메뉴 건너뛰기




Volumn 61, Issue 6, 2014, Pages 1407-1417

Hepatitis B flares in chronic hepatitis B: Pathogenesis, natural course, and management

Author keywords

Alpha fetoprotein; Chemotherapy; Cirrhosis; Hepatitis B virus; Hepatocellular carcinoma; Immune clearance; Immune restoration; Interferona; Nucleos(t)ide analogue; Pregnancy

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA FETOPROTEIN; ANTIVIRUS AGENT; CD20 ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; HLA ANTIGEN CLASS 1; INTERFERON; PEGINTERFERON; TUMOR NECROSIS FACTOR INHIBITOR; VIRUS DNA;

EID: 84922716957     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.08.033     Document Type: Review
Times cited : (242)

References (96)
  • 1
    • 59749096640 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Y.F. Liaw, and C.M. Chu Hepatitis B virus infection Lancet 373 2009 582 592
    • (2009) Lancet , vol.373 , pp. 582-592
    • Liaw, Y.F.1    Chu, C.M.2
  • 2
    • 0035123958 scopus 로고    scopus 로고
    • Acute flares in chronic hepatitis B: The natural and unnatural history of an immunologically mediated liver disease
    • R.P. Perrillo Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease Gastroenterology 120 2001 1009 1022
    • (2001) Gastroenterology , vol.120 , pp. 1009-1022
    • Perrillo, R.P.1
  • 3
    • 0037366499 scopus 로고    scopus 로고
    • Hepatitis flares and hepatitis B e antigen seroconversion: Implication in anti-hepatitis B virus therapy
    • Y.F. Liaw Hepatitis flares and hepatitis B e antigen seroconversion: implication in anti-hepatitis B virus therapy J Gastroenterol Hepatol 18 2003 246 252
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 246-252
    • Liaw, Y.F.1
  • 4
    • 0020666891 scopus 로고
    • Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis
    • Y.F. Liaw, C.M. Chu, I.J. Su, M.J. Huang, D.Y. Lin, and C.S. ChangChien Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis Gastroenterology 84 1983 216 219
    • (1983) Gastroenterology , vol.84 , pp. 216-219
    • Liaw, Y.F.1    Chu, C.M.2    Su, I.J.3    Huang, M.J.4    Lin, D.Y.5    Changchien, C.S.6
  • 5
    • 0025128658 scopus 로고
    • Acute exacerbations in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology
    • A.S. Lok, and C.L. Lai Acute exacerbations in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology J Hepatol 10 1990 29 34
    • (1990) J Hepatol , vol.10 , pp. 29-34
    • Lok, A.S.1    Lai, C.L.2
  • 6
    • 0035189597 scopus 로고    scopus 로고
    • Practice Guidelines Committee, American Association for the Study of Liver Diseases. Chronic hepatitis B
    • A.S. Lok, and B.J. McMahon Practice Guidelines Committee, American Association for the Study of Liver Diseases. Chronic hepatitis B Hepatology 34 2001 1225 1241
    • (2001) Hepatology , vol.34 , pp. 1225-1241
    • Lok, A.S.1    McMahon, B.J.2
  • 7
    • 0001760398 scopus 로고    scopus 로고
    • Pathogenesis and clinical significance of spontaneous exacerbation and remissions in chronic HBV infection
    • Y.F. Liaw, and S.L. Tsai Pathogenesis and clinical significance of spontaneous exacerbation and remissions in chronic HBV infection Viral Hepat Rev 3 1997 143 154
    • (1997) Viral Hepat Rev , vol.3 , pp. 143-154
    • Liaw, Y.F.1    Tsai, S.L.2
  • 8
    • 0021815180 scopus 로고
    • Acute exacerbation in hepatitis B e antigen-positive chronic type B hepatitis: A clinicopathological study
    • Y.F. Liaw, S.S. Yang, T.J. Chen, and C.M. Chu Acute exacerbation in hepatitis B e antigen-positive chronic type B hepatitis: a clinicopathological study J Hepatol 1 1985 227 233
    • (1985) J Hepatol , vol.1 , pp. 227-233
    • Liaw, Y.F.1    Yang, S.S.2    Chen, T.J.3    Chu, C.M.4
  • 9
    • 0023091377 scopus 로고
    • Acute exacerbation in chronic type B hepatitis: Comparison between HBeAg and antibody positive patients
    • Y.F. Liaw, D.I. Tai, C.M. Chu, C.C. Pao, and T.J. Chen Acute exacerbation in chronic type B hepatitis: comparison between HBeAg and antibody positive patients Hepatology 7 1987 20 23
    • (1987) Hepatology , vol.7 , pp. 20-23
    • Liaw, Y.F.1    Tai, D.I.2    Chu, C.M.3    Pao, C.C.4    Chen, T.J.5
  • 10
    • 0036614299 scopus 로고    scopus 로고
    • Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B
    • Y.S. Hsu, R.N. Chien, C.T. Yeh, I.S. Sheen, H.Y. Chiou, and C.M. Chu Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B Hepatology 35 2002 1522 1527
    • (2002) Hepatology , vol.35 , pp. 1522-1527
    • Hsu, Y.S.1    Chien, R.N.2    Yeh, C.T.3    Sheen, I.S.4    Chiou, H.Y.5    Chu, C.M.6
  • 11
    • 0141749185 scopus 로고    scopus 로고
    • Chronic hepatitis B e antigen (HBeAg) negative, anti-HBe positive hepatitis B: An overview
    • F. Bonino, and M.R. Brunetto Chronic hepatitis B e antigen (HBeAg) negative, anti-HBe positive hepatitis B: an overview J Hepatol 39 2003 S160 S163
    • (2003) J Hepatol , vol.39 , pp. S160-S163
    • Bonino, F.1    Brunetto, M.R.2
  • 12
    • 0021816456 scopus 로고
    • Hepatic decompensation associated with hepatitis B e antigen clearance in chronic type B hepatitis
    • I.S. Sheen, Y.F. Liaw, D.I. Tai, and C.M. Chu Hepatic decompensation associated with hepatitis B e antigen clearance in chronic type B hepatitis Gastroenterology 89 1985 732 735
    • (1985) Gastroenterology , vol.89 , pp. 732-735
    • Sheen, I.S.1    Liaw, Y.F.2    Tai, D.I.3    Chu, C.M.4
  • 13
