Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice - Potential role for transient receptor potential ankyrin1 in gout

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Moilanen, Lauri J ^a   Hämäläinen, Mari ^a   Lehtimäki, Lauri ^a   Nieminen, Riina M ^a   Moilanen, Eeva ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; CXCL2 CHEMOKINE; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; NEUROPEPTIDE; SUBSTANCE P; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; URATE; 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE; ACETANILIDE DERIVATIVE; PURINE DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, MOUSE; URIC ACID;

ANIMAL EXPERIMENT; ARTHRALGIA; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GOUT; INFLAMMATION; INFLAMMATORY CELL; INTRAPLANTAR DRUG ADMINISTRATION; MOUSE; NONHUMAN; PAW EDEMA; SWELLING; WILD TYPE; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PAIN;

ANIMALIA; MURINAE; MUS;

ACETANILIDES; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; GOUT; INFLAMMATION; MICE; MICE, KNOCKOUT; PAIN; PURINES; TRANSIENT RECEPTOR POTENTIAL CHANNELS; URIC ACID;

EID: 84922592759     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117770     Document Type: Article

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