Antidiabetic claims of Tinospora cordifolia (Willd.) Miers: Critical appraisal and role in therapy

Asian Pacific Journal of Tropical Biomedicine

Volumn 5, Issue 1, 2015, Pages 68-78

  Sharma, Rohit ^a   Amin, Hetal ^a   Galib, ^a   Prajapati, Pradeep Kumar ^a  

^a GUJARAT AYURVED UNIVERSITY   (India)

Author keywords

Diabetes mellitus; Guduchi; Herbal remedies; Tinospora cordifolia; Traditional medicine

Indexed keywords

METFORMIN; TINOSPORA CORDIFOLIA EXTRACT;

ABDOMINAL PAIN; ANTIDIABETIC ACTIVITY; ARTHRITIS; ARTICLE; BLOATING; CHRONIC DISEASE; DEPRESSION; DIABETES MELLITUS; DIABETIC FOOT; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DIARRHEA; DIET SUPPLEMENTATION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; DYSENTERY; DYSPEPSIA; ERECTILE DYSFUNCTION; ERUCTATION; FLATULENCE; HEART INFARCTION; HEART PROTECTION; HUMAN; HYPERLIPIDEMIA; IMMUNOMODULATION; IMPOTENCE; IN VITRO STUDY; IN VIVO STUDY; LIVER PROTECTION; MENTAL STRESS; NEUROPROTECTION; NONHUMAN; OSTEOPOROSIS; OXIDATIVE STRESS; PEPTIC ULCER; PHYTOCHEMISTRY; PREGNANCY DIABETES MELLITUS; QUALITY OF LIFE; RENAL PROTECTION; STOMACH DISEASE; STOMACH PAIN; WEIGHT REDUCTION;

TINOSPORA; TINOSPORA CORDIFOLIA;

EID: 84922711883     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(15)30173-8     Document Type: Review