    • 0024562337 scopus 로고
    • The etiology of acute hepatitis superimposed upon previously unrecognized asymptomatic HBsAg carriers
    • C.M. Chu, Y.F. Liaw, C.C. Pao, and M.J. Huang The etiology of acute hepatitis superimposed upon previously unrecognized asymptomatic HBsAg carriers Hepatology 9 1989 452 456
    • (1989) Hepatology , vol.9 , pp. 452-456
    • Chu, C.M.1    Liaw, Y.F.2    Pao, C.C.3    Huang, M.J.4
  • 14
    • 0025173368 scopus 로고
    • Acute exacerbation in patients with liver cirrhosis: A clinicopathological study
    • Y.F. Liaw, J.J. Chen, and T.J. Chen Acute exacerbation in patients with liver cirrhosis: a clinicopathological study Liver 10 1990 177 184
    • (1990) Liver , vol.10 , pp. 177-184
    • Liaw, Y.F.1    Chen, J.J.2    Chen, T.J.3
  • 15
    • 0023189612 scopus 로고
    • IgM anti-HBc in anti-HBe positive chronic type B hepatitis with acute exacerbations
    • K. Koike, S. Iino, K. Kurai, K. Mitamura, Y. Endo, and H. Oka IgM anti-HBc in anti-HBe positive chronic type B hepatitis with acute exacerbations Hepatology 7 1987 573 576
    • (1987) Hepatology , vol.7 , pp. 573-576
    • Koike, K.1    Iino, S.2    Kurai, K.3    Mitamura, K.4    Endo, Y.5    Oka, H.6
  • 16
    • 0023003223 scopus 로고
    • Alpha-fetoprotein changes in the course of chronic hepatitis: Relation to bridging hepatic necrosis and hepatocellular carcinoma
    • Y.F. Liaw, D.Y. Tai, T.J. Chen, C.M. Chu, and M.J. Huang Alpha-fetoprotein changes in the course of chronic hepatitis: relation to bridging hepatic necrosis and hepatocellular carcinoma Liver 6 1986 133 137
    • (1986) Liver , vol.6 , pp. 133-137
    • Liaw, Y.F.1    Tai, D.Y.2    Chen, T.J.3    Chu, C.M.4    Huang, M.J.5
  • 18
    • 0023147172 scopus 로고
    • Changes of serum hepatitis B virus DNA in two types of clinical events preceding spontaneous hepatitis B e antigen seroconversion in chronic type B hepatitis
    • Y.F. Liaw, C.C. Pao, C.M. Chu, I.S. Sheen, and M.J. Huang Changes of serum hepatitis B virus DNA in two types of clinical events preceding spontaneous hepatitis B e antigen seroconversion in chronic type B hepatitis Hepatology 7 1987 1 3
    • (1987) Hepatology , vol.7 , pp. 1-3
    • Liaw, Y.F.1    Pao, C.C.2    Chu, C.M.3    Sheen, I.S.4    Huang, M.J.5
  • 19
    • 0023766749 scopus 로고
    • Changes of serum HBV DNA in relation to serum transaminase level during acute exacerbation in patients with chronic type B hepatitis
    • Y.F. Liaw, C.C. Pao, and C.M. Chu Changes of serum HBV DNA in relation to serum transaminase level during acute exacerbation in patients with chronic type B hepatitis Liver 8 1988 231 235
    • (1988) Liver , vol.8 , pp. 231-235
    • Liaw, Y.F.1    Pao, C.C.2    Chu, C.M.3
  • 20
    • 84984585828 scopus 로고    scopus 로고
    • A prospective study characterizing full-length hepatitis B virus genomes during acute exacerbation
    • C.J. Liu, P.J. Chen, M.Y. Lai, J.H. Kao, C.F. Chang, and H.L. Wu A prospective study characterizing full-length hepatitis B virus genomes during acute exacerbation Gastroenterology 124 2003 80 90
    • (2003) Gastroenterology , vol.124 , pp. 80-90
    • Liu, C.J.1    Chen, P.J.2    Lai, M.Y.3    Kao, J.H.4    Chang, C.F.5    Wu, H.L.6
  • 21
    • 0027306019 scopus 로고
    • Serology of acute exacerbation in chronic hepatitis B virus infection
    • T. Maruyama, S. Iino, K. Koike, K. Yasuda, and D.R. Milich Serology of acute exacerbation in chronic hepatitis B virus infection Gastroenterology 105 1993 1141 1151
    • (1993) Gastroenterology , vol.105 , pp. 1141-1151
    • Maruyama, T.1    Iino, S.2    Koike, K.3    Yasuda, K.4    Milich, D.R.5
  • 22
    • 0023203608 scopus 로고
    • Intrahepatic distribution of HBsAg and HBcAg in chronic hepatitis B virus infection: Hepatocyte with cytoplasmic/membranous HBcAg as a possible target for immune hepatocytolysis
    • C.M. Chu, and Y.F. Liaw Intrahepatic distribution of HBsAg and HBcAg in chronic hepatitis B virus infection: hepatocyte with cytoplasmic/membranous HBcAg as a possible target for immune hepatocytolysis Gastroenterology 92 1987 220 225
    • (1987) Gastroenterology , vol.92 , pp. 220-225
    • Chu, C.M.1    Liaw, Y.F.2
  • 23
    • 0024009535 scopus 로고
    • HLA class i antigen display on hepatocyte membrane in chronic hepatitis B virus infection: Its role in the pathogenesis of chronic type B hepatitis
    • C.M. Chu, W.C. Shyu, R.W. Kuo, and Y.F. Liaw HLA class I antigen display on hepatocyte membrane in chronic hepatitis B virus infection: its role in the pathogenesis of chronic type B hepatitis Hepatology 8 1988 712 717
    • (1988) Hepatology , vol.8 , pp. 712-717
    • Chu, C.M.1    Shyu, W.C.2    Kuo, R.W.3    Liaw, Y.F.4
  • 24
    • 0026527586 scopus 로고
    • Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion
    • S.L. Tsai, P.J. Chen, M.Y. Lai, P.M. Yang, J.L. Sung, and J.H. Huang Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion J Clin Invest 89 1992 87 96
    • (1992) J Clin Invest , vol.89 , pp. 87-96
    • Tsai, S.L.1    Chen, P.J.2    Lai, M.Y.3    Yang, P.M.4    Sung, J.L.5    Huang, J.H.6
  • 25
    • 0026655867 scopus 로고
    • Hepatitis B core antigen-specific interferon gamma production of peripheral blood mononuclear cells during acute exacerbation of chronic hepatitis B
