Systematic review of retention of pediatric patients on HIV treatment in low and middle-income countries 2008-2013

AIDS

Volumn 29, Issue 4, 2015, Pages 493-502

  Fox, Matthew P ^a,b,c   Rosen, Sydney ^a,c  

^a Crosstown Center   (United States)

^b BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^c School of clinical medicine   (South Africa)

Author keywords

antiretroviral therapy; attrition; HIV; loss to follow up; low and middle income countries; meta analysis; pediatric; retention; systematic review

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

AFRICA; ANTIVIRAL THERAPY; ASIA; CARIBBEAN; CD4 LYMPHOCYTE COUNT; CHILDHOOD DISEASE; COHORT ANALYSIS; EASTERN EUROPE; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFORMED CONSENT; LOWEST INCOME GROUP; MEDICATION COMPLIANCE; META ANALYSIS; MIDDLE EAST; PRIORITY JOURNAL; RESOURCE ALLOCATION; REVIEW; SOUTH AFRICA; SOUTH AND CENTRAL AMERICA; SURVIVAL RATE; SYSTEMATIC REVIEW; TREATMENT RETENTION; CHILD; DEVELOPING COUNTRY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; PRESCHOOL CHILD; STATISTICS AND NUMERICAL DATA;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CHILD; CHILD, PRESCHOOL; DEVELOPING COUNTRIES; HIV INFECTIONS; HUMANS; LOST TO FOLLOW-UP; MEDICATION ADHERENCE;

EID: 84922398513     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000559     Document Type: Review

References (54)

