메뉴 건너뛰기




Volumn 27, Issue 2, 2015, Pages 141-150

Cell cycle control as a promising target in melanoma

Author keywords

CDK; Cell cycle control; MDM2; Melanoma; p53

Indexed keywords

ABEMACICLIB; CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PALBOCICLIB; PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53; RETINOBLASTOMA PROTEIN; RIBOCICLIB; CARRIER PROTEIN;

EID: 84922662201     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0000000000000159     Document Type: Article
Times cited : (61)

References (50)
  • 1
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • Beroukhim R, Mermel CH, Porter D, et al. The landscape of somatic copy-number alteration across human cancers. Nature 2010; 463:899-905.
    • (2010) Nature , vol.463 , pp. 899-905
    • Beroukhim, R.1    Mermel, C.H.2    Porter, D.3
  • 2
    • 84901647365 scopus 로고    scopus 로고
    • Immunohistochemical analysis of molecular drivers in melanoma identifies p16 as an independent prognostic biomarker
    • Lade-Keller J, Riber-Hansen R, Guldberg P, et al. Immunohistochemical analysis of molecular drivers in melanoma identifies p16 as an independent prognostic biomarker. J Clin Pathol 2014; 67:520-528.
    • (2014) J Clin Pathol , vol.67 , pp. 520-528
    • Lade-Keller, J.1    Riber-Hansen, R.2    Guldberg, P.3
  • 3
    • 84927571470 scopus 로고    scopus 로고
    • Increased prevalence of lung, breast, and pancreatic cancers in addition to melanoma risk in families bearing the cyclin-dependent kinase inhibitor 2A mutation: Implications for genetic counseling
    • Potrony M, Puig-Butillé JA, Aguilera P, et al. Increased prevalence of lung, breast, and pancreatic cancers in addition to melanoma risk in families bearing the cyclin-dependent kinase inhibitor 2A mutation: Implications for genetic counseling. J Am Acad Dermatol 2014.
    • (2014) J Am Acad Dermatol
    • Potrony, M.1    Puig-Butillé, J.A.2    Aguilera, P.3
  • 4
    • 84902546671 scopus 로고    scopus 로고
    • Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines
    • Young RJ, Waldeck K, Martin C, et al. Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines. Pigment Cell Melanoma Res 2014; 27:590-600.
    • (2014) Pigment Cell Melanoma Res , vol.27 , pp. 590-600
    • Young, R.J.1    Waldeck, K.2    Martin, C.3
  • 5
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis E, Watson IR, Kryukov GV, et al. A landscape of driver mutations in melanoma. Cell 2012; 150:251-263.
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1    Watson, I.R.2    Kryukov, G.V.3
  • 6
    • 84893849823 scopus 로고    scopus 로고
    • Genetic alterations and personalized medicine in melanoma: Progress and future prospects
    • Griewank KG, Scolyer RA, Thompson JF, et al. Genetic alterations and personalized medicine in melanoma: progress and future prospects. J Natl Cancer Inst 2014; 106:djt435.
    • (2014) J Natl Cancer Inst , vol.106
    • Griewank, K.G.1    Scolyer, R.A.2    Thompson, J.F.3
  • 7
    • 0030467624 scopus 로고    scopus 로고
    • The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
    • Bartkova J, Lukas J, Guldberg P, et al. The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 1996; 56:5475-5483.
    • (1996) Cancer Res , vol.56 , pp. 5475-5483
    • Bartkova, J.1    Lukas, J.2    Guldberg, P.3
  • 8
    • 84874394983 scopus 로고    scopus 로고
    • p16(INK) (4a) deficiency promotes DNA hyper-replication and genetic instability in melanocytes
    • Fung C, Pupo GM, Scolyer RA, et al. p16(INK) (4a) deficiency promotes DNA hyper-replication and genetic instability in melanocytes. Pigment Cell Melanoma Res 2013; 26:236-246.
    • (2013) Pigment Cell Melanoma Res , vol.26 , pp. 236-246
    • Fung, C.1    Pupo, G.M.2    Scolyer, R.A.3
  • 9
    • 84883482902 scopus 로고    scopus 로고
    • Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436)
    • Nathanson KL, Martin AM, Wubbenhorst B, et al. Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436). Clin Cancer Res 2013; 19:4868-4878.
