Glucocorticoids and 11β-hydroxysteroid dehydrogenases: Mechanisms for hypertension

Current Opinion in Pharmacology

Volumn 21, Issue , 2015, Pages 105-114

  Hunter, Robert W ^a   Bailey, Matthew A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR;

ARTICLE; BLOOD PRESSURE REGULATION; DISEASE ACTIVITY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HYPERTENSION; KIDNEY DISTAL TUBULE; KIDNEY MEDULLA; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SODIUM RETENTION; SODIUM TRANSPORT; ANIMAL; BLOOD PRESSURE; KIDNEY; PATHOPHYSIOLOGY; PHYSIOLOGY;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BLOOD PRESSURE; GLUCOCORTICOIDS; HUMANS; HYPERTENSION; KIDNEY; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID;

EID: 84922732654     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2015.01.005     Document Type: Review

References (83)

1. M.A. Magiakou, P. Smyrnaki, and G.P. Chrousos Hypertension in Cushing's syndrome Best Pract Res Clin Endocrinol Metab 20 2006 467 482
2. M.V. Cicala, and F. Mantero Hypertension in Cushing's syndrome: from pathogenesis to treatment Neuroendocrinology 92 Suppl 1 2010 44 49
3. J.E. Goodwin, and D.S. Geller Glucocorticoid-induced hypertension Pediatr Nephrol 27 2012 1059 1066
4. R.W. Hunter, J.R. Ivy, and M.A. Bailey Glucocorticoids and renal Na+ transport: implications for hypertension and salt sensitivity J Physiol (Lond) 592 2014 1731 1744
5. K. Usa, R.J. Singh, B.C. Netzel, Y. Liu, H. Raff, and M. Liang Renal interstitial corticosterone and 11-dehydrocorticosterone in conscious rats Am J Physiol Renal Physiol 293 2007 F186 F192
6. S.A. Morgan, E.L. McCabe, L.L. Gathercole, Z.K. Hassan-Smith, D.P. Larner, I.J. Bujalska, P.M. Stewart, J.W. Tomlinson, and G.G. Lavery 11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess Proc Natl Acad Sci USA 111 2014 E2482 E2491
7. B.L. Conway-Campbell, J.R. Pooley, G.L. Hager, and S.L. Lightman Molecular dynamics of ultradian glucocorticoid receptor action Mol Cell Endocrinol 348 2012 383 393
8. R.H. Stimson, N.A. Mohd-Shukri, J.L. Bolton, R. Andrew, R.M. Reynolds, and B.R. Walker The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production J Clin Endocrinol Metab 99 2014 160 168
9. D.E. Henley, and S.L. Lightman Cardio-metabolic consequences of glucocorticoid replacement: relevance of ultradian signalling Clin Endocrinol (Oxf) 80 2014 621 628
10. J.L. Arriza, C. Weinberger, G. Cerelli, T.M. Glaser, B.L. Handelin, D.E. Housman, and R.M. Evans Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor Science 237 1987 268 275
11. B.J.F. Robles, A.R.H. Sandoval, J.D.P. Dardon, and C.A. Blas Lethal liquorice lollies (liquorice abuse causing pseudohyperaldosteronism) BMJ Case Rep 2013 2013
12. P.M. Stewart, Z.S. Krozowski, A. Gupta, D.V. Milford, A.J. Howie, M.C. Sheppard, and C.B. Whorwood Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene Lancet 347 1996 88 91
13. Y.V. Kotelevtsev, R.W. Brown, S. Fleming, C. Kenyon, C.R. Edwards, J.R. Seckl, and J.J. Mullins Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 J Clin Invest 103 1999 683 689
14. P.M. Stewart, J.E. Corrie, C.H. Shackleton, and C.R. Edwards Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle J Clin Invest 82 1988 340 349
15. M.A. Bailey, R.J. Unwin, and D.G. Shirley In vivo inhibition of renal 11beta-hydroxysteroid dehydrogenase in the rat stimulates collecting duct sodium reabsorption Clin Sci (Lond) 101 2001 195 198
