-
1
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
G.L. Semenza Targeting HIF-1 for cancer therapy Nat Rev Cancer 3 2003 721
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721
-
-
Semenza, G.L.1
-
2
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
G.L. Semenza Hypoxia-inducible factors in physiology and medicine Cell 148 2012 399
-
(2012)
Cell
, vol.148
, pp. 399
-
-
Semenza, G.L.1
-
3
-
-
44149092895
-
Hypoxia in prostate cancer: A powerful shield against tumour destruction?
-
L. Marignol, M. Coffey, and M. Lawler Hypoxia in prostate cancer: a powerful shield against tumour destruction? Cancer Treat Rev 34 2008 313
-
(2008)
Cancer Treat Rev
, vol.34
, pp. 313
-
-
Marignol, L.1
Coffey, M.2
Lawler, M.3
-
4
-
-
84883501150
-
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
-
G.L. Semenza HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations J Clin Invest 123 2013 3664
-
(2013)
J Clin Invest
, vol.123
, pp. 3664
-
-
Semenza, G.L.1
-
5
-
-
84655161946
-
HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression
-
B. Keith, R.S. Johnson, and M.C. Simon HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression Nat Rev Cancer 12 2011 9
-
(2011)
Nat Rev Cancer
, vol.12
, pp. 9
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
6
-
-
33646007333
-
An immunohistochemical assessment of hypoxia in prostate carcinoma using pimonidazole: Implications for radioresistance
-
D.M. Carnell, R.E. Smith, and F.M. Daley An immunohistochemical assessment of hypoxia in prostate carcinoma using pimonidazole: implications for radioresistance Int J Radiat Oncol Biol Phys 65 2006 91
-
(2006)
Int J Radiat Oncol Biol Phys
, vol.65
, pp. 91
-
-
Carnell, D.M.1
Smith, R.E.2
Daley, F.M.3
-
7
-
-
0034798395
-
Hypoxia in human prostate carcinoma: An Eppendorf PO2 study
-
B. Movsas, J.D. Chapman, and A.L. Hanlon Hypoxia in human prostate carcinoma: an Eppendorf PO2 study Am J Clin Oncol 24 2001 458
-
(2001)
Am J Clin Oncol
, vol.24
, pp. 458
-
-
Movsas, B.1
Chapman, J.D.2
Hanlon, A.L.3
-
8
-
-
0030249455
-
Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: A pretherapy study of 37 patients
-
J.S. Rasey, W.J. Koh, and M.L. Evans Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients Int J Radiat Oncol Biol Phys 36 1996 417
-
(1996)
Int J Radiat Oncol Biol Phys
, vol.36
, pp. 417
-
-
Rasey, J.S.1
Koh, W.J.2
Evans, M.L.3
-
9
-
-
10744221495
-
Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer
-
C. Parker, M. Milosevic, and A. Toi Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer Int J Radiat Oncol Biol Phys 58 2004 750
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, pp. 750
-
-
Parker, C.1
Milosevic, M.2
Toi, A.3
-
10
-
-
80455174743
-
Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniques
-
R. Garcia-Parra, D. Wood, and R.B. Shah Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniques Eur J Nucl Med Mol Imaging 38 2011 1816
-
(2011)
Eur J Nucl Med Mol Imaging
, vol.38
, pp. 1816
-
-
Garcia-Parra, R.1
Wood, D.2
Shah, R.B.3
-
11
-
-
1842426907
-
Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis
-
H. Zhong, G.L. Semenza, and J.W. Simons Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis Cancer Detect Prev 28 2004 88
-
(2004)
Cancer Detect Prev
, vol.28
, pp. 88
-
-
Zhong, H.1
Semenza, G.L.2
Simons, J.W.3
-
12
-
-
84872467458
-
The role of hypoxia-inducible factor 1α in determining the properties of castrate-resistant prostate cancers
-
W.K. Ranasinghe, L. Xiao, and S. Kovac The role of hypoxia-inducible factor 1α in determining the properties of castrate-resistant prostate cancers PLoS One 8 2013 e54251
-
(2013)
PLoS One
, vol.8
, pp. e54251
-
-
Ranasinghe, W.K.1
Xiao, L.2
Kovac, S.3
-
13
-
-