    • (2013) Clin Cancer Res , vol.19 , pp. 4868-4878
    • Nathanson, K.L.1    Martin, A.M.2    Wubbenhorst, B.3
  • 10
    • 84901612215 scopus 로고    scopus 로고
    • A novel variant in the 3'untranslated region of the CDK4 Gene: Interference with microRNA target sites and role in increased risk of cutaneous melanoma
    • Pedace L, Cozzolino AM, Barboni L, et al. A novel variant in the 3'untranslated region of the CDK4 gene: interference with microRNA target sites and role in increased risk of cutaneous melanoma. Cancer Genet 2014.
    • (2014) Cancer Genet
    • Pedace, L.1    Cozzolino, A.M.2    Barboni, L.3
  • 11
    • 78149464297 scopus 로고    scopus 로고
    • High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma
    • Jonsson A, Tuominen R, Grafstrom E, et al. High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma. J Invest Dermatol 2010; 130:2809-2817.
    • (2010) J Invest Dermatol , vol.130 , pp. 2809-2817
    • Jonsson, A.1    Tuominen, R.2    Grafstrom, E.3
  • 12
    • 84870289371 scopus 로고    scopus 로고
    • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
    • Kwong LN, Costello JC, Liu H, et al. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat Med 2012; 18:1503-1510.
    • (2012) Nat Med , vol.18 , pp. 1503-1510
    • Kwong, L.N.1    Costello, J.C.2    Liu, H.3
  • 13
    • 41049114747 scopus 로고    scopus 로고
    • How to make a melanoma: What do we know of the primary clonal events?
    • Bennett DC. How to make a melanoma: what do we know of the primary clonal events? Pigment Cell Melanoma Res 2008; 21:27-38.
    • (2008) Pigment Cell Melanoma Res , vol.21 , pp. 27-38
    • Bennett, D.C.1
  • 14
    • 84890801711 scopus 로고    scopus 로고
    • Frequency of somatic BRAF mutations in melanocytic lesions from patients in a CDK4 melanoma family
    • Puntervoll HE, Molven A, Akslen LA. Frequency of somatic BRAF mutations in melanocytic lesions from patients in a CDK4 melanoma family. Pigment Cell Melanoma Res 2014; 27:149-151.
    • (2014) Pigment Cell Melanoma Res , vol.27 , pp. 149-151
    • Puntervoll, H.E.1    Molven, A.2    Akslen, L.A.3
  • 15
    • 44949106363 scopus 로고    scopus 로고
    • Frequent p16-independent inactivation of p14ARF in human melanoma
    • Freedberg DE, Rigas SH, Russak J, et al. Frequent p16-independent inactivation of p14ARF in human melanoma. J Natl Cancer Inst 2008; 100:784-795.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 784-795
    • Freedberg, D.E.1    Rigas, S.H.2    Russak, J.3
  • 16
    • 84904855599 scopus 로고    scopus 로고
    • Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53
    • Viros A, Sanchez-Laorden B, Pedersen M, et al. Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53. Nature 2014; 511:478-482.
    • (2014) Nature , vol.511 , pp. 478-482
    • Viros, A.1    Sanchez-Laorden, B.2    Pedersen, M.3
  • 17
    • 84887622751 scopus 로고    scopus 로고
    • Targeting cyclin-dependent kinases in antineoplastic therapy
    • Bruyere C, Meijer L. Targeting cyclin-dependent kinases in antineoplastic therapy. Curr Opin Cell Biol 2013; 25:772-779.
    • (2013) Curr Opin Cell Biol , vol.25 , pp. 772-779
    • Bruyere, C.1    Meijer, L.2
  • 18
    • 84907200254 scopus 로고    scopus 로고
    • Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo
    • Zhang Y-X, Sicinska E, Czaplinski JT, et al. Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo. Mol Cancer Ther 2014; 13:2184-2193.
    • (2014) Mol Cancer Ther , vol.13 , pp. 2184-2193
    • Zhang, Y.-X.1    Sicinska, E.2    Czaplinski, J.T.3
  • 19
    • 84903829287 scopus 로고    scopus 로고
    • Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6-Reactivating Rb in cancer
    • Kim S, Loo A, Chopra R, et al. Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6-Reactivating Rb in cancer. Mol Cancer Ther 2013; 12 (11 Supplement):R02-R.