    • T. Takehara, N. Hayashi, K. Katayama, A. Kasahara, H. Fusamoto, and T. Kamada Hepatitis B core antigen-specific interferon gamma production of peripheral blood mononuclear cells during acute exacerbation of chronic hepatitis B Scand J Gastroenterol 27 1992 727 731
    • (1992) Scand J Gastroenterol , vol.27 , pp. 727-731
    • Takehara, T.1    Hayashi, N.2    Katayama, K.3    Kasahara, A.4    Fusamoto, H.5    Kamada, T.6
  • 26
    • 0028997806 scopus 로고
    • The expression of IL-2, IL-4 and interferon-gamma (IFN-gamma) mRNA using liver biopsies at different phases of acute exacerbation of chronic hepatitis B
    • R. Fukuda, N. Ishimura, T.X. Nguyen, A. Chowdhury, S. Ishihara, and N. Kohge The expression of IL-2, IL-4 and interferon-gamma (IFN-gamma) mRNA using liver biopsies at different phases of acute exacerbation of chronic hepatitis B Clin Exp Immunol 100 1995 446 451
    • (1995) Clin Exp Immunol , vol.100 , pp. 446-451
    • Fukuda, R.1    Ishimura, N.2    Nguyen, T.X.3    Chowdhury, A.4    Ishihara, S.5    Kohge, N.6
  • 27
    • 73449125874 scopus 로고    scopus 로고
    • Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B
    • J.Y. Zhang, Z. Zhang, F. Lin, Z.S. Zou, R.N. Xu, and L. Jin Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B Hepatology 51 2010 81 91
    • (2010) Hepatology , vol.51 , pp. 81-91
    • Zhang, J.Y.1    Zhang, Z.2    Lin, F.3    Zou, Z.S.4    Xu, R.N.5    Jin, L.6
  • 28
    • 33847096821 scopus 로고    scopus 로고
    • HBcAg-specific CD4+CD25+ regulatory T cells modulate immune tolerance and acute exacerbation on the natural history of chronic hepatitis B virus infection
    • I.C. Feng, L.B. Koay, M.J. Sheu, H.T. Kuo, C.S. Sun, and C. Lee HBcAg-specific CD4+CD25+ regulatory T cells modulate immune tolerance and acute exacerbation on the natural history of chronic hepatitis B virus infection J Biomed Sci 14 2007 43 57
    • (2007) J Biomed Sci , vol.14 , pp. 43-57
    • Feng, I.C.1    Koay, L.B.2    Sheu, M.J.3    Kuo, H.T.4    Sun, C.S.5    Lee, C.6
  • 29
    • 84872428254 scopus 로고    scopus 로고
    • Acute exacerbations of chronic hepatitis B are accompanied by decline of core antigen-specific regulatory T-cell frequencies: Implications for successful anti-HBV treatments
    • S.L. Tsai, S.L. Wang, I.C. Feng, H.T. Kuo, L.B. Koay, and M.J. Sheu Acute exacerbations of chronic hepatitis B are accompanied by decline of core antigen-specific regulatory T-cell frequencies: implications for successful anti-HBV treatments Hepat Monthly 7 2007 183 200
    • (2007) Hepat Monthly , vol.7 , pp. 183-200
    • Tsai, S.L.1    Wang, S.L.2    Feng, I.C.3    Kuo, H.T.4    Koay, L.B.5    Sheu, M.J.6
  • 30
    • 84860389996 scopus 로고    scopus 로고
    • Hepatitis B virus (HBV) core antigen-specific regulatory T cells confer sustained remission to anti-HBV therapy in chronic hepatitis B with acute exacerbation
    • L.B. Koay, I.C. Feng, M.J. Sheu, H.T. Kuo, C.Y. Lin, and J.J. Chen Hepatitis B virus (HBV) core antigen-specific regulatory T cells confer sustained remission to anti-HBV therapy in chronic hepatitis B with acute exacerbation Hum Immunol 72 2011 687 698
    • (2011) Hum Immunol , vol.72 , pp. 687-698
    • Koay, L.B.1    Feng, I.C.2    Sheu, M.J.3    Kuo, H.T.4    Lin, C.Y.5    Chen, J.J.6
  • 31
    • 84867308365 scopus 로고    scopus 로고
    • IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection
    • A. Das, G. Ellis, C. Pallant, A.R. Lopes, P. Khanna, and D. Peppa IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection J Immunol 189 2012 3925 3935
    • (2012) J Immunol , vol.189 , pp. 3925-3935
    • Das, A.1    Ellis, G.2    Pallant, C.3    Lopes, A.R.4    Khanna, P.5    Peppa, D.6
  • 32
    • 33947411395 scopus 로고    scopus 로고
    • Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage
    • C. Dunn, M. Brunetto, G. Reynolds, T. Christophides, P.T. Kennedy, and P. Lampertico Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage J Exp Med 204 2007 667 680
    • (2007) J Exp Med , vol.204 , pp. 667-680
    • Dunn, C.1    Brunetto, M.2    Reynolds, G.3    Christophides, T.4    Kennedy, P.T.5    Lampertico, P.6
  • 33
    • 77249098281 scopus 로고    scopus 로고
    • A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B
    • A.T. Tan, S. Koh, W. Goh, H.Y. Zhe, A.J. Gehring, and S.G. Lim A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B J Hepatol 52 2010 330 339
    • (2010) J Hepatol , vol.52 , pp. 330-339
    • Tan, A.T.1    Koh, S.2    Goh, W.3    Zhe, H.Y.4    Gehring, A.J.5    Lim, S.G.6
  • 34
    • 84864952157 scopus 로고    scopus 로고
    • Longitudinal fluctuations in PD1 and PD-L1 expression in association with changes in anti-viral immune response in chronic hepatitis B
    • Z. Wenjin, P. Chuanhui, W. Yunle, S.A. Lateef, and Z. Shusen Longitudinal fluctuations in PD1 and PD-L1 expression in association with changes in anti-viral immune response in chronic hepatitis B BMC Gastroenterol 12 2012 109
    • (2012) BMC Gastroenterol , vol.12 , pp. 109
    • Wenjin, Z.1    Chuanhui, P.2    Yunle, W.3    Lateef, S.A.4    Shusen, Z.5
  • 35
    • 84865376141 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2012 update
    • Y.F. Liaw, J.H. Kao, T. Piratvisuth, H.L.Y. Chan, R.N. Chien, and C.J. Liu Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update Hepatol Int 6 2012 531 561
    • (2012) Hepatol Int , vol.6 , pp. 531-561
    • Liaw, Y.F.1    Kao, J.H.2    Piratvisuth, T.3    Chan, H.L.Y.4    Chien, R.N.5    Liu, C.J.6
  • 36
