메뉴 건너뛰기




Volumn 36, Issue , 2014, Pages 68-73

Lovastatin decreases the synthesis of inflammatory mediators during epileptogenesis in the hippocampus of rats submitted to pilocarpine-induced epilepsy

Author keywords

Cytokines; Epileptogenesis; Lovastatin; Pilocarpine; Temporal lobe epilepsy

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MEVINOLIN; PILOCARPINE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; HYPOCHOLESTEROLEMIC AGENT; MUSCARINIC AGENT;

EID: 84901236081     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2014.04.009     Document Type: Article
Times cited : (34)

References (42)
  • 1
    • 0001490738 scopus 로고    scopus 로고
    • Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
    • Pitkanen A., Sutula T.P. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol 2002, 1(3):173-181.
    • (2002) Lancet Neurol , vol.1 , Issue.3 , pp. 173-181
    • Pitkanen, A.1    Sutula, T.P.2
  • 2
    • 57349144887 scopus 로고    scopus 로고
    • Epilepsy surgery for pharmacoresistant temporal lobe epilepsy: a decision analysis
    • Choi H., Sell R.L., Lenert L., Muennig P., Goodman R.R., Gilliam F.G., et al. Epilepsy surgery for pharmacoresistant temporal lobe epilepsy: a decision analysis. JAMA 2008, 300(21):2497-2505.
    • (2008) JAMA , vol.300 , Issue.21 , pp. 2497-2505
    • Choi, H.1    Sell, R.L.2    Lenert, L.3    Muennig, P.4    Goodman, R.R.5    Gilliam, F.G.6
  • 3
    • 29744460702 scopus 로고    scopus 로고
    • Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system
    • Ravizza T., Vezzani A. Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system. Neuroscience 2006, 137(1):301-308.
    • (2006) Neuroscience , vol.137 , Issue.1 , pp. 301-308
    • Ravizza, T.1    Vezzani, A.2
  • 4
    • 33644625777 scopus 로고    scopus 로고
    • Brain inflammation in epilepsy: experimental and clinical evidence
    • Vezzani A., Granata T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 2005, 46(11):1724-1743.
    • (2005) Epilepsia , vol.46 , Issue.11 , pp. 1724-1743
    • Vezzani, A.1    Granata, T.2
  • 6
    • 12144287562 scopus 로고    scopus 로고
    • The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy
    • Arganaraz G.A., Silva J.A., Perosa S.R., Pessoa L.G., Carvalho F.F., Bascands J.L., et al. The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. Brain Res 2004, 1006(1):114-125.
    • (2004) Brain Res , vol.1006 , Issue.1 , pp. 114-125
    • Arganaraz, G.A.1    Silva, J.A.2    Perosa, S.R.3    Pessoa, L.G.4    Carvalho, F.F.5    Bascands, J.L.6
  • 7
    • 78651250696 scopus 로고    scopus 로고
    • Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus
    • Gouveia T.L., Scorza F.A., Silva M.J., Bandeira Tde A., Perosa S.R., Arganaraz G.A., et al. Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus. Epilepsy Behav 2011, 20(1):1-5.
    • (2011) Epilepsy Behav , vol.20 , Issue.1 , pp. 1-5
    • Gouveia, T.L.1    Scorza, F.A.2    Silva, M.J.3    Bandeira Tde, A.4    Perosa, S.R.5    Arganaraz, G.A.6
  • 8
    • 33846862253 scopus 로고    scopus 로고
    • Kinin B1 and B2 receptors are overexpressed in the hippocampus of humans with temporal lobe epilepsy
    • Perosa S.R., Arganaraz G.A., Goto E.M., Costa L.G., Konno A.C., Varella P.P., et al. Kinin B1 and B2 receptors are overexpressed in the hippocampus of humans with temporal lobe epilepsy. Hippocampus 2007, 17(1):26-33.
    • (2007) Hippocampus , vol.17 , Issue.1 , pp. 26-33
    • Perosa, S.R.1    Arganaraz, G.A.2    Goto, E.M.3    Costa, L.G.4    Konno, A.C.5    Varella, P.P.6
  • 10
    • 79952349864 scopus 로고    scopus 로고
    • Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis
    • Varella P.P., Santiago J.F., Carrete H., Higa E.M., Yacubian E.M., Centeno R.S., et al. Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis. Arq Neuropsiquiatr 2011, 69(1):91-99.
    • (2011) Arq Neuropsiquiatr , vol.69 , Issue.1 , pp. 91-99
