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Volumn 176, Issue 2, 2014, Pages 386-393

Androgen attenuates cardiac fibroblasts activations throughmodulations of transforming growth factor-β and angiotensin II signaling

Author keywords

Angiotensin; Fibroblasts; Heart failure; Testosterone; Transforming growth factor

Indexed keywords

ANGIOTENSIN II; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGEN TYPE 4; GELATINASE A; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN KINASE B; SMAD2 PROTEIN; SMAD3 PROTEIN; SYNAPTOPHYSIN; TESTOSTERONE; TRANSFORMING GROWTH FACTOR BETA; ANDROGEN;

EID: 84922404602     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2014.07.077     Document Type: Article
Times cited : (48)

References (43)
  • 1
    • 3142745348 scopus 로고    scopus 로고
    • Trends in heart failure incidence and survival in a community-based population
    • Roger VL, Weston SA, Redfield MM, et al. Trends in heart failure incidence and survival in a community-based population. JAMA 2004; 292: 344-50.
    • (2004) JAMA , vol.292 , pp. 344-350
    • Roger, V.L.1    Weston, S.A.2    Redfield, M.M.3
  • 2
    • 33750548421 scopus 로고    scopus 로고
    • Anabolic deficiency in men with chronic heart failure: Prevalence and detrimental impact on survival
    • Jankowska EA, Biel B, Majda J, et al. Anabolic deficiency in men with chronic heart failure: Prevalence and detrimental impact on survival. Circulation 2006; 114: 1829-37.
    • (2006) Circulation , vol.114 , pp. 1829-1837
    • Jankowska, E.A.1    Biel, B.2    Majda, J.3
  • 3
    • 77950551563 scopus 로고    scopus 로고
    • Low circulating androgens and mortality risk in heart failure
    • Güder G, Frantz S, Bauersachs J, et al. Low circulating androgens and mortality risk in heart failure. Heart 2010; 96: 504-9.
    • (2010) Heart , vol.96 , pp. 504-509
    • Güder, G.1    Frantz, S.2    Bauersachs, J.3
  • 4
    • 28944442442 scopus 로고    scopus 로고
    • Testosterone therapy in men with moderate severity heart failure: A double-blind randomized placebo controlled trial
    • Malkin CJ, Pugh PJ, West JN, van Beek EJR, Jones TH, Channer KS. Testosterone therapy in men with moderate severity heart failure: A double-blind randomized placebo controlled trial. Eur Heart J 2006; 27: 57-64.
    • (2006) Eur Heart J , vol.27 , pp. 57-64
    • Malkin, C.J.1    Pugh, P.J.2    West, J.N.3    Van Beek, E.J.R.4    Jones, T.H.5    Channer, K.S.6
  • 7
    • 0242468515 scopus 로고    scopus 로고
    • Depressive symptoms are the strongest predictors of short-Term declines in health status in patients with heart failure
    • Rumsfeld JS, Havranek E, Masoudi FA, et al. Depressive symptoms are the strongest predictors of short-Term declines in health status in patients with heart failure. J Am Coll Cardiol 2003; 42: 1811-7.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1811-1817
    • Rumsfeld, J.S.1    Havranek, E.2    Masoudi, F.A.3
  • 8
    • 0037991446 scopus 로고    scopus 로고
    • Acute haemodynamic effects of testosterone in men with chronic heart failure
    • Pugh PJ, Jones TH, Channer KS. Acute haemodynamic effects of testosterone in men with chronic heart failure. Eur Heart J 2003; 24: 909-15.
    • (2003) Eur Heart J , vol.24 , pp. 909-915
    • Pugh, P.J.1    Jones, T.H.2    Channer, K.S.3
  • 9
    • 68949172537 scopus 로고    scopus 로고
    • Effect of long-Acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure: A double-blind, placebo-controlled, randomized study
    • Caminiti G, VolterraniM, Iellamo F, et al. Effect of long-Acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure: A double-blind, placebo-controlled, randomized study. J Am Coll Cardiol 2009; 54: 919-27.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 919-927
    • Caminiti, G.1    Volterrani, M.2    Iellamo, F.3
  • 10
    • 77957334994 scopus 로고    scopus 로고
    • Testosterone therapy in women with chronic heart failure: A pilot double-blind, randomized, placebo-controlled study
