Prognosis: Does exercise training reduce adverse events in heart failure?

Heart Failure Clinics

Volumn 11, Issue 1, 2015, Pages 59-72

  Myers, Jonathan ^a   Brawner, Clinton A ^b   Haykowsky, Mark J F ^c   Taylor, Rod S ^d,e  

^a STANFORD UNIVERSITY   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

^d UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Aerobic capacity; Cardiac output; Cardiac rehabilitation; Oxygen uptake; Prognosis

Indexed keywords

ADAPTATION; CARDIOVASCULAR SYSTEM; ENDURANCE TRAINING; EXERCISE; FEMALE; HEART FAILURE; HOSPITAL ADMISSION; HUMAN; LUNG VENTILATION; MALE; META ANALYSIS (TOPIC); MORTALITY; OUTCOME ASSESSMENT; PROGNOSIS; QUALITY OF LIFE; REVIEW; SKELETAL MUSCLE; SYSTEMATIC REVIEW (TOPIC); DISEASE COURSE; EXERCISE TOLERANCE; KINESIOTHERAPY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

DISEASE PROGRESSION; EXERCISE THERAPY; EXERCISE TOLERANCE; HEART FAILURE; HUMANS; PROGNOSIS; QUALITY OF LIFE;

EID: 84922736858     PISSN: 15517136     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hfc.2014.08.012     Document Type: Review

References (70)