58049194196
-
HIF-1alpha mRNA gene expression levels in improved diagnosis of early stages of prostate cancer
-
C.P. Pipinikas, N.D. Carter, and C.M. Corbishley HIF-1alpha mRNA gene expression levels in improved diagnosis of early stages of prostate cancer Biomarkers 13 2008 680
-
(2008)
Biomarkers
, vol.13
, pp. 680
-
-
Pipinikas, C.P.1
Carter, N.D.2
Corbishley, C.M.3
-
14
-
-
77954688642
-
HIF1alpha isoforms in benign and malignant prostate tissue and their correlation to neuroendocrine differentiation
-
N. Monsef, M. Soller, and I. Panagopoulos HIF1alpha isoforms in benign and malignant prostate tissue and their correlation to neuroendocrine differentiation BMC Cancer 10 2010 385
-
(2010)
BMC Cancer
, vol.10
, pp. 385
-
-
Monsef, N.1
Soller, M.2
Panagopoulos, I.3
-
15
-
-
47049091483
-
Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype
-
K.T. Butterworth, H.O. McCarthy, and A. Devlin Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype Int J Cancer 123 2008 760
-
(2008)
Int J Cancer
, vol.123
, pp. 760
-
-
Butterworth, K.T.1
McCarthy, H.O.2
Devlin, A.3
-
16
-
-
0032189844
-
Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1alpha
-
M.S. Wiesener, H. Turley, and W.E. Allen Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha Blood 92 1998 2260
-
(1998)
Blood
, vol.92
, pp. 2260
-
-
Wiesener, M.S.1
Turley, H.2
Allen, W.E.3
-
17
-
-
44849100198
-
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
-
J. Rius, M. Guma, and C. Schachtrup NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha Nature 453 2008 807
-
(2008)
Nature
, vol.453
, pp. 807
-
-
Rius, J.1
Guma, M.2
Schachtrup, C.3
-
18
-
-
33748193395
-
A novel role for 3, 4-dichloropropionanilide (DCPA) in the inhibition of prostate cancer cell migration, proliferation, and hypoxia-inducible factor 1alpha expression
-
B.H. Jiang, L.Z. Liu, and R. Schafer A novel role for 3, 4-dichloropropionanilide (DCPA) in the inhibition of prostate cancer cell migration, proliferation, and hypoxia-inducible factor 1alpha expression BMC Cancer 6 2006 204
-
(2006)
BMC Cancer
, vol.6
, pp. 204
-
-
Jiang, B.H.1
Liu, L.Z.2
Schafer, R.3
-
20
-
-
33646420620
-
Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to androgen-independent prostate cancer
-
C.H. Chau, M.G. Permenter, and S.M. Steinberg Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to androgen-independent prostate cancer Cancer Biol Ther 4 2005 1222
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 1222
-
-
Chau, C.H.1
Permenter, M.G.2
Steinberg, S.M.3
-
21
-
-
79951810386
-
Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α
-
M. Koslowski, U. Luxemburger, and O. Türeci Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α Oncogene 30 2011 876
-
(2011)
Oncogene
, vol.30
, pp. 876
-
-
Koslowski, M.1
Luxemburger, U.2
Türeci, O.3
-
23
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
J.R. Gnarra, K. Tory, and Y. Weng Mutations of the VHL tumour suppressor gene in renal carcinoma Nat Genet 7 1994 85
-
(1994)
Nat Genet
, vol.7
, pp. 85
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
24
-
-
84861403891
-
Association between VHL single nucleotide polymorphism (rs779805) and the susceptibility to prostate cancer in Chinese
-
J. Chen, Y. Wu, and P. Shao Association between VHL single nucleotide polymorphism (rs779805) and the susceptibility to prostate cancer in Chinese DNA Cell Biol 31 2012 790
-
(2012)
DNA Cell Biol
, vol.31
, pp. 790
-
-
Chen, J.1
Wu, Y.2
Shao, P.3
-
25
-
-
0036000028
-
Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia
-
K.J. Lang, A. Kappel, and G.J. Goodall Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia Mol Biol Cell 13 2002 1792
-
(2002)
Mol Biol Cell
, vol.13
, pp. 1792
-
-
