Epigenetic repression of interleukin 2 expression in senescent CD4+ T cells during chronic HIV type 1 infection

Journal of Infectious Diseases

Volumn 211, Issue 1, 2015, Pages 28-39

  Nakayama Hosoya, Kaori ^a,b   Ishida, Takaomi ^a,c   Youngblood, Ben ^a,d   Nakamura, Hitomi ^a,e   Hosoya, Noriaki ^a   Koga, Michiko ^b   Koibuchi, Tomohiko ^c   Iwamoto, Aikichi ^d   Kawana Tachikawa, Ai ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b International Research Center for Infectious Diseases   (Japan)

^c Research Center for Asian Infectious Diseases   (Japan)

^d THE UNIVERSITY OF TOKYO   (Japan)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD4+ T cell dysfunction; DNA methylation; HIV 1; immunosenescence; repression of IL 2 expression; T cell differentiation

Indexed keywords

CD57 ANTIGEN; INTERLEUKIN 2; MESSENGER RNA; IL2 PROTEIN, HUMAN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELL SELECTION; CLINICAL ARTICLE; CPG ISLAND; CYTOKINE PRODUCTION; DNA METHYLATION; EPIGENETIC REPRESSION; FLOW CYTOMETRY; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IL2 GENE; MEMORY T LYMPHOCYTE; PHENOTYPE; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; BIOSYNTHESIS; CELL CULTURE; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL;

ADULT; ANTIGENS, CD57; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CPG ISLANDS; DNA METHYLATION; EPIGENETIC REPRESSION; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; PROMOTER REGIONS, GENETIC;

EID: 84922446230     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu376     Document Type: Article

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