Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model

Neurobiology of Aging

Volumn 36, Issue 2, 2015, Pages 710-719

  Schmöle, Anne Caroline ^a,b   Lundt, Ramona ^a   Ternes, Svenja ^a   Albayram, Önder ^a   Ulas, Thomas ^a   Schultze, Joachim L ^a   Bano, Daniele ^b   Nicotera, Pierluigi ^b   Alferink, Judith ^a,c,d   Zimmer, Andreas ^a  

^a UNIVERSITY OF BONN   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d CiM   (Germany)

Author keywords

Alzheimer's disease; CB2; CCL2; Endocannabinoid system; Microglia; Neuroinflammation

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CANNABINOID 2 RECEPTOR; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; AMYLOID BETA PROTEIN; AUTACOID; CHEMOKINE; CNR2 PROTEIN, MOUSE; CYTOKINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL INVASION; CONTROLLED STUDY; CYTOKINE RELEASE; GLIOSIS; IN VITRO STUDY; IN VIVO STUDY; MICROGLIA; MOLECULAR PATHOLOGY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEWBORN; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; SPATIAL LEARNING; SPATIAL MEMORY; ANIMAL; BRAIN; CELL CULTURE; COGNITION; DEFICIENCY; DISEASE COURSE; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; PSYCHOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINES; COGNITION; CYTOKINES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; INFLAMMATION MEDIATORS; MICE, TRANSGENIC; MICROGLIA; RECEPTOR, CANNABINOID, CB2;

EID: 84922843126     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.09.019     Document Type: Article

References (22)

1. Aso E., Juvés S., Maldonado R., Ferrer I. CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AβPP/PS1 mice. J.Alzheimers Dis. 2013, 35:847-858.
2. Benito C., Kim W.K., Kim W.K., Chavarría I., Hillard C.J., Mackie K., Tolón R.M., Williams K., Romero J. Aglial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis. J.Neurosci. 2005, 25:2530-2536.
3. Benito C., Tolo R.M., Carrier E.J., Ra A., Hillard C.J. Cannabinoid CB 2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. Neurology 2003, 23:11136-11141.
4. Benito C., Tolón R.M., Pazos M.R., Núñez E., Castillo A.I., Romero J. Cannabinoid CB2 receptors in human brain inflammation. Br. J. Pharmacol. 2008, 153:277-285.
5. Bolmont T., Haiss F., Eicke D., Radde R., Mathis C.A., Klunk W.E., Kohsaka S., Jucker M., Calhoun M.E. Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J.Neurosci. 2008, 28:4283-4292.
6. Buckley N.E., McCoy K.L., Mezey E., Bonner T., Zimmer A., Felder C.C., Glass M. Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. Eur. J. Pharmacol. 2000, 396:141-149.
7. Chen R., Zhang J., Fan N., Teng Z.Q., Wu Y., Yang H., Tang Y.P., Sun H., Song Y., Chen C. δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell 2013, 155:1154-1165.
8. Ehrhart J., Obregon D., Mori T., Hou H., Sun N., Bai Y., Klein T., Fernandez F., Tan J., Shytle R.D. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J.Neuroinflammation 2005, 2:29.
9. Gordon M.N., King D.L., Diamond D.M., Jantzen P.T., Boyett K.V., Hope C.E., Hatcher J.M., DiCarlo G., Gottschall W.P., Morgan D., Arendash G.W. Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice. Neurobiol. Aging 2001, 22:377-385.
10. Heneka M.T., O'Banion M.K., Terwel D., Kummer M.P. Neuroinflammatory processes in Alzheimer's disease. J.Neural Transm. 2010, 117:919-947.
11. Kiyota T., Gendelman H.E., Weir R.A., Higgins E.E., Zhang G., Jain M. CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease. Neurobiol. Aging 2013, 34:1060-1068.
12. 2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. Mol. Med. 2013, 19:357-364.
13. Lee M.K., Borchelt D.R., Kim G., Thinakaran G., Slunt H.H., Ratovitski T., Martin L.J., Kittur A., Gandy S., Levey A.I., Jenkins N., Copeland N., Price D.L., Sisodia S.S. Hyperaccumulation of FAD-linked presenilin 1 variants invivo. Nat. Med. 1997, 3:756-760.
14. Martín-Moreno A.M., Brera B., Spuch C., Carro E., García-García L., Delgado M., Pozo M.A., Innamorato N.G., Cuadrado A., de Ceballos M.L., de Ceballos M.L. Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice. J.Neuroinflamm. 2012, 9:8.
15. Martín-Moreno A.M., Reigada D., Ramírez G., Mechoulam R., Innamorato N., Cuadrado A., de Ceballos M.L. Cannabidiol and other cannabinoids reduce microglial activation invitro and invivo: relevance to Alzheimer's disease. Mol. Pharmacol. 2011, 79:964-973.
16. Michelucci A., Heurtaux T., Grandbarbe L., Morga E., Heuschling P. Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: effects of oligomeric and fibrillar amyloid-beta. J.Neuroimmunol. 2009, 210:3-12.
17. Murray P.J., Allen J.E., Biswas S.K., Fisher E.A., Gilroy D.W., Goerdt S., Gordon S., Hamilton J.A., Ivashkiv L.B., Lawrence T., Locati M., Mantovani A., Martinez F.O., Mege J.-L., Mosser D.M., Natoli G., Saeji J.P., Schultze J.L., Shirey K.A., Sica A., Suttles J., Udalova I., vanGinderachter J.A., Vogel S.N., Wynn T.A. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 2014, 41:14-20.
18. Pacher P., Mechoulam R. Is lipid signaling through cannabinoid 2 receptors part of a protective system?. Prog. Lipid Res. 2011, 50:193-211.
19. Ramírez B.G., Blázquez C., Gómez del Pulgar T., Guzmán M., de Ceballos M.L. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J.Neurosci. 2005, 25:1904-1913.
20. Saura J., Tusell J.M., Serratosa J. High-yield isolation of murine microglia by mild trypsinization. Glia 2003, 44:183-189.
21. Shi C., Pamer E.G. Monocyte recruitment during infection and inflammation. Nat. Rev. Immunol. 2011, 11:762-774.
22. Wu J., Bie B., Yang H., Xu J.J., Brown D.L., Naguib M. Activation of the CB2 receptor system reverses amyloid-induced memory deficiency. Neurobiol. Aging 2013, 34:791-804.