Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats

Food Chemistry

Volumn 141, Issue 3, 2013, Pages 1587-1596

  Shaban, Nadia Z ^a   El Kersh, Mohamed A L ^a   El Rashidy, Fatma H ^a   Habashy, Noha H ^a  

^a Alexandria University Faculty Of Science   (Egypt)

Author keywords

Antioxidant; Apoptosis; Caspase 3; Diethylnitrosoamine; DNA fragmentation; Hepatic injury; Lipid peroxidation; Pomegranate

Indexed keywords

ANTIOXIDANTS; CELL DEATH; DNA; ENZYMES; OILS AND FATS; OXYGEN; PEPTIDES; RATS;

CASPASE-3; DIETHYLNITROSOAMINE; DNA FRAGMENTATION; HEPATIC INJURY; LIPID PEROXIDATION; POMEGRANATE;

PLANTS (BOTANY);

3,4 METHYLENEDIOXYAMPHETAMINE; 3,5 DICAFFEOYL QUINIC ACID; 4,5 DICAFFEOYL QUINIC ACID; CAFFEIC ACID; CASPASE 3; CHLOROGENIC ACID; DIETHYLNITROSAMINE; FLAVONOID; GALLIC ACID; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; PHENOBARBITAL; POMEGRANATE EXTRACT; RUTOSIDE; SUPEROXIDE DISMUTASE; TANNIN; UNCLASSIFIED DRUG; VEGETABLE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER FUNCTION; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; POMEGRANATE; RAT;

LYTHRACEAE; PUNICA GRANATUM; RATTUS;

EID: 84884604483     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.04.134     Document Type: Article

References (42)