    • 0030811412 scopus 로고    scopus 로고
    • Current trends in therapy for chronic viral hepatitis
    • Y.F. Liaw Current trends in therapy for chronic viral hepatitis J Gastroenterol Hepatol 12 1997 S346 S353
    • (1997) J Gastroenterol Hepatol , vol.12 , pp. S346-S353
    • Liaw, Y.F.1
  • 37
    • 0037371501 scopus 로고    scopus 로고
    • A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: Implications for antiviral therapy
    • M.F. Yuen, H.J. Yuan, C.K. Hui, D.K. Wong, W.M. Wong, and A.O. Chan A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implications for antiviral therapy Gut 52 2003 416 419
    • (2003) Gut , vol.52 , pp. 416-419
    • Yuen, M.F.1    Yuan, H.J.2    Hui, C.K.3    Wong, D.K.4    Wong, W.M.5    Chan, A.O.6
  • 39
    • 23444443850 scopus 로고    scopus 로고
    • Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: A longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline
    • C.M. Chu, and Y.F. Liaw Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline J Hepatol 43 2005 411 417
    • (2005) J Hepatol , vol.43 , pp. 411-417
    • Chu, C.M.1    Liaw, Y.F.2
  • 40
    • 33947432473 scopus 로고    scopus 로고
    • Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: Implication for early HBeAg seroconversion
    • M.F. Yuen, D.K. Wong, B.J. Zheng, C.C. Chan, J.C. Yuen, and B.C. Wong Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion J Viral Hepat 14 2007 269 275
    • (2007) J Viral Hepat , vol.14 , pp. 269-275
    • Yuen, M.F.1    Wong, D.K.2    Zheng, B.J.3    Chan, C.C.4    Yuen, J.C.5    Wong, B.C.6
  • 41
    • 77952742728 scopus 로고    scopus 로고
    • Hepatitis B virus DNA level predicts hepatic decompensation in patients with acute exacerbation of chronic hepatitis B
    • W.J. Jeng, I.S. Sheen, and Y.F. Liaw Hepatitis B virus DNA level predicts hepatic decompensation in patients with acute exacerbation of chronic hepatitis B Clin Gastroenterol Hepatol 8 2010 541 545
    • (2010) Clin Gastroenterol Hepatol , vol.8 , pp. 541-545
    • Jeng, W.J.1    Sheen, I.S.2    Liaw, Y.F.3
  • 42
    • 75449105399 scopus 로고    scopus 로고
    • Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B
    • Y.C. Chen, C.M. Chu, and Y.F. Liaw Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B Hepatology 51 2010 435 444
    • (2010) Hepatology , vol.51 , pp. 435-444
    • Chen, Y.C.1    Chu, C.M.2    Liaw, Y.F.3
  • 43
    • 0023762809 scopus 로고
    • The development of cirrhosis in patients with chronic type B hepatitis: A prospective study
    • Y.F. Liaw, D.I. Tai, C.M. Chu, and T.J. Chen The development of cirrhosis in patients with chronic type B hepatitis: a prospective study Hepatology 8 1988 493 496
    • (1988) Hepatology , vol.8 , pp. 493-496
    • Liaw, Y.F.1    Tai, D.I.2    Chu, C.M.3    Chen, T.J.4
  • 44
    • 0034761964 scopus 로고    scopus 로고
    • Serum alanine aminotransferase flares during interferon treatment of chronic hepatitis B: Is sustained clearance of HBV DNA dependent on levels of pretreatment viremia?
    • S. Nair, and R.P. Perrillo Serum alanine aminotransferase flares during interferon treatment of chronic hepatitis B: is sustained clearance of HBV DNA dependent on levels of pretreatment viremia? Hepatology 34 2001 1021 1026
    • (2001) Hepatology , vol.34 , pp. 1021-1026
    • Nair, S.1    Perrillo, R.P.2
  • 45
    • 0030959049 scopus 로고    scopus 로고
    • Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B
    • S. Rossol, G. Marinos, P. Carucci, M.V. Singer, R. Williams, and N.V. Naoumov Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B J Clin Invest 99 1997 3025 3033
    • (1997) J Clin Invest , vol.99 , pp. 3025-3033
    • Rossol, S.1    Marinos, G.2    Carucci, P.3    Singer, M.V.4    Williams, R.5    Naoumov, N.V.6
  • 46
    • 21244447705 scopus 로고    scopus 로고
    • Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B
    • Peginterferon Alfa-2a HBeAg-Positive Chronic Hepatitis B Study Group
    • G.K. Lau, T. Piratvisuth, K.X. Luo, P. Marcellin, S. Thongsawat, G. Cooksley Peginterferon Alfa-2a HBeAg-Positive Chronic Hepatitis B Study Group Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B N Engl J Med 352 2005 2682 2695
    • (2005) N Engl J Med , vol.352 , pp. 2682-2695
    • Lau, G.K.1    Piratvisuth, T.2    Luo, K.X.3    Marcellin, P.4    Thongsawat, S.5    Cooksley, G.6
  • 47
    • 4544239807 scopus 로고    scopus 로고
    • Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B
    • Peginterferon Alfa-2a HBeAg-Negative Chronic Hepatitis B Study Group
    • P. Marcellin, G.K. Lau, F. Bonino, P. Farci, S. Hadziyannis, R. Jin Peginterferon Alfa-2a HBeAg-Negative Chronic Hepatitis B Study Group Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B N Engl J Med 351 2004 1206 1217
    • (2004) N Engl J Med , vol.351 , pp. 1206-1217
    • Marcellin, P.1    Lau, G.K.2    Bonino, F.3    Farci, P.4    Hadziyannis, S.5    Jin, R.6
  • 48
    • 27444446933 scopus 로고    scopus 로고
    • Flares in chronic hepatitis B patients induced by the host or the virus? Relation to treatment response during Peg-interferon {alpha}-2b therapy
    • HBV 99-01 Study Group
    • H.J. Flink, D. Sprengers, B.E. Hansen, M. van Zonneveld, R.A. de Man, S.W. Schalm HBV 99-01 Study Group Flares in chronic hepatitis B patients induced by the host or the virus? Relation to treatment response during Peg-interferon {alpha}-2b therapy Gut 54 2005 1604 1609