Lang, K.J.1
Kappel, A.2
Goodall, G.J.3
-
26
-
-
0037044578
-
Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia
-
R. Karni, Y. Dor, and E. Keshet Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia J Biol Chem 277 2002 42919
-
(2002)
J Biol Chem
, vol.277
, pp. 42919
-
-
Karni, R.1
Dor, Y.2
Keshet, E.3
-
27
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
H. Zhong, K. Chiles, and D. Feldser Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics Cancer Res 60 2000 1541
-
(2000)
Cancer Res
, vol.60
, pp. 1541
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
-
29
-
-
35649001888
-
A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer
-
S. Braunstein, K. Karpisheva, and C. Pola A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer Mol Cell 28 2007 501
-
(2007)
Mol Cell
, vol.28
, pp. 501
-
-
Braunstein, S.1
Karpisheva, K.2
Pola, C.3
-
30
-
-
33746794674
-
Expression of mTOR signaling pathway markers in prostate cancer progression
-
C.L. Kremer, R.R. Klein, and J. Mendelson Expression of mTOR signaling pathway markers in prostate cancer progression Prostate 66 2006 1203
-
(2006)
Prostate
, vol.66
, pp. 1203
-
-
Kremer, C.L.1
Klein, R.R.2
Mendelson, J.3
-
31
-
-
84876151675
-
Zinc and zinc transporters in prostate carcinogenesis
-
V. Kolenko, E. Teper, and A. Kutikov Zinc and zinc transporters in prostate carcinogenesis Nat Rev Urol 10 2013 219
-
(2013)
Nat Rev Urol
, vol.10
, pp. 219
-
-
Kolenko, V.1
Teper, E.2
Kutikov, A.3
-
32
-
-
35148870019
-
HIF-1alpha promotes survival of prostate cells at a high zinc environment
-
S.E. Park, J.W. Park, and Y.S. Cho HIF-1alpha promotes survival of prostate cells at a high zinc environment Prostate 67 2007 1514
-
(2007)
Prostate
, vol.67
, pp. 1514
-
-
Park, S.E.1
Park, J.W.2
Cho, Y.S.3
-
34
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
-
S. Zhao, Y. Lin, and W. Xu Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha Science 324 2009 261
-
(2009)
Science
, vol.324
, pp. 261
-
-
Zhao, S.1
Lin, Y.2
Xu, W.3
-
35
-
-
33745512245
-
Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
-
K.K. Singh, M.M. Desouki, and R.B. Franklin Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues Mol Cancer 5 2006 14
-
(2006)
Mol Cancer
, vol.5
, pp. 14
-
-
Singh, K.K.1
Desouki, M.M.2
Franklin, R.B.3
-
36
-
-
40949120482
-
Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: A retrospective analysis of two randomised radiotherapy trials and one surgical cohort study
-
R. Vergis, C.M. Corbishley, and A.R. Norman Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one surgical cohort study Lancet Oncol 9 2008 342
-
(2008)
Lancet Oncol
, vol.9
, pp. 342
-
-
Vergis, R.1
Corbishley, C.M.2
Norman, A.R.3
-
37
-
-
84891827953
-
The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration
-
A. Fraga, R. Ribeiro, and P. Principe The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration Eur J Cancer 50 2014 359
-
(2014)
Eur J Cancer
, vol.50
, pp. 359
-
-
Fraga, A.1
Ribeiro, R.2
Principe, P.3
-
38
-
-
84862229124
-
The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy
-
D.C. Weber, J.C. Tille, and C. Combescure The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy Radiat Oncol 7 2012 66
-
(2012)
Radiat Oncol
, vol.7
, pp. 66
-
-
Weber, D.C.1
Tille, J.C.2
Combescure, C.3
-
39
-
-
27744489232
-
The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer
-
J.L. Boddy, S.B. Fox, and C. Han The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer Clin Cancer Res 11 2005 7658
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7658
-
-
Boddy, J.L.1
Fox, S.B.2
Han, C.3
-
40
-
-
77958449506
-
The relationship between proangiogenic gene expression levels in prostate cancer and their prognostic value for clinical outcomes