1. World Health Organization. Global update on HIV treatment 2013: results, impact and opportunities. Geneva: World Health Organization; 2013
2. World Health Organization (WHO). Antiretroviral therapy for HIV infection in infants and children: towards universal access. Recommendations for a public health approach. 2010 revision. Geneva: World Health Organization; 2010
3. Hansudewechakul R, Sirisanthana V, Kurniati N, Puthanakit T, Lumbiganon P, Saphonn V, et al. Antiretroviral therapy outcomes of HIV-infected children in the TREAT Asia pediatric HIV observational database. J Acquir Immune Defic Syndr 2010; 55:503-509
4. Kabue MM, Buck WC, Wanless SR, Cox CM, McCollum ED, Caviness A C, et al. Mortality and clinical outcomes in HIVinfected children on antiretroviral therapy in Malawi, Lesotho, and Swaziland. Pediatrics 2012; 130:e591-e599
5. Raguenaud M-E, Isaakidis P, Zachariah R, Te V, Soeung S, Akao K, et al. Excellent outcomes among HIVR children on ART, but unacceptably high pre-ART mortality and losses to follow-up: a cohort study from Cambodia. BMC Pediatr 2009; 9:54
6. Matida LH, Ramos AN, Heukelbach J, Hearst N. Continuing improvement in survival for children with acquired immunodeficiency syndrome in Brazil. Pediatr Infect Dis J 2009; 28:920-922
7. Rosen S, Fox MP, Gill CJ. Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Med 2007; 4:e298
8. Fox MP, Rosen S. Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007-2009: systematic review. Trop Med Int Heal 2010; 15 (Suppl 1):1-15
9. Freeman M, Tukey J. Transformations related to the angular and the square root. Ann Inst Stat Math 1950; 21:607-611
10. Gomilla A. Antiretroviral therapy (ART) in children less than 24 months of age at the Botswana Baylor Childrens Clinical Centre of Excellence (COE) in Gaborone, Botswana: characteristics at initiation and outcomes after 52 weeks of ART. 6th IAS Conf HIV Pathog Treat; Abstract MOPE235, Rome, 17-20 July 2011
11. Auld AF. Predictors of treatment outcomes among children initiating antiretroviral therapy in Cote dIvoire during 2004-2008
12. Edmonds A, Yotebieng M, Lusiama J, Matumona Y, Kitetele F, Napravnik S, et al. The effect of highly active antiretroviral therapy on the survival of HIV-infected children in a resourcedeprived setting: a cohort study. PLoS Med 2011; 8:e1001044
13. Asfawesen GY, Solomie J, Bisirat T, Berhanu GM, Mebratu B, Rahlenbeck S. Outcome in a paediatric cohort receiving ART in Addis Abeba, Ethiopia. Acta Paediatr 2011; 100:1164-1167
14. Koye DN, Ayele TA, Zeleke BM. Predictors of mortality among children on antiretroviral therapy at a referral hospital, Northwest Ethiopia: a retrospective follow up study. BMC Pediatr 2012; 12:161
15. Hagstromer O, Lundstedt L, Balcha TT, Bjorkman P. Decentralised paediatric HIV care in Ethiopia: a comparison between outcomes of patients managed in health centres and in a hospital clinic. Glob Health Action 2013; 6:22274
16. Okomo U, Togun T, Oko F, Peterson K, Townend J, Peterson I, et al. Treatment outcomes among HIV-1 and HIV-2 infected children initiating antiretroviral therapy in a concentrated low prevalence setting in West Africa. BMC Pediatr 2012; 12:95
17. Mcnairy ML, Lamb MR, Carter RJ, Fayorsey R, Tene G, Mutabazi V, et al. Retention of HIV-infected children on antiretroviral treatment in HIV care and treatment programs in Kenya, Mozambique, Rwanda, and Tanzania. J Acquir Immune Defic Syndr 2013; 62:17-19
18. Nyandiko W, Vreeman R, Liu H, Shangani S, Sang E, Ayaya S, et al. Nonadherence to clinic appointments among HIVinfected children in an ambulatory care program in Western Kenya. J Acquir Immune Defic Syndr 2013; 63:49-55
19. Sivapalasingam S, Mendillo M, Ahmed A, Mwamzuka M, Said S, Marshed F, et al. The importance of caregivers in the outcome of pediatric HIV management, Mombasa, Kenya. AIDS Care 2013; 00:1-9
20. Cohen R. Nurse-driven, community-supported HIV/AIDS care and treatment: 2 year antiretroviral treatment outcomes from a primary care level programme in rural Lesotho. 5th IAS Conf HIV Pathog Treat; Abstract MOAD102, Cape Town, 19-22 July 2009
21. Ardura Garcia C. Risk factors and true outcomes of children lost to follow-up from antiretroviral therapy in Lilongwe, Malawi. 19th Int AIDS Conf; Abstract WEAE0203, Washington, 22-27 July 2012
22. Weigel R, Phiri S, Chiputula F, Gumulira J, Brinkhof M, Gsponer T, et al. Growth response to antiretroviral treatment in HIVinfected children: a cohort study from Lilongwe, Malawi. Trop Med Int Health 2010; 15:934-944
23. Germanaud D, Derache A, Traore M, Madec Y, Toure S, Dicko F, et al. Level of viral load and antiretroviral resistance after 6 months of nonnucleoside reverse transcriptase inhibitor firstline treatment in HIV-1-infected children in Mali. J Antimicrob Chemother 2010; 65:118-124
24. Fenner L, Brinkhof MWG, Keiser O, Weigel R, Cornell M, Moultrie H, et al. Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa. J Acquir Immune Defic Syndr 2010; 54:524-532
25. Omoni AO, Christian PS, Sadoh WE, Okechukwu A, Olateju E, Omoigberale A, et al. Immunologic outcomes of antiretroviral therapy among HIV-infected Nigerian children and its association with early infant feeding and nutritional status at treatment initiation. Pediatr Infect Dis J 2013; 32:e291-e297
26. Tene G, Lahuerta M, Teasdale C, Mugisha V, Kayonde L, Muhayimpundu R, et al. High retention among HIV-infected children in Rwanda during scale-up and decentralization of HIV care and treatment programs to. Pediatr Infect Dis J 2013; 32:e341-e347
27. Van Griensven J, De Naeyer L, Uwera J, Asiimwe A, Gazille C, Reid T. Success with antiretroviral treatment for children in Kigali, Rwanda: experience with health center/nurse-based care. BMC Pediatr 2008; 8:39