    • (2005) Gut , vol.54 , pp. 1604-1609
    • Flink, H.J.1    Sprengers, D.2    Hansen, B.E.3    Van Zonneveld, M.4    De Man, R.A.5    Schalm, S.W.6
  • 49
    • 0038045171 scopus 로고    scopus 로고
    • Peginterferon alpha-2a (40 kDa): An advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B
    • W.G. Cooksley, T. Piratvisuth, S.D. Lee, V. Mahachai, Y.C. Chao, and T. Tanwandee Peginterferon alpha-2a (40 kDa): an advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B J Viral Hepat 10 2003 298 305
    • (2003) J Viral Hepat , vol.10 , pp. 298-305
    • Cooksley, W.G.1    Piratvisuth, T.2    Lee, S.D.3    Mahachai, V.4    Chao, Y.C.5    Tanwandee, T.6
  • 50
    • 84872380975 scopus 로고    scopus 로고
    • Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B
    • L. Micco, D. Peppa, E. Loggi, A. Schurich, L. Jefferson, and C. Cursaro Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B J Hepatol 58 2013 225 233
    • (2013) J Hepatol , vol.58 , pp. 225-233
    • Micco, L.1    Peppa, D.2    Loggi, E.3    Schurich, A.4    Jefferson, L.5    Cursaro, C.6
  • 51
    • 84856514985 scopus 로고    scopus 로고
    • IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
    • L. Belloni, L. Allweiss, F. Guerrieri, N. Pediconi, T. Volz, and T. Pollicino IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome J Clin Invest 122 2012 529 537
    • (2012) J Clin Invest , vol.122 , pp. 529-537
    • Belloni, L.1    Allweiss, L.2    Guerrieri, F.3    Pediconi, N.4    Volz, T.5    Pollicino, T.6
  • 52
    • 84896029673 scopus 로고    scopus 로고
    • Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
    • J. Lucifora, Y. Xia, F. Reisinger, K. Zhang, D. Stadler, and X. Cheng Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA Science 343 2014 1221 1228
    • (2014) Science , vol.343 , pp. 1221-1228
    • Lucifora, J.1    Xia, Y.2    Reisinger, F.3    Zhang, K.4    Stadler, D.5    Cheng, X.6
  • 53
    • 84894064916 scopus 로고    scopus 로고
    • Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration
    • L. Allweiss, T. Volz, M. Lütgehetmann, K. Giersch, T. Bornscheuer, and A.W. Lohse Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration J Hepatol 60 2014 500 507
    • (2014) J Hepatol , vol.60 , pp. 500-507
    • Allweiss, L.1    Volz, T.2    Lütgehetmann, M.3    Giersch, K.4    Bornscheuer, T.5    Lohse, A.W.6
  • 54
    • 0032869876 scopus 로고    scopus 로고
    • Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B
    • for Asian Hepatitis Lamivudine Trial Group
    • R.N. Chien, Y.F. Liaw, M. Atkins for Asian Hepatitis Lamivudine Trial Group Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B Hepatology 30 1999 770 774
    • (1999) Hepatology , vol.30 , pp. 770-774
    • Chien, R.N.1    Liaw, Y.F.2    Atkins, M.3
  • 55
    • 0034235528 scopus 로고    scopus 로고
    • Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B
    • Asian hepatitis lamivudine study group
    • Y.F. Liaw, N.W.Y. Leung, T.T. Chang, R. Guan, D.I. Tai, K.Y. Ng Asian hepatitis lamivudine study group Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B Gastroenterology 119 2000 172 180
    • (2000) Gastroenterology , vol.119 , pp. 172-180
    • Liaw, Y.F.1    Leung, N.W.Y.2    Chang, T.T.3    Guan, R.4    Tai, D.I.5    Ng, K.Y.6
  • 56
    • 0033844153 scopus 로고    scopus 로고
    • Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B
    • Y.F. Liaw, S.L. Tsai, R.N. Chien, C.T. Yeh, and C.M. Chu Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B Hepatology 32 2000 604 609
    • (2000) Hepatology , vol.32 , pp. 604-609
    • Liaw, Y.F.1    Tsai, S.L.2    Chien, R.N.3    Yeh, C.T.4    Chu, C.M.5
  • 57
    • 0037468421 scopus 로고    scopus 로고
    • Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    • Adefovir Dipivoxil 437 Study Group
    • P. Marcellin, T.T. Chang, S.G. Lim, M.J. Tong, W. Sievert, M.L. Shiffman Adefovir Dipivoxil 437 Study Group Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B N Engl J Med 348 2003 808 816
    • (2003) N Engl J Med , vol.348 , pp. 808-816
    • Marcellin, P.1    Chang, T.T.2    Lim, S.G.3    Tong, M.J.4    Sievert, W.5    Shiffman, M.L.6
  • 58
    • 21244455293 scopus 로고    scopus 로고
    • Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B
    • Adefovir Dipivoxil 438 Study Group
    • S.J. Hadziyannis, N.C. Tassopoulos, E.J. Heathcote, T.T. Chang, G. Kitis, M. Rizzetto Adefovir Dipivoxil 438 Study Group Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B N Engl J Med 352 2005 2673 2681
    • (2005) N Engl J Med , vol.352 , pp. 2673-2681
    • Hadziyannis, S.J.1    Tassopoulos, N.C.2    Heathcote, E.J.3    Chang, T.T.4    Kitis, G.5    Rizzetto, M.6
  • 59
    • 33644818518 scopus 로고    scopus 로고
    • A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    • BEHoLD AI463022 Study Group
    • T.T. Chang, R.G. Gish, R. de Man, A. Gadano, J. Sollano, Y.C. Chao BEHoLD AI463022 Study Group A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B N Engl J Med 354 2006 1001 1010
    • (2006) N Engl J Med , vol.354 , pp. 1001-1010
    • Chang, T.T.1    Gish, R.G.2    De Man, R.3    Gadano, A.4    Sollano, J.5    Chao, Y.C.6
  • 60
    • 33745921497 scopus 로고    scopus 로고
    • A double-blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg-positive chronic hepatitis B
    • M. Zeng, Y. Mao, G. Yao, H. Wang, J. Hou, and Y. Wang A double-blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg-positive chronic hepatitis B Hepatology 44 2006 108 116
