.55 , Issue.1 , pp. 1-26
    • Aldskogius, H.1    Kozlova, E.N.2
  • 41
    • 0034523577 scopus 로고    scopus 로고
    • Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment
    • DOI 10.1016/S0896-6273(00)00154-9
    • Leiserson, W.M., Harkins, E.W. & Keshishian, H. Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment. Neuron 28, 793-806 (2000). (Pubitemid 32038072)
    • (2000) Neuron , vol.28 , Issue.3 , pp. 793-806
    • Leiserson, W.M.1    Harkins, E.W.2    Keshishian, H.3
  • 42
    • 0029011452 scopus 로고
    • Distribution classification and development of Drosophila glial cells in the late embryonic and early larval ventral nerve cord
    • Ito, K., Urban, J. & Technau, G.M. Distribution, classification and development of Drosophila glial cells in the late embryonic and early larval ventral nerve cord. Rouxs Arch. Dev. Biol. 209, 289-307 (1995).
    • (1995) Rouxs Arch. Dev. Biol. , vol.209 , pp. 289-307
    • Ito, K.1    Urban, J.2    Technau, G.M.3
  • 44
    • 79959348596 scopus 로고    scopus 로고
    • Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila
    • Han, C., Jan, L.Y. & Jan, Y.N. Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. Proc. Natl. Acad. Sci. USA 108, 9673-9678 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 9673-9678
    • Han, C.1    Jan, L.Y.2    Jan, Y.N.3
  • 45
    • 8144231056 scopus 로고    scopus 로고
    • PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis
    • DOI 10.1038/sj.emboj.7600417
    • Ishimaru, S., Ueda, R., Hinohara, Y., Ohtani, M. & Hanafusa, H. PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis. EMBO J. 23, 3984-3994 (2004). (Pubitemid 39472420)
    • (2004) EMBO Journal , vol.23 , Issue.20 , pp. 3984-3994
    • Ishimaru, S.1    Ueda, R.2    Hinohara, Y.3    Ohtani, M.4    Hanafusa, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.