Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007-2009: Systematic review

Tropical Medicine and International Health

Volumn 15, Issue SUPPL. 1, 2010, Pages 1-15

  Fox, Matthew P ^a,b,c   Rosen, Sydney ^a,b,c  

^a BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Antiretroviral therapy; Attrition; Human immuno deficiency virus; Retention; Sub Saharan Africa; Systematic review

Indexed keywords

ANTIRETROVIRUS AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; COHORT ANALYSIS; DISEASE TREATMENT; DRUG PRESCRIBING; HEALTH RISK; HEALTH SERVICES; HOSPITAL SECTOR; HUMAN IMMUNODEFICIENCY VIRUS; MEDICINE; META-ANALYSIS; PUBLIC HEALTH; SENSITIVITY ANALYSIS;

AFRICA; ARTICLE; CAUSE OF DEATH; CD4 LYMPHOCYTE COUNT; FOLLOW UP; HEALTH CARE ACCESS; HEALTH PROGRAM; HEALTH SERVICE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONG TERM CARE; MORTALITY; PATIENT COMPLIANCE; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TREATMENT DURATION;

ADULT; AFRICA SOUTH OF THE SAHARA; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HUMANS; MALE; MEDICATION ADHERENCE; PATIENT DROPOUTS;

SUB-SAHARAN AFRICA;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77951864630     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2010.02508.x     Document Type: Article

References (53)

