Oleic acid increases mitochondrial reactive oxygen species production and decreases endothelial nitric oxide synthase activity in cultured endothelial cells

European Journal of Pharmacology

Volumn 751, Issue , 2015, Pages 67-72

  Gremmels, Hendrik ^a   Bevers, Lonneke M ^a   Fledderus, Joost O ^a   Braam, Branko ^b,c   Jan Van Zonneveld, Anton ^a   Verhaar, Marianne C ^a,d   Joles, Jaap A ^a,e  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Endothelium; Fatty acids; Nitric oxide synthase; Oleic acid; Reactive oxygen species

Indexed keywords

BOVINE SERUM ALBUMIN; CALCIUM IONOPHORE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; OLEIC ACID; REACTIVE OXYGEN METABOLITE; THENOYLTRIFLUOROACETONE; BIOPTERIN; NITRIC OXIDE; SAPROPTERIN;

ARTICLE; BIOSYNTHESIS; CELL LINE; CELL LINE BEND.3; CELL STRESS; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM; ANALOGS AND DERIVATIVES; ANIMAL; BOVINE; DRUG EFFECTS; METABOLISM; MITOCHONDRION; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BIOPTERIN; CATTLE; CELL LINE; ENDOTHELIAL CELLS; HUMANS; MITOCHONDRIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OLEIC ACID; REACTIVE OXYGEN SPECIES;

EID: 84922771071     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.01.005     Document Type: Article

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