IL-1 receptor antagonist attenuates neonatal lipopolysaccharide-induced long-lasting learning impairment and hippocampal injury in adult rats

Toxicology Letters

Volumn 234, Issue 1, 2015, Pages 30-39

  Lan, Kuo Mao ^a,b   Tien, Lu Tai ^b   Pang, Yi ^c   Bhatt, Abhay J ^c   Fan, Lir Wan ^c  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Hippocampus; Interleukin 1 receptor antagonist; Interleukin 1 ; Lipopolysaccharide; Microglia

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; INTERLEUKIN 1 RECEPTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN SIZE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ELEVATED PLUS MAZE TEST; FEMALE; HIPPOCAMPAL INJURY; HIPPOCAMPUS; LEARNING DISORDER; LOCOMOTION; MALE; MICROGLIA; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TASK PERFORMANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; AVOIDANCE BEHAVIOR; CHEMICALLY INDUCED; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; INJURIES; LEARNING DISORDERS; MAZE TEST; MOTOR ACTIVITY; NEWBORN; NISSL SUBSTANCE; PREGNANCY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; ANIMALS, NEWBORN; AVOIDANCE LEARNING; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEARNING DISORDERS; LIPOPOLYSACCHARIDES; MALE; MAZE LEARNING; MOTOR ACTIVITY; NISSL BODIES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-1;

EID: 84922734495     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2015.02.002     Document Type: Article

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