SIRT1 Inhibition Affects Angiogenic Properties of Human MSCs

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Chiara, Botti ^a,b   Ilaria, Caiafa ^a   Antonietta, Coppola ^a   Francesca, Cuomo ^a   Marco, Miceli ^c   Lucia, Altucci ^a,c   Gilda, Cobellis ^a,b  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

RNA; SIRTINOL; SIRTUIN 1; BENZAMIDE DERIVATIVE; NAPHTHOL DERIVATIVE; SIRT1 PROTEIN, HUMAN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPOXIA; MESENCHYMAL STEM CELL; PHENOTYPE; ANOXIA; ANTAGONISTS AND INHIBITORS; CELL LINE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; DRUG EFFECTS; GENE SILENCING; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM;

ANOXIA; BENZAMIDES; CELL LINE; CELL PHYSIOLOGICAL PROCESSES; GENE SILENCING; HUMANS; MESENCHYMAL STROMAL CELLS; NAPHTHOLS; NEOVASCULARIZATION, PHYSIOLOGIC; SIRTUIN 1;

EID: 84922513541     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/783459     Document Type: Article

References (39)

1. G. Ren, X. Chen, F. Dong et al., "Concise review: mesenchymal stem cells and translational medicine: emerging issues, " Stem Cells Translational Medicine, vol. 1, no. 1, pp. 51-58, 2012.
2. C. Stamm, B. Westphal, H. D. Kleine et al., "Autologous bonemarrow stem-cell transplantation formyocardial regeneration, " The Lancet, vol. 361, no. 9351, pp. 45-46, 2003.
3. A. Schiavetta, C.Maione, C. Botti et al., "Aphase II trialof autologous transplantation of bone marrow stem cells for critical limb ischemia: results of theNaples and Pietra Ligure evaluation of stem cells study, " Stem Cells TranslationalMedicine, vol. 1, no. 7, pp. 572-578, 2012.
4. T. Kinnaird, E. Stabile, M. S. Burnett et al., "Marrow-derived stromal cells express genes encoding a broad spectrumof arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms, " Circulation Research, vol. 94, no. 5, pp. 678-685, 2004.
5. J. Rehman, D. Traktuev, J. Li et al., "Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells, " Circulation, vol. 109, no. 10, pp. 1292-1298, 2004.
6. H. M. Mi, Y. K. Sun, J. K. Yeon et al.,Human adipose tissuederived mesenchymal stem cells improve postnatal neovascularization in a mouse model of hindlimb ischemia, " Cellular Physiology and Biochemistry, vol. 17, no. 5-6, pp. 279-290, 2006.
7. R. Estrada, N. Li, H. Sarojini, J. An, M. Lee, and E. Wang, "Secretome from mesenchymal stem cells induces angiogenesis via Cyr61, " Journal of Cellular Physiology, vol. 219, no. 3, pp. 563- 571, 2009.
8. G. Cobellis, C. Maione, C. Botti et al., "Beneficial effects of VEGF secreted fromstromal cells in supporting endothelial cell functions: therapeutic implications for critical limb ischemia, " Cell Transplantation, vol. 19, no. 11, pp. 1425-1437, 2010.
9. R. H. Lee, J. Y. Oh, H. Choi, and N. Bazhanov, "Therapeutic factors secreted bymesenchymal stromal cells and tissue repair, " Journal of Cellular Biochemistry, vol. 112, no. 11, pp. 3073-3078, 2011.
10. P. Simic, K. Zainabadi, E. Bell et al., "SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating catenin, " EMBO Molecular Medicine, vol. 5, no. 3, pp. 430-440, 2013.
11. A. Z. Herskovits and L. Guarente, "Sirtuin deacetylases in neurodegenerative diseases of aging, " Cell Research, vol. 23, no. 6, pp. 746-758, 2013.
12. M. C.Haigis and D.A. Sinclair, "Mammalian sirtuins: Biological insights and disease relevance, " Annual Review of Pathology: Mechanisms of Disease, vol. 5, pp. 253-295, 2010.
13. T. Finkel, C.Deng, and R.Mostoslavsky, "Recent progress in the biology and physiology of sirtuins, " Nature, vol. 460, no. 7255, pp. 587-591, 2009.
14. L. Guarente, "Sirtuins, aging, and medicine, " The New England Journal of Medicine, vol. 364, no. 23, pp. 2235-2244, 2011.
15. V. Carafa, A.Nebbioso, and L. Altucci, "Sirtuins and disease: the road ahead, " Frontiers in Pharmacology, vol. 3, article 4, Article ID Article 4, 2012.
16. G.Corbi, A. Bianco, V. Turchiarelli et al., "Potentialmechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on sirtuins, " International Journal of Molecular Sciences, vol. 14, no. 6, pp. 12696-12713, 2013.
17. E. M. Dioum, R. Chen, M. S. Alexander et al., "Regulation of hypoxia-inducible factor 2alpha signaling by the stressresponsive deacetylase sirtuin 1, " Science, vol. 324, no. 5932, pp. 1289-1293, 2009.