References (103)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2009; 32(Suppl 1): S62-S67.
2. Dey L, Attele AS, Yuan CS. Alternative therapies for type 2 diabetes. Altern Med Rev 2002; 7: 45-58.
3. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 2007; 40: 163-173.
4. Mandlik RV, Desai SK, Naik SR, Sharma G, Kohli RK. Antidiabetic activity of a polyherbal formulation (DRF/AY/5001). Indian J Exp Biol 2008; 46: 599-606.
5. Acharya YT. Siddha Yoga Sangraha. Jwaradhikara. 13th ed. Nagpur: Baidyanath Ayurveda Bhavan Ltd; 2008, p. 4.
6. Acharya YT. Sushruta Samhita, Chikitsa Sthana. Reprint ed. Ch. 12, Verse 6. Varanasi: Chaukhambha Krishanadas Academy; 2004, p. 459.
7. Tripathi I, editor. Chakradatta of Chakrapani Datta. Prameha Chikitsa. Ch. 35, Ver. 25, Reprint edition. Varanasi: Chaukhambha Sanskrit Sansthana; 1997, p. 217.
8. Chunekar KC, Pandey GS. Guduchyadi Varga. Bhavaprakash Nighantu. Varanasi: Chaukhamba Bharati Academy; 2006, p. 269.
9. Shastri P, editor. Sharangadhara Samhita of Sharangadhara. Madhyam Khanda. Ch. 1, Ver. 7, 7 ed. Varanasi: Chaukhamba Orientalia Prakashan; 2008, p. 126.
10. Anonymous. The Ayurvedic Pharmacopoeia of India. Part 1, Vol 1. 1st ed. New Delhi: Govt. of India, Ministry of Health and Family Welfare; 2001. p. 53.
11. Tambekar DH, Khante BS, Chandak BR, Titare AS, Boralkar SS, Aghadte SN. Screening of antibacterial potentials of some medicinal plants from Melghat forest in India. Afr J Tradit Complement Altern Med 2009; 6(3): 228-232.
12. Sudha P, Zinjarde SS, Bhargava SY, Kumar AR. Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants. BMC Complement Altern Med 2011; 11: 5.
13. Rout GR. Identification of Tinospora cordifolia (Willd.) Miers ex Hook F & Thomas using RAPD markers. Z Naturforsch C 2006; 61(1-2): 118-122.
14. Patel MB, Mishra S. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine 2011; 18: 1045-1052.
15. Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008; 93(7): 2559-2565.
16. Yin J, Xingh H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008; 57(5): 712-717.
17. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, et al. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med 2009; 15(11): 1307-1311.
18. Sharma A, Batra A. Berberine a novel antidiabetic drug. Int J Res Rev Pharm Appl Sci 2013; 3(2): 216-230.
19. Gupta SS, Verma SC, Garg VP, Rai M. Anti-diabetic effects of Tinospora cardifolia. I. Effect on fasting blood sugar level, glucose tolerance and adrenaline induced hyperglycaemia. Indian J Med Res 1967; 55: 733-745.
20. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000; 73(3): 461-470.
21. Stanely P, Prince M, Menon VP. Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats. J Ethnopharmacol 2000; 70(1): 9-15.
22. Dhaliwal KS, inventor. Method and composition for treatment of diabetes. United States patent US 5886029. 1999.
23. Prince PSM, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003; 17(4): 410-413.
24. Rathi SS, Grover JK, Vikrant V, Biswas NR. Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts. Phytother Res 2002; 16(8): 774-777.
25. George M, Venkatraman PR, Pandalai KM. Investigation on plant antibiotics, part II: A search for antibiotic substances in some Indian medicinal plants. J Sci Ind Res 1947; 3: 42-46.
26. Prince PSM, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999; 64: 53-57.
27. Tomar A, Singh A, Thakur G, Agarwal AK, Singh VK. In vitro and in vivo study of Tinospora cordifolia as an antidiabetic agent in rat. Biochem Cell Biol 2010; 10: 175-177.
28. Prince PSM, Kamalakkannan N, Menon VP. Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats. Acta Pol Pharm 2004; 61: 283-287.
29. Prince PSM, Padmanabhan M, Menon VP. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney. Phytother Res 2004; 18: 785-787.
30. Dhulia I, Parcha V, Pant G, Kumar D, Maithani A. Antihyperglycemic effect of methanolic extract of Tinospora cordifolia (Willd.) stem on experimentally induced diabetic rats. J Pharm Res 2011; 4(8): 2828-2830.
