메뉴 건너뛰기




Volumn 57, Issue 23, 2014, Pages 10130-10143

Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMOINDOLE; 2 ETHOXY 4 NITROBENZOIC ACID; 2 HYDROXY 4 NITROBENZOIC ACID; 2 HYDROXYCINNAMATE; 3 [4 [(1 [[2 (5 CHLORO PYRIMIDIN 2 YL) 3 CYCLOPENTYL 1METHYL 1H INDOLE 6 CARBONYL] AMINO] CYCLOBUTANECARBONYL) AMINO 2 ETHOXY PHENYL] ACRYLIC ACID; 4 AMINO ETHOXYCINNAMIC ACID METHYL ESTER; 6 INDOLE CARBOXYLIC ACID; AMIDE; ANTIVIRUS AGENT; BENZALDEHYDE DERIVATIVE; BI 207524; CINNAMIC ACID; CYCLOBUTANE DERIVATIVE; CYCLOPROPANE DERIVATIVE; INDOLE 6 CARBOXYLIC ACID DERIVATIVE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG; (E)-3-(4-((1-((2-(5-CHLORO-PYRIMIDIN-2-YL)-3-CYCLOPENTYL-1-METHYL-1H-INDOLE-6-CARBONYL)-AMINO)-CYCLOBUTANECARBONYL)-AMINO)-2-ETHOXY-PHENYL)-ACRYLIC ACID; ACRYLIC ACID DERIVATIVE; CINNAMIC ACID DERIVATIVE; ENZYME INHIBITOR; NS-5 PROTEIN, HEPATITIS C VIRUS; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN;

EID: 84918540329     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501532z     Document Type: Article
Times cited : (13)

