Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda

AIDS

Volumn 22, Issue 18, 2008, Pages 2493-2499

  Kiboneka, Andrew ^a,c   Wangisi, Jonathan ^b   Nabiryo, Christine ^a   Tembe, Juliet ^b   Kusemererwa, Sylvia ^b   Olupot Olupot, Peter ^c   Joffres, Michel ^d   Anema, Aranka ^c,e   Cooper, Curtis L ^c,f   Montaner, Julio S ^e   Mills, Edward J ^c,e,g  

^a THE AIDS SUPPORT ORGANIZATION   (Uganda)

^b TASO ^*  (Uganda)

^c Mbale Project (M PROJ)   (Uganda)

^d SIMON FRASER UNIVERSITY   (Canada)

^e BRITISH COLUMBIA CENTRE FOR EXCELLENCE IN HIV AIDS   (Canada)

^f UNIVERSITY OF OTTAWA   (Canada)

^g ST PAUL S HOSPITAL   (Canada)

Author keywords

Africa; children; HIV AIDS; paediatrics

Indexed keywords

ANTIRETROVIRUS AGENT; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; ARTICLE; CD4 LYMPHOCYTE COUNT; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SEVERITY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HEALTH PROGRAM; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; IMMUNE RESPONSE; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NAUSEA; NEUROPATHY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RASH; SEX DIFFERENCE; TREATMENT OUTCOME; UGANDA; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; AGE DISTRIBUTION; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, ORPHANED; EPIDEMIOLOGIC METHODS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; REVERSE TRANSCRIPTASE INHIBITORS; TREATMENT OUTCOME; UGANDA; VIRAL LOAD;

EID: 57349158455     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328318f148     Document Type: Article

References (40)

