Evaluation of the antiosteoporotic potential of Tinospora cordifolia in female rats

Maturitas

Volumn 59, Issue 4, 2008, Pages 329-338

  Kapur, P ^a   Jarry, H ^b   Wuttke, W ^b   Pereira, B M J ^a   Seidlova Wuttke, D ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Bone mineral density; Estradiol; Osteoporosis; Ovariectomized; Tinospora cordifolia; Uterus

Indexed keywords

ALKALINE PHOSPHATASE; BENZYL BENZOATE; CASTOR OIL; CHOLESTEROL; ESTRADIOL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OSTEOCALCIN; TINOSPORA CORDIFOLIA EXTRACT;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; CHOLESTEROL BLOOD LEVEL; COMPUTER ASSISTED TOMOGRAPHY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; MAMMARY GLAND; NONHUMAN; OSTEOLYSIS; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; RAT; SHAM PROCEDURE; THERAPY EFFECT; TIBIA; TINOSPORA; TISSUE SECTION; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; UTERUS;

ANIMALS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; DISEASE MODELS, ANIMAL; ESTRADIOL; ESTROGENS; FEMALE; HUMANS; OSTEOCALCIN; OSTEOPOROSIS, POSTMENOPAUSAL; PHYTOTHERAPY; PLANT EXTRACTS; PLANT STEMS; RATS; RATS, SPRAGUE-DAWLEY; TINOSPORA; UTERUS;

ANIMALIA; RATTUS; TINOSPORA CORDIFOLIA;

EID: 44349133854     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2008.03.006     Document Type: Article

References (40)

