Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

Neuropharmacology

Volumn 93, Issue , 2015, Pages 15-27

  Rojas, Asheebo ^a   Ganesh, Thota ^a   Lelutiu, Nadia ^a   Gueorguieva, Paoula ^a   Dingledine, Raymond ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

COX 2; DFP; EP2; Hippocampus; Inflammation; Neurodegeneration; Organophosphorus; PGE2; Status epilepticus

Indexed keywords

CYCLOOXYGENASE 2; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; TG 6 10 1; UNCLASSIFIED DRUG; ACETYLCHOLINESTERASE; CHEMOKINE; CHOLINESTERASE INHIBITOR; DYFLOS; INDOLE DERIVATIVE; NEUROPROTECTIVE AGENT; TG6-10-1;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASTROCYTOSIS; BRAIN DEGENERATION; CELL ACTIVATION; CONTROLLED STUDY; CONVALESCENCE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG HALF LIFE; DRUG MECHANISM; ENZYME INDUCTION; EPILEPTIC STATE; GLIOSIS; MALE; MAXIMUM PLASMA CONCENTRATION; MICROGLIA; NEUROPROTECTION; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; WEIGHT REDUCTION; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; BODY WEIGHT; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENETICS; HIPPOCAMPUS; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT; STATUS EPILEPTICUS; TIME FACTOR;

ACETYLCHOLINESTERASE; ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; CHEMOKINES; CHOLINESTERASE INHIBITORS; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; GLIOSIS; HIPPOCAMPUS; INDOLES; ISOFLUROPHATE; MALE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECOVERY OF FUNCTION; STATUS EPILEPTICUS; TIME FACTORS;

EID: 84922573371     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.01.017     Document Type: Article

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