Prenatal Alcohol Exposure Alters Steady-State and Activated Gene Expression in the Adult Rat Brain

Alcoholism: Clinical and Experimental Research

Volumn 39, Issue 2, 2015, Pages 251-261

  Lussier, Alexandre A ^a   Stepien, Katarzyna A ^a   Neumann, Sarah M ^b   Pavlidis, Paul ^c   Kobor, Michael S ^b   Weinberg, Joanne ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Arthritis; Ethanol; Gene Expression; Inflammation; Prenatal Alcohol Exposure; Rat

Indexed keywords

ALCOHOL; FREUND ADJUVANT; MESSENGER RNA; SODIUM CHLORIDE; CENTRAL DEPRESSANT AGENT; IMMUNOLOGICAL ADJUVANT;

ADJUVANT ARTHRITIS; ADULT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; ENERGY METABOLISM; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENETIC REGULATION; GENETIC SUSCEPTIBILITY; HIPPOCAMPUS; IMMUNE RESPONSE; MALE; MICROARRAY ANALYSIS; NERVE CELL DIFFERENTIATION; NONHUMAN; PREFRONTAL CORTEX; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; STEADY STATE; ANIMAL; BRAIN; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; INFLAMMATION; METABOLISM; PREGNANCY;

ANIMALIA; RATTUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; APOPTOSIS; BRAIN; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ENERGY METABOLISM; ETHANOL; FEMALE; FREUND'S ADJUVANT; GENE EXPRESSION; GENE EXPRESSION PROFILING; HIPPOCAMPUS; INFLAMMATION; PREFRONTAL CORTEX; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS;

EID: 84922730203     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12622     Document Type: Article

References (49)