    • (2013) Mol Cancer Ther , vol.12 , Issue.11 , pp. R02-R
    • Kim, S.1    Loo, A.2    Chopra, R.3
  • 20
    • 84905669286 scopus 로고    scopus 로고
    • A phase I study of the singleagent CDK4/6 inhibitor LEE011 in pts with advanced solid tumors and lymphomas
    • Infante JR, Shapiro G, Witteveen P et al, editors. A phase I study of the singleagent CDK4/6 inhibitor LEE011 in pts with advanced solid tumors and lymphomas. J Clin Oncology (Meeting Abstracts) 2014; 32 (15 suppl):2528.
    • (2014) J Clin Oncology (Meeting Abstracts) , vol.32 , Issue.15 , pp. 2528
    • Infante, J.R.1    Shapiro, G.2    Witteveen, P.3
  • 21
    • 84912110744 scopus 로고    scopus 로고
    • Aphase Ib/2 study ofLEE011 in combination with binimetinib (MEK162) in patients with advanced NRASmutant melanoma: Early encouraging clinical activity
    • Sosman JA, Kittaneh M, MartijnPLolkema, et al. Aphase Ib/2 study ofLEE011 in combination with binimetinib (MEK162) in patients with advanced NRASmutant melanoma: Early encouraging clinical activity. J Clin Oncol 2014.
    • (2014) J Clin Oncol
    • Sosman, J.A.1    Kittaneh, M.2    Lolkema, M.P.3
  • 22
    • 79958149971 scopus 로고    scopus 로고
    • Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1)
    • Schwartz GK, LoRusso PM, Dickson MA, et al. Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1). Brit J Cancer 2011; 104:1862-1868.
    • (2011) Brit J Cancer , vol.104 , pp. 1862-1868
    • Schwartz, G.K.1    LoRusso, P.M.2    Dickson, M.A.3
  • 23
    • 84922602854 scopus 로고    scopus 로고
    • Targeted therapy for cutaneous melanoma: Beyond BRAF
    • Davies MA. Targeted therapy for cutaneous melanoma: beyond BRAF. J Patient-Centered Res Rev 2014; 1:12-20.
    • (2014) J Patient-Centered Res Rev , vol.1 , pp. 12-20
    • Davies, M.A.1
  • 24
    • 84875697676 scopus 로고    scopus 로고
    • Results of a randomized phase 2 study of PD 0332991, a cyclin-dependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs. Letrozole alone for first-line treatment of ERþ /HER2-advanced breast cancer (BC)
    • Finn R, Crown J, Lang I, et al. Results of a randomized phase 2 study of PD 0332991, a cyclin-dependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs. letrozole alone for first-line treatment of ERþ /HER2-advanced breast cancer (BC). Cancer Res 2012; 72 (24 Suppl):S1-S6.
    • (2012) Cancer Res , vol.72 , Issue.24 , pp. S1-S6
    • Finn, R.1    Crown, J.2    Lang, I.3
  • 25
    • 84930696140 scopus 로고    scopus 로고
    • Preclinical characterization of the CDK4/6 inhibitor LY2835219: In-vivo cell cycle-dependent/independent antitumor activities alone/in combination with gemcitabine
    • Gelbert LM, Cai S, Lin X, et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent antitumor activities alone/in combination with gemcitabine. Invest New Drugs 2014; 32:825-837.
    • (2014) Invest New Drugs , vol.32 , pp. 825-837
    • Gelbert, L.M.1    Cai, S.2    Lin, X.3
  • 26
    • 84891011530 scopus 로고    scopus 로고
    • A first-in-human phase I study of the CDK4/6 inhibitor, LY2835219, for patients with advanced cancer
    • Shapiro G, Rosen LS, Tolcher AW, et al., editors. A first-in-human phase I study of the CDK4/6 inhibitor, LY2835219, for patients with advanced cancer. ASCO Meeting; Abstracts 2013; 31:2500.
    • (2013) ASCO Meeting; Abstracts , vol.31 , pp. 2500
    • Shapiro, G.1    Rosen, L.S.2    Tolcher, A.W.3
  • 27
    • 84886438147 scopus 로고    scopus 로고
    • The cell-cycle regulator CDK4: An emerging therapeutic target in melanoma
    • Sheppard KE, McArthur GA. The cell-cycle regulator CDK4: an emerging therapeutic target in melanoma. Clin Cancer Res 2013; 19:5320-5328.
    • (2013) Clin Cancer Res , vol.19 , pp. 5320-5328
    • Sheppard, K.E.1    McArthur, G.A.2
  • 28
    • 84902546671 scopus 로고    scopus 로고
    • Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines
    • Young RJ, Waldeck K, Martin C, et al. Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines. Pigment Cell Melanoma Res 2014.