16. P. Ferrari The role of 11beta-hydroxysteroid dehydrogenase type 2 in human hypertension [Internet] Biochim Biophys Acta 2009 [no volume]
17. A.W. Cowley The genetic dissection of essential hypertension Nat Rev 7 2006 829 840
18. M.A. Bailey, J.M. Paterson, P.W. Hadoke, N. Wrobel, C.O. Bellamy, D.G. Brownstein, J.R. Seckl, and J.J. Mullins A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess J Am Soc Nephrol 19 2008 47 58
19. Z. Hassan-Smith, and P.M. Stewart Inherited forms of mineralocorticoid hypertension Curr Opin Endocrinol Diabetes Obes 18 2011 177 185
20. D. Ackermann, N. Gresko, M. Carrel, D. Loffing-Cueni, D. Habermehl, C. Gomez-Sanchez, B.C. Rossier, and J. Loffing In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule Am J Physiol 299 2010 F1473-85
21. H.P. Gaeggeler, E. Gonzalez-Rodriguez, N.F. Jaeger, D. Loffing-Cueni, R. Norregaard, J. Loffing, J.D. Horisberger, and B.C. Rossier Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line J Am Soc Nephrol 16 2005 878 891
22. T. Bergann, A. Fromm, S.A. Borden, M. Fromm, and J.D. Schulzke Glucocorticoid receptor is indispensable for physiological responses to aldosterone in epithelial Na(+) channel induction via the mineralocorticoid receptor in a human colonic cell line Eur J Cell Biol 90 2011 432 439
23. M. Nishi, M. Tanaka, K. Matsuda, M. Sunaguchi, and M. Kawata Visualization of glucocorticoid receptor and mineralocorticoid receptor interactions in living cells with GFP-based fluorescence resonance energy transfer J Neurosci 24 2004 4918 4927
24. M.A. Bailey, E. Craigie, D.E.W. Livingstone, Y.V. Kotelevtsev, E.A.S. Al-Dujaili, C.J. Kenyon, and J.J. Mullins Hsd11b2 haploinsufficiency in mice causes salt sensitivity of blood pressure Hypertension 57 2011 515 520
25. E. Craigie, L.C. Evans, J.J. Mullins, and M.A. Bailey Failure to downregulate the epithelial sodium channel causes salt sensitivity in Hsd11b2 heterozygote mice Hypertension 60 2012 684 690
26. R.W. Hunter, J.R. Ivy, P.W. Flatman, C.J. Kenyon, E. Craigie, L.J. Mullins, M.A. Bailey, and J.J. Mullins Hypertrophy in the distal convoluted tubule of an 11β-hydroxysteroid dehydrogenase type 2 knockout model J Am Soc Nephrol 2014 10.1681/ASN.2013060634
27. Z. Chen, D.A. Vaughn, P. Blakely, and D.D. Fanestil Adrenocortical steroids increase renal thiazide diuretic receptor density and response J Am Soc Nephrol 5 1994 1361 1368
28. S. Mu, T. Shimosawa, S. Ogura, H. Wang, Y. Uetake, F. Kawakami-Mori, T. Marumo, Y. Yatomi, D.S. Geller, and H. Tanaka Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension Nat Med 17 2011 573 580
29. N. Van der Lubbe, C.H. Lim, M.E. Meima, R. van Veghel, L.L. Rosenbaek, K. Mutig, A.H.J. Danser, R.A. Fenton, R. Zietse, and E.J. Hoorn Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway Pflugers Arch 463 2012 853 863
30. Z. Kyossev, P.D. Walker, and W.B. Reeves Immunolocalization of NAD-dependent 11 beta-hydroxysteroid dehydrogenase in human kidney and colon Kidney Int 49 1996 271 281
31. G. Hirasawa, H. Sasano, K. Takahashi, K. Fukushima, T. Suzuki, N. Hiwatashi, T. Toyota, Z.S. Krozowski, and H. Nagura Colocalization of 11 beta-hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human epithelia J Clin Endocrinol Metab 82 1997 3859 3863
32. T.A. Williams, P. Mulatero, F. Filigheddu, C. Troffa, A. Milan, G. Argiolas, P.P. Parpaglia, F. Veglio, and N. Glorioso Role of HSD11B2 polymorphisms in essential hypertension and the diuretic response to thiazides Kidney Int 67 2005 631 637