31. Rajalakshmi M, Eliza J, Priya CE, Nirmala A. Daisy P. Anti-diabetic properties of Tinospora cordifolia stem extracts on streptozotocin-induced diabetic rats. Afr J Pharm Pharmacol 2009; 3: 171-180.
32. Sivakumar V, Rajan MSD. Hypoglycemic and antioxidant activity of T. cordifolia in experimental diabetes. Int J Pharm Sci Res 2011; 2(3): 608-613.
33. Puranik NK, Kammar KF, Devi S. Modulation of morphology and some gluconeogenic enzymes activity by Tinospora cordifolia (Willd.) in diabetic rat kidney. Biomed Res 2007; 18: 179-183.
34. Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. Screening of Indian plants for biological activity: I. Indian J Exp Biol 1968; 6: 232-247.
35. Raghunathan K, Sharma PV. Effect of Tinospora cordifolia Miers (Guduchi) on adrenaline induced hyperglycaemia. J Res Indian Med 1969; 4(1): 59-62.
36. Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003; 84(1): 105-108.
37. Puranik N, Kammar KF, Devi S. Anti-diabetic activity of Tinospora cordifolia (Willd.) in streptozotocin diabetic rats; does it act like sulfonylureas? Turkish J Med Sci 2010; 40: 265-270.
38. Chougale AD, Ghadyale VA, Panaskar SN, Arvindekar AU. Alpha glucosidase inhibition by stem extract of Tinospora cordifolia. J Enzyme Inhib Med Chem 2009; 24: 998-1001.
39. Patel MB, Mishra S. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine 2011; 18: 1045-1052.
40. Sangeetha MK, Balaji Raghavendran HR, Gayathri V, Vasanthi HR. Tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabetes in rats. J Nat Med 2011; 65: 544-550.
41. Sivakumar V, Mohamed Sadiq A. Hypoglycemic activity of Tinospora cordifolia in Alloxan induced diabetic rats. The Bioscan 2009; 4: 75-78.
42. Reddy SS, Ramatholisamma P, Karuna R, Saralakumari D. Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. Food Chem Toxicol 2009; 47(9): 2224-2229.
43. Reddy SS, Ramatholisamma P, Ramesh B, Baskar R, Saralakumari D. Beneficiary effect of Tinospora cordifolia against high-fructose diet induced abnormalities in carbohydrate and lipid metabolism in Wistar rats. Horm Metab Res 2009; 41(10): 741-746.
44. Wadood N, Wadood A, Shah SA. Effect of Tinospora cordifolia on blood glucose and total lipid levels of normal and alloxan-diabetic rabbits. Planta Med 1992; 58(2): 131-136.
45. Sengupta S, Mukherjee A, Goswami R, Basu S. Hypoglycemic activity of the antioxidant saponarin, characterized as alpha-glucosidase inhibitor present in Tinospora cordifolia. J Enzyme Inhib Med Chem 2009; 24: 684-690.
46. Grover JK, Rathi, SS, Vats V. Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plants (Eugenia jambolana, Mucurna pruriens and Tinospora cordifolia) extracts. Indian J Exp Biol 2002; 40: 273-276.
47. Grover JK, Vats V, Rathi SS, Dawar R. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. J Ethnopharmacol 2001; 76: 233-238.
48. Raghunathan K, Sharma PV. The aqueous extract of T. cordifolia caused reduction of blood sugar in alloxan induced hyperglycemic rats and rabbits. J Res Ind Med 1969; 3: 203-209.
49. Noor H, Ashcroft SJ. Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract. J Ethnopharmacol 1998; 62(1): 7-13.
50. Ruan CT, Lam SH, Chi TC, Lee SS, Su MJ. Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice. Phytomedicine 2012; 19(8-9): 719-724.
51. Umamaheswari S, Prince PSM. Antihyperglycaemic effect of 'Ilogen-Excel', an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus. Acta Pol Pharm 2007; 64(1): 53-61.
52. Babu PS, Prince PSM. Antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. J Pharm Pharmacol 2004; 56: 1435-1442.
53. Bhattacharya SK, Satyan KS, Chakrabarti A. Effect of Trasina, an Ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycaemic rats. Indian J Exp Biol 1997; 35(3): 297-299.
54. Patel SS, Shah RS, Goyal RK. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp Biol 2009; 47: 564-570.
55. Joladarashi D, Chilkunda ND, Salimath PV. Glucose uptake-stimulatory activity of Tinospora cordifolia stem extracts in Ehrlich ascites tumor cell model system. J Food Sci Technol 2014; 51(1): 178-182.