    • (2014) Pigment Cell Melanoma Res
    • Young, R.J.1    Waldeck, K.2    Martin, C.3
  • 29
    • 84875082183 scopus 로고    scopus 로고
    • The antimelanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling
    • Desai BM, Villanueva J, Nguyen TT, et al. The antimelanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling. PloS One 2013; 8:e59588.
    • (2013) PloS One , vol.8
    • Desai, B.M.1    Villanueva, J.2    Nguyen, T.T.3
  • 30
    • 84896115544 scopus 로고    scopus 로고
    • Non-BRAF targeted therapies for melanoma: Protein kinase inhibitors in Phase II clinical trials
    • Bhatia S, Emdad L, Das SK, et al. Non-BRAF targeted therapies for melanoma: protein kinase inhibitors in Phase II clinical trials. Expert Opin Investig Drugs 2014; 23:489-500.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 489-500
    • Bhatia, S.1    Emdad, L.2    Das, S.K.3
  • 31
    • 0029665778 scopus 로고    scopus 로고
    • Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells
    • Carlson BA, Dubay MM, Sausville EA, et al. Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res 1996; 56:2973-2978.
    • (1996) Cancer Res , vol.56 , pp. 2973-2978
    • Carlson, B.A.1    Dubay, M.M.2    Sausville, E.A.3
  • 32
    • 54049158957 scopus 로고    scopus 로고
    • Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas
    • Smalley KS, Lioni M, Dalla Palma M, et al. Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas. Mol Cancer Ther 2008; 7:2876-2883.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2876-2883
    • Smalley, K.S.1    Lioni, M.2    Dalla Palma, M.3
  • 33
    • 84905740364 scopus 로고    scopus 로고
    • The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells
    • Wang F-Z, Fei H-R, Cui Y-J, et al. The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis 2014; 19:1389-1398.
    • (2014) Apoptosis , vol.19 , pp. 1389-1398
    • Wang, F.-Z.1    Fei, H.-R.2    Cui, Y.-J.3
  • 34
    • 80655141261 scopus 로고    scopus 로고
    • Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation
    • Davies KD, Cable PL, Garrus JE, et al. Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation. Cancer Biol Ther 2011; 12:788-796.
    • (2011) Cancer Biol Ther , vol.12 , pp. 788-796
    • Davies, K.D.1    Cable, P.L.2    Garrus, J.E.3
  • 35
    • 52949139387 scopus 로고    scopus 로고
    • AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
    • Zabludoff SD, Deng C, Grondine MR, et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol Cancer Ther 2008; 7:2955-2966.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2955-2966
    • Zabludoff, S.D.1    Deng, C.2    Grondine, M.R.3
  • 36
    • 34848887018 scopus 로고    scopus 로고
    • Imaging with FLT-PET demonstrates that PF-477736, an inhibitor of CHK1 kinase, overcomes a cell cycle checkpoint induced by gemcitabine in PC-3 xenografts
    • McArthur GA, Raleigh J, Blasina A, et al., editors. Imaging with FLT-PET demonstrates that PF-477736, an inhibitor of CHK1 kinase, overcomes a cell cycle checkpoint induced by gemcitabine in PC-3 xenografts. J Clin Oncol (Meeting Abstracts) 2006; 24:3045.
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , pp. 3045
    • McArthur, G.A.1    Raleigh, J.2    Blasina, A.3
  • 37
    • 84873739385 scopus 로고    scopus 로고
    • A potent CHK1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress
    • Brooks K, Oakes V, Edwards B, et al. A potent CHK1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress.Oncogene 2012; 32:788-796.
    • (2012) Oncogene , vol.32 , pp. 788-796
    • Brooks, K.1    Oakes, V.2    Edwards, B.3
  • 38
    • 53349156857 scopus 로고    scopus 로고
    • Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1
    • Blasina A, Hallin J, Chen E, et al. Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Mol Cancer Ther 2008; 7:2394-2404.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2394-2404
    • Blasina, A.1    Hallin, J.2    Chen, E.3
  • 39
    • 84896735637 scopus 로고    scopus 로고
    • CHEK again: Revisiting the development of CHK1 inhibitors for cancer therapy
    • McNeely S, Beckmann R, Bence Lin AK. CHEK again: Revisiting the development of CHK1 inhibitors for cancer therapy. Pharmacol Ther 2014; 142:1-10.
