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Volumn 18, Issue 12, 2011, Pages 1045-1052

Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia

Author keywords

Hyperglycemia; Rat hepatocytes; RINm5F pancreatic cell line; Tinospora cordifolia

Indexed keywords

GLUCOSE; ISOQUINOLINE ALKALOID; JATRORRHIZINE; MAGNOFLORINE; PALMATINE; TINOSPORA CORDIFOLIA EXTRACT; TOLBUTAMIDE;

EID: 80052470394     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.05.006     Document Type: Article
Times cited : (148)

References (46)
  • 2
    • 0022834814 scopus 로고
    • Immunomodulating agents of plant origin. I. Preliminary screening
    • C.K. Atal, M.L. Sharma, A. Kaul, and A. Khajuria Immunomodulating agents of plant origin. I: preliminary screening J. Ethnopharmacol. 18 1986 133 141 (Pubitemid 17220725)
    • (1986) Journal of Ethnopharmacology , vol.18 , Issue.2 , pp. 133-141
    • Atal, C.K.1    Sharma, M.L.2    Kaul, A.3    Khajuria, A.4
  • 5
    • 0031106691 scopus 로고    scopus 로고
    • Cissaglaberrimine, an aporphine alkaloid from Cissampelos glaberrima
    • DOI 10.1016/S0031-9422(96)00689-9, PII S0031942296006899
    • J.M. Barbosa-Filho, E.V.L. Da-Cunha, M.L. Corni-Lio, C.D.S. Dias, and A.I. Gray Cissaglaberrimine, an aporphine alkaloid from Cissampelos glaberrima Phytochemistry 44 1997 959 961 (Pubitemid 27093179)
    • (1997) Phytochemistry , vol.44 , Issue.5 , pp. 959-961
    • Barbosa-Filho, J.M.1    Da-Cunha, E.V.L.2    Cornelio, M.L.3    Da Silva Dias, C.4    Gray, A.I.5
  • 6
    • 0028298449 scopus 로고
    • Catharanthus roseus cell cultures: Growth, alkaloid synthesis and antidiabetic activity
    • DOI 10.1002/ptr.2650080315
    • B.D. Benjamin, S.M. Kelkar, M.S. Pote, G.S. Kaklij, A.T. Sipahimalani, and M.R. Heble Catharanthus roseus cell cultures: growth, alkaloid synthesis and antidiabetic activity Phytother. Res. 8 1994 185 186 (Pubitemid 24171850)
    • (1994) Phytotherapy Research , vol.8 , Issue.3 , pp. 185-186
    • Benjamin, B.D.1    Kelkar, S.M.2    Pote, M.S.3    Kaklij, G.S.4    Sipahimalani, A.T.5    Heble, M.R.6
  • 8
    • 0021066162 scopus 로고
    • Quaternary alkaloids of Tinospora species
    • N.G. Bisset, and J. Nwaiwu Quaternary alkaloids of Tinospora species Planta Med. 48 1983 275 279 (Pubitemid 14226276)
    • (1983) Planta Medica , vol.48 , Issue.4 , pp. 275-279
    • Bisset, N.G.1    Nwaiwu, J.2
  • 9
    • 0032888513 scopus 로고    scopus 로고
    • A comparative evaluation of some blood sugar lowering agents of plant origin
    • DOI 10.1016/S0378-8741(99)00095-1, PII S0378874199000951
    • R.R. Chattopadhyay A comparative evaluation of some blood sugar lowering agents of plant origin J. Ethnopharmacol. 67 1999 367 372 (Pubitemid 29469749)
    • (1999) Journal of Ethnopharmacology , vol.67 , Issue.3 , pp. 367-372
    • Chattopadhyay, R.R.1
  • 13
    • 78649427289 scopus 로고    scopus 로고
    • Antidiabetic and hypolipidemic effects of mahanimbine (carbazole alkaloid) from murraya koenigii (rutaceae) leaves
    • B. Dineshkumar, A. Mitra, and M. Mahadevappa Antidiabetic and hypolipidemic effects of mahanimbine (carbazole alkaloid) from murraya koenigii (rutaceae) leaves Int. J. Phytomed. 2 2010 22 30