56. Ahmed F, Siddaraju NS, Urooj A. In vitro hypoglycemic effects of Gymnema sylvestre, Tinospora cordifolia, Eugenia jambolana and Aegle marmelos. J Nat Pharm 2011; 2: 52-55.
57. Agrawal SS, Naqvi S, Gupta SK, Srivastava S. Prevention and management of diabetic retinopathy in STZ diabetic rats by Tinospora cordifolia and its molecular mechanisms. Food Chem Toxicol 2012; 50: 3126-3132.
58. Nadig PD, Revankar RR, Dethe SM, Narayanswamy SB, Aliyar MA. Effect of Tinospora cordifolia on experimental diabetic neuropathy. Indian J Pharmacol 2012; 44: 580-583.
59. Jaspan J, Maselli R, Herold K, Bartkus C. Treatment of severely painful diabetic neuropathy with an aldose reductase inhibitor: relief of pain and improved somatic and autonomic nerve function. Lancet 1983; 2: 758-762.
60. Joladarashi D, Chilkunda ND, Salimath PV. Tinospora cordifolia consumption ameliorates changes in kidney chondroitin sulphate/dermatan sulphate in diabetic rats. J Nutr Sci 2012; 1: e7.
61. Purandare H, Supe A. Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled study. Indian J Med Sci 2007; 61(6): 347-355.
62. Rawal A, Muddeshwar M, Biswas S. Effect of Rubia cordifolia, Fagonia cretica Linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices. Biochem Biophys Res Commun 2004; 324(2): 588-596.
63. Rawal AK, Muddeshwar MG, Biswas SK. Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation. BMC Complement Altern Med 2004; 4: 11-19.
64. Mary NK, Babu BH, Padikkala J. Antiatherogenic effect of Caps HT2, a herbal Ayurvedic medicine formulation. Phytomedicine 2003; 10(6): 474-482.
65. Rao PR, Kumar VK, Viswanath RK, Subbaraju GV. Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. Biol Pharm Bull 2005; 28: 2319-2322.
66. Nagaraja PK, Kammar KF, Sheela DR. Efficacy of Tinospora cordifolia (Willd.) extracts on blood lipid profile in streptozotocin diabetic rats. Is it beneficial to the heart? Biomed Res 2008; 19: 92-96.
67. Rai M, Gupta SS. Experimental evaluation of Tinospora cordifolia (Guduchi) for dissolution of urinary calculi. J Res Indian Med 1967; 2(1): 115-116.
68. Gupta RS, Sharma A. Antifertility effect of Tinospora cordifolia (Willd.) stem extract in male rats. Indian J Exp Biol 2003; 41: 885-889.
69. Kapur P, Jarry H, Wuttke W, Pereira BM, Seidlova-Wuttke D. Evaluation of the antiosteoporotic potential of Tinospora cordifolia in female rats. Maturitas 2008; 59: 329-338.
70. Utpalendu J, Chattopadhyay RN, Badri PS. Preliminary studies on anti-inflammatory activity of Zingiber officinale Rosc., Vitex negundo Linn. and Tinospora cordifolia (Willd) Miers in albino rats. Indian J Pharmacol 1999; 31: 232-233.
71. Kamble R, Sathaye S, Shah DP. Evaluation of antispasmodic activity of different Shodhit guggul using different shodhan process. Indian J Pharm Sci 2008; 70(3): 368-372.
72. Ayushveda. Dyspepsia (Ajirna) Ayurvedic treatment. India: Ayushveda Informatics. [Online] Available from: http://www.ayushveda.com/health/dyspepsia.htm [Accessed on 28th March, 2011]
73. Shivananjappa MM, Muralidhara. Abrogation of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of Tinospora cordifolia. Nutrition 2012; 28: 581-587.
74. Sai KS, Srividya N. Blood glucose lowering effect of the leaves of Tinospora cordifolia and Sauropus androgynus in diabetic subjects. J Nat Remedies 2002; 2: 28-32.
75. Sharma R, Shukla VJ, Ravishankar B, Prajapati PK. The effect of two different dosage forms of Guduchi i.e. Satva and Ghana WSR antihyperglycemic effect on madhumeha (NIDDM) [dissertation]. Jamnagar: Gujarat Ayurveda University, IPGT and RA; 2012, p. 132-133.
76. Chakraborty SK, Barman NN. Clinical evaluation of Tinospora cordifolia (wild) Miers (Guduci) in the management of diabetic foot ulcer [dissertation]. Gauhati: University of Gauhati, Government Ayurvedic college 2012. [Online] Available from: shodhganga.inflibnet.ac.in:8080/jspui/bitstream/10603/27526/3/03_abstract.pdf [Accessed on 4th December, 2014]
