Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 12, 2013, Pages 3650-3653

  Bauman, David R ^a   Whitehead, Alan ^a   Contino, Lisa C ^a   Cui, Jisong ^a   Garcia Calvo, Margarita ^a   Gu, Xin ^a   Kevin, Nancy ^a   Ma, Xiuying ^a   Pai, Lee Yuh ^a   Shah, Kashmira ^a   Shen, Xiaolan ^a   Stribling, Sloan ^a   Zokian, Hratch J ^a   Metzger, Joe ^a   Shevell, Diane E ^a   Waddell, Sherman T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

1,2,4 Triazoles; 11 HSD1; 11 HSD1 KO; Hypertension; Spontaneous hypertensive rat

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ANTIHYPERTENSIVE AGENT; ENZYME INHIBITOR; MK 0736; MK 0916; UNCLASSIFIED DRUG;

ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE REGULATION; DRUG BLOOD LEVEL; HUMAN; HYPERTENSION; IC 50; IN VITRO STUDY; NONHUMAN;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; ENZYME INHIBITORS; HUMANS; HYPERTENSION; MICE; MICE, KNOCKOUT; RATS; RATS, INBRED SHR; TRIAZOLES;

RATTUS;

EID: 84878106198     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.011     Document Type: Article

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