    • (2010) Int. J. Phytomed. , vol.2 , pp. 22-30
    • Dineshkumar, B.1    Mitra, A.2    Mahadevappa, M.3
  • 14
    • 0028519210 scopus 로고
    • Cordifolisides A, B, C: Norditerpene furan glycosides from Tinospora cordifolia
    • DOI 10.1016/S0031-9422(00)90358-3
    • V.D. Gangan, P. Pradhan, A.T. Sipahimalani, and A. Banerji Cordifolisides A, B, C: norditerpene furan glycosides from Tinospora cordifolia Phytochemistry 37 1994 781 786 (Pubitemid 2156161)
    • (1994) Phytochemistry , vol.37 , Issue.3 , pp. 781-786
    • Gangan, V.D.1    Pradhan, P.2    Sipahimalani, A.T.3    Banerji, A.4
  • 15
    • 0009611219 scopus 로고
    • Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor
    • DOI 10.1073/pnas.77.6.3519
    • F. Gazdar, W.L. Chick, H.K. Oie, H.L. Sims, D.L. King, G.C. Weir, and V. Lauris Continuous, clonal, insulin and somatostatin secreting cell lines established from a transplantable rat islet cell tumor Cell Biol. 77 1980 3519 3523 (Pubitemid 10012266)
    • (1980) Proceedings of the National Academy of Sciences of the United States of America , vol.77 , Issue.6 , pp. 3519-3523
    • Gazdar, A.F.1    Chick, W.L.2    Oie, H.K.3
  • 17
    • 0036277949 scopus 로고    scopus 로고
    • Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection
    • H.C. Goel, I. Prem Kumar, and S.V. Rana Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection Indian J. Exp. Biol. 40 2002 727 734 (Pubitemid 34604543)
    • (2002) Indian Journal of Experimental Biology , vol.40 , Issue.6 , pp. 727-734
    • Goel, H.C.1    Prem Kumar, I.2    Rana, S.V.S.3
  • 18
    • 0033712738 scopus 로고    scopus 로고
    • Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism
    • J.K. Grover, V. Vats, and S.S. Rathi Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism J. Ethnopharmacol. 73 2000 461 470
    • (2000) J. Ethnopharmacol. , vol.73 , pp. 461-470
    • Grover, J.K.1    Vats, V.2    Rathi, S.S.3
  • 19
    • 0034936590 scopus 로고    scopus 로고
    • Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice
    • DOI 10.1016/S0378-8741(01)00246-X, PII S037887410100246X
    • J.K. Grover, V. Vats, S.S. Rathi, and R. Dawar Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice J. Ethnopharmacol. 76 2001 233 238 (Pubitemid 32633849)
    • (2001) Journal of Ethnopharmacology , vol.76 , Issue.3 , pp. 233-238
    • Grover, J.K.1    Vats, V.2    Rathi, S.S.3    Dawar, R.4
  • 20
    • 0036000246 scopus 로고    scopus 로고
    • Medicinal plants of India with anti-diabetic potential
    • DOI 10.1016/S0378-8741(02)00059-4, PII S0378874102000594
    • J.K. Grover, S. Yadav, and V. Vats Medicinal plants of India with anti-diabetic potential J. Ethnopharmacol. 81 2002 81 100 (Pubitemid 34518472)
    • (2002) Journal of Ethnopharmacology , vol.81 , Issue.1 , pp. 81-100
    • Grover, J.K.1    Yadav, S.2    Vats, V.3
  • 21
    • 0014107228 scopus 로고
    • Antidiabetic effect of Tinospora cordifolia. I. Effect on fasting blood sugar level, glucose tolerance and adrenaline induced hyperglycemia
    • S.S. Gupta, S.C.L. Varma, V.P. Garg, and M. Rai Antidiabetic effect of Tinospora cordifolia. I. Effect on fasting blood sugar level, glucose tolerance and adrenaline induced hyperglycemia Indian J. Exp. Biol. 55 1967 733 745