77. Kamini S. To study the effect of Guduchi Churna in Prameha [dissertation]. Nasik: Pune University; 2000.
78. Karkal YR, Bairy LK. Safety of aqueous extract of Tinospora cordifolia (Tc) in healthy volunteers: a double blind randomised placebo controlled study. Iran J Pharmacol Ther 2007; 6: 59-61.
79. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997; 58(2): 89-95.
80. Kalikar MV, Thawani VR, Varadpande UK, Sontakke SD, Singh RP, Khiyani RK. Immunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patients. Indian J Pharmacol 2008; 40: 107-110.
81. Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 1999; 13(4): 275-291.
82. Prince PSM, Menon VP. Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytother Res 2001; 15(3): 213-218.
83. Prince PSM, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999; 65(3): 277-281.
84. Bishayi B, Roychowdhury S, Ghosh S, Sengupta M. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats. J Toxicol Sci 2002; 27(3): 139-146.
85. Vincent AM, Russell JW, Low P, Feldman EL. Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev 2004; 25(4): 612-628.
86. Harrison LC, Honeyman MC. Cow's milk and type 1 diabetes: the real debate is about mucosal immune function. Diabetes 1999; 48: 1501-1507.
87. Mitra A. Diabetes and stress: a review. Ethnomedicine 2008; 2(2): 131-135.
88. American Diabetes Association. Stress. Alexandria: American Diabetes Association; 2013. [Online] Available from: http://www.diabetes.org/living-with-diabetes/complications/mental-health/stress.html [Accessed on 15th March, 2014]
89. Patil M, Patki P, Kamath HV, Patwardhan B. Antistress activity of Tinospora cordifolia (wild) Miers. Indian Drugs 1997; 34: 211-215.
90. Sarma DN, Khosa RL, Chansauria JP, Ray AK. Effect of Tinospora cordifolia on brain neurotransmitters in stressed rats. Fitoterapia 1995; 67(5): 421-422.
91. Dhingra D, Goyal PK. Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of Tinospora cordifolia in mice. Indian J Pharm Sci 2008; 70(6): 761-767.
92. Geeta K, Sharda K. Nutritional evaluation of Giloe (Tinospora cordifolia) extract incorporated energy dense food products. Indian J Res 2013; 2(9): 41-43.
93. Nile SH, Khobragade CNN. Determination of nutritive value and mineral elements of some important medicinal plants from western part of India. J Med Plants 2009; 8: 79-88.
94. Madhav M, Maitreyee M. Tinospora cordifolia and its varied activities: what is believed and what is known? Int J Curr Res Rev 2011; 3(12): 94-109.
95. Gambert S, Pinkstaff S. Emerging epidemic: diabetes in older adults: demography, economic impact, and pathophysiology. Diabetes Spectr 2006; 19: 221-228.
96. Vinutha B, Prashanth D, Salma K, Sreeja SL, Pratiti D, Padmaja R, et al. Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity. J Ethnopharmacol 2007; 109(2); 359-363.
97. Manjusha GV, Rajathi K, Alphonse JKM, Meera KS. Antioxidant potential and antimicrobial activity of Andrographis paniculata and Tinospora cordifolia against pathogenic organisms. J Pharm Res 2011; 4(2): 452-455.
98. Patwardhan B. The quest for evidence-based Ayurveda: lessons learned. Curr Sci 2012; 102(10): 1406-1417.
99. Prabhakar PK, Doble M. Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes. Phytomedicine 2009; 16(12): 1119-1126.
100. Lather A, Gupta V, Bansal P, Sahu M, Sachdeva K, Ghaiye P. An Ayurvedic polyherbal formulation Kaishore Guggulu: a review. Int J Pharm Biol Arch 2011; 2(1): 497-503.
101. Caranasos GJ, Stewart RB, Cluff LE. Clinically desirable drug interactions. Annu Rev Pharmacol Toxicol 1985; 25: 67-95.
102. Gupta AK, Gupta N, Sharma M, Indian Council of Medical Research. Quality standards of Indian medicinal plants. Vol. 1. New Delhi: Indian Council of Medical Research; 2003, p. 212.
103. Upadhyay AK, Kumar K, Kumar A, Mishra HS. Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Guduchi)-validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res 2010; 1: 112-121.