    • (2006) Hepatology , vol.44 , pp. 108-116
    • Zeng, M.1    Mao, Y.2    Yao, G.3    Wang, H.4    Hou, J.5    Wang, Y.6
  • 61
    • 33644822860 scopus 로고    scopus 로고
    • Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
    • BEHoLD AI463027 Study Group Erratum in: N Engl J Med. 2006;354:1863
    • C.L. Lai, D. Shouval, A.S. Lok, T.T. Chang, H. Cheinquer, Z. Goodman BEHoLD AI463027 Study Group Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B N Engl J Med 354 2006 1011 1020 Erratum in: N Engl J Med. 2006;354:1863
    • (2006) N Engl J Med , vol.354 , pp. 1011-1020
    • Lai, C.L.1    Shouval, D.2    Lok, A.S.3    Chang, T.T.4    Cheinquer, H.5    Goodman, Z.6
  • 62
    • 37349120537 scopus 로고    scopus 로고
    • Telbivudine versus lamivudine in patients with chronic hepatitis B
    • Globe Study Group
    • C.L. Lai, E. Gane, Y.F. Liaw, C.W. Hsu, S. Thongsawat, Y. Wang Globe Study Group Telbivudine versus lamivudine in patients with chronic hepatitis B N Engl J Med 357 2007 2576 2588
    • (2007) N Engl J Med , vol.357 , pp. 2576-2588
    • Lai, C.L.1    Gane, E.2    Liaw, Y.F.3    Hsu, C.W.4    Thongsawat, S.5    Wang, Y.6
  • 63
    • 39549113880 scopus 로고    scopus 로고
    • Telbivudine versus lamivudine in Chinese patients with chronic hepatitis B: Results at 1 year of a randomized, double-blind trial
    • J. Hou, Y.K. Yin, D. Xu, D. Tan, J. Niu, and X. Zhou Telbivudine versus lamivudine in Chinese patients with chronic hepatitis B: results at 1 year of a randomized, double-blind trial Hepatology 47 2008 447 454
    • (2008) Hepatology , vol.47 , pp. 447-454
    • Hou, J.1    Yin, Y.K.2    Xu, D.3    Tan, D.4    Niu, J.5    Zhou, X.6
  • 64
    • 58649096155 scopus 로고    scopus 로고
    • 2-Year GLOBE trial results: Telbivudine is superior to lamivudine in patients with chronic hepatitis B
    • The GLOBE Study Group
    • Y.F. Liaw, E. Gane, N. Leung, S. Zeuzem, Y. Wang, C.L. Lai The GLOBE Study Group 2-Year GLOBE trial results: telbivudine is superior to lamivudine in patients with chronic hepatitis B Gastroenterology 136 2009 486 495
    • (2009) Gastroenterology , vol.136 , pp. 486-495
    • Liaw, Y.F.1    Gane, E.2    Leung, N.3    Zeuzem, S.4    Wang, Y.5    Lai, C.L.6
  • 65
    • 57349095400 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B
    • P. Marcellin, E.J. Heathcote, M. Buti, E. Gane, R.A. de Man, and Z. Krastev Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B N Engl J Med 359 2008 2442 2455
    • (2008) N Engl J Med , vol.359 , pp. 2442-2455
    • Marcellin, P.1    Heathcote, E.J.2    Buti, M.3    Gane, E.4    De Man, R.A.5    Krastev, Z.6
  • 66
    • 12444252951 scopus 로고    scopus 로고
    • Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
    • Erratum in: J Hepatol 2004;40:1053-1054
    • C. Boni, A. Penna, A. Bertoletti, V. Lamonaca, I. Rapti, and G. Missale Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B J Hepatol 39 2003 595 605 Erratum in: J Hepatol 2004;40:1053-1054
    • (2003) J Hepatol , vol.39 , pp. 595-605
    • Boni, C.1    Penna, A.2    Bertoletti, A.3    Lamonaca, V.4    Rapti, I.5    Missale, G.6
  • 67
    • 51349132036 scopus 로고    scopus 로고
    • Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion
    • A. Evans, A. Riva, H. Cooksley, S. Phillips, S. Puranik, and A. Nathwani Programmed death 1 expression during antiviral treatment of chronic hepatitis B: impact of hepatitis B e-antigen seroconversion Hepatology 48 2008 759 769
    • (2008) Hepatology , vol.48 , pp. 759-769
    • Evans, A.1    Riva, A.2    Cooksley, H.3    Phillips, S.4    Puranik, S.5    Nathwani, A.6
  • 68
    • 0032783679 scopus 로고    scopus 로고
    • Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy
    • Y.F. Liaw, R.N. Chien, C.T. Yeh, S.L. Tsai, and C.M. Chu Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy Hepatology 30 1999 567 572
    • (1999) Hepatology , vol.30 , pp. 567-572
    • Liaw, Y.F.1    Chien, R.N.2    Yeh, C.T.3    Tsai, S.L.4    Chu, C.M.5
  • 69
    • 2342430923 scopus 로고    scopus 로고
    • No benefit to continue lamivudine therapy after emergence of YMDD mutations
    • Y.F. Liaw, R.N. Chien, and C.T. Yeh No benefit to continue lamivudine therapy after emergence of YMDD mutations Antivir Ther 9 2004 257 262
    • (2004) Antivir Ther , vol.9 , pp. 257-262
    • Liaw, Y.F.1    Chien, R.N.2    Yeh, C.T.3
  • 70
    • 84862664371 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of chronic hepatitis B virus infection
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver EASL clinical practice guidelines: management of chronic hepatitis B virus infection J Hepatol 57 2012 167 185
    • (2012) J Hepatol , vol.57 , pp. 167-185
  • 71
    • 67649224111 scopus 로고    scopus 로고
    • Antiviral therapy of chronic hepatitis B: Opportunities and challenges in Asia
    • Y.F. Liaw Antiviral therapy of chronic hepatitis B: opportunities and challenges in Asia J Hepatol 51 2009 403 410
    • (2009) J Hepatol , vol.51 , pp. 403-410
    • Liaw, Y.F.1
  • 72
    • 0033839986 scopus 로고    scopus 로고
    • Acute exacerbation of chronic hepatitis B virus infection after withdrawal of lamivudine therapy
    • P. Honkoop, R.A. de Man, H.G. Niesters, P.E. Zondervan, and S.W. Schalm Acute exacerbation of chronic hepatitis B virus infection after withdrawal of lamivudine therapy Hepatology 32 2000 635 639