    • Iellamo F, Volterrani M, Caminiti G, et al. Testosterone therapy in women with chronic heart failure: A pilot double-blind, randomized, placebo-controlled study. J Am Coll Cardiol 2010; 56: 1310-6.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1310-1316
    • Iellamo, F.1    Volterrani, M.2    Caminiti, G.3
  • 11
    • 84862805821 scopus 로고    scopus 로고
    • Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure
    • Kang NN, Fu L, Xu J, et al. Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure. Arch Cardiovasc Dis 2012; 105: 68-76.
    • (2012) Arch Cardiovasc Dis , vol.105 , pp. 68-76
    • Kang, N.N.1    Fu, L.2    Xu, J.3
  • 13
    • 0023906624 scopus 로고
    • Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium
    • Weber K, Janicki J, Shroff S, Pick R, Chen R, Bashey R. Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res 1988; 62: 757-65.
    • (1988) Circ Res , vol.62 , pp. 757-765
    • Weber, K.1    Janicki, J.2    Shroff, S.3    Pick, R.4    Chen, R.5    Bashey, R.6
  • 14
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: Insights from the randomized aldactone evaluation study (RALES)
    • Zannad F, Alla F, Dousset B, Perez A, Pitt B. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: Insights from the randomized aldactone evaluation study (RALES). Circulation 2000; 102: 2700-6.
    • (2000) Circulation , vol.102 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3    Perez, A.4    Pitt, B.5
  • 15
    • 34648843625 scopus 로고    scopus 로고
    • Mechanisms of cardiac fibrosis in hypertension
    • Díez J.Mechanisms of cardiac fibrosis in hypertension. J Clin Hypertens (Greenwich) 2007; 9: 546-50.
    • (2007) J Clin Hypertens (Greenwich) , vol.9 , pp. 546-550
    • Díez, J.1
  • 16
    • 77953808712 scopus 로고    scopus 로고
    • Potential therapeutic targets for cardiac fibrosis
    • Leask A. Potential therapeutic targets for cardiac fibrosis. Circ Res 2010; 106: 1675-80.
    • (2010) Circ Res , vol.106 , pp. 1675-1680
    • Leask, A.1
  • 17
    • 0028275578 scopus 로고
    • Collagen metabolism in cultured adult rat cardiac fibroblasts: Response to angiotensin II and aldosterone
    • Brilla CG, Zhou G, Matsubara L, Weber KT. Collagen metabolism in cultured adult rat cardiac fibroblasts: Response to angiotensin II and aldosterone. J Mol Cell Cardiol 1994; 26: 809-20.
    • (1994) J Mol Cell Cardiol , vol.26 , pp. 809-820
    • Brilla, C.G.1    Zhou, G.2    Matsubara, L.3    Weber, K.T.4
  • 18
    • 84886307237 scopus 로고    scopus 로고
    • Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure
    • Kao YH, Liou JP, Chung CC, et al. Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure. Int J Cardiol 2013; 168: 4178-83.
    • (2013) Int J Cardiol , vol.168 , pp. 4178-4183
    • Kao, Y.H.1    Liou, J.P.2    Chung, C.C.3
  • 19
    • 84886853090 scopus 로고    scopus 로고
    • Cyr61 induces the expression of monocyte chemoattractant protein-1 via the integrin aνβ3, FAK, PI3K/Akt, and NF-κB pathways in retinal vascular endothelial cells
    • You JJ, Yang CH, Yang CM, Chen MS. Cyr61 induces the expression of monocyte chemoattractant protein-1 via the integrin aνβ3, FAK, PI3K/Akt, and NF-κB pathways in retinal vascular endothelial cells. Cell Signal 2014; 26: 133-40.
    • (2014) Cell Signal , vol.26 , pp. 133-140
    • You, J.J.1    Yang, C.H.2    Yang, C.M.3    Chen, M.S.4
  • 20
    • 84861229654 scopus 로고    scopus 로고
    • Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast
    • Catalán M, Smolic C, Contreras A, et al. Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast. Toxicol Appl Pharmacol 2012; 261: 300-8.
    • (2012) Toxicol Appl Pharmacol , vol.261 , pp. 300-308
    • Catalán, M.1    Smolic, C.2    Contreras, A.3
  • 21
    • 33745353771 scopus 로고    scopus 로고
    • 17β-estradiol modulation of angiotensin II-stimulated response in cardiac fibroblasts
