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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 5, 2015, Pages 1140-1145

Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity

(11) Beaulieu, Pierre L a Bolger, Gordon a Deon, Dan a Duplessis, Martin a Fazal, Gulrez a Gagnon, Alexandre a Garneau, Michel a Laplante, Steven a Stammers, Timothy a Kukolj, George a Duan, Jianmin a

a BOEHRINGER INGELHEIM CANADA LTD (Canada)

Author keywords

HCV NS5B polymerase; Lipophilicity; Non nucleoside inhibitor; Promiscuity; Thumb pocket 1

Indexed keywords

BI 207524; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG; (E)-3-(4-((1-((2-(5-CHLORO-PYRIMIDIN-2-YL)-3-CYCLOPENTYL-1-METHYL-1H-INDOLE-6-CARBONYL)-AMINO)-CYCLOBUTANECARBONYL)-AMINO)-2-ETHOXY-PHENYL)-ACRYLIC ACID; ACRYLIC ACID DERIVATIVE; ANTIVIRUS AGENT; INDOLE DERIVATIVE; LIPID; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; LIPOPHILICITY; NONHUMAN; SEXUAL PROMISCUITY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOG; DRUG EFFECTS; HAPLORHINI; HEPACIVIRUS; HEPATITIS C; LIVER; METABOLISM; RAT; VIROLOGY;

HEPATITIS C VIRUS; RATTUS;

ACRYLATES; ANIMALS; ANTIVIRAL AGENTS; DOGS; HAPLORHINI; HEPACIVIRUS; HEPATITIS C; HUMANS; INDOLES; LIPIDS; LIVER; RATS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84922733798 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.12.078 Document Type: Article

Times cited : (7)

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