Vaccine-elicited CD4 t cells induce immunopathology after chronic lcmv infection

Science

Volumn 347, Issue 6219, 2015, Pages 278-282

  Penaloza MacMaster, Pablo ^a   Barber, Daniel L ^b   Wherry, E John ^c   Provine, Nicholas M ^a   Teigler, Jeffrey E ^a,i   Parenteau, Lily ^a   Blackmore, Stephen ^a   Borducchi, Erica N ^a   Larocca, Rafael A ^a   Yates, Kathleen B ^d   Shen, Hao ^c   Haining, W Nicholas ^d   Sommerstein, Rami ^e   Pinschewer, Daniel D ^e,f   Ahmed, Rafi ^g   Barouch, Dan H ^a,h  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF GENEVA   (Switzerland)

^f UNIVERSITY OF BASEL   (Switzerland)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

ⁱ WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VACCINE; CYTOKINE; EPITOPE; VIRUS ANTIBODY; VIRUS ANTIGEN;

CYTOLOGY; IMMUNE RESPONSE; IMMUNOASSAY; PATHOLOGY; VACCINE; VIRUS;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHRONIC LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION; CONTROLLED STUDY; CYTOKINE STORM; DISEASE ASSOCIATION; IMMUNOPATHOLOGY; INFLAMMATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS LOAD; VIRUS STRAIN; ANIMAL; ARENAVIRUS INFECTION; BLOOD; C57BL MOUSE; IMMUNE SYSTEM DISEASES; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MULTIPLE ORGAN FAILURE; PATHOLOGY; PHYSIOLOGY; VACCINATION; VIROLOGY; VIRUS REPLICATION;

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUS;

ADAPTIVE IMMUNITY; ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; ARENAVIRIDAE INFECTIONS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; EPITOPES, T-LYMPHOCYTE; IMMUNE SYSTEM DISEASES; IMMUNOLOGIC MEMORY; INFLAMMATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE, INBRED C57BL; MULTIPLE ORGAN FAILURE; VACCINATION; VIRAL LOAD; VIRAL VACCINES; VIRUS REPLICATION;

EID: 84922482118     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa2148     Document Type: Article

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