Laminin-5γ-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration, and invasion by modulating signaling of EGFR

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 1, 2014, Pages

  Garg, Manoj ^a   Kanojia, Deepika ^a   Okamoto, Ryoko ^c   Jain, Saket ^a   Jain, Vikasw ^a   Chien, Wenwen ^a   Sampath, Abhishek ^a   Ding, Ling Wen ^a   Xuan, Meng ^a   Said, Jonathan W ^c   Doan, Ngan B ^c   Liu, Li Zhen ^a   Yang, Henry ^a   Gery, Sigal ^c   Braunstein, Glenn D ^c   Koeffler, H Phillip ^a,b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; LAMININ GAMMA2; MEMBRANE PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ANAPLASTIC CARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; LAMC2 GENE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; THYROID CARCINOMA; WOUND HEALING;

ANIMALS; CELL MOVEMENT; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LAMININ; MICE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THYROID NEOPLASMS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84892185425     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-2994     Document Type: Article

References (36)

1. Sherman SI. Thyroid carcinoma. Lancet. 2003;361:501-511.
2. Carter WG, Ryan MC, Gahr PJ. Epiligrin, a new adhesion ligand for integrin a3b1 in epithelial basement membranes. Cell. 1991;65:599-619.
3. Rousselle P, Lunstrum GP, Keene DR, Burgeson RE. Kalinin an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol. 1991;114:567-576.
4. Ryan MC, Christiano AM, Engvall E, et al. The functions of laminins: lessons from in vivo studies. Matrix Biol. 1996;15:369-381.
5. Marinkovich MP. Laminin 332 in squamous-cell carcinoma. Nat Rev Cancer. 2007;7:370-380.
6. Soini Y, Maatta M, Salo S, Tryggvason K, Autio-Harmainen H. Expression of the laminin γ2 chain in pancreatic adenocarcinoma. J Pathol. 1996;180:290-294.
7. Takahashi S, Hasebe T, Oda T, et al. Cytoplasmic expression of laminin γ2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma. Cancer. 2002;94:1894-1901.
8. Koshikawa N, Moriyama K, Takamura H, et al. Overexpression of lamininγ2 chain monomer in invading gastric carcinoma cells. Cancer Res. 1999;59:5596-5601.
9. Ono Y, Nakanishi Y, Ino Y, et al. Clinicopathologic significance of laminin-5 γ 2 chain expression in squamous cell carcinoma of the tongue: immunohistochemical analysis of 67 lesions. Cancer. 1999; 85:2315-2321.
10. Sordat I, Bosman FT, Rousselle P, et al. Differential expression of laminin-5 subunits and integrin receptors in human colorectal neoplasia. J Pathol. 1998;185:44-52.
11. Hlubek F, Jung A, Kotzor N, Kirchner T, Brabletz T. Expression of the invasion factor laminin γ 2 in colorectal carcinomas is regulated by γ-catenin. Cancer Res. 2001;61:8089-8093.
12. Kagesato Y, Mizushima H, Koshikawa N, et al. Sole expression of laminin γ 2 chain in invading tumor cells and its association with stromal fibrosis in lung adenocarcinomas. Japan J Cancer Res. 2001; 92:184-192.
13. Skyldberg B, Salo S, Eriksson E, et al. Laminin-5 as a marker of invasiveness in cervical lesions. J Natl Cancer Inst. 1999;91:1882-1887.
14. Yamamoto H, Itoh F, Iku S, Hosokawa M, Imai K. Expression of the γ 2 chain of laminin-5 at the invasive front is associated with recurrence and poor prognosis in human oesophageal squamous cell carcinoma. Clin Cancer Res. 2001;7:896-900.
15. Gasparoni A, Della Casa M, Milillo L, et al. Prognostic value of differential expression of laminin-5 γ2 in oral squamous cell carcinomas: correlation with survival. Oncol Rep. 2007;18:793-800.
