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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 5, 2015, Pages 1135-1139

Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite

(8) Beaulieu, Pierre L a Bolger, Gordon a Duplessis, Martin a Gagnon, Alexandre a Garneau, Michel a Stammers, Timothy a Kukolj, George a Duan, Jianmin a

a BOEHRINGER INGELHEIM CANADA LTD (Canada)

Author keywords

Ames; Antiviral; Genotoxicity; Hepatitis C virus; NS5B polymerase

Indexed keywords

ANILINE DERIVATIVE; BI 207524; NONSTRUCTURAL PROTEIN 5B; NONSTRUCTURAL PROTEIN 5B POLYMERASE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; (E)-3-(4-((1-((2-(5-CHLORO-PYRIMIDIN-2-YL)-3-CYCLOPENTYL-1-METHYL-1H-INDOLE-6-CARBONYL)-AMINO)-CYCLOBUTANECARBONYL)-AMINO)-2-ETHOXY-PHENYL)-ACRYLIC ACID; ACRYLIC ACID DERIVATIVE; ANILINE; ANTIVIRUS AGENT; ENZYME INHIBITOR; INDOLE DERIVATIVE; VIRUS PROTEIN;

ALLOMETRY; AMES TEST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; GENOTOXICITY; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; NONHUMAN; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOG; DRUG EFFECTS; ENZYMOLOGY; HAPLORHINI; HEPACIVIRUS; HEPATITIS C; METABOLISM; VIROLOGY;

HEPATITIS C VIRUS;

ACRYLATES; ANILINE COMPOUNDS; ANIMALS; ANTIVIRAL AGENTS; DOGS; ENZYME INHIBITORS; HAPLORHINI; HEPACIVIRUS; HEPATITIS C; HUMANS; INDOLES; RATS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84922752398 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.12.028 Document Type: Article

Times cited : (9)

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