    • Varella, P.P.1    Santiago, J.F.2    Carrete, H.3    Higa, E.M.4    Yacubian, E.M.5    Centeno, R.S.6
  • 11
    • 0033943296 scopus 로고    scopus 로고
    • Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus
    • De Simoni M.G., Perego C., Ravizza T., Moneta D., Conti M., Marchesi F., et al. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur J Neurosci 2000, 12(7):2623-2633.
    • (2000) Eur J Neurosci , vol.12 , Issue.7 , pp. 2623-2633
    • De Simoni, M.G.1    Perego, C.2    Ravizza, T.3    Moneta, D.4    Conti, M.5    Marchesi, F.6
  • 12
    • 0032568084 scopus 로고    scopus 로고
    • Effects of statins on triglyceride metabolism
    • Ginsberg H.N. Effects of statins on triglyceride metabolism. Am J Cardiol 1998, 81(4A):32B-35B.
    • (1998) Am J Cardiol , vol.81 , Issue.4 A
    • Ginsberg, H.N.1
  • 13
    • 33750431077 scopus 로고    scopus 로고
    • Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders
    • Griffin J.L., Nicholls A.W. Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders. Pharmacogenomics 2006, 7(7):1095-1107.
    • (2006) Pharmacogenomics , vol.7 , Issue.7 , pp. 1095-1107
    • Griffin, J.L.1    Nicholls, A.W.2
  • 14
    • 34548291482 scopus 로고    scopus 로고
    • Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    • Li G., Larson E.B., Sonnen J.A., Shofer J.B., Petrie E.C., Schantz A., et al. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 2007, 69(9):878-885.
    • (2007) Neurology , vol.69 , Issue.9 , pp. 878-885
    • Li, G.1    Larson, E.B.2    Sonnen, J.A.3    Shofer, J.B.4    Petrie, E.C.5    Schantz, A.6
  • 16
    • 2442589337 scopus 로고    scopus 로고
    • Are statins a treatment option for multiple sclerosis?
    • Neuhaus O., Stuve O., Zamvil S.S., Hartung H.P. Are statins a treatment option for multiple sclerosis?. Lancet Neurol 2004, 3(6):369-371.
    • (2004) Lancet Neurol , vol.3 , Issue.6 , pp. 369-371
    • Neuhaus, O.1    Stuve, O.2    Zamvil, S.S.3    Hartung, H.P.4
  • 17
    • 32244441580 scopus 로고    scopus 로고
    • Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results
    • Rangel P., Cysneiros R.M., Arida R.M., De Albuquerque M., Colugnati D.B., Scorza C.A., et al. Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results. Arq Neuropsiquiatr 2005, 63(4):972-976.
    • (2005) Arq Neuropsiquiatr , vol.63 , Issue.4 , pp. 972-976
    • Rangel, P.1    Cysneiros, R.M.2    Arida, R.M.3    De Albuquerque, M.4    Colugnati, D.B.5    Scorza, C.A.6
  • 18
    • 0020545095 scopus 로고
    • Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study
    • Turski W.A., Cavalheiro E.A., Schwarz M., Czuczwar S.J., Kleinrok Z., Turski L. Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res 1983, 9(3):315-335.
    • (1983) Behav Brain Res , vol.9 , Issue.3 , pp. 315-335
    • Turski, W.A.1    Cavalheiro, E.A.2    Schwarz, M.3    Czuczwar, S.J.4    Kleinrok, Z.5    Turski, L.6
  • 19
    • 0026340904 scopus 로고
    • Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures
    • Cavalheiro E.A., Leite J.P., Bortolotto Z.A., Turski W.A., Ikonomidou C., Turski L. Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures. Epilepsia 1991, 32:778-782.
    • (1991) Epilepsia , vol.32 , pp. 778-782
    • Cavalheiro, E.A.1    Leite, J.P.2    Bortolotto, Z.A.3    Turski, W.A.4    Ikonomidou, C.5    Turski, L.6
  • 20
    • 0346749450 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity
    • Zacco A., Togo J., Spence K., Ellis A., Lloyd D., Furlong S., et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J Neurosci 2003, 23(35):11104-11111.
    • (2003) J Neurosci , vol.23 , Issue.35 , pp. 11104-11111
    • Zacco, A.1    Togo, J.2    Spence, K.3    Ellis, A.4    Lloyd, D.5    Furlong, S.6
  • 21
    • 0035825928 scopus 로고    scopus 로고
    • Preclinical and clinical pharmacology of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
    • Mctaggart F., Buckett L., Davidson R., Holdgate G., Mccormick A., Schneck D., et al. Preclinical and clinical pharmacology of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am J Cardiol 2001, 87(5A):28B-32B.