1. Ajaikumar, K. B., Asheef, M., Babu, B. H., & Padikkala, J. (2005). The inhibition of gastric mucosal injury by Punica granatum L. (pomegranate) methanolic extract. Jour (Pubitemid 39575048)
2. Bishayee, A., Bhatia, D., Thoppil, R. J., Darvesh, A. S., Nevo, E., & Lansky, E. P. (2011). Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms. Carcinogenesis, 32(6), 888-896.
3. Blair, I. A. (2006). Endogenous glutathione adducts. Current Drug Metabolism, 7(8), 853-872. (Pubitemid 44873711)
4. Cilla, A., González-Sarrías, A., Tomás- Barberán, F. A., Espín, J. C., & Barberá, R. (2009). Availability of polyphenols in fruit beverages subjected to in vitro gastrointestinal digestion and their effects on proliferation, cell-cycle and apoptosis in human colon cancer Caco-2 cells. Food Chemistry, 114, 813-820.
5. Dahlawi, H., Jordan-Mahy, N., Clench, M. R., & Le Maitre, C. L. (2012). Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic agents for leukemia. Nutrition and Cancer, 64(1), 100-110.
6. D'Aquino, S., Palma, A., Schirra, M., Continella, A., Tribulato, E., & La Malfa, S. (2010). Influence of film wrapping and fludioxonil application on quality of pomegranate fruit. Postharvest Biology and Technology, 55, 121-128.
7. Doumas, B. T., Watson, W. A., & Biggs, H. G. (1971). Albumin standards and the measurement of serum albumin with bromcresol green. Clinica Chimica Acta, 31(1), 87-96.
8. Ellman, G. L. (1959). Tissue sulphydryl groups. Archives of Biochemistry and Biophysics, 82, 70-77.
9. Faubel, S., & Edelstein, C. L. (2005). Caspases as drug targets in ischemic organ injury. Current Drug Targets: Immune, Endocrine and Metabolic Disorders, 5(3), 269-287. (Pubitemid 41131706)
10. Goldberg, D. M., & Spooner, R. J. (1983). In H. V. Bergmeyer (Ed.). Methods of enzymatic analysis (3rd ed.) (Vol. 3, pp. 258-265). Deerfield Beach, FL: Verlag Chemice.
11. Gornall, A. G., Bardawill, C. J., & David, M. M. (1949). Determination of serum proteins by means of the biuret reaction. Journal of Biological Chemistry, 177(2), 751-766.
12. Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974). Glutathione S-transferases the first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, 249(22), 7130-7139.
13. Jendrassik, L., & Grof, P. (1938). Determination of bilirubin in serum of rat. Biochemistry, 297, 281-289.
14. Katayama, M., Sugie, S., Yoshimi, N., Yamada, Y., Sakata, K., Qiao, Z., et al. (2003). Preventive effect of fermented brown rice and rice bran on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. Oncology Reports, 10, 875-880.
15. Kaufman, K. K., James, G., Sheedy, D., Harper, C., & Matsumoto, I. (2006). Differential protein expression in the perfrontal white matter of human alcoholics: A proteomics study. Molecular Psychiatry, 11, 56-65. (Pubitemid 43251088)
16. Kim, M. D., Mehta, R., Yu, W., Neeman, I., Livney, T., Amichay, A., et al. (2002). Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Research and Treatment, 71, 203-217. (Pubitemid 34263985)
17. Kohno, H., Suzuki, R., Yasui, Y., Hosokawa, M., Miyashita, K., & Tanaka, T. (2004). Pomegranate seed oil rich in conjugated linolenic acid suppress chemically induced colon carcinogenesis in rats. Cancer Science, 95(6), 481-486. (Pubitemid 38832696)
18. Lansky, E. P., & Newman, R. A. (2007). Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. Journal of Ethnopharmacology, 109, 177-206. (Pubitemid 44959707)
19. Laskin, D. L., & Pendino, K. J. (1995). Macrophage and inflammatory mediators in tissue injury. Annual Review of Pharmacology and Toxicology, 35, 655-677.
20. Li, X., Fu, G. F., Fan, Y. R., Shi, C. F., Liu, X. J., Xu, G. X., et al. (2003). Potent inhibition of angiogenesis and liver tumor growth by administration of an aerosol containing a transferrin-liposome endostatin complex. World Journal of Gastroenterology, 9(2), 262-266. (Pubitemid 36215800)
21. Marcocci, L., Maguire, J. J., Droy-Lefaix, M. T., & Packer, L. (1994). The nitric oxide scavenging property of Ginkgo biloba extract EGb 761. Biochemical and Biophysical Research Communications, 201, 748-755. (Pubitemid 24206935)
22. Marklund, S., & Marklund, G. (1974). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry, 47, 469-474.
23. Mittal, G., Bar, A. P. S., & Soni, G. (2006). Impact of hypercholesterolemia on toxicity of N-nitrosodiethylamine: Biochemical and histopathological effects. Pharmacological Reports, 58, 413-419. (Pubitemid 44111077)
24. Moskaug, J., Carlsen, H., Myhrstad, M. C., & Blomhoff, R. (2005). Polyphenols and glutathione synthesis regulation. The American Journal of Clinical Nutrition, 81, 277S-283S.
25. Murthy, K. N., Jayaprakasha, G. K., & Singh, R. P. (2002). Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. Journal of Agriculture and Food Chemistry, 50(17), 4791-4795. (Pubitemid 34856146)
26. Nakae, D., Kobayashi, Y., & Akai, H. (1997). Involvement of 8 hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of Nnitrosodiethylamine. Cancer Research, 57, 1281-1287. (Pubitemid 27152552)
27. Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95(2), 351-358. (Pubitemid 9194347)
28. Pradeep, K., Mohan, C. V. R., Gobianand, K., & Karthikeyan, S. (2007). Effect of Cassia fistula Linn. Leaf extract on diethylnitrosamine induced hepatic injury in rats. Chemico-Biological Interactions, 167(1), 12-18. (Pubitemid 46413233)
29. Reitman, S., & Frankel, S. (1957). A colorimetric method for the glutamic-pyruvate transaminase. American Journal of Clinical Pathology, 28, 56-63.
30. Rotruck, J. T., Pope, A. L., Gauther, H. E., Swanson, A. B., Hafeman, D. G., & Hoekstna, W. G. (1973). Selenium: Biochemical roles as a component of glutathione peroxidase. Science, 179, 588-590.
31. Route, S., & Banerjee, R. (2007). Free radical scavenging, anti-glycation and tyrosinase inhibition properties of a polysaccharide fraction isolated from the rind from Punica granatum. Bioresource Technology, 98, 3159-3163. (Pubitemid 46603255)
32. Saravanan, R., Viswanathan, P., & Pugalendi, K. V. (2006). Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. Life Sciences, 78, 713-718. (Pubitemid 41821127)
33. Shaban, N. Z., Helmy, M. H., El-Kersh, M. A. R., & Mahmoud, B. F. (2003). Effects of Bacillius thuringiensis toxin on hepatic lipid peroxidation and free-radical scavengers in rats given alpha-tocopherol or acetylsalicylate. Comparative Biochemistry and Physiology C, 135, 405-414. (Pubitemid 38367464)
34. Singh, H. P., & Kar, A. (2007). Protective role of Citrus sinensis, Musa paradisiacal, and Punica granatum peels against diet-induced atherosclerosis and thyroid dysfunctions in rats. Nutrition Research, 27, 710-718. (Pubitemid 350086768)
35. Sivaramakrishnan, V., & Devaraj, N. (2009). Morin regulates the expression of NFkappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chemico-Biological Interactions, 180, 353-359.
36. Sribnick, E. A., Matzelle, D. D., Ray, S. K., & Banik, N. L. (2006). Estrogen treatment of spinal cord injury attenuates calpain activation and apoptosis. Journal of Neuroscience Research, 84(5), 1064-1075. (Pubitemid 44521051)
37. Taga, M. S., Miller, E. E., & Pratt, D. E. (1984). Chia seeds as a source of natural lipid antioxidant. Journal of the American Oil Chemists Society, 61, 928-931. (Pubitemid 14588727)
38. Talanian, R. V., Quin Pan, C., Trauz, S., Hackett, M. C., Mankovich, J. A., et al. (1997). Substrate specificities of caspase family proteases. Journal of Biological Chemistry, 272(15), 9677-9682. (Pubitemid 27171628)
39. Tyagi, S. N., Rakshit Ajeet Singh Raghvendra Anamika Saxena & Patel, B. D. (2010). In vitro antioxidant activity of methanolic and aqueous extract of Flacourtia indica Mer. American-Eurasian Journal of Scientific Research, 5(3), 201-206.
40. Vidal, A., Fallarero, A., Peña, B. R., Medina, M. E., Gra, B., Rivera, F., et al. (2003). Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. Journal of Ethnopharmacology, 89, 295-300. (Pubitemid 37378206)
41. 2+-dependent endonuclease in apoptosis and its inhibition by poly(ADP-ribose) polymerase. Journal of Biological Chemistry, 275, 21302-21308. (Pubitemid 30481828)
42. Zhishen, J., Mengcheng, T., & Jianming, W. (1999). Research on antioxidant activity of flavonoids from natural materials. Food Chemistry, 64, 555-559.