Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 2, 2015, Pages 725-735

  Garg, Manoj ^a   Okamoto, Ryoko ^b   Nagata, Yasunobu ^c   Kanojia, Deepika ^a   Venkatesan, Subhashree ^a   Anand, M T ^a   Braunstein, Glenn D ^b   Said, Jonathan W ^d   Doan, Ngan B ^d   Ho, Quoc ^b   Akagi, Tadayuki ^b   Gery, Sigal ^b   Liu, Li Zhen ^a   Tan, Kar Tong ^a   Chng, Wee Joo ^a   Yang, Henry ^a   Ogawa, Seishi ^c   Koeffler, H Phillip ^a,b,e  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; COLONY STIMULATING FACTOR; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR 2; COLONY STIMULATING FACTOR 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; UNCLASSIFIED DRUG;

ANAPLASTIC THYROID CANCER; ANAPLASTIC THYROID CANCER CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CELL INFILTRATION; CLONAL EVOLUTION; CONTROLLED STUDY; COPY NUMBER VARIATION; CYTOKINE PRODUCTION; GENE DELETION; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC ASSOCIATION; GENOMICS; HUMAN; HUMAN CELL; IN VIVO STUDY; LYMPH NODE METASTASIS; MACROPHAGE; METASTASIS; MOLECULAR EVOLUTION; MOUSE; NEUTROPHILIA; NEXT GENERATION SEQUENCING; NONHUMAN; ONCOGENE; PARD3 GENE; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; SPLENOMEGALY; THYROID CANCER CELL LINE; UPREGULATION; WHOLE EXOME SEQUENCING; AGED; ANIMAL; CANCER TRANSPLANTATION; CELL PROLIFERATION; COMPLICATION; MALE; NEUTROPHIL; NONOBESE DIABETIC MOUSE; PATHOLOGY; THYROID CARCINOMA; THYROID TUMOR; TUMOR CELL LINE;

MUS;

AGED; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MALE; MICE; MICE, INBRED NOD; NEOPLASM TRANSPLANTATION; NEUTROPHILS; SPLENOMEGALY; THYROID CARCINOMA, ANAPLASTIC; THYROID NEOPLASMS;

EID: 84922496761     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-2359     Document Type: Article

References (35)

1. Neff RL, Farrar WB, Kloos RT, Burman KD. Anaplastic thyroid cancer. Endocrinol Metab Clin North Am. 2008; 37: 525-538, xi.
2. O'Neill JP, Shaha AR. Anaplastic thyroid cancer. Oral Oncol. 2013; 49: 702-706.
3. DeLellis RA, Williams ED. Tumors of the thyroid and parathyroid. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C, eds. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Endocrine Organs. Lyon, France: IARC Press; 2004: 49-93.
4. Hebrant A, Dom G, Dewaele M, et al. mRNA expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch. Plos One. 2012; 7(10): e37807.
5. Ding L, Ellis MJ, Li S, et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature. 2010; 464: 999-1005.
6. Lee JJ, Foukakis T, Hashemi J, et al. Molecular cytogenetic profiles of novel and established human anaplastic thyroid carcinoma models. Thyroid. 2007; 17: 289-301.
7. Schweppe RE, Klopper JP, Korch C, et al. Deoxyribonucleic acid profiling analysisof40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab. 2008; 93: 4331-4341.
8. Rodrigues RF, Roque L, Krug T, Leite V. Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines. Br J Cancer. 2007; 96: 1237-1245.
9. Okamoto R, Ogawa S, Nowak D, et al. Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. Haematologica. 2010; 95: 1481-1488.
10. Yamamoto G, Nannya Y, Kato M, et al. Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am J Hum Genet. 2007; 81: 114-126.
11. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of affymetrix genechip probe level data. Nucleic Acids Res. 2003; 31: e15.
12. Chua SW, Vijayakumar P, Nissom P, Yam CY, Wong VV, Yang H. A novel normalization method for effective removal of systematic variation in microarray data. Nucleic Acids Res. 2006; 34: e38.
13. Yoshida K, Sanada M, Shiraishi Y, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 2011; 478: 64-69.
14. Hayano T, Garg M, Yin D, et al. SOX7 is down-regulated in lung cancer. J Exp Clin Cancer Res. 2013; 32: 17.
15. Garg M, Kanojia D, Okamoto R, et al. Laminin-57-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration, and invasion by modulating signaling of EGFR. J Clin Endocrinol Metab. 2014; 99: E62-72.
16. Garg M, Kanojia D, Suri S, et al. Sperm-associated antigen 9: a novel diagnostic marker for thyroid cancer. J Clin Endocrinol Metab. 2009; 94: 4613-4618.
17. Garg M, Kanojia D, Khosla A, et al. Sperm-Associated Antigen 9 is associated with tumor growth, migration, and invasion in renal cell carcinoma. Cancer Res. 2008; 68: 8240-8248.
18. Mansouri A, Chowdhury K, Gruss P. Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet. 1998; 19: 87-90.
19. Bishop JA, Sharma R, Westra WH. PAX8 immunostaining of anaplastic thyroid carcinoma: a reliable means of discerning thyroid origin for undifferentiated tumors of the head and neck. Hum Pathol. 2011; 42: 1873-1877.
20. Hoang-Vu C, Dralle H, Scheumann G, et al. Gene expression of differentiation- and dedifferentiation markers in normal and malignant human thyroid tissues. Exp Clin Endocrinol. 1992; 100: 51-56.
21. Eskens FA, Sleijfer S. The use of bevacizumab in colorectal, lung, breast, renal and ovarian cancer: where does it fit? Eur J Cancer. 2008; 44: 2350-2356.
22. Borgström P, Hillan KJ, Sriramarao P, et al. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res. 1996; 56: 4032-4039.
23. Rothenberg SM, Mohapatra G, Rivera MN, et al. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 2010; 70: 2158-2164.
24. Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature. 2013; 500: 415-421.
25. Puente XS, Pinyol M, Quesada V, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011; 475: 101-105.
26. Smallridge RC, Ain KB, Asa SL, et al. American thyroid association guidelines for management of patients with anaplastic thyroid cancer. Thyroid. 2012; 22: 1104-1139.
27. Ryder M, Glid M, Hohl TM, et al. Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor associated macrophages and impairs BRAF-induced thyroid cancer progression. Plos One. 2013; 8: e54302.
28. Paolini R, Toffoli S, Poletti A, et al. Splenomegaly as the first manifestation of thyroid cancer metastases. Tumori. 1997; 83: 779-782.
29. Bateman A. Growing a tumor stroma: a role for granulin and the bone marrow. J Clin Invest. 2011; 121: 516-519.
30. Bilder D, Li M, Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science. 2000; 289: 113-116.
31. Pagliarini RA, Xu T. A genetic screen in Drosophila for metastatic behavior. Science. 2003; 302: 1227-1231.
32. Duncavage EJ, Magrini V, Becker N, et al. Hybrid capture and nextgeneration sequencing identify viral integration sites from formalin-fixed, paraffin-embedded tissue. JMol Diagn. 2011; 13: 325-333.
33. Fagin JA, Matsuo K, Karmakar A, et al. High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Invest. 1993; 91: 179-184.
34. Ding L, Ley TJ, Larson DE, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012; 481: 506-510.
35. Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. NEngl J Med. 2012; 366: 883-892.