    • (2014) Pharmacol Ther , vol.142 , pp. 1-10
    • McNeely, S.1    Beckmann, R.2    Bence Lin, A.K.3
  • 40
    • 84886644238 scopus 로고    scopus 로고
    • Wee1 kinase as a target for cancer therapy
    • Do K, Doroshow JH, Kummar S. Wee1 kinase as a target for cancer therapy. Cell Cycle 2013; 12:3159-3264.
    • (2013) Cell Cycle , vol.12 , pp. 3159-3264
    • Do, K.1    Doroshow, J.H.2    Kummar, S.3
  • 41
    • 84879607314 scopus 로고    scopus 로고
    • WEE1 tyrosine kinase, a novel epigenetic modifier
    • Mahajan K, Mahajan NP. WEE1 tyrosine kinase, a novel epigenetic modifier. Trends Genet 2013; 29:394-402.
    • (2013) Trends Genet , vol.29 , pp. 394-402
    • Mahajan, K.1    Mahajan, N.P.2
  • 42
    • 84879687956 scopus 로고    scopus 로고
    • Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma
    • Bhattacharya A, Schmitz U, Wolkenhauer O, et al. Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma. Oncogene 2013; 32:3175-3183.
    • (2013) Oncogene , vol.32 , pp. 3175-3183
    • Bhattacharya, A.1    Schmitz, U.2    Wolkenhauer, O.3
  • 43
    • 84864677524 scopus 로고    scopus 로고
    • MDM4 is a key therapeutic target in cutaneous melanoma
    • Gembarska A, Luciani F, Fedele C, et al. MDM4 is a key therapeutic target in cutaneous melanoma. Nat Med 2012; 18:1239-1247.
    • (2012) Nat Med , vol.18 , pp. 1239-1247
    • Gembarska, A.1    Luciani, F.2    Fedele, C.3
  • 44
    • 84899957701 scopus 로고    scopus 로고
    • MDM2 SNP309 promoter polymorphism confers risk for hereditary melanoma
    • Thunell LK, Bivik C, Wäster P, et al. MDM2 SNP309 promoter polymorphism confers risk for hereditary melanoma. Melanoma Res 2014; 24:190-197.
    • (2014) Melanoma Res , vol.24 , pp. 190-197
    • Thunell, L.K.1    Bivik, C.2    Wäster, P.3
  • 45
    • 84875740623 scopus 로고    scopus 로고
    • p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis
    • Matin RN, Chikh A, Chong SL, et al. p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. J Exp Med 2013; 210:581-603.
    • (2013) J Exp Med , vol.210 , pp. 581-603
    • Matin, R.N.1    Chikh, A.2    Chong, S.L.3
  • 46
    • 84877826693 scopus 로고    scopus 로고
    • Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP
    • Lu M, Breyssens H, Salter V, et al. Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer Cell 2013; 23:618-633.
    • (2013) Cancer Cell , vol.23 , pp. 618-633
    • Lu, M.1    Breyssens, H.2    Salter, V.3
  • 47
    • 84898608024 scopus 로고    scopus 로고
    • Dissecting the p53-Mdm2 feedback loop in vivo: Uncoupling the role in p53 stability and activity
    • Pant V, Lozano G. Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity. Oncotarget 2014; 5:1149.
    • (2014) Oncotarget , vol.5 , pp. 1149
    • Pant, V.1    Lozano, G.2
  • 48
    • 84906283263 scopus 로고    scopus 로고
    • Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway
    • Potu H, Peterson LF, Pal A, et al. Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget 2014; 5:5559-5569.
    • (2014) Oncotarget , vol.5 , pp. 5559-5569
    • Potu, H.1    Peterson, L.F.2    Pal, A.3
  • 49
    • 84890556331 scopus 로고    scopus 로고
    • Reactivation of p53 as therapeutic intervention for malignant melanoma
    • Jochemsen AG. Reactivation of p53 as therapeutic intervention for malignant melanoma. Curr Opin Oncol 2014; 26:114-119.
    • (2014) Curr Opin Oncol , vol.26 , pp. 114-119
    • Jochemsen, A.G.1
  • 50
    • 84882992810 scopus 로고    scopus 로고
    • Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth
    • Ji Z, Kumar R, Taylor M, et al. Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth. Clin Cancer Res 2013; 19:4383-4391.
    • (2013) Clin Cancer Res , vol.19 , pp. 4383-4391
    • Ji, Z.1    Kumar, R.2    Taylor, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.