1. Ahoua L, Guenther G, Pinoges L et al. (2009) Risk factors for virological failure and subtherapeutic antiretroviral drug concentrations in HIV-positive adults treated in rural northwestern Uganda. BMC Infectious Diseases 9, 81.
2. Anglaret X, Toure S, Gourvellec G et al. (2004) Impact of vital status investigation procedures on estimates of survival in cohorts of HIV-infected patients from Sub-Saharan Africa. Journal of Acquired Immune Deficiency Syndromes 35, 320 323.
3. Auld AF (2009) Treatment Outcomes of HIV-Infected Adults Enrolled in the National Antiretroviral Therapy Program -Mozambique, 2004-2007. HIV/AIDS Implementers' Meeting Windhoek
4. Badri M, Cleary S, Maartens G et al. (2006) When to initiate highly active antiretroviral therapy in sub-Saharan Africa? A South African cost-effectiveness study. Antiviral Therapy 11, 63 72.
5. Bajunirwe F, Arts EJ, Tisch DJ, Debanne SM Sethi AK (2007) Survival, Adherence to Care and Antiretroviral Treatment (ART) Among HIV-Infected Adults in Rural Western Uganda. 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention WEPEB049.
6. Barth RE, Tempelman HA Hoepelman AIM (2009) Long-Term Follow Up of HIV-Infected Adults in Rural South Africa; Good Virological Results in Spite of Early Mortality. IAS 2009 Cape Town
7. Bisson G, Ndwapi N, Rollins C et al. (2007) High Rates of Death Among Patients Lost to Follow-Up in Botswana's National Art Program: Implications for Monitoring and Evaluation. 14th Conference on Retroviruses and Opportunistic Infections (CROI) Abstract 537(no poster)
8. Bisson GP et al. (2008) Overestimates of survival after HAART: implications for global scale-up efforts. PLoS ONE 3, e1725.
9. Boulle A, Bock P, Osler M et al. (2008) Antiretroviral therapy and early mortality in South Africa. Bulletin of the World Health Organization 86, 678 687.
10. Brinkhof MW, Pujades-Rodriguez M Egger M (2009) Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis. PLoS ONE 4, e5790.
11. Bussmann H, Wester CW, Ndwapi N et al. (2008) Five-year outcomes of initial patients treated in Botswana's National Antiretroviral Treatment Program. AIDS 22, 2303 2311.
12. Chalamilla G (2008) Predictors of Clinical and Immunological Outcomes among HIV-infected Subjects on ART in Tanzania. 15th Conference on Retroviruses and Opportunistic Infections Abstract 824.
13. Chang LVW, Alamo S, Guma S et al. (2009) Two-Year Virologic Outcomes of an Alternative AIDS Care Model: evaluation of a Peer Health Worker and Nurse-Staffed Community-Based Program in Uganda. Journal of Acquired Immune Deficiency Syndromes 50, 276 282.
14. Chi BH, Cantrell RA, Zulu I et al. (2009) Adherence to first-line antiretroviral therapy affects non-virologic outcomes among patients on treatment for more than 12 months in Lusaka, Zambia. International Journal of Epidemiology 38, 746 756.
15. Chiliade P (2008) Long-term immunologic outcomes of patients started on antiretroviral therapy in 2 Sub-Saharan resource-limited countries. XVII International AIDS Conference CDB0233.
16. Coetzee D, Hildebrand K, Boulle A et al. (2004) Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa. AIDS 18, 887 895.
17. Collini P, Schwab U, Sarfo S et al. (2009) Sustained immunological responses to highly active antiretroviral therapy at 36 months in a Ghanaian HIV cohort. Clinical Infectious Diseases 48, 988 991.
18. Culbert H, Tu D, O'Brien DP et al. (2007) HIV treatment in a conflict setting: outcomes and experiences from Bukavu, Democratic Republic of the Congo. PLoS Medicine 4, e129.
19. Dahab M (2008) Off the radar screen: comparing reasons for treatment default in a workplace ART programme and a public sector clinic in South Africa. XVII International AIDS Conference THPE0123.
20. DeSilva MB, Merry SP, Fischer PR et al. (2009) Youth, unemployment, and male gender predict mortality in AIDS patients started on HAART in Nigeria. Aids Care-Psychological and Socio-Medical Aspects of Aids/HIV 21, 70 77.
21. Egger M, Davey Smith G Altman DG (2001) Systematic Reviews in Health Care: Meta-analysis in Context, 2nd edn. BMJ Books
22. Egger M, May M, Chene G et al. (2002) Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet 360, 119 129. (Pubitemid 34786200)
23. Fairall LR, Bachmann MO, Louwagie GM et al. (2008) Effectiveness of antiretroviral treatment in a South African program: a cohort study. Archives of Internal Medicine 168, 86 93.
24. Fox MP, Brennan A, Maskew M et al. (2010) Using Vital Registration Data to Update Mortality among Patients Lost to Follow-up from ART Programs: Evidence from the Themba Lethu Clinic, South Africa. Tropical Medicine and International Health 15, 405 413.
25. Freeman MF Tukey JW (1950) Transformations related to the angular and the square root. Annals of the Institute of Statistical Mathematics 21, 607 611.
26. Geng EH, Emenyonu N, Bwana MB, Glidden DV Martin JN (2008) Sampling-based approach to determining outcomes of patients lost to follow-up in antiretroviral therapy scale-up programs in Grimwood A (2008) Public-private partnership achieves long-term ARV adherence in South Africa. XVII International AIDS Conference CDB0221.
27. Gugsa S (2008) Determinants of retention and mortality during 6-month follow-up after initiation of HAART in an Ethiopian public HIV treatment program. XVII International AIDS Conference CDB0246.