    • (1967) Indian J. Exp. Biol. , vol.55 , pp. 733-745
    • Gupta, S.S.1    Varma, S.C.L.2    Garg, V.P.3    Rai, M.4
  • 22
    • 0026607265 scopus 로고
    • Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: Evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression
    • C.A. Hofmann, C.W. Edwards, R.M. Hillman, and J.R. Colca Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression Endocrinology 130 1992 735 740
    • (1992) Endocrinology , vol.130 , pp. 735-740
    • Hofmann, C.A.1    Edwards, C.W.2    Hillman, R.M.3    Colca, J.R.4
  • 23
    • 33646437743 scopus 로고    scopus 로고
    • Antioxidant and cytotoxic activities of Thai medicinal plants named Khaminkhruea: Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria
    • N. Keawpradub, S. Dej-adisai, and S. Yuenyongsawad Antioxidant and cytotoxic activities of Thai medicinal plants named Khaminkhruea: Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria Songklanakarin J. Sci. Technol. 27 Suppl. 2 2005 455 467
    • (2005) Songklanakarin J. Sci. Technol. , vol.27 , Issue.SUPPL. 2 , pp. 455-467
    • Keawpradub, N.1    Dej-Adisai, S.2    Yuenyongsawad, S.3
  • 25
    • 0012773527 scopus 로고
    • A new hypoglyceamic agent from Tinospora cordifolia Miers
    • V.R. Mahajan, and C.I. Jolly A new hypoglyceamic agent from Tinospora cordifolia Miers Indian Drugs 23 1985 119 120
    • (1985) Indian Drugs , vol.23 , pp. 119-120
    • Mahajan, V.R.1    Jolly, C.I.2
  • 27
    • 0012884520 scopus 로고
    • Study of antiallergic acid Bronchodilator effects of Tinospora cordifolia
    • S. Nayampalli, S.S. Ainapure, and P.M. Nadkarni Study of antiallergic acid Bronchodilator effects of Tinospora cordifolia Indian J. Pharm. 14 1982 64 66
    • (1982) Indian J. Pharm. , vol.14 , pp. 64-66
    • Nayampalli, S.1    Ainapure, S.S.2    Nadkarni, P.M.3
  • 29
    • 0027247998 scopus 로고
    • The regulation of gene expression by insulin is differentially impaired in the liver of the genetically obese-hyperglycemic Wistar fatty rat
    • DOI 10.1016/0014-5793(93)80982-Z
    • T. Noguchi, T. Matsuda, Y. Tomari, K. Yamada, E. Imai, Z. Wang, H. Ikeda, and T. Tanaka The regulation of gene expression by insulin is differentially impaired in the liver of the genetically obese-hyperglycemic Wistar fatty rat FEBS Lett. 328 1993 145 148 (Pubitemid 23234782)
    • (1993) FEBS Letters , vol.328 , Issue.1-2 , pp. 145-148
    • Noguchi, T.1    Matsuda, T.2    Tomari, Y.3    Yamada, K.4    Imai, E.5    Wang, Z.6    Ikeda, H.7    Tanaka, T.8
  • 30
    • 0019467862 scopus 로고
    • ALKALOIDE AUS TINOSPORA CORDIFOLIA MIERS
    • DOI 10.1002/ardp.19813140311
    • P. Pachaly, and C. Schneider Alkaloids from Tinospora cordifolia Miers Arch. Pharm. 314 1981 251 256 (Pubitemid 11157336)
    • (1981) Archiv der Pharmazie , vol.314 , Issue.3 , pp. 251-256
    • Pachaly, P.1    Schneider, C.2
  • 31
    • 0012784546 scopus 로고
    • Biosynthesis of isoquinoline alkaloid berberine in tissue cultures of Tinospora cordifolia
    • M.A. Padhya Biosynthesis of isoquinoline alkaloid berberine in tissue cultures of Tinospora cordifolia Indian Drugs 24 1986 47 48
