Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient mice

Obesity

Volumn 23, Issue 2, 2015, Pages 335-344

  Xu, Jialin ^a,b   Donepudi, Ajay C ^a   More, Vijay R ^a   Kulkarni, Supriya R ^a   Li, Liya ^a,b   Guo, Liangran ^a   Yan, Bingfang ^a   Chatterjee, Tapan ^c   Weintraub, Neal ^c   Slitt, Angela L ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b NORTHEASTERN UNIVERSITY   (China)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; FATTY ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; TRANSCRIPTION FACTOR NRF2; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; NFE2L2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL SIZE; CONTROLLED STUDY; DYSLIPIDEMIA; ENZYME PHOSPHORYLATION; FATTY LIVER; FOOD INTAKE; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LIPID LIVER LEVEL; LIPID STORAGE; LIPOPROTEIN SECRETION; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOGENESIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING; WHITE ADIPOSE TISSUE; ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; CYTOLOGY; DEFICIENCY; LIVER; METABOLISM; MOUSE MUTANT;

MUS;

ADIPOSE TISSUE; ANIMALS; INSULIN RESISTANCE; LEPTIN; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; NF-E2-RELATED FACTOR 2; OBESITY; TRANSCRIPTION FACTORS;

EID: 84922599414     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20929     Document Type: Article

References (36)

1. Ogden CL, Carroll MD, Kit BK, Flegal KM,. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief, 2012.
2. Kim JB, Spiegelman BM,. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 1996; 10: 1096-1107.
3. Tontonoz P, Hu E, Spiegelman BM,. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994; 79: 1147-1156.
4. Yang X, Jansson PA, Nagaev I, et al. Evidence of impaired adipogenesis in insulin resistance. Biochem Biophys Res Commun 2004; 317: 1045-1051.
5. Danforth E, Jr,. Failure of adipocyte differentiation causes type II diabetes mellitus? Nat Genet 2000; 26: 13.
6. Choi SH, Ginsberg HN,. Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. Trends Endocrinol Metab 2011; 22: 353-363.
7. Cabezas MC, de Bruin TW, Jansen H, Kock LA, Kortlandt W, Erkelens DW,. Impaired chylomicron remnant clearance in familial combined hyperlipidemia. Arterioscler Thromb 1993; 13: 804-814.
8. Pi J, Leung L, Xue P, et al. Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem 2010; 285: 9292-9300.
9. Chartoumpekis DV, Ziros PG, Psyrogiannis AI, et al. Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice. Diabetes 2011; 60: 2465-2473.
10. More VR, Xu J, Shimpi PC, et al. Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. Free Radic Biol Med 2013; 61C: 85-94.
11. Xu J, Kulkarni SR, Donepudi AC, More VR, Slitt AL,. Enhanced nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. Diabetes 2012; 61: 3208-3218.
12. Shin S, Wakabayashi N, Misra V, et al. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol 2007; 27: 7188-7197.
13. Shin S, Wakabayashi J, Yates MS, et al. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. Eur J Pharmacol 2009; 620: 138-144.
14. Chan K, Lu R, Chang JC, Kan YW,. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci USA 1996; 93: 13943-13948.
15. Okada K, Shoda J, Taguchi K, et al. Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am J Physiol Gastrointest Liver Physiol 2008; 295: G735-G747.
16. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM,. Transcriptional regulation of adipogenesis. Genes Dev 2000; 14: 1293-1307.
17. Xue P, Hou Y, Chen Y, et al. Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes 2013; 62: 845-854.
18. Huang J, Tabbi-Anneni I, Gunda V, Wang L,. Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism. Am J Physiol Gastrointest Liver Physiol 2010; 299: G1211-G1221.
19. Wu KC, Liu J, Klaassen CD,. Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicol Appl Pharmacol 2012; 262: 321-329.
20. Horton JD, Goldstein JL, Brown MS,. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109: 1125-1131.
21. Pascot A, Lemieux I, Prud'homme D, et al. Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity. J Lipid Res 2001; 42: 2007-2014.
22. Chan DC, Watts GF, Redgrave TG, Mori TA, Barrett PH,. Apolipoprotein B-100 kinetics in visceral obesity: associations with plasma apolipoprotein C-III concentration. Metabolism 2002; 51: 1041-1046.
23. McCormick SP, Ng JK, Veniant M, et al. Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene. J Biol Chem 1996; 271: 11963-11970.
24. Chen Z, Newberry EP, Norris JY, et al. ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. J Lipid Res 2008; 49: 2013-2022.
25. Yu Z, Shao W, Chiang Y, et al. Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. Diabetologia 2011; 54: 922-934.
26. Uruno A, Furusawa Y, Yagishita Y, et al. The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol 2013; 33: 2996-3010.
27. Xu J, Donepudi AC, Moscovitz JE, Slitt AL,. Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue. PLoS One 2013; 8: e79841.
28. Tanaka Y, Aleksunes LM, Yeager RL, et al. NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. J Pharmacol Exp Ther 2008; 325: 655-664.
29. Aleksunes LM, Reisman SA, Yeager RL, Goedken MJ, Klaassen CD,. Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. J Pharmacol Exp Ther 2010; 333: 140-151.
30. Zhang YK, Wu KC, Liu J, Klaassen CD,. Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. Toxicol Appl Pharmacol 2012; 264: 305-314.
31. Kulkarni SR, Donepudi AC, Xu J, et al. Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human. Antioxid Redox Signal 2014; 20: 15-30.
32. Okada K, Warabi E, Sugimoto H, et al. Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. J Gastroenterol 2012; 47: 924-935.
33. Zhou R, Lin J, Wu D,. Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis. Biochim Biophys Acta 2014; 1840: 209-218.
34. Wu KC, Cui JY, Klaassen CD,. Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicol Sci 2011; 123: 590-600.
35. Singh A, Happel C, Manna SK, et al. Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. J Clin Invest 2013; 123: 2921-2934.
36. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ,. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348: 1625-1638.