28. Kaplan R. Long term programmatic outcomes for adults and children at a primary healthcare antiretroviral clinic in South Africa. 5th IAS Conf HIV Pathog Treat; Abstract MOAD105, Cape Town, 19-22 July 2009
29. Sengayi M, Dwane N, Marinda E, Sipambo N, Fairlie L, Moultrie H. Predictors of loss to follow-up among children in the first and second years of antiretroviral treatment in Johannesburg, South Africa. Glob Health Action 2013; 6:19248
30. Chhagan MK, Kauchali S, Van den Broeck J. Clinical and contextual determinants of anthropometric failure at baseline and longitudinal improvements after starting antiretroviral treatment among South African children. Trop Med Int Heal 2012; 17:1092-1099
31. Colvin CJ. Paediatric outcomes after five years on ART in Khayelitsha Township, South Africa. 5th IAS Conf HIV Pathog Treat; Abstract CDB109, Cape Town, 19-22 July 2009
32. Barth RE, TempelmanHA, Smelt E, WensingAMJ, Hoepelman AI, Geelen SP. Long-term outcome of children receiving antiretroviral treatment in rural South Africa: substantial virologic failure on firstline treatment. Pediatr Infect Dis J 2011; 30:52-56
33. Janssen N, Ndirangu J, Newell M-L, Bland RM. Successful paediatric HIV treatment in rural primary care in Africa. Arch Dis Child 2010; 95:414-421
34. Zanoni BC, Phungula T, Zanoni HM, France H, Feeney ME. Risk factors associated with increased mortality among HIV infected children initiating antiretroviral therapy (ART) in South Africa. PLoS One 2011; 6:e22706
35. Meyer-Rath G, Brennan A, Long L, Ndibongo B, Technau K, Moultrie H, et al. Cost and outcomes of paediatric antiretroviral treatment in South Africa. AIDS 2013; 27:243-250
36. Fatti G, Shaikh N, Eley B, Grimwood A. Improved virological suppression in children on antiretroviral treatment receiving community-based adherence support: a multicentre cohort study from South Africa. AIDS Care 2014; 26:448-453
37. Mwiru RS, Spiegelman D, Duggan C, Seage GR, Semu H, Chalamilla G, et al. Nutritional status and other baseline predictors of mortality among HIV-infected children initiating antiretroviral therapy in Tanzania. J Int Assoc Provid AIDS Care 2013(Published Online First: 8 October; doi: 10.1177/2325957413500852).
38. Kiboneka A, Wangisi J, Nabiryo C, Tembe J, Kusemererwa S, Olupot-Olupot P, et al. Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda. AIDS 2008; 22:2493-2499
39. Scott C, Iyer H, Bwalya DL, McCoy K, Meyer-Rath G, Moyo C, et al. Retention in care and outpatient costs for children receiving antiretroviral therapy in zambia: a retrospective cohort analysis. PLoS One 2013; 8:e67910
40. Sikazwe I. Clinical outcomes and factors contributing to loss to follow-up of paediatric patients on ART in rural Zambia: retrospective cohort study 2004-2010. 6th IAS Conf HIV Pathog Treat, Abstract CDD081, Rome, 17-20 July 2011
41. Isaakidis P, Raguenaud M-E, Te V, Tray CS, Akao K, Kumar V, et al. High survival and treatment success sustained after two and three years of first-line ART for children in Cambodia. J Int AIDS Soc 2010; 13:11
42. Zhao Y, Li C, Sun X, Mu W, McGoogan JM, He Y, et al. Mortality and treatment outcomes of Chinas National Pediatric antiretroviral therapy program. Clin Infect Dis 2013; 56:735-744
43. Rajasekaran S, Jeyaseelan L, Ravichandran N, Gomathi C, Thara F, Chandrasekar C. Efficacy of antiretroviral therapy program in children in India: prognostic factors and survival analysis. J Trop Pediatr 2009; 55:225-232
44. Collins IJ, Jourdain G, Hansudewechakul R, KanjanaVanit S, Hongsiriwon S, Ngampiyasakul C, et al. Long-term survival of HIV-infected children receiving antiretroviral therapy in Thailand: a 5-year observational cohort study. Clin Infect Dis 2010; 51:1449-1457
45. McConnell MS, Chasombat S, Siangphoe U, Yuktanont P, Lolekha R, Pattarapayoon N, et al. National program scaleup and patient outcomes in a pediatric antiretroviral treatment program Thailand. J Acquir Immune Defic Syndr 2010; 54:423-429
46. Duong B. Application of ART cohort analysis and HIV drug resistance early warning indicators as tools to monitor HIV/AIDS care and treatment program in Viet Nam. AIDS 2010-XVIII Int AIDS Conf; Abstract CDC0508, Vienna, 18-23 July 2010
47. Lu D. First-line antiretroviral therapy in HIV-infected children in Vietnam: a 12-month outcome analysis. AIDS 2010-XVIII Int AIDS Conf; Abstract THPE0178, Vienna, 18-23 July 2010
48. Souza ES, dos Santos NR, Valentini SZ, da Silva GA, Figueiroa JN, Falbo AR. Predictors of long-term antiretroviral therapy effectiveness among Brazilian HIV-1-infected children in a hybrid scenario: what really matters? J Trop Pediatr 2011; 57:197-203
49. Fox MP, Rosen S. Retention of adult patients on antiretroviral therapy in low-and middle-income countries: systematic review 2008-2013. Boston: Center for Global Health &Development; 2014
50. Violari A, Cotton MF, Gibb DM, Babiker AG, Steyn J, Madhi SA, et al. Early antiretroviral therapy and mortality among HIVinfected infants. N Engl J Med ; 359:2233-2244
51. Geng EH, Emenyonu N, Bwana MB, Glidden DV, Martin JN. Sampling-based approach to determining outcomes of patients lost to follow-up in antiretroviral therapy scale-up programs in Africa. J Am Med Assoc 2008; 300:506-507
52. Egger M, Spycher BD, Sidle J, Weigel R, Geng EH, Fox MP, et al. Correcting mortality for loss to follow-up: a nomogram applied to antiretroviral treatment programmes in sub-Saharan Africa. PLoS Med 2011; 8:e1000390
53. Brinkhof MWG, Spycher BD, Yiannoutsos C, Weigel R, Wood R, Messou E, et al. Adjusting mortality for loss to follow-up: analysis of five ART programmes in sub-Saharan Africa. PLoS One 2010; 5:e14149
54. Fox MP, Brennan A, Maskew M, MacPhail P, Sanne I. Using vital registration data to update mortality among patients lost to follow-up from ART programmes: evidence from the Themba Lethu Clinic, South Africa. Trop Med Int Health 2010; 15:405-413