    • Stewart Jr. JA, Cashatt DO, Borck AC, Brown JE, CarverWE. 17β-estradiol modulation of angiotensin II-stimulated response in cardiac fibroblasts. J Mol Cell Cardiol 2006; 41: 97-107.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 97-107
    • Stewart, J.A.1    Cashatt, D.O.2    Borck, A.C.3    Brown, J.E.4    Carver, W.E.5
  • 22
    • 74049128799 scopus 로고    scopus 로고
    • Tumor necrosis factor-A decreases sarcoplasmic reticulum Ca2+-ATPase expressions via the promoter methylation in cardiomyocytes
    • Kao YH, Chen YC, Cheng CC, Lee TI, Chen YJ, Chen SA. Tumor necrosis factor-A decreases sarcoplasmic reticulum Ca2+-ATPase expressions via the promoter methylation in cardiomyocytes. Crit Care Med 2010; 38: 217-22.
    • (2010) Crit Care Med , vol.38 , pp. 217-222
    • Kao, Y.H.1    Chen, Y.C.2    Cheng, C.C.3    Lee, T.I.4    Chen, Y.J.5    Chen, S.A.6
  • 24
    • 39049189613 scopus 로고    scopus 로고
    • Coronary calcification in body builders using anabolic steroids
    • Santora LJ, Marin J, Vangrow J, et al. Coronary calcification in body builders using anabolic steroids. Prev Cardiol 2006; 9: 198-201.
    • (2006) Prev Cardiol , vol.9 , pp. 198-201
    • Santora, L.J.1    Marin, J.2    Vangrow, J.3
  • 25
    • 0034680343 scopus 로고    scopus 로고
    • Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study
    • English KM, Steeds RP, Jones TH, Diver MJ, Channer KS. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study. Circulation 2000; 102: 1906-11.
    • (2000) Circulation , vol.102 , pp. 1906-1911
    • English, K.M.1    Steeds, R.P.2    Jones, T.H.3    Diver, M.J.4    Channer, K.S.5
  • 26
    • 0035853043 scopus 로고    scopus 로고
    • Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase
    • Nathan L, Shi W, Dinh H, et al. Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase. Proc Natl Acad Sci U S A 2001; 98: 3589-93.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3589-3593
    • Nathan, L.1    Shi, W.2    Dinh, H.3
  • 27
    • 0036182871 scopus 로고    scopus 로고
    • Stimulation of collagen production by transforming growth factor-β1 during differentiation of cardiac fibroblasts to myofibroblasts
    • Petrov VV, Fagard RH, Lijnen PJ. Stimulation of collagen production by transforming growth factor-β1 during differentiation of cardiac fibroblasts to myofibroblasts. Hypertension 2002; 39: 258-63.
    • (2002) Hypertension , vol.39 , pp. 258-263
    • Petrov, V.V.1    Fagard, R.H.2    Lijnen, P.J.3
  • 29
    • 0032967436 scopus 로고    scopus 로고
    • Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3
    • Eickelberg O, Kfhler E, Reichenberger F, et al. Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3. Am J Physiol 1999; 276: L814-24.
    • (1999) Am J Physiol , vol.276 , pp. L814-L824
    • Eickelberg, O.1    Köhler, E.2    Reichenberger, F.3
  • 30
    • 52449132324 scopus 로고    scopus 로고
    • Inhibition of superoxide dismutase induces collagen production in cardiac fibroblasts
    • Lijnen P, Petrov V, van Pelt J, Fagard R. Inhibition of superoxide dismutase induces collagen production in cardiac fibroblasts. Am J Hypertens 2008; 21: 1129-36.
    • (2008) Am J Hypertens , vol.21 , pp. 1129-1136
    • Lijnen, P.1    Petrov, V.2    Van Pelt, J.3    Fagard, R.4
  • 31
    • 0036645337 scopus 로고    scopus 로고
    • Transforming growth factor-β function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats
    • Kuwahara F, Kai H, Tokuda K, et al. Transforming growth factor-β function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 2002; 106: 130-5.
    • (2002) Circulation , vol.106 , pp. 130-135
    • Kuwahara, F.1    Kai, H.2    Tokuda, K.3
  • 32
    • 84879836715 scopus 로고    scopus 로고
    • Comparing effects of low-And high-volume moderateintensity exercise on sexual function and testosterone in obese men
    • Khoo J, Tian HH, Tan B, et al. Comparing effects of low-And high-volume moderateintensity exercise on sexual function and testosterone in obese men. J Sex Med 2013; 10: 1823-32.
