Dietary saturated lipids in alcoholic liver disease: New microbiota-targeting bullets?

Gastroenterology

Volumn 148, Issue 1, 2015, Pages 16-19

  Tilg, Herbert ^a   Gao, Bin ^b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; HEPTADECANOIC ACID; LONG CHAIN FATTY ACID; OLEIC ACID; PALMITIC ACID; PALMITOLEIC ACID; PENTADECANOIC ACID; POLYUNSATURATED FATTY ACID; PROBIOTIC AGENT; SATURATED FATTY ACID; STEARIC ACID; UNCLASSIFIED DRUG; FATTY ACID;

ALCOHOL CONSUMPTION; ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; BACTERIAL OVERGROWTH; BACTERIAL TRANSLOCATION; BACTEROIDETES; CELL JUNCTION; CHRONIC LIVER DISEASE; COLON MUCOSA; COMMENSALISM; DIET SUPPLEMENTATION; DIETARY INTAKE; DYSBIOSIS; EDITORIAL; FATTY ACID SYNTHESIS; FIRMICUTES; GENE EXPRESSION; HIGH THROUGHPUT SEQUENCING; HUMAN; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; LACTOBACILLUS; LACTOBACILLUS RHAMMOSUS; LIPID DIET; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; MICROBIOME; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA GENE; SUGAR INTAKE; VERRUCOMICROBIA; WESTERN DIET; ANIMAL; BACTERIA; INTESTINE; LIVER DISEASES, ALCOHOLIC; MALE; METABOLISM; MICROBIOLOGY;

ANIMALS; BACTERIA; DIETARY SUPPLEMENTS; ETHANOL; FATTY ACIDS; INTESTINES; LIVER DISEASES, ALCOHOLIC; MALE;

EID: 84922879211     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.11.023     Document Type: Editorial

References (26)

1. C. Owyang, and G.D. Wu The gut microbiome in health and disease Gastroenterology 146 2014 1433 1436
2. B. Schnabl, and D.A. Brenner Interactions between the intestinal microbiome and liver diseases Gastroenterology 146 2014 1513 1524
3. T. Uesugi, M. Froh, and G.E. Arteel Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice Hepatology 34 2001 101 108
4. B. Gao, and R. Bataller Alcoholic liver disease: pathogenesis and new therapeutic targets Gastroenterology 141 2011 1572 1585
5. A.W. Yan, D.E. Fouts, and J. Brandl Enteric dysbiosis associated with a mouse model of alcoholic liver disease Hepatology 53 2011 96 105
6. S. Tuomisto, T. Pessi, and P. Collin Changes in gut bacterial populations and their translocation into liver and ascites in alcoholic liver cirrhotics BMC Gastroenterol 14 2014 40
7. C.B. Forsyth, A. Farhadi, and S.M. Jakate Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis Alcohol 43 2009 163 172
8. Y. Wang, I. Kirpich, and Y. Liu Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury Am J Pathol 179 2011 2866 2875
9. P. Chen, M. Torralba, and J. Tan Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice Gastroenterology 148 2015 203 214
10. H. Tilg, and A.M. Diehl Cytokines in alcoholic and nonalcoholic steatohepatitis N Engl J Med 343 2000 1467 1476
11. M. Fujimoto, M. Uemura, and Y. Nakatani Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance Alcohol Clin Exp Res 24 2000 48S 54S
12. A.K. Singal, P.S. Kamath, and G.J. Gores Alcoholic hepatitis: current challenges and future directions Clin Gastroenterol Hepatol 12 2014 555 564
13. S. Basuroy, P. Sheth, and C.M. Mansbach Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine Am J Physiol Gastrointest Liver Physiol 289 2005 G367 G375
14. E. Mutlu, A. Keshavarzian, and P. Engen Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats Alcohol Clin Exp Res 33 2009 1836 1846
15. L.G. Albenberg, and G.D. Wu Diet and the intestinal microbiome: associations, functions, and implications for health and disease Gastroenterology 146 2014 1564 1572
16. L.A. David, C.F. Maurice, and R.N. Carmody Diet rapidly and reproducibly alters the human gut microbiome Nature 505 2014 559 563
17. Z.W. Wu, H.F. Lu, and J. Wu Assessment of the fecal lactobacilli population in patients with hepatitis B virus-related decompensated cirrhosis and hepatitis B cirrhosis treated with liver transplant Microb Ecol 63 2012 929 937
18. D. Ristic-Medic, M. Takic, and V. Vucic Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study J Clin Biochem Nutr 53 2013 49 54
19. E.O. Petrof, K. Kojima, and M.J. Ropeleski Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition Gastroenterology 127 2004 1474 1487
20. V. Stadlbauer, R.P. Mookerjee, and S. Hodges Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis J Hepatol 48 2008 945 9451
21. H. Sokol, B. Pigneur, and L. Watterlot Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients Proc Natl Acad Sci U S A 105 2008 16731 16736
22. A.A. Nanji, S.M. Sadrzadeh, and E.K. Yang Dietary saturated fatty acids: a novel treatment for alcoholic liver disease Gastroenterology 109 1995 547 554
23. M. You, R.V. Considine, and T.C. Leone Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice Hepatology 42 2005 568 577
24. A.K. Leamy, R.A. Egnatchik, and J.D. Young Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease Prog Lipid Res 52 2013 165 174
25. Y. Chen, F. Yang, and H. Lu Characterization of fecal microbial communities in patients with liver cirrhosis Hepatology 54 2011 562 572
26. L. Zhu, S.S. Baker, and C. Gill Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH Hepatology 57 2013 601 609