    • (2001) Am J Cardiol , vol.87 , Issue.5 A
    • Mctaggart, F.1    Buckett, L.2    Davidson, R.3    Holdgate, G.4    Mccormick, A.5    Schneck, D.6
  • 22
    • 15344341734 scopus 로고    scopus 로고
    • Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1
    • Chen C., Mireles R.J., Campbell S.D., Lin J., Mills J.B., Xu J.J., et al. Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos 2005, 33(4):537-546.
    • (2005) Drug Metab Dispos , vol.33 , Issue.4 , pp. 537-546
    • Chen, C.1    Mireles, R.J.2    Campbell, S.D.3    Lin, J.4    Mills, J.B.5    Xu, J.J.6
  • 23
    • 0038443056 scopus 로고    scopus 로고
    • Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke
    • Chen J., Zhang Z.G., Li Y., Wang Y., Wang L., Jiang H., et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 2003, 53(6):743-751.
    • (2003) Ann Neurol , vol.53 , Issue.6 , pp. 743-751
    • Chen, J.1    Zhang, Z.G.2    Li, Y.3    Wang, Y.4    Wang, L.5    Jiang, H.6
  • 24
    • 7244250060 scopus 로고    scopus 로고
    • Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury
    • Lu D., Mahmood A., Goussev A., Schallert T., Qu C., Zhang Z.G., et al. Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury. J Neurosurg 2004, 101(5):813-821.
    • (2004) J Neurosurg , vol.101 , Issue.5 , pp. 813-821
    • Lu, D.1    Mahmood, A.2    Goussev, A.3    Schallert, T.4    Qu, C.5    Zhang, Z.G.6
  • 25
    • 34547098112 scopus 로고    scopus 로고
    • Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury
    • Lu D., Qu C., Goussev A., Jiang H., Lu C., Schallert T., et al. Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrauma 2007, 24(7):1132-1146.
    • (2007) J Neurotrauma , vol.24 , Issue.7 , pp. 1132-1146
    • Lu, D.1    Qu, C.2    Goussev, A.3    Jiang, H.4    Lu, C.5    Schallert, T.6
  • 26
    • 0037996880 scopus 로고    scopus 로고
    • Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability
    • Hering H., Lin C.C., Sheng M. Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. J Neurosci 2003, 23(8):3262-3271.
    • (2003) J Neurosci , vol.23 , Issue.8 , pp. 3262-3271
    • Hering, H.1    Lin, C.C.2    Sheng, M.3
  • 27
    • 0037333737 scopus 로고    scopus 로고
    • Statin effects on cholesterol micro-domains in brain plasma membranes
    • Kirsch C., Eckert G.P., Mueller W.E. Statin effects on cholesterol micro-domains in brain plasma membranes. Biochem Pharmacol 2003, 65(5):843-856.
    • (2003) Biochem Pharmacol , vol.65 , Issue.5 , pp. 843-856
    • Kirsch, C.1    Eckert, G.P.2    Mueller, W.E.3
  • 28
    • 78650035858 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of excitotoxic neuronal death
    • Wang Y., Qin Z.-H. Molecular and cellular mechanisms of excitotoxic neuronal death. Apoptosis 2010, 15(11):1382-1402.
    • (2010) Apoptosis , vol.15 , Issue.11 , pp. 1382-1402
    • Wang, Y.1    Qin, Z.-H.2
  • 29
    • 44849104999 scopus 로고    scopus 로고
    • Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathways
    • Dolga A.M., Nijholt I.M., Ostroveanu A., Ten Bosch Q., Luiten P.G., Eisel U.L. Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathways. J Alzheimers Dis 2008, 13(2):111-122.
    • (2008) J Alzheimers Dis , vol.13 , Issue.2 , pp. 111-122
    • Dolga, A.M.1    Nijholt, I.M.2    Ostroveanu, A.3    Ten Bosch, Q.4    Luiten, P.G.5    Eisel, U.L.6
  • 30
    • 0036548875 scopus 로고    scopus 로고
    • Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2
    • Fontaine V., Mohand-Said S., Hanoteau N., Fuchs C., Pfizenmaier K., Eisel U. Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci 2002, 22(7):RC216.
    • (2002) J Neurosci , vol.22 , Issue.7
    • Fontaine, V.1    Mohand-Said, S.2    Hanoteau, N.3    Fuchs, C.4    Pfizenmaier, K.5    Eisel, U.6
  • 31
    • 3543046113 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway
    • Marchetti L., Klein M., Schlett K., Pfizenmaier K., Eisel U.L. Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem 2004, 279(31):32869-32881.
    • (2004) J Biol Chem , vol.279 , Issue.31 , pp. 32869-32881
    • Marchetti, L.1    Klein, M.2    Schlett, K.3    Pfizenmaier, K.4    Eisel, U.L.5
  • 32
    • 68949212050 scopus 로고    scopus 로고
    • Interleukin-10 provides direct trophic support to neurons
    • Zhou Z., Peng X., Insolera R., Fink D.J., Mata M. Interleukin-10 provides direct trophic support to neurons. J Neurochem 2009, 110(5):1617-1627.
    • (2009) J Neurochem , vol.110 , Issue.5 , pp. 1617-1627
    • Zhou, Z.1    Peng, X.2    Insolera, R.3    Fink, D.J.4    Mata, M.5
  • 33
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: signaling and modulation
    • Ashkenazi A., Dixit V.M. Death receptors: signaling and modulation. Science 1998, 281(5381):1305-1308.
    • (1998) Science , vol.281 , Issue.5381 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 34
    • 0033915344 scopus 로고    scopus 로고
    • Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase
    • Pahan K., Khan M., Singh I. Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase. J Neurochem 2000, 75(2):576-582.
    • (2000) J Neurochem , vol.75 , Issue.2 , pp. 576-582
    • Pahan, K.1    Khan, M.2    Singh, I.3
  • 35
    • 0035341472 scopus 로고    scopus 로고
    • Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity
    • Bachis A., Colangelo A.M., Vicini S., Doe P.P., De Bernardi M.A., Brooker G., et al. Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity. J Neurosci 2001, 21(9):3104-3112.
    • (2001) J Neurosci , vol.21 , Issue.9 , pp. 3104-3112
    • Bachis, A.1    Colangelo, A.M.2    Vicini, S.3    Doe, P.P.4    De Bernardi, M.A.5    Brooker, G.6
  • 37
    • 0030607219 scopus 로고    scopus 로고
    • Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes
    • Brodie C. Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes. FEBS Lett 1996, 394(2):117-120.
    • (1996) FEBS Lett , vol.394 , Issue.2 , pp. 117-120
    • Brodie, C.1
  • 38
    • 0033930743 scopus 로고    scopus 로고
    • Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage
    • Grilli M., Barbieri I., Basudev H., Brusa R., Casati C., Lozza G., et al. Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage. Eur J Neurosci 2000, 12:2265-2272.
    • (2000) Eur J Neurosci , vol.12 , pp. 2265-2272
    • Grilli, M.1    Barbieri, I.2    Basudev, H.3    Brusa, R.4    Casati, C.5    Lozza, G.6
  • 39
    • 0034733804 scopus 로고    scopus 로고
    • Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10-deficient mice
    • Agnello D., Villa P., Ghezzi P. Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10-deficient mice. Brain Res 2000, 869:241-243.
    • (2000) Brain Res , vol.869 , pp. 241-243
    • Agnello, D.1    Villa, P.2    Ghezzi, P.3
  • 40
    • 0035873382 scopus 로고    scopus 로고
    • IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance
    • Sewnath M.E., Olszyna D.P., Birjmohun R., ten Kate F.J., Gouma D.J., van Der Poll T. IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance. J Immunol 2001, 166:6323-6331.
    • (2001) J Immunol , vol.166 , pp. 6323-6331
    • Sewnath, M.E.1    Olszyna, D.P.2    Birjmohun, R.3    ten Kate, F.J.4    Gouma, D.J.5    van Der Poll, T.6
  • 41
    • 13744264525 scopus 로고
    • Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain
    • Schobitz B., De Kloet E.R., Holsboer F. Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain. Prog Neurobiol 1994, 44:397-432.
    • (1994) Prog Neurobiol , vol.44 , pp. 397-432
    • Schobitz, B.1    De Kloet, E.R.2    Holsboer, F.3
  • 42
    • 0026638409 scopus 로고
    • Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action
    • Benveniste E.N. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am J Physiol 1992, 263:C1-16.
    • (1992) Am J Physiol , vol.263
    • Benveniste, E.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.