1. Barilla ML, Carsons SE (2000) Fibronectin fragments and their role in inflammatory arthritis. Semin Arthritis Rheum 29:252-265.
2. Bodnar T, Weinberg J (2013) Prenatal alcohol exposure: impact on neuroendocrine - neuroimmune networks, in Neural-Immune Interactions in Brain Function (Cui C, Grandison L, Noronha A eds), pp 307-357. Springer Science+Business Media, New York, NY.
3. Borck G, Mollà-Herman A, Boddaert N, Encha-Razavi F, Philippe A, Robel L, Desguerre I, Brunelle F, Benmerah A, Munnich A, Colleaux L (2008) Clinical, cellular, and neuropathological consequences of AP1S2 mutations: further delineation of a recognizable X-linked mental retardation syndrome. Hum Mutat 29:966-974.
4. Brand JM, Frohn C, Cziupka K, Brockmann C, Kirchner H, Luhm J (2004) Prolactin triggers pro-inflammatory immune responses in peripheral immune cells. Eur Cytokine Netw 15:99-104.
5. Carter JL, Lubahn C, Lorton D, Osredkar T, Der TC, Schaller J, Evelsizer S, Flowers S, Ruff N, Reese B, Bellinger DL (2011) Adjuvant-induced arthritis induces c-Fos chronically in neurons in the hippocampus. J Neuroimmunol 230:85-94.
6. Crofford LJ, Sano H, Karalis K, Webster EL, Goldmuntz EA, Chrousos GP, Wilder RL (1992) Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis. J Clin Invest 90:2555-2564.
7. Cuadrado A, Nebreda AR (2010) Mechanisms and functions of p38 MAPK signalling. Biochem J 429:403-417.
8. Dumas A, Lagarde S, Laflamme C, Pouliot M (2012) Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo. J Cell Mol Med 16:1274-1285.
9. Gauthier TW, Drews-Botsch C, Falek A, Coles C, Brown LA (2005) Maternal alcohol abuse and neonatal infection. Alcohol Clin Exp Res 29:1035-1043.
10. Green ML, Singh AV, Zhang Y, Nemeth KA, Sulik KK, Knudsen TB (2007) Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome. Dev Dyn 236:613-631.
11. Guo Y, Chen Y, Carreon S, Qiang M (2012) Chronic intermittent ethanol exposure and its removal induce a different miRNA expression pattern in primary cortical neuronal cultures. Alcohol Clin Exp Res 36:1058-1066.
12. Hard ML, Abdolell M, Robinson BH, Koren G (2005) Gene-expression analysis after alcohol exposure in the developing mouse. J Lab Clin Med 145:47-54.
13. Harper KM, Tunc-Ozcan E, Graf EN, Redei EE (2014) Intergenerational effects of prenatal ethanol on glucose tolerance and insulin response. Physiol Genomics 46:159-168.
14. Harris A, Seckl J (2011) Glucocorticoids, prenatal stress and the programming of disease. Horm Behav 59:279-289.
15. Hellemans KG, Sliwowska JH, Verma P, Weinberg J (2010) Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders. Neurosci Biobehav Rev 34:791-807.
16. Hwang J, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I (2011) FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. J Immunol 187:987-998.
17. Johnson S, Knight R, Marmer DJ, Steele RW (1981) Immune deficiency in fetal alcohol syndrome. Pediatr Res 15:908-911.
18. Kim SH, Shin SY, Lee KY, Joo EJ, Song JY, Ahn YM, Lee YH, Kim YS (2012) The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity. Prog Neuropsychopharmacol Biol Psychiatry 37:41-49.
19. Kleiber ML, Laufer BI, Wright E, Diehl EJ, Singh SM (2012) Long-term alterations to the brain transcriptome in a maternal voluntary consumption model of fetal alcohol spectrum disorders. Brain Res 1458:18-33.
20. Kleiber ML, Mantha K, Stringer RL, Singh SM (2013) Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure. J Neurodev Disord 5:6.
21. Kobor MS, Weinberg J (2011) Focus on: epigenetics and fetal alcohol spectrum disorders. Alcohol Res Health 34:29-37.
22. Lan N, Yamashita F, Halpert AG, Sliwowska JH, Viau V, Weinberg J (2009) Effects of prenatal ethanol exposure on hypothalamic-pituitary-adrenal function across the estrous cycle. Alcohol Clin Exp Res 33:1075-1088.
23. Lee HK, Braynen W, Keshav K, Pavlidis P (2005) ErmineJ: tool for functional analysis of gene expression data sets. BMC Bioinformatics 6:269.
24. Leek JT, Storey JD (2007) Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet 3:1724-1735.
25. Liu X, Wu Z, Hayashi Y, Nakanishi H (2012) Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation. Neuroscience 216:133-142.
26. Mattson SN, Crocker N, Nguyen TT (2011) Fetal alcohol spectrum disorders: neuropsychological and behavioral features. Neuropsychol Rev 21:81-101.
27. May PA, Gossage JP, Kalberg WO, Robinson LK, Buckley D, Manning M, Hoyme HE (2009) Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies. Dev Disabil Res Rev 15:176-192.
28. Moncada-Pazos A, Obaya AJ, Llamazares M, Heljasvaara R, Suárez MF, Colado E, Noël A, Cal S, López-Otín C (2012) ADAMTS-12 metalloprotease is necessary for normal inflammatory response. J Biol Chem 287:39554-39563.
29. National Research Council (2011) Guide for the Care and Use of Laboratory Animals. 8th ed. The National Academies Press, Washington, DC.
30. Nolan T, Hands RE, Bustin SA (2006) Quantification of mRNA using real-time RT-PCR. Nat Protoc 1:1559-1582.
31. Norman AL, Crocker N, Mattson SN, Riley EP (2009) Neuroimaging and fetal alcohol spectrum disorders. Dev Disabil Res Rev 15:209-217.
32. Ousman SS, Kubes P (2012) Immune surveillance in the central nervous system. Nat Neurosci 15:1096-1101.
33. Ozer E, Sarioglu S, Güre A (2000) Effects of prenatal ethanol exposure on neuronal migration, neuronogenesis and brain myelination in the mice brain. Clin Neuropathol 19:21-25.
34. Portales-Casamar E, Ch'ng C, Lui F, St-Georges N, Zoubarev A, Lai AY, Lee M, Kwok C, Kwok W, Tseng L, Pavlidis P (2013) Neurocarta: aggregating and sharing disease-gene relations for the neurosciences. BMC Genomics 14:129.
35. Raab RM, Bullen J, Kelleher J, Mantzoros C, Stephanopoulos G (2005) Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction. Nutr Metab (Lond) 2:15.
36. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative CT method. Nat Protoc 3:1101-1108.
37. Sliwowska JH, Lan N, Yamashita F, Halpert AG, Viau V, Weinberg J (2008) Effects of prenatal ethanol exposure on regulation of basal hypothalamic-pituitary-adrenal activity and hippocampal 5-HT1A receptor mRNA levels in female rats across the estrous cycle. Psychoneuroendocrinology 33:1111-1123.
38. Smyth GK (2005) limma: linear models for microarray data, in Bioinformatics and Computational Biology Solutions Using R and Bioconductor (Gentleman R, Carey VJ, Huber W, Irizarry RA, Dudoit S eds), pp 397-420. Springer, New York, NY.
39. Streissguth AP, Clarren SK, Jones KL (1985) Natural history of the fetal alcohol syndrome: a 10-year follow-up of eleven patients. Lancet 2:85-91.
40. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:RESEARCH0034.
41. Waschek JA (2013) VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair. Br J Pharmacol 169:512-523.
42. Weinberg J, Jerrells TR (1991) Suppression of immune responsiveness: sex differences in prenatal ethanol effects. Alcohol Clin Exp Res 15:525-531.
43. Werts RL, Van Calcar SC, Wargowski DS, Smith SM (2014) Inappropriate feeding behaviors and dietary intakes in children with fetal alcohol spectrum disorder or probable prenatal alcohol exposure. Alcohol Clin Exp Res 38:871-878.
44. Whitacre CC (2001) Sex differences in autoimmune disease. Nat Immunol 2:777-780.
45. Zhang X, Lan N, Bach P, Nordstokke D, Yu W, Ellis L, Meadows GG, Weinberg J (2012) Prenatal alcohol exposure alters the course and severity of adjuvant-induced arthritis in female rats. Brain Behav Immun 26:439-450.
46. Zhang X, Sliwowska JH, Weinberg J (2005) Prenatal alcohol exposure and fetal programming: effects on neuroendocrine and immune function. Exp Biol Med (Maywood) 230: 376-388.
47. Zhi-Liang H, Bao J, Reecy J (2008) CateGOrizer: a web-based program to batch analyze gene ontology classification categories. Online J Bioinformatics 9:108-122.
48. Zhou FC, Zhao Q, Liu Y, Goodlett CR, Liang T, McClintick JN, Edenberg HJ, Li L (2011) Alteration of gene expression by alcohol exposure at early neurulation. BMC Genomics 12:124.
49. Zhou W, Cao Q, Peng Y, Zhang QJ, Castrillon DH, DePinho RA, Liu ZP (2009) FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation. Gastroenterology 137:1403-1414.