References (38)
  • 1
    • 78751621217 scopus 로고    scopus 로고
    • Evolving epidemiology of hepatitis C virus
    • Lavanchy, D. Evolving epidemiology of hepatitis C virus Clin. Microbiol. Infect. 2011, 17, 107-115
    • (2011) Clin. Microbiol. Infect. , vol.17 , pp. 107-115
    • Lavanchy, D.1
  • 2
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo, Q.-L.; Kuo, G.; Weiner, A. J.; Overby, L. R.; Bradley, D. W.; Houghton, M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome Science 1989, 244, 359-362
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.-L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 3
    • 23944476834 scopus 로고    scopus 로고
    • Unraveling hepatitis C virus replication from genome to function
    • Lindenbach, B. D.; Rice, M. C. Unraveling hepatitis C virus replication from genome to function Nature 2005, 436, 933-938
    • (2005) Nature , vol.436 , pp. 933-938
    • Lindenbach, B.D.1    Rice, M.C.2
  • 4
    • 72049091527 scopus 로고    scopus 로고
    • The efficacy and safety of telaprevir - A new protease inhibitor against hepatitis C virus
    • Gentile, I.; Carleo, M. A.; Borgia, F.; Castaldo, G.; Borgia, G. The efficacy and safety of telaprevir-a new protease inhibitor against hepatitis C virus Expert Opin. Investig. Drugs 2010, 19, 151-159
    • (2010) Expert Opin. Investig. Drugs , vol.19 , pp. 151-159
    • Gentile, I.1    Carleo, M.A.2    Borgia, F.3    Castaldo, G.4    Borgia, G.5
  • 5
    • 80755159054 scopus 로고    scopus 로고
    • Discovery and development of telaprevir: An NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus
    • Kwong, D. A.; Kauffman, R. S.; Mueller, P. Discovery and development of telaprevir: An NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus Nat. Biotechnol. 2011, 29, 993-1003
    • (2011) Nat. Biotechnol. , vol.29 , pp. 993-1003
    • Kwong, D.A.1    Kauffman, R.S.2    Mueller, P.3
  • 6
    • 67650523017 scopus 로고    scopus 로고
    • Boceprevir, an NS3 protease inhibitor of HCV
    • Berman, K.; Kwo, P. Y. Boceprevir, an NS3 protease inhibitor of HCV Clin. Liver Dis. 2009, 13, 429-439
    • (2009) Clin. Liver Dis. , vol.13 , pp. 429-439
    • Berman, K.1    Kwo, P.Y.2
  • 7
    • 78650928878 scopus 로고    scopus 로고
    • New direct-acting antivirals combination for the treatment of chronic hepatitis C
    • Asselah, T.; Marcellin, P. New direct-acting antivirals combination for the treatment of chronic hepatitis C Liver Int. 2011, 31, 68-77
    • (2011) Liver Int. , vol.31 , pp. 68-77
    • Asselah, T.1    Marcellin, P.2
  • 12
    • 84895762620 scopus 로고    scopus 로고
    • Sofosbuvir: First global approval
    • Keating, G. M.; Vaidya, A. Sofosbuvir: First global approval Drugs 2014, 74, 273-282
    • (2014) Drugs , vol.74 , pp. 273-282
    • Keating, G.M.1    Vaidya, A.2
  • 16
    • 84894297488 scopus 로고    scopus 로고
    • Efficacy of nucleotide polymerase inhibitor sofosbuvir plus the NS5A inhibitor ledipasvir or the NS5B non-nucleoside inhibitor GS-9669 against HCV genotype 1 infection
    • Gane, E. J.; Stedman, C. A.; Hyland, R. H.; Ding, X.; Svarovskaia, E.; Subramanian, G. M.; Symonds, W. T.; McHutchison, J. G.; Pang, P. S. Efficacy of nucleotide polymerase inhibitor sofosbuvir plus the NS5A inhibitor ledipasvir or the NS5B non-nucleoside inhibitor GS-9669 against HCV genotype 1 infection Gastroenterology 2014, 146, 736-743
    • (2014) Gastroenterology , vol.146 , pp. 736-743
    • Gane, E.J.1    Stedman, C.A.2    Hyland, R.H.3    Ding, X.4    Svarovskaia, E.5    Subramanian, G.M.6    Symonds, W.T.7    McHutchison, J.G.8    Pang, P.S.9
  • 20
    • 67649303095 scopus 로고    scopus 로고
    • Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection
    • Beaulieu, P. L. Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection Expert Opin.Ther. Pat. 2009, 19, 145-164
    • (2009) Expert Opin.Ther. Pat. , vol.19 , pp. 145-164
    • Beaulieu, P.L.1
  • 22
    • 84858722318 scopus 로고    scopus 로고
    • Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase
    • Sofia, M. J.; Chang, W.; Furman, P. A.; Mosley, R. T.; Ross, B. S. Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase J. Med. Chem. 2012, 55, 2532-2531
    • (2012) J. Med. Chem. , vol.55 , pp. 2532-2531
    • Sofia, M.J.1    Chang, W.2    Furman, P.A.3    Mosley, R.T.4    Ross, B.S.5
  • 23
    • 67649625180 scopus 로고    scopus 로고
    • Progress towards improving antiviral therapy for hepatitis C virus polymerase inhibitors. Part 1: Nucleoside analogues
    • Brown, N. A. Progress towards improving antiviral therapy for hepatitis C virus polymerase inhibitors. Part 1: Nucleoside analogues Expert Opin. Investig. Drugs 2009, 18, 709-725
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 709-725
    • Brown, N.A.1
  • 24
    • 77953463393 scopus 로고    scopus 로고
    • Nucleoside analog inhibitors of hepatitis C virus replication: Recent advances, challenges and trends
    • Furman, P. A.; Lam, A. M.; Murakami, E. Nucleoside analog inhibitors of hepatitis C virus replication: Recent advances, challenges and trends Future Med. Chem. 2009, 1, 1429-1452
    • (2009) Future Med. Chem. , vol.1 , pp. 1429-1452
    • Furman, P.A.1    Lam, A.M.2    Murakami, E.3
  • 25
    • 84863110363 scopus 로고    scopus 로고
    • Nucleotide prodrugs for HCV therapy
    • Sofia, M. J. Nucleotide prodrugs for HCV therapy Antiviral Chem. Chemother. 2011, 22, 23-49
    • (2011) Antiviral Chem. Chemother. , vol.22 , pp. 23-49
    • Sofia, M.J.1
  • 38
    • 1542771886 scopus 로고
    • Tetracycline studies. Part 5. New syntheses of anthracenes and anthraquinones through benzophenone carbanions
    • Broadhurst, M. J.; Hassall, C. H.; Thomas, G. J. Tetracycline studies. Part 5. New syntheses of anthracenes and anthraquinones through benzophenone carbanions J. Chem. Soc., Perkin 1 Trans. 1977, 2502-2512
    • (1977) J. Chem. Soc., Perkin 1 Trans. , pp. 2502-2512
    • Broadhurst, M.J.1    Hassall, C.H.2    Thomas, G.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.