28. Ivers LC, Kendrick D Doucette K (2005) Efficacy of antiretroviral therapy programs in resource-poor settings: a meta-analysis of the published literature. Clinical Infectious Diseases 41, 217 224.
29. Jahn A (2008) Antiretroviral regimen substitutions and switches due to drug toxicity and treatment failure: a national survey three years after the start of antiretroviral therapy roll-out in Malawi. XVII International AIDS Conference MOPE0044.
30. Johannessen A, Naman E, Ngowi BJ et al. (2008) Predictors of mortality in HIV-infected patients starting antiretroviral therapy in a rural hospital in Tanzania. BMC Infectious Diseases 8, 52.
31. Kaplan R, Orrell C, Zwane E, Bekker LG Wood R (2008) Loss to follow-up and mortality among pregnant women referred to a community clinic for antiretroviral treatment. AIDS 22, 1679 1681.
32. Keiser O, Anastos K, Schechter M et al. (2008) Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America. Tropical Medicine and International Health 13, 870 879.
33. Khan MSH (2009) Retention and Attrition of Patients Commenced on HAART at Ladysmith Provincial Hospital in South Africa. IAS 2009 Cape Town
34. Laurent C, Ngom Gueye NF, Ndour CT et al. (2005) Long-term benefits of highly active antiretroviral therapy in Senegalese HIV-1-infected adults. Journal of Acquired Immune Deficiency Syndromes 38, 14 17.
35. Lawn SD, Myer L Wood R (2005) Efficacy of antiretroviral therapy in resource-poor settings: are outcomes comparable to those in the developed world? Clinical Infectious Diseases 41, 1683 1684.
36. Lawn SD, Harries AD, Anglaret X, Myer L Wood R (2008) Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. AIDS 22, 1897 1908.
37. Lowrance DW, Ndamage F, Kayirangwa E et al. (2009) Adult clinical and immunologic outcomes of the national antiretroviral treatment program in Rwanda during 2004-2005. Journal of Acquired Immune Deficiency Syndromes 52, 49 55.
38. MacPherson P, Moshabela M, Martinson N Pronyk P (2009) Mortality and loss to follow-up among HAART initiators in rural South Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 103, 588 593.
39. Marazzi MC, Liotta G, Germano P et al. (2008) Excessive early mortality in the first year of treatment in HIV type 1-infected patients initiating antiretroviral therapy in resource-limited settings. AIDS Research and Human Retroviruses 24, 555 560.
40. Martin J (2008) Initial Treatment Outcomes from a Rural-based ART Scale-up Program in East Africa: The UARTO Cohort. 15th Conference on Retroviruses and Opportunistic Infections Abstract 816.
41. Mocroft AJ, Lundgren JD, d'Armino MA et al. (1997) Survival of AIDS patients according to type of AIDS-defining event. The AIDS in Europe Study Group. International Journal of Epidemiology 26, 400 407.
42. Morgan D, Mahe C, Mayanja B et al. (2002) HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries? AIDS 16, 597 603.
43. Nachega JB, Hislop M, Dowdy DW et al. (2008) Efavirenz versus nevirapine-based initial treatment of HIV infection: clinical and virological outcomes in Southern African adults. AIDS 22, 2117 2125.
44. O'Brien DP, Mills C, Hamel C, Ford N Pottie K (2009) Universal access: the benefits and challenges in bringing integrated HIV care to isolated and conflict affected populations in the Republic of Congo. Conflict and Health 3, 1.
45. Ojikutu BO, Zheng H, Walensky RP et al. (2008) Predictors of mortality in patients initiating antiretroviral therapy in Durban, South Africa. South African Medical Journal 98, 204 208.
46. Palombi L, Marazzi MC, Guidotti G et al. (2009) Incidence and Predictors of Death, Retention, and Switch to Second-Line Regimens in Antiretroviral- Treated Patients in Sub-Saharan African Sites with Comprehensive Monitoring Availability. Clinical Infectious Diseases 48, 115 122.
47. Rosen S, Fox MP Gill CJ (2007) Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Medicine 4, e298.
48. Rosen S, Long L Sanne I (2008) The outcomes and outpatient costs of different models of antiretroviral treatment delivery in South Africa. Tropical Medicine and International Health 13, 1005 1015.
49. Sieleunou I, Souleymanou M, Schonenberger AM, Menten J Boelaert M (2009) Determinants of survival in AIDS patients on antiretroviral therapy in a rural centre in the Far-North Province, Cameroon. Tropical Medicine and International Health 14, 36 43.
50. Souteyrand Y, Akwara P, Warner Smith M et al. (2009) Scaling up access to antiretroviral therapy (ART) in low- and middle-income countries: global and regional progress in 2008. International AIDS Society Conference WELBD105.
51. Toure S, Kouadio B, Seyler C et al. (2008) Rapid scaling-up of antiretroviral therapy in 10000 adults in Cote d'Ivoire: 2-year outcomes and determinants. AIDS 22, 873 882.
52. Unge C, Sodergard B, Ekstrom AM et al. (2009) Challenges for scaling up ART in a resource-limited setting: a retrospective study in kibera, Kenya. Jaids-Journal of Acquired Immune Deficiency Syndromes 50, 397 402.
53. Yiannoutsos CT, An MW, Frangakis CE et al. (2008) Sampling-based approaches to improve estimation of mortality among patient dropouts: experience from a large PEPFAR-funded program in Western Kenya. PLoS ONE 3, e3843.