33. P. Ferrari, M.G. Bianchetti, A. Sansonnens, and F.J. Frey Modulation of renal calcium handling by 11 beta-hydroxysteroid dehydrogenase type 2 J Am Soc Nephrol 13 2002 2540 2546
34. M.K. Gehr, and M. Goldberg Hypercalciuria of mineralocorticoid escape: clearance and micropuncture studies in the rat Am J Physiol 251 1986 F879 F888
35. L.C. Evans, D.E. Livingstone, C.J. Kenyon, M.A. Jansen, J.W. Dear, J.J. Mullins, and M.A. Bailey A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice Am J Physiol Renal Physiol 303 2012 F494 F502
36. S. Diederich, M. Quinkler, P. Burkhardt, C. Grossmann, V. Bahr, and W. Oelkers 11Beta-hydroxysteroid-dehydrogenase isoforms: tissue distribution and implications for clinical medicine Eur J Clin Invest 30 Suppl 3 2000 21 27
37. X.L. Moore, I. Hoong, and T.J. Cole Expression of the 11beta-hydroxysteroid dehydrogenase 2 gene in the mouse Kidney Int 57 2000 1307 1312
38. D. Lienhard, M. Lauterburg, G. Escher, F.J. Frey, and B.M. Frey High salt intake down-regulates colonic mineralocorticoid receptors, epithelial sodium channels and 11(-hydroxysteroid dehydrogenase type 2 PLoS ONE 7 2012 e37898
39. A. Serra, D.E. Uehlinger, P. Ferrari, B. Dick, B.M. Frey, F.J. Frey, and B. Vogt Glycyrrhetinic acid decreases plasma potassium concentrations in patients with anuria J Am Soc Nephrol 13 2002 191 196
40. P.W. Hadoke, C. Christy, Y.V. Kotelevtsev, B.C. Williams, C.J. Kenyon, J.R. Seckl, J.J. Mullins, and B.R. Walker Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11beta-hydroxysteroid dehydrogenase Circulation 104 2001 2832 2837
41. E.P. Gomez-Sanchez, and C.E. Gomez-Sanchez Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone Am J Physiol 263 1992 E1125 E1130
42. L.C. Evans, M. Holmes, J. Mullins, and M.A. Bailey Evaluation of salt appetite in brain specific 11beta hydroxysteroid dehydrogenase type 2 knockout (11betaHSD2-/-) mice FASEB J 26 2012 1069.7
43. J.C. Geerling, and A.D. Loewy Aldosterone in the brain Am J Physiol Renal Physiol 297 2009 F559 F576
44. E.P. Gomez-Sanchez, D.G. Romero, A.F. de Rodriguez, M.P. Warden, Z. Krozowski, and C.E. Gomez-Sanchez Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat Endocrinology 149 2008 525 533
45. J.W. Tomlinson, E.A. Walker, I.J. Bujalska, N. Draper, G.G. Lavery, M.S. Cooper, M. Hewison, and P.M. Stewart 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response Endocr Rev 25 2004 831 866
46. R. Gong, D.J. Morris, and A.S. Brem Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2 Life Sci 82 2008 631 637
47. P.M. Stewart, B.A. Murry, and J.I. Mason Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform J Clin Endocrinol Metab 79 1994 480 484
48. Y. Liu, R.J. Singh, K. Usa, B.C. Netzel, and M. Liang Renal medullary 11 beta-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension Physiol Genomics 36 2008 52 58
49. M. Liang, B. Yuan, E. Rute, A.S. Greene, M. Olivier, and A.W. Cowley Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression Physiol Genomics 12 2003 229 237
50. D.F. Cobice, C.L. Mackay, R.J.A. Goodwin, A. McBride, P.R. Langridge-Smith, S.P. Webster, B.R. Walker, and R. Andrew Mass spectrometry imaging for dissecting steroid intracrinology within target tissues Anal Chem 85 2013 11576 11584
51. A. Odermatt, and P. Klusonova 11(-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story J Steroid Biochem Mol Biol 2014 10.1016/j.jsbmb.2014.08.011