    • (2000) Hepatology , vol.32 , pp. 635-639
    • Honkoop, P.1    De Man, R.A.2    Niesters, H.G.3    Zondervan, P.E.4    Schalm, S.W.5
  • 73
    • 0036785331 scopus 로고    scopus 로고
    • Fatal hepatitis B reactivation following discontinuation of nucleoside analogues for chronic hepatitis B
    • S.G. Lim, C.T. Wai, A. Rajnakova, T. Kajiji, and R. Guan Fatal hepatitis B reactivation following discontinuation of nucleoside analogues for chronic hepatitis B Gut 51 2002 597 599
    • (2002) Gut , vol.51 , pp. 597-599
    • Lim, S.G.1    Wai, C.T.2    Rajnakova, A.3    Kajiji, T.4    Guan, R.5
  • 74
    • 84888287261 scopus 로고    scopus 로고
    • Off therapy durability of response to Entecavir therapy in hepatitis B e antigen negative chronic hepatitis B patients
    • W.J. Jeng, I.S. Sheen, Y.C. Chen, C.W. Hsu, R.N. Chien, and C.M. Chu Off therapy durability of response to Entecavir therapy in hepatitis B e antigen negative chronic hepatitis B patients Hepatology 58 2013 1888 1896
    • (2013) Hepatology , vol.58 , pp. 1888-1896
    • Jeng, W.J.1    Sheen, I.S.2    Chen, Y.C.3    Hsu, C.W.4    Chien, R.N.5    Chu, C.M.6
  • 75
    • 79959591362 scopus 로고    scopus 로고
    • Frequency and clinical outcomes of flares related to nucleos(t)ide analogue therapy in patients with chronic hepatitis B
    • N.P. Zhang, J.G. Reijnders, M. Perquin, B.E. Hansen, and H.L. Janssen Frequency and clinical outcomes of flares related to nucleos(t)ide analogue therapy in patients with chronic hepatitis B J Viral Hepat 18 2011 e252 e257
    • (2011) J Viral Hepat , vol.18 , pp. e252-e257
    • Zhang, N.P.1    Reijnders, J.G.2    Perquin, M.3    Hansen, B.E.4    Janssen, H.L.5
  • 76
    • 0033797827 scopus 로고    scopus 로고
    • Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea
    • B.C. Song, D.J. Suh, H.C. Lee, Y.H. Chung, and Y.S. Lee Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea Hepatology 32 2000 803 806
    • (2000) Hepatology , vol.32 , pp. 803-806
    • Song, B.C.1    Suh, D.J.2    Lee, H.C.3    Chung, Y.H.4    Lee, Y.S.5
  • 77
    • 0142244873 scopus 로고    scopus 로고
    • The determinants for sustained HBeAg response to lamivudine therapy
    • R.N. Chien, C.T. Yeh, S.L. Tsai, C.M. Chu, and Y.F. Liaw The determinants for sustained HBeAg response to lamivudine therapy Hepatology 38 2003 1267 1273
    • (2003) Hepatology , vol.38 , pp. 1267-1273
    • Chien, R.N.1    Yeh, C.T.2    Tsai, S.L.3    Chu, C.M.4    Liaw, Y.F.5
  • 78
    • 75449093009 scopus 로고    scopus 로고
    • Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg-positive chronic hepatitis B
    • H.W. Lee, H.J. Lee, J.S. Hwang, J.H. Sohn, J.Y. Jang, and K.J. Han Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg-positive chronic hepatitis B Hepatology 51 2010 415 421
    • (2010) Hepatology , vol.51 , pp. 415-421
    • Lee, H.W.1    Lee, H.J.2    Hwang, J.S.3    Sohn, J.H.4    Jang, J.Y.5    Han, K.J.6
  • 79
    • 84865487986 scopus 로고    scopus 로고
    • Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir
    • S.J. Hadziyannis, V. Sevastianos, I. Rapti, D. Vassilopoulos, and E. Hadziyannis Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir Gastroenterology 143 2012 629 636
    • (2012) Gastroenterology , vol.143 , pp. 629-636
    • Hadziyannis, S.J.1    Sevastianos, V.2    Rapti, I.3    Vassilopoulos, D.4    Hadziyannis, E.5
  • 80
    • 33645098806 scopus 로고    scopus 로고
    • Mother's little helpers: Mechanisms of maternal-fetal tolerance
    • J. Trowsdale, and A.G. Betz Mother's little helpers: mechanisms of maternal-fetal tolerance Nat Immunol 7 2006 241 246
    • (2006) Nat Immunol , vol.7 , pp. 241-246
    • Trowsdale, J.1    Betz, A.G.2
  • 82
    • 84899078129 scopus 로고    scopus 로고
    • Anti-viral therapy for prevention of perinatal HBV transmission: Extending therapy beyond birth does not protect against post-partum flare
    • V. Nguyen, P.K. Tan, A.J. Greenup, A. Glass, S. Davison, and D. Samarasinghe Anti-viral therapy for prevention of perinatal HBV transmission: extending therapy beyond birth does not protect against post-partum flare Aliment Pharmacol Ther 39 2014 1225 1234
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 1225-1234
    • Nguyen, V.1    Tan, P.K.2    Greenup, A.J.3    Glass, A.4    Davison, S.5    Samarasinghe, D.6
  • 83
    • 69749104406 scopus 로고    scopus 로고
    • Chronic hepatitis B virus (HBV) infection in pregnancy
    • H.H. Tan, H.F. Lui, and W.C. Chow Chronic hepatitis B virus (HBV) infection in pregnancy Hepatol Int 2 2008 370 375
    • (2008) Hepatol Int , vol.2 , pp. 370-375
    • Tan, H.H.1    Lui, H.F.2    Chow, W.C.3
  • 84
    • 3042788480 scopus 로고    scopus 로고
    • Immune reconstitution hepatitis in HIV and hepatitis B coinfection, despite lamivudine therapy as part of HAART
    • A. Drake, A. Mijch, and J. Sasadeusz Immune reconstitution hepatitis in HIV and hepatitis B coinfection, despite lamivudine therapy as part of HAART Clin Infect Dis 39 2004 129 132
    • (2004) Clin Infect Dis , vol.39 , pp. 129-132
    • Drake, A.1    Mijch, A.2    Sasadeusz, J.3
  • 85
    • 65549123645 scopus 로고    scopus 로고
    • Immunopathogenesis of hepatic flare in HIV/hepatitis B virus (HBV)-coinfected individuals after the initiation of HBV-active antiretroviral therapy
