Dose-and time-dependent gene expression alterations in prostate and colon cancer cells after in vitro exposure to carbon ion and X-irradiation

Journal of Radiation Research

Volumn 56, Issue 1, 2014, Pages 11-21

  Suetens, Annelies ^a,b   Moreels, Marjan ^a   Quintens, Roel ^a   Soors, Els ^a   Buset, Jasmine ^a   Chiriotti, Sabina ^a,b   Tabury, Kevin ^a   Gregoire, Vincent ^b   Baatout, Sarah ^a,c  

^a BELGIAN NUCLEAR RESEARCH CENTRE   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

Caco 2 colon adenocarcinoma; carbon ion irradiation; colony survival assay; gene expression; motility genes; PC3 prostate adenocarcinoma

Indexed keywords

ASSAYS; CARBON; CELL CULTURE; DISEASES; GENE EXPRESSION; ION BOMBARDMENT; IONS; ONCOLOGY; POLYMERASE CHAIN REACTION; UROLOGY;

CACO-2 COLON ADENOCARCINOMA; CARBON ION IRRADIATION; CARBON IONS; COLONY SURVIVAL ASSAY; GENES EXPRESSION; IONS IRRADIATION; MOTILITY GENE; PC3 PROSTATE ADENOCARCINOMA; PROSTATE ADENOCARCINOMAS; SURVIVAL ASSAYS;

RADIOTHERAPY;

CARBON; HEAVY ION; TUMOR PROTEIN;

CACO 2 CELL LINE; COLON TUMOR; GENE EXPRESSION REGULATION; HUMAN; MALE; METABOLISM; PROSTATE TUMOR; RADIATION DOSE; RADIATION RESPONSE; TUMOR CELL LINE; X RAY;

CACO-2 CELLS; CARBON; CARBON ISOTOPES; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAVY IONS; HUMANS; MALE; NEOPLASM PROTEINS; PROSTATIC NEOPLASMS; RADIATION DOSAGE; X-RAYS;

EID: 84922417429     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1093/jrr/rru070     Document Type: Article

References (48)

