Nifetepimine, a dihydropyrimidone, ensures CD4+ T cell survival in a tumor microenvironment by maneuvering Sarco(endo)plasmic reticulum Ca 2+ ATPase (SERCA)

Journal of Biological Chemistry

Volumn 287, Issue 39, 2012, Pages 32881-32896

  Ghosh, Swatilekha ^a   Adhikary, Arghya ^a   Chakraborty, Samik ^a   Nandi, Pinki ^a   Mohanty, Suchismita ^a   Chakraborty, Supriya ^a   Bhattacharjee, Pushpak ^a   Mukherjee, Sanhita ^a   Putatunda, Salil ^b   Chakraborty, Srabasti ^c   Chakraborty, Arijit ^b   Sa, Gaurisankar ^a   Das, Tanya ^a   Sen, Parimal C ^a  

^a BOSE INSTITUTE   (India)

^b MAULANA AZAD COLLEGE   (India)

^c BEHALA COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUMOR IMMUNITY; CALCIUM HOMEOSTASIS; CYTOSOLS; ENDOPLASMIC RETICULUM STRESS; GENE MANIPULATION; IN-PROCESS; INTRACELLULAR CA; MICE MODELS; NUCLEAR TRANSLOCATIONS; PROSTAGLANDINE; T CELLS; T LYMPHOCYTES; T-CELL APOPTOSIS; TUMOR CELLS; TUMOR MICROENVIRONMENT; UP-REGULATION;

CALCIUM; CARBOXYLATION; CELL DEATH; CELL MEMBRANES; DISEASES; ENZYME ACTIVITY; PHYSIOLOGY; TRANSCRIPTION FACTORS; TUMORS;

MOLECULAR BIOLOGY;

DIHYDROPYRIMIDONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NIFETEPIMINE; PROSTAGLANDIN E2; PROTEIN KINASE C ALPHA; PROTEIN KINASE C THETA; PYRIMIDINONE DERIVATIVE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 3; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CD4+ T LYMPHOCYTE; CELL DEATH; CELL NUCLEUS; CELL PROTECTION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T LYMPHOCYTE ACTIVATION; TUMOR CELL; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; UPREGULATION;

ANIMALS; BREAST NEOPLASMS; CALCIUM; CD4-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; DINOPROSTONE; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOLOGIC FACTORS; LYMPHOCYTE ACTIVATION; MALE; MICE; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; PROTEIN KINASE C-ALPHA; PYRIMIDINONES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SP1 TRANSCRIPTION FACTOR; TRANSPLANTATION, HETEROLOGOUS; TUMOR MICROENVIRONMENT; UP-REGULATION;

MUS;

EID: 84866566150     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.357889     Document Type: Article

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