52. A. Chapagain, P.W. Caton, J. Kieswich, P. Andrikopoulos, N. Nayuni, J.H. Long, S.M. Harwood, S.P. Webster, M.J. Raftery, and C. Thiemermann Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia Proc Natl Acad Sci USA 111 2014 3817 3822
53. H. Masuzaki, H. Yamamoto, C.J. Kenyon, J.K. Elmquist, N.M. Morton, J.M. Paterson, H. Shinyama, M.G.F. Sharp, S. Fleming, and J.J. Mullins Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice J Clin Invest 112 2003 83 90
54. D.R. Bauman, A. Whitehead, L.C. Contino, J. Cui, M. Garcia-Calvo, X. Gu, N. Kevin, X. Ma, L. Pai, and K. Shah Evaluation of selective inhibitors of 11(-HSD1 for the treatment of hypertension Bioorg Med Chem Lett 23 2013 3650 3653
55. Y.H. Lo, M.F. Sheff, S.A. Latif, C. Ribeiro, H. Silver, A.S. Brem, and D.J. Morris Kidney 11β-HSD2 is inhibited by glycyrrhetinic acid-like factors in human urine Hypertension 29 1997 500 505
56. D.J. Morris, S.A. Latif, Y.H. Lo, K. Abrampah, A.S. Brem, W.R. Lichtfield, and G.H. Williams Correlation of glycyrrhetinic acid-like factors (kidney 11beta-HSD2-GALFs) with urinary free cortisol and plasma renin activity in essential hypertension J Am Soc Hypertens 2 2008 286 293
57. N. Farman, and B. Bocchi Mineralocorticoid selectivity: molecular and cellular aspects Kidney Int 57 2000 1364 1369
58. M. Rezaei, T. Andrieu, S. Neuenschwander, R. Bruggmann, D. Mordasini, F.J. Frey, B. Vogt, and B.M. Frey Regulation of 11β-hydroxysteroid dehydrogenase type 2 by MicroRNA Hypertension 64 2014 860 866
59. L. Martinerie, E. Pussard, G. Meduri, A.-L. Delezoide, P. Boileau, and M. Lombès Lack of renal 11 beta-hydroxysteroid dehydrogenase type 2 at birth, a targeted temporal window for neonatal glucocorticoid action in human and mice PLoS ONE 7 2012 e31949
60. C. Campino, A. Martinez-Aguayo, R. Baudrand, C.A. Carvajal, M. Aglony, H. Garcia, O. Padilla, A.M. Kalergis, and C.E. Fardella Age-related changes in 11β-hydroxysteroid dehydrogenase type 2 activity in normotensive subjects Am J Hypertens 26 2013 481 487
61. K. Chapman, M. Holmes, and J. Seckl 11β-Hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action Physiol. Rev. 93 2013 1139 1206
62. J.W. Funder Aldosterone and mineralocorticoid receptors in the cardiovascular system Prog Cardiovasc Dis 52 2010 393 400
63. R. Andrew, J. Westerbacka, J. Wahren, H. Yki-Järvinen, and B.R. Walker The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans Diabetes 54 2005 1364 1370
64. E.P. Gomez-Sanchez, V. Ganjam, Y.J. Chen, Y. Liu, M.Y. Zhou, C. Toroslu, D.G. Romero, M.D. Hughson, A. de Rodriguez, and C.E. Gomez-Sanchez Regulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol Am J Physiol Endocrinol Metab 285 2003 E272 E279
65. D.R. Dunbar, H. Khaled, L.C. Evans, E.A.S. Al-Dujaili, L.J. Mullins, J.J. Mullins, C.J. Kenyon, and M.A. Bailey Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney Physiol Genomics 40 2010 158 166
66. J. McKinnell, D. Roscoe, M.C. Holmes, S.A. Lloyd-MacGilp, and C.J. Kenyon Regulation of 11beta-hydroxysteroid dehydrogenase enzymes by dietary sodium in the rat Endocr Res 26 2000 81 95
67. A. Thompson, M.A. Bailey, A.E. Michael, and R.J. Unwin Effects of changes in dietary intake of sodium and potassium and of metabolic acidosis on 11beta-hydroxysteroid dehydrogenase activities in rat kidney Exp Nephrol 8 2000 44 51