18. J. H. Lim, Y. M. Lee, Y. S. Chun, J. Chen, J. Kim, and J. Park, "Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha, " Molecular Cell, vol. 38, no. 6, pp. 864-878, 2010.
19. A. Laemmle, A. Lechleiter, V. Roh et al., "Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF- 1 protein under hypoxic conditions, " PLoS ONE, vol. 7, no. 3, Article ID e33433, 2012.
20. C. W. Pugh and P. J. Ratcliffe, "Regulation of angiogenesis by hypoxia: role of the HIF system, " Nature Medicine, vol. 9, no. 6, pp. 677-684, 2003.
21. M. Potente, L. Ghaeni, D. Baldessari et al., "SIRT1 controls endothelial angiogenic functions during vascular growth, " Genes and Development, vol. 21, no. 20, pp. 2644-2658, 2007.
22. H. Ota, M. Akishita, M. Eto, K. Iijima, M. Kaneki, and Y. Ouchi, "Sirt1 modulates premature senescence-like phenotype in human endothelial cells, " Journal of Molecular and Cellular Cardiology, vol. 43, no. 5, pp. 571-579, 2007.
23. S. Portmann, R. Fahrner, A. Lechleiter et al., "Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo, " Molecular CancerTherapeutics, vol. 12, no. 4, pp. 499- 508, 2013.
24. D. Rotili, D. Tarantino, A. Nebbioso et al., "Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells, " Journal of Medicinal Chemistry, vol. 55, no. 24, pp. 10937- 10947, 2012.
25. I. Gorenne, S. Kumar, K. Gray et al., "Vascular smooth muscle cell sirtuin 1 protects against dna damage and inhibits atherosclerosis, " Circulation, vol. 127, no. 3, pp. 386-396, 2013.
26. M. Potente, "An energy-sensor network takes center stage during endothelial aging, " Circulation Research, vol. 106, no. 8, pp. 1316-1318, 2010.
27. M. Miceli, G. Franci, C. Dell'Aversana et al., "MePR: A novel human mesenchymal progenitor model with characteristics of pluripotency, " Stem Cells and Development, vol. 22, no. 17, pp. 2368-2383, 2013.
28. A. G. Bodnar, M. Ouellette, M. Frolkis et al., "Extension of lifespan by introduction of telomerase into normal human cells, " Science, vol. 279, no. 5349, pp. 349-352, 1998.
29. T. Okamoto, T. Aoyama, T. Nakayama et al., "Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells, " Biochemical and Biophysical Research Communications, vol. 295, no. 2, pp. 354-361, 2002.
30. S. S. Akimov, A. Ramezani, T. S. Hawley, and R. G. Hawley, "Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells, " Stem Cells, vol. 23, no. 9, pp. 1423-1433, 2005.
31. M. F.Oellerich and M. Potente, "FOXOs and sirtuins in vascular growth, maintenance, and aging, " Circulation Research, vol. 110, no. 9, pp. 1238-1251, 2012.
32. J. Gracia-Sancho, G. Villarreal, Y. Zhang, and G. Garćia- Cardeña, "Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype, " Cardiovascular Research, vol. 85, no. 3, pp. 514-519, 2010.
33. A. Cardus, A. K. Uryga, G. Walters, and J. D. Erusalimsky, "SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence, " Cardiovascular Research, vol. 97, no. 3, pp. 571-579, 2013.
34. E. Langley, M. Pearson, M. Faretta et al., "Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence, " EMBO Journal, vol. 21, no. 10, pp. 2383-2396, 2002.
35. H. Ota, E. Tokunaga, K. Chang et al., "Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras- MAPK signaling in human cancer cells, " Oncogene, vol. 25, no. 2, pp. 176-185, 2006.
36. S. D. Barros, S. Dehez, E. Arnaud et al., "Aging-related decrease of human ASC angiogenic potential is reversed by hypoxia preconditioning through ROS production, " MolecularTherapy, vol. 21, no. 2, pp. 399-408, 2013.
37. N. Engel and U.Mahlknecht, "Aging and anti-aging: unexpected side effects of everyday medication through sirtuin 1 modulation, " International Journal ofMolecularMedicine, vol. 21, no. 2, pp. 223-232, 2008.
38. M. E. Hubbi, H. Hu, D.M. Gilkes, and G. L. Semenza, "Sirtuin- 7 inhibits the activity of hypoxia-inducible factors, " Journal of Biological Chemistry, vol. 288, no. 29, pp. 20768-20775, 2013.
39. R. Chen, M. Xu, R. T. Hogg et al., "The acetylase/deacetylase couple CREB-binding protein/sirtuin 1 controls hypoxiainducible factor 2 signaling, " The Journal of Biological Chemistry, vol. 287, no. 36, pp. 30800-30811, 2012.