1. Thariat J, Hannoun-Levi JM, Sun Myint A, et al. Past, present, and future of radiotherapy for the benefit of patients. Nat Rev Clin Oncol 2013;10:52-60
2. Wilson RR. Radiological use of fast protons. Radiology 1946;47:487-91
3. Karger CP, Jakel O. Current status and new developments in ion therapy. Strahlenther Onkol 2007;183:295-300
4. Kramer M, Weyrather WK, Scholz M. The increased biological effectiveness of heavy charged particles: from radiobiology to treatment planning. Technol Cancer Res Treat 2003;2:427-36
5. Iwadate Y, Mizoe J, Osaka Y, et al. High linear energy transfer carbon radiation effectively kills cultured glioma cells with either mutant or wild-type p53. Int J Radiat Oncol Biol Phys 2001;50:803-8
6. Wada S, Kobayashi Y, Funayama T, et al. Detection of DNA damage in individual cells induced by heavy-ion irradiation with an non-denaturing comet assay. J Radiat Res (Tokyo) 2002;43 Suppl:S153-6
7. Hamada N. Recent insights into the biological action of heavy-ion radiation. J Radiat Res (Tokyo) 2009;50:1-9
8. Suetens A, Moreels M, Quintens R, et al. Carbon ion irradiation of the human prostate cancer cell line PC3: a whole genome microarray study. Int J Oncol 2014;44:1056-72
9. Wild-Bode C, Weller M, Rimner A, et al. Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer Res 2001;61:2744-50
10. Zhou YC, Liu JY, Li J, et al. Ionizing radiation promotes migration and invasion of cancer cells through transforming growth factor-beta-mediated epithelial-mesenchymal transition. Int J Radiat Oncol Biol Phys 2011;81:1530-7
11. Yao H, Zeng ZZ, Fay KS, et al. Role of alpha(5)beta(1) integrin up-regulation in radiation-induced invasion by human pancreatic cancer cells. Transl Oncol 2011;4:282-92
12. Cordes N, Blaese MA, Meineke V, et al. Ionizing radiation induces up-regulation of functional beta1-integrin in human lung tumour cell lines in vitro. Int J Rad Biol 2002;78:347-57
13. De Bacco F, Luraghi P, Medico E, et al. Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. JNCI 2011;103:645-61
14. Fujita M, Otsuka Y, Yamada S, et al. X-ray irradiation and Rho-kinase inhibitor additively induce invasiveness of the cells of the pancreatic cancer line, MIAPaCa-2, which exhibits mesenchymal and amoeboid motility. Cancer Sci 2011;102: 792-8
15. Mikheeva SA, Mikheev AM, Petit A, et al. TWIST1 promotes invasion through mesenchymal change in human glioblastoma. Mol Cancer 2010;9:194
16. Goetze K, Scholz M, Taucher-Scholz G, et al. The impact of conventional and heavy ion irradiation on tumor cell migration in vitro. Int J Rad Biol 2007;83:889-96
17. Akino Y, Teshima T, Kihara A, et al. Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells. Int J Radiat Oncol Biol Phys 2009;75:475-81
18. Ogata T, Teshima T, Kagawa K, et al. Particle irradiation suppresses metastatic potential of cancer cells. Cancer Res 2005;65:113-20
19. Fujita M, Otsuka Y, Imadome K, et al. Carbon-ion radiation enhances migration ability and invasiveness of the pancreatic cancer cell, PANC-1, in vitro. Cancer Sci 2012;103:677-83
20. Goetze K, Scholz M, Taucher-Scholz G, et al. Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or 12C heavy ions. Radiat Environ Biophys 2010;49:427-35
21. Meador JA, Ghandhi SA, Amundson SA. p53-independent downregulation of histone gene expression in human cell lines by high- and low-let radiation. Radiat Res 2011;175:689-99
22. Ding LH, Shingyoji M, Chen F, et al. Gene expression changes in normal human skin fibroblasts induced by HZE-particle radiation. Radiat Res 2005;164:523-6
23. Matsumoto Y, Iwakawa M, Furusawa Y, et al. Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams. Int J Radiat Biol 2008;84:299-314
24. Girdhani S, Lamont C, Hahnfeldt P, et al. Proton irradiation suppresses angiogenic genes and impairs cell invasion and tumor growth. Rad Res 2012;178:33-45
25. Fushimi K, Uzawa K, Ishigami T, et al. Susceptible genes and molecular pathways related to heavy ion irradiation in oral squamous cell carcinoma cells. Radiother Oncol 2008;89: 237-44
26. Higo M, Uzawa K, Kawata T, et al. Enhancement of SPHK1 in vitro by carbon ion irradiation in oral squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2006;65:867-75
27. Sanzari JK, Nuth M, Kennedy AR. Induction of cytokine gene expression in human thyroid epithelial cells irradiated with HZE particles (iron ions). Radiat Res 2009;172:437-43
28. Murray-Zmijewski F, Slee EA, Lu X. A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol 2008;9:702-12
29. Amundson SA, Do KT, Vinikoor LC, et al. Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Res 2008;68:415-24
30. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45
31. Franken NA, Rodermond HM, Stap J, et al. Clonogenic assay of cells in vitro. Nat Protoc 2006;1:2315-9
32. Friedrich T, Scholz U, Elsasser T, et al. Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation. J Radiat Res 2013;54: 494-514
33. Balcer-Kubiczek EK, Zhang XF, Harrison GH, et al. Delayed expression of hpS2 and prolonged expression of CIP1/WAF1/SDI1 in human tumour cells irradiated with X-rays, fission neutrons or 1 GeV/nucleon Fe ions. Int J Radiat Biol 1999;75:529-41
34. Zhai GG, Malhotra R, Delaney M, et al. Radiation enhances the invasive potential of primary glioblastoma cells via activation of the Rho signaling pathway. J Neurooncol 2006;76: 227-37
35. Liu C, Xue H, Lu Y, et al. Stem cell gene Girdin: a potential early liver metastasis predictor of colorectal cancer. Mol Biol Rep 2012;39:8717-22
36. Narumiya S, Tanji M, Ishizaki T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev 2009;28:65-76
37. Lin SL, Chiang A, Chang D, et al. Loss of mir-146a function in hormone-refractory prostate cancer. RNA 2008;14:417-24
38. Sandquist JC, Swenson KI, Demali KA, et al. Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. J Biol Chem 2006;281:35873-83
39. Derycke L, Stove C, Vercoutter-Edouart AS, et al. The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells. Int J Dev Biol 2011;55:835-40
40. Garcia-Marcos M, Jung BH, Ear J, et al. Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J 2011;25:590-9
41. Leiss M, Beckmann K, Giros A, et al. The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol 2008;20:502-7
42. Oppenheimer SB. Cellular basis of cancer metastasis: a review of fundamentals and new advances. Acta Histochem 2006; 108:327-34
43. Ding J, Li D, Wang X, et al. Fibronectin promotes invasiveness and focal adhesion kinase tyrosine phosphorylation of human colon cancer cell. Hepatogastroenterology 2008;55: 2072-6
44. Qian P, Zuo Z, Wu Z, et al. Pivotal role of reduced let-7 g expression in breast cancer invasion and metastasis. Cancer Res 2011;71:6463-74
45. Hébrant A, Dom G, Dewaele M, et al. mRNA expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch. PLoS One 2012;7:e37807
46. Amundson SA, Smilenov LB. Integration of biological knowledge and gene expression data for biomarker selection: FN1 as a potential predictor of radiation resistance in head and neck cancer. Cancer Biol Ther 2010;10:1252-5
47. Yang HJ, Kim N, Seong KM, et al. Investigation of radiation-induced transcriptome profile of radioresistant nonsmall cell lung cancer A549 cells using RNA-seq. PLoS One 2013;8:e59319
48. Hei TK, Zhao YL, Roy D, et al. Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. Adv Space Res 2001;27:411-9