1. Downing J., Balady G.J. The role of exercise training in heart failure. JAm Coll Cardiol 2011, 58:561-569.
2. Piepoli M.F., Guazzi M., Boriani G., et al. Exercise intolerance in chronic heart failure: mechanisms and therapies. Part 1. Eur J Cardiovasc Prev Rehabil 2010, 17:637-642.
3. Myers J., Froelicher V.F. Hemodynamic determinants of exercise capacity in chronic heart failure. Ann Intern Med 1991, 115:377-386.
4. Pina I.L., Apstein C.S., Balady G.J., et al. Exercise and heart failure: a statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. Circulation 2003, 107:1210-1225.
5. Haykowsky M., Scott J., Esch B., et al. Ameta-analysis of the efforts of exercise training on left ventricular remodeling following myocardial infarction: start early and go longer for greatest exercise benefits on remodeling. Trials 2011, 12:92.
6. Davies E.J., Moxham T., Rees K., et al. Exercise training for systolic heart failure: Cochrane systematic review and meta-analysis. Eur J Heart Fail 2010, 12:706-715.
7. Davies E.J., Moxham T., Rees K., et al. Exercise based rehabilitation for heart failure. Cochrane Database Syst Rev 2010, (4). CD003331.
8. 2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training (HF-ACTION). Circulation 2012, 5:579-585.
9. Van Tol B.A., Huijsmans R.J., Droon D.W., et al. Effects of exercise training on cardiac performance, exercise capacity and quality of life in patients with heart failure: a meta-analysis. Eur J Heart Fail 2006, 8:841-850.
10. Haykowsky M.J., Brubaker P.H., Stewart K.P., et al. Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction. JAm Coll Cardiol 2012, 60:120-128.
11. Wisloff U., Stoylen A., Leonnenchen J.P., et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 2007, 115:3086-3094.
12. Giannuzzi P., Temporelli P.L., Corra U., ELVD-CHF Study Group, et al. Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure: results of the Exercise in Left Ventricular Dysfunction and Chronic Heart Failure (ELVD-CHF) trial. Circulation 2003, 108:557-559.
13. Hambrecht R., Gielen S., Linke A., et al. Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: a randomized trial. JAMA 2000, 283:3095-3101.
14. Erbs S., Linke A., Gielen S., et al. Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial. Eur J Cardiovasc Prev Rehabil 2003, 10:336-344.
15. Mezzani A., Corra U., Gianuzzi P. Central adaptations to exercise training in patients with chronic heart failure. Heart Fail Rev 2008, 13:13-20.
16. Erbs S., Hollriegel R., Linke A., et al. Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function. Circ Heart Fail 2010, 3:486-494.
17. Duscha B.D., Schulze P.C., Robbins J.L., et al. Implications of chronic heart failure on peripheral vasculature and skeletal muscle before and after exercise training. Heart Fail Rev 2008, 13:21-37.
18. Peipoli M.F. Exercise training in chronic heart failure: mechanisms and therapies. Neth Heart J 2013, 21:85-90.
19. Gielen S., Schuler G., Adams V. Cardiovascular effects of exercise training: molecular mechanisms. Circulation 2010, 122:1221-1238.
20. Gielen S., Adams V., Mobius-Winkler S., et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. JAm Coll Cardiol 2003, 42:861-868.
21. Tabet J., Meurin P., Driss A.B., et al. Benefits of exercise training in chronic heart failure. Arch Cardiovasc Dis 2009, 102:721-730.
22. Mendes-Ribeiro A.C., Mann G.E., Meirelles L.R., et al. The role of exercise on L-arginine nitric oxide pathway in chronic heart failure. Open Biochem J 2009, 3:55-65.
23. Van Craenebroeck E.M., Hoymans V.Y., Beckers P.J., et al. Exercise training improves function of circulating angiogenic cells in patients with chronic heart failure. Basic Res Cardiol 2010, 105:665-676.
24. Hambrecht M.D., Hillbrich L., Erbs S., et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. JAm Coll Cardiol 2000, 35:706-713.
25. Hambrecht R., Fiehn E., Weigl C., et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998, 98:2709-2715.
26. Linke A., Schoene N., Gielen S., et al. Endothelial dysfunction in patients with chronic heart failure: systemic effects of lower-limb exercise training. JAm Coll Cardiol 2001, 37:392-397.
27. Hornig B., Maier V., Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation 1996, 93:210-214.
28. Hambrecht R., Fiehn E., Yu J., et al. Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure. JAm Coll Cardiol 1997, 29:1067-1073.
29. Hambrecht R., Niebauer J., Fiehn E., et al. Physical training in patients with stable chronic heart failure: effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles. JAm Coll Cardiol 1995, 25:1239-1249.
30. Kao W., Helpern J.A., Goldstein S., et al. Abnormalities of skeletal muscle metabolism during nerve stimulation determined by 31P nuclear magnetic resonance spectroscopy in severe congestive heart failure. Am J Cardiol 1995, 76:606-609.
31. Van Der Ent M., Jeneson J.A., Remme W.J., et al. Anon-invasive selective assessment of type I fibre mitochondrial function using 31P NMR spectroscopy. Evidence for impaired oxidative phosphorylation rate in skeletal muscle in patients with chronic heart failure. Eur Heart J 1998, 19:124-131.
32. Stassijns G., Lysens R., Decramer M. Peripheral and respiratory muscles in chronic heart failure. Eur Respir J 1996, 9:2161-2167.
33. Cohen-Solal A., Laperche T., Morvan D., et al. Prolonged kinetics of recovery of oxygen consumption after maximal graded exercise in patients with chronic heart failure. Analysis with gas exchange measurements and NMR spectroscopy. Circulation 1995, 91:2924-2932.
34. Belardinelli R., Barstow T.J., Nguyen P., et al. Skeletal muscle oxygenation and oxygen uptake kinetics following constant work rate exercise in chronic congestive heart failure. Am J Cardiol 1997, 80:1319-1324.
35. Vasileiadis I., Kravari M., Terrovitis J., et al. Interval exercise training improves tissue oxygenation in patients with chronic heart failure. World J Cardiovasc Dis 2013, 3:301-307.
36. Adamopoulos S., Coats A.J., Brunotte F., et al. Physical training improves skeletal muscle metabolism in patients with chronic heart failure. JAm Coll Cardiol 1993, 21:1101-1106.
37. Gielen S., Sandri M., Kozarez I., et al. Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study. Circulation 2012, 125:2716-2727.
