Longitudinal fluctuations in PD1 and PD-L1 expression in association with changes in anti-viral immune response in chronic hepatitis B

BMC Gastroenterology

Volumn 12, Issue , 2012, Pages

  Wenjin, Zhang ^a   Chuanhui, Peng ^a   Yunle, Wan ^b   Lateef, Shaikh A ^a   Shusen, Zheng ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Hepatitis B; PD L1; PD1

Indexed keywords

ALANINE AMINOTRANSFERASE; CYTOKINE; HEPATITIS B SURFACE ANTIGEN; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; VIRUS DNA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DNA REPLICATION; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER BIOPSY; MALE; PROSPECTIVE STUDY; PROTEIN EXPRESSION; REMISSION; T LYMPHOCYTE; UPREGULATION; VIRUS IMMUNITY; VIRUS LOAD;

ADULT; ALANINE TRANSAMINASE; ANTIGENS, CD274; BIOPSY; CYTOKINES; DNA, VIRAL; FEMALE; FLOW CYTOMETRY; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HLA-A2 ANTIGEN; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LONGITUDINAL STUDIES; MALE; PROGRAMMED CELL DEATH 1 RECEPTOR; PROSPECTIVE STUDIES; T-LYMPHOCYTES;

EID: 84864952157     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-109     Document Type: Article

References (22)

1. Peng G, Li S, Wu W, et al. PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol 2008, 45:963-970. 10.1016/j.molimm.2007.07.038, 17868872.
2. Evans A, Riva A, Cooksley H, et al. Programmed Death 1 Expression During Antiviral Treatment of Chronic Hepatitis B: Impact of Hepatitis B e-Antigen Seroconversion. Hepatology 2008, 48:759-769. 10.1002/hep.22419, 18697210.
3. Rutebemberwa A, Ray SC, Astemborski J, et al. High-Programmed Death-1 Levels on Hepatitis C Virus-Specific T Cells during Acute Infection Are Associated with Viral Persistence and Require Preservation of Cognate Antigen during Chronic Infection1. J Immunol 2008, 181:8215-8225. 2773824, 19050238.
4. Urbani S, Amadei B, Tola D, et al. PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion. J Virol 2006, 80:11398-11403. 10.1128/JVI.01177-06, 1642188, 16956940.
5. Jeong H-Y, Lee Y-J, Seo S-K, et al. Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection. J Leukoc Biol 2008, 83:755-764.
6. Carolina B, Paola F, Caterina V. Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection. J Virol 2007, 81:4215-4225. 10.1128/JVI.02844-06, 1866111, 17287266.
7. Victoria K, Wiesch J, Thomas K, et al. High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specifi CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome. J Virol 2008, 82:3154-3160. 10.1128/JVI.02474-07, 2258997, 18160439.
8. Lucy G-M, Brent P, Jared K, et al. Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction. J Virol 2007, 81:9249-9258. 10.1128/JVI.00409-07, 1951397, 17567698.
9. Selenko-Gebauer N, Majdic O, Szekeres A, et al. B7-H1 (Programmed Death-1 Ligand) on Dendritic Cells Is Involved in the Induction and Maintenance of T Cell Anergy. J Immunol 2003, 170:3637-3644.
10. Iwai Y, Terawaki S, Ikegawa M, et al. PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver. J. Exp. Med 2003, 198:39-50. 10.1084/jem.20022235, 2196084, 12847136.
11. Karrar A, Broome U, Uzunel M, et al. Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut 2007, 56:243-252. 10.1136/gut.2006.093906, 1856767, 16840505.
12. Chen L, Zhang Z, Chen W, et al. B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B. J Immunol 2007, 178:6634-6641.
13. Yu MC, Chen CH, Liang X, et al. Inhibition of T-cell responses by hepatic stellate cells via B7-H1-mediated T-cell apoptosis in mice. Hepatology 2005, 40:1312-1321.
14. Kassel R, Cruise MW, Iezzoni JC, et al. Chronically inflamed livers up-regulate expression of inhibitory B7 family members. Hepatology 2009, 50(5):1625-1637. 10.1002/hep.23173, 2897253, 19739236.
15. Poly M. Tolerance, danger, and the extended family. Annu. Rev.lmmunol 1994, 12:991-1045.
16. By Hiroyuki Y, Kenjiro M, Yanyun Z, et al. Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease. J. Exp. Med 2001, 193:35-49. 10.1084/jem.193.10.F35, 2195882, 11136819.
17. Hiroyuki Y, Kenjiro M, Yanyun Z, et al. Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease. J. Exp. Med 2001, 193:35-49. 10.1084/jem.193.10.F35, 2195882, 11136819.
18. Grant AJ, Goddard S, Ahmed-Choudhury J, et al. Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease. Am J Pathol 2002, 160:1445-1455. 10.1016/S0002-9440(10)62570-9, 1867219, 11943728.
19. Mazanet MM, Hughes CC, et al. B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J Immunol 2002, 169:3581-3588.
20. Rodig N, Ryan T, Allen J. A., Greenfield, E A, et al.: Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur J Immunol 2003, 33:3117-3126. 10.1002/eji.200324270, 14579280.
21. Muhlbauer M, M Fleck C, Schutz T, et al. PD-L1 is induced in hepatocytes by viral infection and by interferon-α andγand mediates T cell apoptosis. J Hepatol 2006, 45:520-528. 10.1016/j.jhep.2006.05.007, 16876901.
22. Abhishek D, Matthew H, Nathan D, et al. Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. J Exp Med 2008, 205(9):2111-2124. 10.1084/jem.20072076, 2526205, 18695005.