    • (1986) Indian Drugs , vol.24 , pp. 47-48
    • Padhya, M.A.1
  • 32
    • 0032792543 scopus 로고    scopus 로고
    • Antioxidant activity of Tinospora cordifolia roots in experimental diabetes
    • DOI 10.1016/S0378-8741(98)00164-0, PII S0378874198001640
    • P.S. Prince, and V.P. Menon Antioxidant activity of Tinospora cordifolia roots in experimental diabetes J. Ethnopharmacol. 65 1999 277 281 (Pubitemid 29336023)
    • (1999) Journal of Ethnopharmacology , vol.65 , Issue.3 , pp. 277-281
    • Stanely Mainzen Prince, P.1    Menon, V.P.2
  • 34
    • 33748675277 scopus 로고    scopus 로고
    • Antidiabetic activity of benzyl tetra isoquinoline alkaloid berberine in streptozotocin-nicotinamide induced type 2 diabetic rats
    • I.S.R. Punitha, A. Shirwaikar, and A. Shirwaikar Antidiabetic activity of benzyl tetra isoquinoline alkaloid berberine in streptozotocin-nicotinamide induced type 2 diabetic rats Diabetol. Croat. 34 2005 117 128
    • (2005) Diabetol. Croat. , vol.34 , pp. 117-128
    • Punitha, I.S.R.1    Shirwaikar, A.2    Shirwaikar, A.3
  • 35
    • 0012847239 scopus 로고
    • Tinospora cordifolia. I. Constituents of the plant fresh from the field
    • M. Qudrat-I-Khuda, A. Khaleque, and N. Ray Tinospora cordifolia. I. Constituents of the plant fresh from the field J. Sci. Res. 1 1964 177 183
    • (1964) J. Sci. Res. , vol.1 , pp. 177-183
    • Qudrat-I-Khuda, M.1    Khaleque, A.2    Ray, N.3
  • 36
    • 0012790586 scopus 로고
    • The aqueous extract of T. cordifolia caused reduction of blood sugar in alloxan induced hyperglycemic rats and rabbits
    • K. Raghunathan, and P.V. Sharma The aqueous extract of T. cordifolia caused reduction of blood sugar in alloxan induced hyperglycemic rats and rabbits J. Res. Ind. Med. 3 1969 203 209
    • (1969) J. Res. Ind. Med. , vol.3 , pp. 203-209
    • Raghunathan, K.1    Sharma, P.V.2
  • 37
    • 0036183110 scopus 로고    scopus 로고
    • The pathophysiologic basis of efficacy and clinical experience with the new oral antidiabetic agents
    • DOI 10.1016/S1056-8727(01)00207-0, PII S1056872701002070
    • C. Rosak The pathophysiologic basis of efficacy and clinical experience with the new oral antidiabetic agents J. Diabetes Complicat. 16 2002 123 132 (Pubitemid 34168514)
    • (2002) Journal of Diabetes and its Complications , vol.16 , Issue.1 , pp. 123-132
    • Rosak, C.1
  • 38
    • 26844536594 scopus 로고    scopus 로고
    • Preventive and curative role of a 43 kD protein from the leaves of the herb Cajanus indicus L on thioacetamide-induced hepatotoxicity in vivo
    • DOI 10.1016/j.hepres.2005.06.007, PII S1386634605001804
    • K. Sarkar, A. Ghosh, and P.C. Sil Preventive and curative role of 43 KDa protein from the leaves of Cajanas indicus L. on the thiaoacetamide induced hepatocytes in vivo Hepatol. Res. 33 2005 39 49 (Pubitemid 41447882)
    • (2005) Hepatology Research , vol.33 , Issue.1 , pp. 39-49
    • Sarkar, K.1    Ghosh, A.2    Sil, P.C.3
  • 39
    • 0028833212 scopus 로고
    • Isolation of jatrorrhizine from Tinospora cordifolia roots
    • D.N.K. Sarma, R.L. Khosa, and M. Sahai Isolation of jatrorrhizine from Tinospora cordifolia roots Planta Med. 61 1995 98 99