68. Y. Huang, X. Li, H. Lin, Y. Chu, B. Chen, Q. Lian, and R.S. Ge Regulation of 11beta-hydroxysteroid dehydrogenase 1 and 2 by IGF-1 in mice [Internet] Biochem Biophys Res Commun 2009 [no volume]
69. J.I. Tang, C.J. Kenyon, J.R. Seckl, and M.J. Nyirenda Prenatal overexposure to glucocorticoids programs renal 11β-hydroxysteroid dehydrogenase type 2 expression and salt-sensitive hypertension in the rat J Hypertens 29 2011 282 289
70. S.M. MacLaughlin, S.K. Walker, D.O. Kleemann, D.N. Tosh, and I.C. McMillen Periconceptional undernutrition and being a twin each alter kidney development in the sheep fetus during early gestation Am J Physiol Regul Integr Comp Physiol 298 2010 R692 R699
71. M. Lauterburg, G. Escher, B. Dick, D. Ackermann, and F.J. Frey Uninephrectomy reduces 11β-hydroxysteroid dehydrogenase type 1 and type 2 concomitantly with an increase in blood pressure in rats J Endocrinol 214 2012 373 380
72. M.L. Zallocchi, L. Matkovic, J.C. Calvo, and M.C. Damasco Adrenal gland involvement in the regulation of renal 11beta-hydroxysteroid dehydrogenase 2 J Cell Biochem 92 2004 591 602
73. B. Rubis, S. Grodecka-Gazdecka, R. Lecybyl, M. Ociepa, Z. Krozowski, and W.H. Trzeciak Contribution of protein kinase A and protein kinase C signalling pathways to the regulation of HSD11B2 expression and proliferation of MCF-7 cells Acta Biochim Pol 51 2004 919 924
74. Z. Balazs, R.A. Schweizer, F.J. Frey, F. Rohner-Jeanrenaud, and A. Odermatt DHEA induces 11-HSD2 by acting on CCAAT/enhancer-binding proteins J Am Soc Nephrol 19 2008 92 101
75. R. Lecybyl, B. Rubis, Z. Krozowski, and W.H. Trzeciak Regulation of 11beta-hydroxysteroid dehydrogenase type II expression in the renal epithelial cells Endocr Res 29 2003 211 216
76. H.L. Brooks, S. Ageloff, T.H. Kwon, W. Brandt, J.M. Terris, A. Seth, L. Michea, S. Nielsen, R. Fenton, and M.A. Knepper cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion Am J Physiol 284 2003 F218 F228
77. J. Song, X. Hu, O. Khan, Y. Tian, J.G. Verbalis, and C.A. Ecelbarger Increased blood pressure, aldosterone activity, and regional differences in renal ENaC protein during vasopressin escape Am J Physiol 287 2004 F1076 F1083
78. R. Franco-Saenz, P. Shen, S.J. Lee, G.T. Cicila, and W.L. Henrich Regulation of the genes for 11beta-hydroxysteroid dehydrogenase type 1 and type 2 in the kidney of the Dahl rat J Hypertension 17 1999 1089 1093
79. R. Norregaard, T.R. Uhrenholt, C. Bistrup, O. Skott, and B.L. Jensen Stimulation of 11-beta-hydroxysteroid dehydrogenase type 2 in rat colon but not in kidney by low dietary NaCl intake Am J Physiol Renal Physiol 285 2003 F348 F358
80. M. Baserga, M.A. Hale, Z.M. Wang, X. Yu, C.W. Callaway, R.A. McKnight, and R.H. Lane Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension Am J Physiol Regul Integr Comp Physiol 292 2007 R1943 R1955
81. C.D. Heiniger, R.M. Kostadinova, M.K. Rochat, A. Serra, P. Ferrari, B. Dick, B.M. Frey, and F.J. Frey Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1 Faseb J 17 2003 917 919
82. R.M. Kostadinova, A.R. Nawrocki, F.J. Frey, and B.M. Frey Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11beta-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-kappaB homodimers and Egr-1 Faseb J 19 2005 650 652
83. S.W. Kim, S. de Seigneux, M.C. Sassen, J. Lee, J. Kim, M.A. Knepper, J. Frokiaer, and S. Nielsen Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats Am J Physiol Renal Physiol 290 2006 F674 F687