38. Adams V., Doring C., Schuler G. Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure. Front Biosci 2008, 13:302-311.
39. Arena R., Myers J., Guazzi M. The clinical and research applications of aerobic capacity and ventilator efficiency in heart failure: an evidence-based review. Heart Fail Rev 2008, 13:245-269.
40. Balady G.J., Arena R., Sietsema K., American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, Interdisciplinary Council on Quality of Care and Outcomes Research, et al. Clinicians guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation 2010, 122:191-225.
41. Ingle L. Theoretical rationale and practical recommendations for cardiopulmonary exercise testing in patients with chronic heart failure. Heart Fail Rev 2007, 12:12-22.
42. Myers J., Gademan M., Brunner K., et al. Effects of high-intensity training on indices of ventilatory efficiency in chronic heart failure. JCardiopulm Rehabil Prev 2012, 32:9-16.
43. Gademan M.G., Swenne C.A., Verwey H.F., et al. Exercise training increases oxygen uptake efficiency slope in chronic heart failure. Eur J Cardiovasc Prev Rehabil 2008, 15:140-144.
44. Cahalin L.P., Semigran M.J., Dec G.W. Inspiratory muscle training in patients with chronic heart failure awaiting cardiac transplantation: results of a pilot clinical trial. Phys Ther 1997, 77:830-838.
45. Lin S., McElfresh J., Hall B., et al. Inspiratory muscle training in patients with heart failure: a systematic review. Cardiopulm Phys Ther J 2012, 23:29-36.
46. Clark A.L., Piepoli M., Coats A.J. Skeletal muscle and the control of ventilation on exercise: evidence for metabolic receptors. Eur J Clin Invest 1995, 25:299-305.
47. Ponikowski P.P., Chua T.P., Francis D.P., et al. Muscle ergoreceptor overactivity reflects deterioration in clinical status and cardiorespiratory reflex control in chronic heart failure. Circulation 2001, 104:2324-2330.
48. Piepoli M., Clark A.L., Volterrani M., et al. Contribution of muscle afferents to the hemodynamic, autonomic, and ventilator responses to exercise in patients with chronic heart failure: effects of physical training. Circulation 1996, 93:940-952.
49. Smart N., Marwick T.H. Exercise training for patients with heart failure: a systematic review of factors that improve mortality and morbidity. Am J Med 2004, 116(10):693-706. 10.1016/j.amjmed.2003.11.033.
50. O'Connor C.M., Whellan D.J., Lee K.L., et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 2009, 301(14):1439-1450. 10.1001/jama.2009.454.
51. Keteyian S.J., Leifer E.S., Houston-Miller N., et al. Relation between volume of exercise and clinical outcomes in patients with heart failure. JAm Coll Cardiol 2012, 60(19):1899-1905. 10.1016/j.jacc.2012.08.958.
52. Reed S.D., Whellan D.J., Li Y., et al. Economic evaluation of the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) randomized controlled trial: an exercise training study of patients with chronic heart failure. Circ Cardiovasc Qual Outcomes 2010, 3(4):374-381. 10.1161/CIRCOUTCOMES.109.907287.
53. Lawson G.J. Cardiac rehabilitation staffing. Contemporary cardiology: cardiac rehabilitation 2007, 277-287. Humana Press, Totowa (NJ). W.E. Kraus, S.J. Keteyian (Eds.).
54. Whellan D.J., O'Connor C.M., Lee K.L., et al. Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale. Am Heart J 2007, 153(2):201-211. 10.1016/j.ahj.2006.11.007.
55. National Heart Lung and Blood Institute. NHLBI fact book, fiscal year 2008. [108]. Bethesda, MD: National Institutes of Health. Available at: . http://www.nhlbi.nih.gov/files/docs/factbook/FactBook2008.pdf.
56. Pina I.L., Kokkinos P., Kao A., et al. Baseline differences in the HF-ACTION by sex. Am Heart J 2009, 158:S16-S23.
57. Pina I.L., Bittner V., Clare R.M., et al. Effects of exercise training on outcomes in women with heart failure: analysis of HF-ACTION (Heart Failure-A Controlled Trial Investigating Outcomes of Exercise Training) by sex. JACC Heart Fail 2014, 2:180-186.
58. Scott J.M., Haykowsky M.J., Eggebeen J., et al. Reliability of peak exercise testing in patients with heart failure with preserved ejection fraction. Am J Cardiol 2012, 110:1809-1813.
59. Gulati M., Pandey D.K., Arnsdorf M.F., et al. Exercise capacity and the risk of death in women: the St James women take heart project. Circulation 2003, 108:1554-1559.
60. Myers J., Prakash M., Froelicher V., et al. Exercise capacity and mortality among men referred for exercise testing. NEngl J Med 2002, 346:793-801.
61. Haykowsky M.J., Ezekowitz J.A., Armstrong P.W. Therapeutic exercise for individuals with heart failure: special attention to older women with heart failure. JCard Fail 2004, 10:165-173.
62. Haykowsky M., Vonder Muhll I., Ezekowitz J., et al. Supervised exercise training improves aerobic capacity and muscle strength in older women with heart failure. Can J Cardiol 2005, 21:1277-1280.
63. Pu C.T., Johnson M.T., Forman D.E., et al. Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure. JAppl Physiol (1985) 2001, 90:2341-2350.
64. Tyni-Lenne R., Gordon A., Jansson E., et al. Skeletal muscle endurance training improves peripheral oxidative capacity, exercise tolerance, and health-related quality of life in women with chronic congestive heart failure secondary to either ischemic cardiomyopathy or idiopathic dilated cardiomyopathy. Am J Cardiol 1997, 80:1025-1029.
65. Gary R.A., Sueta C.A., Dougherty M., et al. Home-based exercise improves functional performance and quality of life in women with diastolic heart failure. Heart Lung 2004, 33:210-218.
66. Niederseer D., Thaler C.W., Niederseer M., et al. Mismatch between heart failure patients in clinical trials and the real world. Int J Cardiol 2013, 168:1859-1865.
67. Cleland J.G., Swedberg K., Follath F., et al. The Euroheart failure survey programme- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. Eur Heart J 2003, 24:442-463.
68. Lee D.S., Gona P., Vasan R.S., et al. Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the Framingham Heart Study of the National Heart, Lung, and Blood Institute. Circulation 2009, 119:3070-3077.
69. Taylor R.S., Sagar V.A., Davies E.J., et al. Exercise-based rehabilitation for heart failure. Cochrane Database Syst Rev 2014, (4). CD003331. 10.1002/14651858.CD003331.pub4.
70. Flynn K.E., Piña I.L., Whellan D.J., et al. Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 2009, 153:1451-1459.