-
R. Mori, T.B. Dorff, and S. Xiong The relationship between proangiogenic gene expression levels in prostate cancer and their prognostic value for clinical outcomes Prostate 70 2010 1692
-
(2010)
Prostate
, vol.70
, pp. 1692
-
-
Mori, R.1
Dorff, T.B.2
Xiong, S.3
-
41
-
-
0038004462
-
Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3′-kinase/protein kinase B in prostate cancer cells
-
N.J. Mabjeesh, M.T. Willard, and C.E. Frederickson Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3′-kinase/protein kinase B in prostate cancer cells Clin Cancer Res 9 2003 2416
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2416
-
-
Mabjeesh, N.J.1
Willard, M.T.2
Frederickson, C.E.3
-
42
-
-
78650572564
-
Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment
-
T. Mitani, R. Yamaji, and Y. Higashimura Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment J Steroid Biochem Mol Biol 123 2011 58
-
(2011)
J Steroid Biochem Mol Biol
, vol.123
, pp. 58
-
-
Mitani, T.1
Yamaji, R.2
Higashimura, Y.3
-
43
-
-
0028944138
-
In vivo amplification of the androgen receptor gene and progression of human prostate cancer
-
T. Visakorpi, E. Hyytinen, and P. Koivisto In vivo amplification of the androgen receptor gene and progression of human prostate cancer Nat Genet 9 1995 401
-
(1995)
Nat Genet
, vol.9
, pp. 401
-
-
Visakorpi, T.1
Hyytinen, E.2
Koivisto, P.3
-
44
-
-
66449130218
-
Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer
-
S. Nanni, V. Benvenuti, and A. Grasselli Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer J Clin Invest 119 2009 1093
-
(2009)
J Clin Invest
, vol.119
, pp. 1093
-
-
Nanni, S.1
Benvenuti, V.2
Grasselli, A.3
-
45
-
-
0033366794
-
Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line
-
X.H. Liu, A. Kirschenbaum, and S. Yao Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line Clin Exp Metastasis 17 1999 687
-
(1999)
Clin Exp Metastasis
, vol.17
, pp. 687
-
-
Liu, X.H.1
Kirschenbaum, A.2
Yao, S.3
-
46
-
-
79959922456
-
A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment
-
E.A. Platz, S. Yegnasubramanian, and J.O. Liu A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment Cancer Discov 1 2011 68
-
(2011)
Cancer Discov
, vol.1
, pp. 68
-
-
Platz, E.A.1
Yegnasubramanian, S.2
Liu, J.O.3
-
47
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
-
H. Zhang, D.Z. Qian, and Y.S. Tan Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth Proc Natl Acad Sci U S A 105 2008 19579
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 19579
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
-
48
-
-
79952391694
-
Tubular injury in a rat model of type 2 diabetes is prevented by metformin: A possible role of HIF-1α expression and oxygen metabolism
-
Y. Takiyama, T. Harumi, and J. Watanabe Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism Diabetes 60 2011 981
-
(2011)
Diabetes
, vol.60
, pp. 981
-
-
Takiyama, Y.1
Harumi, T.2
Watanabe, J.3
-
49
-
-
84874538282
-
Metformin and prostate cancer: Reduced development of castration-resistant disease and prostate cancer mortality
-
D.E. Spratt, C. Zhang, and Z.S. Zumsteg Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality Eur Urol 63 2013 709
-
(2013)
Eur Urol
, vol.63
, pp. 709
-
-
Spratt, D.E.1
Zhang, C.2
Zumsteg, Z.S.3
-
50
-
-
84920271526
-
The effects of nonspecific HIF1α inhibitors on development of castrate resistance and metastases in prostate cancer
-
W.K. Ranasinghe, S. Sengupta, and S. Williams The effects of nonspecific HIF1α inhibitors on development of castrate resistance and metastases in prostate cancer Cancer Med 3 2014 245
-
(2014)
Cancer Med
, vol.3
, pp. 245
-
-
Ranasinghe, W.K.1
Sengupta, S.2
Williams, S.3
|