1. Sutcliffe A. An overview of osteoporosis. Nurs Stand 20 (2005) 58-64
2. World Health Organization. Assessment of fracture risk and its application to screening for Postmenopausal osteoporosis. Report of WHO study group. Technical report series 843. Geneva: WHO; 1994.
3. Riggs B.L., and Melton L.J. Involutional osteoporosis. N Engl J Med 314 (1986) 1676-1686
4. Weitzmann M.N., and Pacifici R. Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest 116 (2006) 1186-1194
5. Spelsberg T.C., Subramaniam M., Riggs B.L., and Khosla S. The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Mol Endocrinol 13 (1999) 819-828
6. Genant H.K., Baylink D.J., and Gallagher J.C. Estrogens in the prevention of osteoporosis in postmenopausal women. Am J Obstet Gynecol 161 (1989) 1842-1846
7. Canalis E., McCarthy T., and Centrella M. Growth factors and the regulation on bone remodeling. J Clin Invest 81 (1988) 277-281
8. Shirwaikar A., Khan S., and Malini S. Antiosteoporotic effects of ethanol extract of Cissus quandrangularis Linn. on ovariectomized rat. J Ethanopharmacol 89 (2003) 245-250
9. Seidlova-Wuttke D., Jarry H., Pitzel L., and Wuttke W. Effects of estradiol-17β, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats. Maturitas 51 (2005) 177-186
10. Dontas I., Halabalaki M., Moutsatsou P., et al. Protective effect of plant extract Onobrychis ebenoides on ovariectomy induced bone loss in rats. Maturitas 53 (2005) 234-242
11. Wang X., Wu J., Chiba H., Yamada K., and Ishimi Y. Puerariae radix prevents bone loss in castrated male mice. Metabolism 54 (2005) 1536-1541
12. Chadha Y.R. "Tinospora" in the wealth of India. New Delhi publication and information directorate (1979), C.S.I.R., India p. 251
13. Bhatt A.D., and Bhatt N.S. Indigenous drugs and liver disease. Indian J Gastroenterol 15 (1996) 63-67
14. Sharma P.C., Yelne M.B., and Dannia T.J. Database on medicinal plants used in Ayurveda. Central council for research in ayurveda and siddha vol. 3 (2001), Government of India, New Delhi
15. Mathew S., and Kuttan G. Anti-oxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. J Exp Clin Cancer Res 16 (1997) 407-411
16. Nayampalli S.S., Desai N.K., and Ainapure S.S. Anti-allergic properties of Tinospora cordifolia in animal models. Indian J Pharm 18 (1986) 250-252
17. Pendse V.K., Dadhich A.P., Mathur P.N., Bal M.S., and Madam B.R. Anti-inflammatory, immunosuppressive and some related pharmacological actions of the water extract of Neem Giloe (Tinospora cordifolia)-a preliminary report. Indian J Pharm 9 (1977) 221-224
18. Kapil A., and Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 58 (1997) 89-95
19. Ahmed S.M., Manhas L.R., Verma V., and Khajuria R.K. Quantitative determination of four constituents of Tinospora sps. By a reversed phase HPLC-UV-DAD method. Broad based studies revealing variation in content of four secondary metabolites in the plant from different eco geographical regions in India. J Chromatogr Sci 44 (2006) 504-509
20. Singh S.S., Pandey S.C., Srivastava S., Gupta V.S., Patro B., and Ghosh A.C. Chemistry and medicinal properrties of Tinospora cordifolia (Guduchi). Indian J Pharmacol 35 (2003) 83-91
21. Jarry H., Metten M., Spengler B., Christoffel V., and Wuttke W. In vitro effects of the Cimicifuga racemosa extract BNO 1055. Maturitas 44 (2003) S31-S38
22. Helterbrand J.D., Higgs Jr. R.E., Iversen P.W., Tysarczyk-Niemeyer G., and Sato M. Application of automatic image segmentation to tibiae and vertebrae from ovariectomized rats. Bone 21 (1997) 401-409
23. Russo I.H., and Russo J. Developmental stage of the rat mammary gland as determinant of its susceptibility to 7,12-dimethylbenz[a]anthracene. J Natl Cancer Inst 61 (1978) 1439-1449
24. Kalu D.N. The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15 (1991) 175-191
25. Puel C., Mathey J., Kati-Coulibaly S., et al. Preventive effect of Abelmoschus manihot (L.) Medik on bone loss in the ovariectomized rats. J Ethnopharmacol 99 (2005) 55-60
26. Nagareddy P.R., and Lakshmana M. Withania somnifera improves bone calcification in calcium-deficient ovariectomized rats. J Pharm Pharmacol 58 (2006) 1-7
27. Yin J., Tezuka Y., Kouda K., et al. Antiosteoporotic activity of the water extract of Dioscorea spongios. Biol Pharm Bull 27 (2004) 583-586
28. Nian H., Qin L.P., Zhang Q.Y., Zheng H.C., Yu Y., and Huang B.K. Antiosteoporotic activity of Er-Xian decoction, a traditional Chinese herbal formula, in ovariectomized rats. J Ethnopharmacol 108 (2006) 96-102
29. Seidlova Wuttke, Jarry H., Becker T., Christoffel V., and Wuttke W. Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. Maturitas 44 Suppl. 1 (2003) S39-S50
30. Mueller S.O., and Korach K.S. Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice. Curr Opin Pharmacol 1 6 (2001) 613-619
31. Hillisch A., Peters O., Kosemund D., et al. Dissecting physiological roles of estrogen receptor alpha and beta with potent selective ligands from structure-based design. Mol Endocrinol 18 (2004) 1599-1609
32. Omi N., and Ezawa I. The effect of ovariectomy on bone metabolism in rats. Bone 17 (1995) 163S-168S
33. Seidlova-Wuttke D., Hesse O., Jarry H., et al. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta. Eur J Endocrinol 149 (2003) 351-362
34. Rickard D.J., Subramaniam M., and Spelsberg T.C. Molecular and cellular mechanisms of estrogen action on the skeleton. J Cell Biochem Suppl 32/33 (1999) 123-132
35. Swaminathan R. Biochemical markers of bone turnover. Clin Chim Acta 313 (2001) 95-105
36. Wronski T.J., Cintron M., Doherty A.L., and Dann L.M. Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123 (1988) 681-686
37. Anwar A., McTernan P.G., Anderson L.A., et al. Site-specific regulation of oestrogen receptor-alpha and -beta by estradiol in human adipose tissue. Diabetes Obes Metab 3 (2001) 338-349
38. Klotz D.M., Hewitt S.C., Ciana P., Raviscioni M., Lindzey J.K., and Foley J. Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J Biol Chem 277 (2002) 8531-8537
39. Adesanya O.O., Zhou J., Samathanam C., Powell-Braxton L., and Bondy C.A. Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle. Proc Natl Acad Sci USA 96 (1999) 3287-3291
40. Tekmal R.R., Liu Y.G., Nair H.B., et al. Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice. J Steroid Biochem Mol Biol 95 (2005) 9-15