Cross-talk between endoplasmic reticulum (ER) stress and the MEK/ERK pathway potentiates apoptosis in human triple negative breast carcinoma cells: Role of a dihydropyrimidone, nifetepimine

Journal of Biological Chemistry

Volumn 290, Issue 7, 2015, Pages 3936-3949

  Ghosh, Swatilekha ^a   Adhikary, Arghya ^a,d   Chakraborty, Supriya ^a   Bhattacharjee, Pushpak ^a   Mazumder, Minakshi ^a   Putatunda, Salil ^b   Gorain, Mahadeo ^c   Chakraborty, Arijit ^b   Kundu, Gopal C ^c   Das, Tanya ^a   Sen, Parimal C ^a  

^a BOSE INSTITUTE   (India)

^b MAULANA AZAD COLLEGE   (India)

^c NATIONAL CENTRE FOR CELL SCIENCE   (India)

^d UNIVERSITY OF CALCUTTA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELL DEATH; DISEASES;

ANTI-CANCER AGENTS; BREAST CARCINOMA CELLS; ENDOPLASMIC RETICULUM STRESS; ER STRESS; MOLECULAR TARGETS; TRIPLE NEGATIVE; TRIPLE-NEGATIVE BREAST CANCERS;

CROSSTALK;

ANTINEOPLASTIC AGENT; CALCIUM; CASPASE; GLUCOSE REGULATED PROTEIN 78; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NIFETEPIMINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR II I; UNCLASSIFIED DRUG; ETHYL 4-(3-NITRO)-PHENYL-6-METHYL-2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE; HEAT SHOCK PROTEIN; MAPK1 PROTEIN, HUMAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MOLECULAR CHAPERONE GRP78; PYRIMIDINONE DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CALCIUM CELL LEVEL; CANCER INHIBITION; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRIPLE NEGATIVE BREAST CANCER; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; ENZYME IMMUNOASSAY; FEMALE; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MAP KINASE KINASE KINASES; MICE; MICE, NUDE; MICE, SCID; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PYRIMIDINONES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84922775824     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.594028     Document Type: Article

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