NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor

Cancer Research

Volumn 67, Issue 17, 2007, Pages 8058-8064

  Nakayama, Kentaro ^a   Nakayama, Naomi ^a   Wang, Tian Li ^a   Shih, Ie Ming ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE 45 GAMMA INTERACTING PROTEIN; HOMODIMER; NAC 1 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE REPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; MULTIGENE FAMILY; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; RECURRENT CANCER; SERIAL ANALYSIS OF GENE EXPRESSION; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; NUCLEAR PROTEINS; REPRESSOR PROTEINS; TRANSFECTION;

EID: 34548561691     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-1357     Document Type: Article

References (43)

1. Stogios PJ, Downs GS, Jauhal JJ, Nandra SK, Prive GG. Sequence and structural analysis of BTB domain proteins. Genome Biol 2005;6:R82.
2. Bardwell VJ, Treisman R. The POZ domain: a conserved protein-protein interaction motif. Genes Dev 1994;8:1664-77.
3. Albagli O, Dhordain P, Deweindt C, Lecocq G, Leprince D. The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins. Cell Growth Differ 1995;6:1193-8.
4. Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S. Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. J Biol Chem 2002;277:22045-52.
5. Wong CW, Privalsky ML. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARα, and BCL-6. J Biol Chem 1998;273:27695-702.
6. Dhordain P, Lin RJ, Quief S, et al. The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression. Nucleic Acids Res 1998;26:4645-51.
7. Huynh KD, Fischle W, Verdin E, Bardwell VJ. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev 2000;14:1810-23.
8. Chen Z, Brand NJ, Chen A, et al. Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-α locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J 1993;12:1161-7.
9. Polo JM, Dell'Oso T, Ranuncolo SM, et al. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med 2004;10:1329-35.
10. Yeyati PL, Shaknovich R, Boterashvili S, et al. Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene 1999;18:925-34.
11. Maeda T, Hobbs RM, Merghoub T, et al. Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. Nature 2005;433:278-85.
12. Maeda T, Hobbs RM, Pandolfi PP. The transcription factor Pokemon: a new key player in cancer pathogenesis. Cancer Res 2005;65:8575-8.
13. van Roy FMMcCrea PD. A role for Kaiso-p120ctn complexes in cancer? Nat Rev Cancer 2005;5:956-64.
14. Park JI, Kim SW, Lyons JP, et al. Kaiso/p120-catenin and TCF/β-catenin complexes coordinately regulate canonical Wnt gene targets. Dev Cell 2005;8:843-54.
15. Nakayama K, Nakayama N, Davidson B, et al. A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. Proc Natl Acad Sci U S A 2006;103:18739-44.
16. Wang J, Rao S, Chu J, et al. A protein interaction network for pluripotency of embryonic stem cells. Nature 2006;444:364-8.
17. Chung HK, Yi YW, Jung NC, et al. CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. J Biol Chem 2003;278:28079-88.
18. Saha S, Sparks AB, Rago C, et al. Using the transcriptome to annotate the genome. Nat Biotechnol 2002;20:508-12.
19. Buckhaults P, Zhang Z, Chen YC, et al. Identifying tumor origin using a gene expression-based classification map. Cancer Res 2003;63:4144-9.
20. Shih Ie M, Sheu JJ, Santillan A, et al. Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. Proc Natl Acad Sci U S A 2005;102:14004-9.
21. Leers M, Kolgen W, Bjorklund V, et al. Immunocyto-chemical detection and localization of a cytokeratin 18 epitope exposed during early apoptosis. J Pathol 1999;5:567-72.
22. Caulin C, Salvesen GS, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol 1997;138:1379-94.
23. Mackler SA, Korutla L, Cha XY, et al. NAC-1 is a brain POZ/BTB protein that can prevent cocaine-induced sensitization in the rat. J Neurosci 2000;20:6210-7.
24. Mackler SA, Homan YX, Korutla L, Conti AC, Blendy JA. The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger protein, is regulated by AP1. Neuroscience 2003;121:355-61.
25. Smith ML, Chen IT, Zhan Q, et al. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 1994;266:1376-80.
26. Zhang W, Bae I, Krishnaraju K, et al. CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene 1999;18:4899-907.
27. 2-M cell cycle checkpoint. Proc Natl Acad Sci U S A 1999;96:3706-11.
28. Park KC, Song KH, Chung HK, et al. CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation. Mol Endocrinol 2005;19:12-24.
29. Mabuchi S, Ohmichi M, Nishio Y, et al. Inhibition of NFκB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models. J Biol Chem 2004;279:23477-85.
30. Liu GH, Wang SR, Wang B, Kong BH. Inhibition of nuclear factor-κB by an antioxidant enhances paclitaxel sensitivity in ovarian carcinoma cell line. Int J Gynecol Cancer 2006;16:1777-82.
31. Tang G, Minemoto Y, Dibling B, et al. Inhibition of JNK activation through NF-κB target genes. Nature 2001;414:313-7.
32. De Smaele E, Zazzeroni F, Papa S, et al. Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling. Nature 2001;414:308-13.
33. Zerbini LF, Wang Y, Czibere A, et al. NF-κ B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival. Proc Natl Acad Sci U S A 2004;101:13618-23.
34. Mita H, Tsutsui J, Takekawa M, Witten EA, Saito H. Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. Mol Cell Biol 2002;22:4544-55.
35. Ying J, Srivastava G, Hsieh WS, et al. The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors. Clin Cancer Res 2005;11:6442-9.
36. Zerbini LFLibermann TA. Life and death in cancer. GADD45α and γ are critical regulators of NF-κB mediated escape from programmed cell death. Cell Cycle 2005;4:18-20.
37. Verheij M, Bose R, Lin XH, et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996;380:75-9.
38. Baker VV, Borst MP, Dixon D, Hatch KD, Shingleton HM, Miller D. c-myc amplification in ovarian cancer. Gynecol Oncol 1990;38:340-2.
39. Abeysinghe HR, Cedrone E, Tyan T, Xu J, Wang N. Amplification of C-MYC as the origin of the homogeneous staining region in ovarian carcinoma detected by micro-FISH. Cancer Genet Cytogenet 1999;114:136-43.
40. Dimova I, Raitcheva S, Dimitrov R, Doganov N, Toncheva D. Correlations between c-myc gene copy-number and clinicopathological parameters of ovarian tumours. Eur J Cancer 2006;42:674-9.
41. Zerbini LFLibermann TA. GADD45 deregulation in cancer: frequently methylated tumor suppressors and potential therapeutic targets. Clin Cancer Res 2005;11:6409-13.
42. Qiu W, Zhou B, Zou H, et al. Hypermethylation of growth arrest DNA damage-inducible gene 45β promoter in human hepatocellular carcinoma. Am J Pathol 2004;165:1689-99.
43. Nakayama K, Nakayama N, Davidson B, et al. Homozygous deletion of MKK4 in ovarian serous carcinoma. Cancer Biol Ther 2006;5:630-4.