Cyclophilin D-mediated apoptosis attributes to sorafenib-induced cytotoxicity in clear cell-renal cell carcinoma

European Journal of Pharmacology

Volumn 749, Issue , 2015, Pages 142-150

  Hu, Wei ^a   Yuan, Qiong ^c   Liu, Xiu Heng ^a   Zhu, Heng Cheng ^a   Lv, Sheng Qi ^a   Wang, Xing Huan ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Clear cell renal cell carcinoma (ccRCC); Cyclophilin D (CypD); Necrosis; p Extracellular signal regulated kinases (p ERK)

Indexed keywords

CYCLOPHILIN D; CYCLOSPORIN A; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; SMALL INTERFERING RNA; SORAFENIB; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; CYCLOPHILIN; NICOTINAMIDE;

ADULT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL DESTRUCTION; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KIDNEY CARCINOMA; KIDNEY TUBULE EPITHELIUM; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; UPREGULATION; ANALOGS AND DERIVATIVES; APOPTOSIS; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; KIDNEY TUMOR; METABOLISM; MIDDLE AGED; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, RENAL CELL; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CYCLOPHILINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; KIDNEY NEOPLASMS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; NIACINAMIDE; PHENYLUREA COMPOUNDS;

EID: 84922540423     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.12.025     Document Type: Article

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