Determination of neurotoxic acetogenins in Pawpaw (Asimina triloba) fruit by LC-HRMS

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 4, 2015, Pages 1053-1056

  Levine, Robert A ^a   Richards, Kristy M ^a   Tran, Kevin ^a   Luo, Rensheng ^b   Thomas, Andrew L ^c   Smith, Robert E ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

annonacin; Asimina triloba; LC HRMS; Parkinson's disease; pawpaw; squamocin

Indexed keywords

ISOMERS; MASS SPECTROMETRY;

ANNONACIN; ASIMINA TRILOBA; LC-HRMS; PARKINSON'S DISEASE; PAWPAW; SQUAMOCIN;

FRUITS;

ASIMINA TRILOBA;

EID: 84922426593     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf504500g     Document Type: Article

References (18)

1. Templeton, S. B.; Marlette, M.; Pomper, K. W.; Jones, S. C. Favorable taste ratings for several pawpaw products Hort. Technol. 2003, 13, 445-448
2. Ames, G.; Greer, L. Pawpaw-A "Tropical" Fruit for Temperate Climates; National Sustainable Agriculture Information Service: Buttte, MT, 2010.
3. Smith, R. E.; Tran, K.; Richards, K. M. Bioactive annonaceous acetogenins. In Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed.; Elsevier: New York, 2014; Chapter 4, pp 93-117.
4. Adeoye, I. B.; Umeh, U. C.; Ajetunmobi, T. Prospects and problems of marketing pawpaw in the urban environment of Ibadan, Nigeria Libyan Agric. Res. Cent. J. Int. 2012, 3, 80-84
5. Potts, L. F. Annonacin in Asimina triloba fruit: Implication for neurotoxicity Neurotoxicology 2012, 33, 53-58
6. Caparros-Lefebvre, D.; Elbaz, A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study Lancet 1999, 354, 281-285
7. Escobar-Khondiker, M. Annonacin,et al. a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons J. Neurosci. 2007, 27, 7827-7837
8. Lannuzel, A. Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes? Brain 2007, 130, 816-827
9. Escobar-Khondiker, M. Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured Neurons J. Neurosci. 2007, 27, 7827-7837
10. Höllerhage, M. Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies Exp. Neurol. 2009, 220, 133-142
11. Champy, P. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe J. Neurochem. 2004, 88, 63-69
12. Smith, R. E. Medicinal Chemistry-Fusion of Traditional and Western Medicine; Bentham Science: Sharjah, U.A.E., 2013; pp 212-215.
13. Richter, B. E.; Jones, B. A.; Ezzell, J. L.; Porter, N. L. Accelerated solvent extraction: A technique for sample preparation Anal. Chem. 1996, 68, 1033-1039
14. Richards, K. M. Improved extraction of soluble solids from some Brazilian and North American fruits Nat. Prod. J. 2014, 4, 201-210
15. Champy, P. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe J. Neurochem. 2004, 88, 63-69
16. Champy, P.; Guérineau, V.; Laprévote, O. MALDI-TOF MS Profiling of annonaceousa acetogenins in Annona muricata products for human consumption Molecules 2009, 14, 5235-5246
17. Allegrand, J. Structural study of acetogenins by tandem mass spectrometry under high and low collision energy Rapid Commun. Mass Spectrom. 2010, 24, 3602-3608
18. Luo, R. NMR Analysis of Potentially Neurotoxic Annonaceous Fruits Nat. Prod. J. 2013, 230-241