16. Smallridge RC, Marlow LA, Copland JA. Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies. Endocr Relat Cancer. 2009;16:17-44.
17. Lee DH, Lee GK, Kong SY, et al. Epidermal growth factor receptor status in anaplastic thyroid carcinoma. J Clin Pathol. 2007;60:881-884.
18. Ensinger C, Spizzo G, Moser P, et al. Epidermal growth factor receptor as a novel therapeutic target in anaplastic thyroid carcinomas. Ann NY Acad Sci. 2004;1030:69-77.
19. Van der Laan BF, Freeman JL, Asa SL. Expression of growth factors and growth factor receptors in normal and tumorous human thyroid tissues. Thyroid. 1995;5:67-73.
20. Hoelting T, Siperstein AE, Clark OH, Duh QY. Epidermal growth factor enhances proliferation, migration, and invasion of follicular and papillary thyroid cancer in vitro and in vivo. J Clin Endocrinol Metab. 1994;79:401-408.
21. Bechtner G, Schopohl D, Rafferzeder M, Gartner R, Welsch U. Stimulation of thyroid cell proliferation by epidermal growth factor is different from cell growth induced by thyrotropin or insulin-like growth factor I. Eur J Endocrinol. 1996;134:639-648.
22. Waterman EA, Sakai N, Nguyen NT, et al. Alaminin-collagen complex drives human epidermal carcinogenesis through phosphoinositol-3-kinase activation. Cancer Res. 2007;67:4264-4270.
23. Schenk S, Hintermann E, Bilban M, et al. Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. J Cell Biol. 2003;161:197-209.
24. Schweppe RE, Klopper JP, Korch C, et al. Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals crosscontamination resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab. 2008;93:4331-4341.
25. Garg M, Kanojia D, Suri S, Gupta S, Gupta A, Suri A. Sperm associated antigen 9: a novel diagnostic marker for thyroid cancer. J Clin Endocrinol Metab. 2009;94:4613-4618.
26. Hayano T, Garg M, Yin D, Sudo M, et al. SOX7 is down-regulated in lung cancer. J Exp Clin Cancer Res. 2013;32:17.
27. Sudo M, Chin TM, Akashi M, Koeffler HP, et al. Inhibiting proliferation of gefitinib-resistant, non-small lung cancer. Cancer Chemother Pharmacol. 2013;71:1325-1334.
28. Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med. 1994;97:418-428.
29. Sherman SI, Brierley JD, Sperling M, et al. Prospective multicenter study of thyroid carcinoma treatment: initial analysis of staging and outcome. National Thyroid Cancer Treatment Cooperative Study Registry Group. Cancer. 1998;83:1012-1021.
30. Vaysburd M. Anaplastic thyroid carcinoma. In: Braunstein GD, ed. Thyroid Cancer. New York: Springer; 2012:189-200.
31. Kiyoshima K, Oda Y, Kinukawa N, Naito S, Tsuneyoshi M. Overexpression of laminin-5 γ2 chain and its prognostic significance in urothelial carcinoma of urinary bladder: association with expression of cyclooxygenase 2, epidermal growth factor receptor and human epidermal growth factor receptor. Hum Pathol. 2005;36:522-530.
32. Pyke C, Salo S, Ralfkiaer E, Romer J, Dano K, Tryggvason K. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res. 1995;55:4132-4139.
33. Westermarck J, Holstorm TH, Ahonen M, Eriksson JE, Kahari VM. Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38. Matrix Biol. 1998; 17:547-557.
34. Reunanen N, Li SP, Ahonen M, Foschi M, Han J, Kahari VM. Activation of p38- A MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. J Biol Chem. 2002;277:32360-32368.
35. Bottone FG Jr, Moon Y, Kim JS, Alston-Mills B, Ishibashi M, Eling TE. The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3). Mol Cancer Ther. 2005;4:693-703.
36. Prenzel N, Fischer OM, Streit S, Hart S, Ullrich A. The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer. 2001;8:11-31.