In vitro steatosis hepatic cell model to compare the lipid-lowering effects of pomegranate peel polyphenols with several other plant polyphenols as well as its related cholesterol efflux mechanisms

Toxicology Reports

Volumn 1, Issue , 2014, Pages 945-954

  Zhao, Wei ^a   Li, Jianke ^a   He, Xiaoye ^a   Lv, Ou ^a   Cheng, Yujiang ^a   Liu, Run ^a  

^a SHAANXI NORMAL UNIVERSITY   (China)

Author keywords

Hepatic cell; Lipid lowering effects; Molecular mechanisms; Plant polyphenols; Pomegranate peel polyphenols (PPPs)

Indexed keywords

ABC TRANSPORTER A1; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; ELLAGIC ACID; ELLAGITANNIN; EPIGALLOCATECHIN GALLATE; GALLIC ACID; LIVER X RECEPTOR ALPHA; MEVINOLIN; PHLORIZIN; POLYPHENOL DERIVATIVE; POMEGRANATE PEEL POLYPHENOL; PUNICALAGIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; CELL SURVIVAL; CELL VIABILITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FATTY LIVER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER CELL; MRNA EXPRESSION ASSAY; MTT ASSAY; POMEGRANATE; REAL TIME POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84922754354     PISSN: 22147500     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxrep.2014.10.013     Document Type: Article

References (27)

1. Teixeira da Silva J.A., Rana T.S., Narzary D., Verma N., Meshram D.T., Ranade S.A. Pomegranate biology and biotechnology: a review. Sci. Hortic. 2013, 160:85-107.
2. Ismail T., Sestili P., Akhtar S. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J. Ethnopharmacol. 2012, 143:397-405.
3. Çam M., I˙çyer N.C., Erdoğan F. Pomegranate peel phenolics: microencapsulation, storage stability and potential ingredient for functional food development. LWT-Food Sci. Technol. 2014, 55:117-123.
4. Shaban N.Z., El-Kersh M.A.L., El-Rashidy F.H., Habashy N.H. Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats. Food Chem. 2013, 141:1587-1596.
5. Wu D., Ma X., Tian W. Pomegranate husk extract, punicalagin and ellagic acid inhibit fatty acid synthase and adipogenesis of 3T3-L1 adipocyte. J. Funct. Foods 2013, 5:633-641.
6. Al-Muammar M.N., Khan F. Obesity: the preventive role of the pomegranate (Punica granatum). Nutrition 2012, 28(6):595-604.
7. Esmaillzadeh A., Tahbaz F., Gaieni I., Alavi-Majd H., Azadbakht L. Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia. Int. J. Vitam. Nutr. Res. 2006, 76(3):147-151.
8. Hashemi M., Kelishadi R., Hashemipour M., Zakerameli A., Khavarian N., Ghatrehsamani S., Poursafa P. Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome. Cardiol. Young 2010, 20(1):73-77.
9. Rosenblat M., Hayek T., Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 2006, 187(2):363-371.
10. n. Food Chem. 2011, 127:807-821.
11. Aqil F., Munagala R., Vadhanam M.V., Kausar H., Jeyabalan J., Schultz D.J., Gupta R.C. Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk. Food Res. Int. 2012, 49:345-353.
12. Pande G., Akoh C.C. Antioxidant capacity and lipid characterization of six Georgia-grown pomegranate cultivars. J. Agric. Food Chem. 2009, 57(20):9427-9436.
13. Park S.H., Kim J.L., Lee E.S., Han S.Y., Gong J.H., Kang M.K., Kang Y.H. Dietary ellagic acid attenuates oxidized LDL uptake and stimulates cholesterol efflux in murine macrophages. J. Nutr. 2011, 141(11):1931-1937.
14. Negi P.S., Jayaprakasha G.K., Jena B.S. Antioxidant and antimutagenic activities of pomegranate peel extracts. Food Chem. 2003, 80:393-397.
15. Lei F., Zhang X.N., Wang W., Xing D.M., Xie W.D., Su H., Du L.J. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int. J. Obesity (London) 2007, 31:1023-1029.
16. Bursill C.A., Roach P.D. Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells. J. Agric. Food Chem. 2006, 54(5):1621-1626.
17. Huang J., Zhang Y., Zhou Y., Zhang Z., Xie Z., Zhang J., Wan X. Green tea polyphenols alleviate obesity in broiler chickens through the regulation of lipid-metabolism-related genes and transcription factor expression. J. Agric. Food Chem. 2013, 61(36):8565-8572.
18. Zhou Y.B., Wan X.C., Shang Y.Y., Hu J.W., Shao L., Chen W., Li D.X. Polyphenol content of plasma and litter after the oral administration of green tea and tea polyphenols in chickens. J. Agric. Food Chem. 2012, 60(7):1619-1627.
19. Schmid B., Rippmann J.F., Tadayyon M., Hamilton B.S. Inhibition of fatty acid synthase prevents preadipocyte differentiation. Biochem. Biophys. Res. Commun. 2005, 328:1073-1082.
20. Moon H.S., Chung C.S., Lee H.G., Kim T.G., Choi Y.J., Cho C.S. Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3T3-L1 cells. Obesity 2007, 15:2571-2582.
21. Chen J.H., Wang C.J., Wang C.P., Sheu J.Y., Lin C.L., Lin H.H. Hibiscus sabdariffa leaf polyphenolic extract inhibits LDL oxidation and foam cell formation involving up-regulation of LXRa/ABCA1 pathway. Food Chem. 2013, 141:397-406.
22. Yang C.M., Lu Y.L., Chen H.Y., Lu M.L. Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway. J. Nutr. Biochem. 2012, 23:1155-1162.
23. Chawla A., Boisvert W.A., Lee C.H., Laffitte B.A., Barak Y., Joseph S.B., Liao D., Nagy L., Edwards P.A., Curtiss L.K., Evans R.M., Tontonoz P. A PPAR-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol. Cell 2001, 7:161-171.
24. Michalik M., Soczek E., Kosińska M., Rak M., Wójcik K.A., Lasota S., Pierzchalska M., Czyz˙ J., Madeja Z. Lovastatin-induced decrease of intracellular cholesterol level attenuates fibroblast-to-myofibroblast transition in bronchial fibroblasts derived from asthmatic patients. Eur. J. Pharmacol. 2013, 704:23-32.
25. Henninger C., Huelsenbeck J., Huelsenbeck S., Grösch S., Schad A., Lackner K.J., Kaina B., Fritz G. The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 2012, 261(1):66-73.
26. Raederstorff D.G., Schlachter M.F., Elste V., Weber P. Effect of EGCG on lipid absorption and plasma lipid levels in rats. J. Nutr. Biochem. 2003, 14(6):326-332.
27. Shan D., Fang Y., Ye Y., Liu J. EGCG reducing the susceptibility to cholesterol gallstone formation through the regulation of inflammation. Biomed. Pharmacother. 2008, 62(10):677-683.