    • M. Crane, B. Oliver, G. Matthews, A. Avihingsanon, S. Ubolyam, and V. Markovska Immunopathogenesis of hepatic flare in HIV/hepatitis B virus (HBV)-coinfected individuals after the initiation of HBV-active antiretroviral therapy J Infect Dis 199 2009 974 981
    • (2009) J Infect Dis , vol.199 , pp. 974-981
    • Crane, M.1    Oliver, B.2    Matthews, G.3    Avihingsanon, A.4    Ubolyam, S.5    Markovska, V.6
  • 87
    • 0026088152 scopus 로고
    • Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study
    • A.S. Lok, R.H. Liang, E.K. Chiu, K.L. Wong, T.K. Chan, and D. Todd Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study Gastroenterology 100 1991 182 188
    • (1991) Gastroenterology , vol.100 , pp. 182-188
    • Lok, A.S.1    Liang, R.H.2    Chiu, E.K.3    Wong, K.L.4    Chan, T.K.5    Todd, D.6
  • 88
    • 0036730423 scopus 로고    scopus 로고
    • Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation
    • G.K. Lau, M.L. He, D.Y. Fong, A. Bartholomeusz, W.Y. Au, and A.K. Lie Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation Hepatology 36 2002 702 709
    • (2002) Hepatology , vol.36 , pp. 702-709
    • Lau, G.K.1    He, M.L.2    Fong, D.Y.3    Bartholomeusz, A.4    Au, W.Y.5    Lie, A.K.6
  • 89
    • 84897988099 scopus 로고    scopus 로고
    • Management of patients with hepatitis B who require immunosuppressive therapy
    • J.P. Hwang, and A.S. Lok Management of patients with hepatitis B who require immunosuppressive therapy Nat Rev Gastroenterol Hepatol 11 2014 209 219
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , pp. 209-219
    • Hwang, J.P.1    Lok, A.S.2
  • 90
    • 33644514992 scopus 로고    scopus 로고
    • A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemo-lipiodolization
    • J.W. Jang, J.Y. Choi, S.H. Bae, S.K. Yoon, U.I. Chang, and C.W. Kim A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemo-lipiodolization Hepatology 43 2006 233 240
    • (2006) Hepatology , vol.43 , pp. 233-240
    • Jang, J.W.1    Choi, J.Y.2    Bae, S.H.3    Yoon, S.K.4    Chang, U.I.5    Kim, C.W.6
  • 91
    • 42249113025 scopus 로고    scopus 로고
    • Systematic review: The effect of preventive lamivudine on hepatitis B reactivation during chemotherapy
    • R. Loomba, A. Rowley, R. Wesley, T.J. Liang, J.H. Hoofnagle, and F. Pucino Systematic review: the effect of preventive lamivudine on hepatitis B reactivation during chemotherapy Ann Intern Med 148 2008 519 528
    • (2008) Ann Intern Med , vol.148 , pp. 519-528
    • Loomba, R.1    Rowley, A.2    Wesley, R.3    Liang, T.J.4    Hoofnagle, J.H.5    Pucino, F.6
  • 92
    • 84984575715 scopus 로고    scopus 로고
    • Lymphoma Committee of Taiwan Cooperative Oncology Group. Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma
    • A.L. Cheng, C.A. Hsiung, I.J. Su, P.J. Chen, M.C. Chang, and C.J. Tsao Lymphoma Committee of Taiwan Cooperative Oncology Group. Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma Hepatology 37 2003 1320 1328
    • (2003) Hepatology , vol.37 , pp. 1320-1328
    • Cheng, A.L.1    Hsiung, C.A.2    Su, I.J.3    Chen, P.J.4    Chang, M.C.5    Tsao, C.J.6
  • 93
    • 84884755581 scopus 로고    scopus 로고
    • Randomized controlled trial of entecavir prophylaxis for rituximab-associated hepatitis B virus reactivation in patients with lymphoma and resolved hepatitis B
    • Y.H. Huang, L.T. Hsiao, Y.C. Hong, T.J. Chiou, Y.B. Yu, and J.P. Gau Randomized controlled trial of entecavir prophylaxis for rituximab-associated hepatitis B virus reactivation in patients with lymphoma and resolved hepatitis B J Clin Oncol 31 2013 2765 2772
    • (2013) J Clin Oncol , vol.31 , pp. 2765-2772
    • Huang, Y.H.1    Hsiao, L.T.2    Hong, Y.C.3    Chiou, T.J.4    Yu, Y.B.5    Gau, J.P.6
  • 94
    • 84901591515 scopus 로고    scopus 로고
    • Chemotherapy-induced hepatitis B reactivation in lymphoma patients with resolved HBV infection: A prospective study
    • on behalf of the Taiwan Cooperative Oncology Group
    • C. Hsu, H.H. Tsou, S.J. Lin, M.C. Wang, M. Yao, W.L. Hwang on behalf of the Taiwan Cooperative Oncology Group Chemotherapy-induced hepatitis B reactivation in lymphoma patients with resolved HBV infection: a prospective study Hepatology 59 2014 2092 2100
    • (2014) Hepatology , vol.59 , pp. 2092-2100
    • Hsu, C.1    Tsou, H.H.2    Lin, S.J.3    Wang, M.C.4    Yao, M.5    Hwang, W.L.6
  • 95
    • 80755140623 scopus 로고    scopus 로고
    • Hepatitis B virus (HBV) reactivation in patients receiving tumor necrosis factor (TNF)-targeted therapy: Analysis of 257 cases
    • BIOGEAS Study Group
    • R. Pérez-Alvarez, C. Díaz-Lagares, F. García-Hernández, L. Lopez-Roses, P. Brito-Zerón, M. Pérez-de-Lis BIOGEAS Study Group Hepatitis B virus (HBV) reactivation in patients receiving tumor necrosis factor (TNF)-targeted therapy: analysis of 257 cases Medicine 90 2011 359 371
    • (2011) Medicine , vol.90 , pp. 359-371
    • Pérez-Alvarez, R.1    Díaz-Lagares, C.2    García-Hernández, F.3    Lopez-Roses, L.4    Brito-Zerón, P.5    Pérez-De-Lis, M.6
  • 96
    • 79960443953 scopus 로고    scopus 로고
    • Viral hepatitis in solid organ transplantation other than liver
    • A. Vallet-Pichard, H. Fontaine, V. Mallet, and S. Pol Viral hepatitis in solid organ transplantation other than liver J Hepatol 55 2011 474 482
    • (2011) J Hepatol , vol.55 , pp. 474-482
    • Vallet-Pichard, A.1    Fontaine, H.2    Mallet, V.3    Pol, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.