    • (2013) J Sex Med , vol.10 , pp. 1823-1832
    • Khoo, J.1    Tian, H.H.2    Tan, B.3
  • 33
    • 84871337680 scopus 로고    scopus 로고
    • Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults
    • deFilippi CR, de Lemos JA, Tkaczuk AT, et al. Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults. J Am Coll Cardiol 2012; 60: 2539-47.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 2539-2547
    • DeFilippi, C.R.1    De Lemos, J.A.2    Tkaczuk, A.T.3
  • 34
    • 64249125022 scopus 로고    scopus 로고
    • Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial
    • O'Connor CM, Whellan DJ, Lee KL, et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 2009; 301: 1439-50.
    • (2009) JAMA , vol.301 , pp. 1439-1450
    • O'Connor, C.M.1    Whellan, D.J.2    Lee, K.L.3
  • 35
    • 0034652478 scopus 로고    scopus 로고
    • Down-regulation of transforming growth factor β receptors by androgen in ovarian cancer cells
    • Evangelou A, Jindal SK, Brown TJ, Letarte M. Down-regulation of transforming growth factor β receptors by androgen in ovarian cancer cells. Cancer Res 2000; 60: 929-35.
    • (2000) Cancer Res , vol.60 , pp. 929-935
    • Evangelou, A.1    Jindal, S.K.2    Brown, T.J.3    Letarte, M.4
  • 37
    • 84866316624 scopus 로고    scopus 로고
    • Heparin-binding EGF-like growth factor induces heart interstitial fibrosis via an Akt/mTor/p70s6k pathway
    • Lian H, Ma Y, Feng J, et al. Heparin-binding EGF-like growth factor induces heart interstitial fibrosis via an Akt/mTor/p70s6k pathway. PLoS One 2012; 7: E44946.
    • (2012) PLoS One , vol.7 , pp. e44946
    • Lian, H.1    Ma, Y.2    Feng, J.3
  • 38
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003; 425: 577-84.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 39
    • 80053452377 scopus 로고    scopus 로고
    • Inhibition of PI3k prevents the proliferation and differentiation of human lung fibroblasts intomyofibroblasts: The role of class I P110 isoforms
    • Conte E, FrucianoM, Fagone E, et al. Inhibition of PI3k prevents the proliferation and differentiation of human lung fibroblasts intomyofibroblasts: The role of class I P110 isoforms. PLoS One 2011; 6: E24663.
    • (2011) PLoS One , vol.6 , pp. e24663
    • Conte, E.1    FrucianoM Fagone, E.2
  • 40
    • 80051923056 scopus 로고    scopus 로고
    • TGFβ-And bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR)
    • Goc A, Choudhary M, Byzova TV, Somanath PR. TGFβ-And bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR). J Cell Physiol 2011; 226: 3004-13.
    • (2011) J Cell Physiol , vol.226 , pp. 3004-3013
    • Goc, A.1    Choudhary, M.2    Byzova, T.V.3    Somanath, P.R.4
  • 41
    • 70349664184 scopus 로고    scopus 로고
    • Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-β/NFAT axis
    • Bonnet S, Paulin R, Sutendra G, et al. Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-β/NFAT axis. Circulation 2009; 120: 1231-40.
    • (2009) Circulation , vol.120 , pp. 1231-1240
    • Bonnet, S.1    Paulin, R.2    Sutendra, G.3
  • 42
    • 18844387660 scopus 로고    scopus 로고
    • Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism
    • Rodríguez-Vita J, Sánchez-López E, Esteban V, Rupérez M, Egido J, Ruiz-Ortega M. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 2005; 111: 2509-17.
    • (2005) Circulation , vol.111 , pp. 2509-2517
    • Rodríguez-Vita, J.1    Sánchez-López, E.2    Esteban, V.3    Rupérez, M.4    Egido, J.5    Ruiz-Ortega, M.6
  • 43
    • 60949097622 scopus 로고    scopus 로고
    • Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts
    • Gao X, He X, Luo B, Peng L, Lin J, Zuo Z. Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts. Eur J Pharmacol 2009; 606: 115-20.
    • (2009) Eur J Pharmacol , vol.606 , pp. 115-120
    • Gao, X.1    He, X.2    Luo, B.3    Peng, L.4    Lin, J.5    Zuo, Z.6


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