    • (1995) Planta Med. , vol.61 , pp. 98-99
    • Sarma, D.N.K.1    Khosa, R.L.2    Sahai, M.3
  • 40
    • 0032434530 scopus 로고    scopus 로고
    • Constituents of Tinospora cordifolia root
    • D.N.K. Sarma, P. Padma, and R.L. Khosa Constituents of Tinospora cordifolia root Fitoterapia 69 1998 541 542 (Pubitemid 29019160)
    • (1998) Fitoterapia , vol.69 , Issue.6 , pp. 541-542
    • Sarma, D.N.K.1    Padma, P.2    Khosa, R.L.3
  • 41
    • 0028158872 scopus 로고
    • Modulation of fetal and placental metabolic pathways in response to maternal thyroid and glucocorticoid hormone excess
    • E. Shafrir, V. Barash, R. Zederman, R. Kissilevitz, and Y.Z. Diamant Modulation of fetal and placental metabolic pathways in response to maternal thyroid and glucocorticoid hormone excess Israel J. Med. Sci. 30 1994 32 41 (Pubitemid 24038985)
    • (1994) Israel Journal of Medical Sciences , vol.30 , Issue.1 , pp. 32-41
    • Shafrir, E.1    Barash, V.2    Zederman, R.3    Kissilevitz, R.4    Diamant, Y.Z.5
  • 42
    • 0034099839 scopus 로고    scopus 로고
    • Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats
    • DOI 10.1016/S0378-8741(99)00136-1, PII S0378874199001361
    • M. Stanely, P. Prince, and V.P. Menon Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxaninduced diabetic rats J. Ethnopharmacol. 70 2000 9 15 (Pubitemid 30138065)
    • (2000) Journal of Ethnopharmacology , vol.70 , Issue.1 , pp. 9-15
    • Stanely, P.1    Prince, M.2    Menon, V.P.3
  • 43
    • 0024357478 scopus 로고
    • Distribution and dynamics of cell surface-associated cellCAM 105 in cultured rat hepatocytes
    • A. Tinstorm, and B. Obrink Distribution and dynamics of cell surface associated cell cam 105 in cultured rat hepatocytes Exp. Cell. Res. 186 1989 132 142 (Pubitemid 19284502)
    • (1989) Experimental Cell Research , vol.185 , Issue.1 , pp. 132-142
    • Tingstrom, A.1    Obrink, B.2
  • 44
    • 0026528102 scopus 로고
    • Effect of Tinospora cordifolia on blood glucose and total lipid levels of normal and alloxan-diabetic rabbits
    • N. Wadood, A. Wadood, and S.A. Shah Effect of Tinospora cordifolia on blood glucose and total lipid levels of normal and alloxan-diabetic rabbits Planta Med. 58 1992 131 136
    • (1992) Planta Med. , vol.58 , pp. 131-136
    • Wadood, N.1    Wadood, A.2    Shah, S.A.3
  • 45
    • 59849116161 scopus 로고    scopus 로고
    • Synergy research: Approaching a new generation of phytopharmaceuticals
    • H. Wagner, and G. Ulrich-Merzenich Synergy research: approaching a new generation of phytopharmaceuticals Phytomedicine 16 2009 97 110
    • (2009) Phytomedicine , vol.16 , pp. 97-110
    • Wagner, H.1    Ulrich-Merzenich, G.2
  • 46
    • 0026095353 scopus 로고
    • Folkloric medicinal plants: Tinospora sagittata var. cravaniana and Mahonia bealei
    • T.F. Zhao, X. Wang, A.M. Rimando, and C. Che Folkloric medicinal plants: Tinospora sagittata var. cravaniana and Mahonia bealei Planta Med. 57 1991 505
    • (1991) Planta Med. , vol.57 , pp. 505
    • Zhao, T.F.1    Wang, X.2    Rimando, A.M.3    Che, C.4


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