Real-time assessment of granule densification in high shear wet granulation and application to scale-up of a placebo and a brivanib alaninate formulation

Journal of Pharmaceutical Sciences

Volumn 104, Issue 3, 2015, Pages 1019-1034

  Narang, ^a   Sheverev, Valery A ^b   Stepaniuk, Vadim ^b   Badawy, Sherif ^a   Stevens, Tim ^a   Macias, Kevin ^a   Wolf, Avi ^a   Pandey, Preetanshu ^a   Bindra, Dilbir ^a   Varia, Sailesh ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Lenterra Inc   (United States)

Author keywords

Analysis; Drag force flow sensor; Focused beam reflectance measurement; Granulation; Particle size; Physical characterization; Porosity; Powder technology; Process analytical technology; Quality by design

Indexed keywords

BRIVANIB ALANINATE; MICROCRYSTALLINE CELLULOSE; PLACEBO; WATER; ALANINE; BRIVANIB; CARBOXYMETHYLCELLULOSE; CELLULOSE; EXCIPIENT; HYDROXYPROPYLCELLULOSE; LACTOSE; POWDER; TABLET; TRIAZINE DERIVATIVE;

ARTICLE; BIOSENSOR; DRUG FORMULATION; DRUG GRANULE; DRUG RELEASE; DRUG SOLUBILITY; INFORMATION; PARTICLE SIZE; POROSITY; QUANTITATIVE ANALYSIS; SHEAR STRESS; TABLET DISINTEGRATION; ANALOGS AND DERIVATIVES; CHEMICAL MODEL; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; KINETICS; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; POWDER; PROCEDURES; QUALITY CONTROL; SOLUBILITY; STANDARDS; STATISTICAL MODEL; TABLET;

ADMINISTRATION, ORAL; ALANINE; CARBOXYMETHYLCELLULOSE SODIUM; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; EQUIPMENT DESIGN; EXCIPIENTS; KINETICS; LACTOSE; MODELS, CHEMICAL; MODELS, STATISTICAL; PARTICLE SIZE; PLACEBOS; POROSITY; POWDERS; QUALITY CONTROL; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TRIAZINES; WATER;

EID: 84922767160     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24233     Document Type: Article

References (24)

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