Physicochemical interactions in solid dosage forms

Pharmaceutical Research

Volumn 29, Issue 10, 2012, Pages 2635-2638

  Narang, Ajit S ^a   Desai, Divyakant ^a   Badawy, Sherif ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Physicochemical interactions; Product development; Quality by design; Solid dosage forms

Indexed keywords

DRUG; EXCIPIENT; POLYMER;

CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DOSAGE FORM; DRUG POTENCY; DRUG QUALITY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; MISCIBILITY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SHELF LIFE; SOLID DOSAGE FORM; TABLET COMPRESSION; TABLET FORMULATION; THERMOSTABILITY;

BIOLOGICAL AVAILABILITY; DOSAGE FORMS; DRUG DISCOVERY; DRUG STABILITY; PHARMACEUTICAL PREPARATIONS; PHYSICOCHEMICAL PHENOMENA;

EID: 84866704905     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0867-5     Document Type: Review

References (5)

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4. Wu Y, Levons J, Narang AS, Raghavan K, Rao VM. Reactive impurities in excipients: profiling, identification and mitigation of drugexcipient incompatibility. AAPS PharmSciTech. 2011;12:1248-63.
5. Narang AS, Yamniuk A, Zhang L, Comezoglu SN, Bindra DS, Varia S, Doyle ML, and Badawy S. Reversible and pH-dependent Weak Drug-Excipient Binding Does Not Affect Oral Bioavailability of High Dose Drugs. Journal of Pharmacy and Pharmacology. In press 2012.