1. Joint United Nations Programme on HIV/AIDS, (UNAIDS). Towards universal access: scaling up priority HIV/AIDS interventions in the health sector. 2007. http://www.who. int/hiv/mediacentre/univeral-access-progress-report-en.pdf. [Accessed 26 November 2007.
2. Nesheim SR, Kapogiannis BG, Soe MM, Sullivan KM, Abrams E, Farley J, et al. Trends in opportunistic infections in the pre and posthighly active antiretroviral therapy eras among HIV-infected children in the Perinatal AIDS Collaborative Transmission Study, 1986-200. Pediatrics 2007;120:100-109.
3. Judd A, Doerholt K, Tookey PA, Sharland M, Riordan A, Menson E, et al., Collaborative HIV Paediatric Study (CHIPS); National Study of HIV in Pregnancy and Childhood (NSHPC). Morbidity, mortality, and response to treatment by children in the United Kingdom and Ireland with perinatally acquired HIV infection during 1996-2006: planning for teenage and adult care. Clin Infect Dis 2007;45:918-924.
4. Patel K, Hernán MA, Williams PL, Seeger JD, McIntosh K, Van Dyke RB, Seage CR 3rd, Pediatric AIDS Clinical Trials Croup 219/219C Study Team. Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study. Clin Infect Dis 2008;46:507-515.
5. O'Brien DP, Sauvageot D, Zachariah R, Humblet P, Medecins Sans Frontieres. In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy. AIDS 2006;20:1955-1960.
6. Diack MBaye A, Signaté Sy H, Diagne Guèye NR, Ba A, Sylla A, Diouf S, et al. Epidemiological and clinical aspects of paediatric HIV infections in Albert-Royer Paediatric Hospital (Dakar, Senegal) [in French]. Arch Pediatr 2005;12:404-409.
7. Eley B, Davies MA, Apolles P, Cowburn C, Buys H, Zampoli M, et al. Antiretroviral treatment for children. S Afr Med J 2006;96 (9 Pt 2):988-993.
8. Reddi A, Leeper SC, Grobler AC, Geddes R, France KH, Dorse GL, et al. Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa. BMC Pediatr 2007;17:13.
9. Fassinou P, Elenga N, Rouet F, Laguide R, Kouakoussui KA, Timite M, et al. Highly active antiretroviral therapies among HIV-1-infected children in Abidjan, Côte d'lvoire. AIDS 2004;18:1905-1913.
10. Nyandiko WM, Ayaya S, Nabakwe E, Tenge C, Sidle JE, Yiannoutsos CT, et al. Outcomes of HIV-infected orphaned and nonorphaned children on antiretroviral therapy in western Kenya. J Acquir Immune Defic Syndr 2006;43:418-425.
11. Arrivé E, Kyabayinze DJ, Marquis B, Tumwesigye N, Kieffer MP, Azondekon A, et al., KIDS-ART-LINC Collaboration. Cohort profile: the paediatric antiretroviral treatment programmes in lower-income countries (KIDS-ART-LINC) collaboration. Int J Epidemiol 2008;37:474- 480.
12. Joint United Nations Programme on HIV/AIDS, (UNAIDS). Report on the global AIDS epidemic. 2006. http://www.unaids.org/en/HIV-data/2006GlobalReport/ default.asp. [Accessed 26 November 2007].
13. Uganda Ministry of Health. National antiretroviral treatment and care guidelines for adults and children. http://www.aidsuganda.org/pdf/ARV-Clinical- Guidelines-Final-draft.pdf. 2003.
14. World Health Organization (WHO). WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. Geneva: WHO; 2008.
15. SAS Institute. SAS, release 9.1.3. SAS Institute; Cary, North Carolina; 2008.
16. Rouet F, Fassinou P, Inwoley A, Anaky MF, Kouakoussui A, Rouzioux C, et al. Long-term survival and immuno-virological response of African HIV-1-infected children to highly active antiretroviral therapy regimens. AIDS 2006;20:2315-2319.
17. Resino S, Resino R, Micheloud D, Gurbindo Gutiérrez D, Léon JA, Ramos JT, et al., Spanish Group of Paediatric HIV Infection. Long-term effects of highly active antiretroviral therapy in pretreated, vertically HIV type 1-infected children: 6 years of follow-up. Clin Infect Dis 2006;42:62-869.
18. Wamalwa DC, Farquhar C, Obimbo EM, Selig S, Mbori-Ngacha DA, Richardson BA, et al. Early response to highly active antiretroviral therapy in HIV-1-infected Kenyan children. J Acquir Immune Defic Syndr 2007;45:311-317.
19. Reddi A, Leeper SC, Grobler AC, Geddes R, France KH, Dorse GL, et al. Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa. BMC Pediatrics 2007;7:13.
20. Bolton-Moore C, Mubiana-Mbewe M, Cantrell RA, Chintu N, Stringer EM, Chi BH, et al. Clinical outcomes and CD4 cell response in children receiving antiretroviral therapy at primary healthcare facilities in Zambia. JAMA 2007;298:1888-1899.
21. Rosen S, Ketlhapile M, Sanne I, DeSilva MB. Cost to patients of obtaining treatment for HIV/AIDS in South Africa. S Afr Med J 2007;97:524-529.
22. Weidle PJ, Wamai N, Solberg P, Liechty C, Sendagala S, Were W, et al. Adherence to antiretroviral therapy in a home-based AIDS care programme in rural Uganda. Lancet 2006;368: 1587-1594.
23. Carlucci JG, Kamanga A, Sheneberger R, Shepherd BE, Jenkins CA, Spurrier J, Vermund SH. Predictors of adherence to antiretroviral therapy in rural Zambia. J Acquir Immune Defic Syndr 2008;47:615-622.
24. Nabukeera-Barungi N, Kalyesubula I, Kekitiinwa A, Byakika- Tusiime J, Musoke P. Adherence to antiretroviral therapy in children attending Mulago Hospital, Kampala. Ann Trop Paediatr 2007;27:123-131.
25. Müller AD, Bode S, Myer L, Roux P, von Steinbüchel N. Electronic measurement of adherence to pediatric antiretroviral therapy in South Africa. Pediatr Infect Dis J 2008;27:257-262.
26. Kiboneka A, Nyatia RJ, Nabiryo C, Olupot-Olupot P, Anema A, Cooper C, Mills E. Pediatric HIV therapy in armed conflict. AIDS 2008;22:1097-1098.
27. Ferradini L, Jeannin A, Pinoges L, Izopet J, Odhiambo D, Mankhambo L, et al. Scaling up of highly active antiretroviral therapy in a rural district of Malawi: an effectiveness assessment. Lancet 2006;367:1335-1342.
28. Prendergast A, Tudor-Williams G, Jeena P, Burchett S, Goulder P. International perspectives, progress, and future challenges of paediatric HIV infection. Lancet 2007;370:68-80.
29. Watson DC, Farley JJ. Efficacy of and adherence to highly active antiretroviral therapy in children infected with human immunodeficiency virus type 1. Pediatr Infect Dis J 1999;18:682-689.
30. Gibb DM, Goodall RL, Giacomet V, McGee L, Compagnucci A, Lyall H, Paediatric European Network for Treatment of AIDS Steering Committee. Adherence to prescribed antiretroviral therapy in human immunodeficiency virus-infected children in the PENTA 5 trial. Pediatr Infect Dis J 2003;22:56-62.
31. Van Dyke RB, Lee S, Johnson GM, Wiznia A, Mohan K, Stanley K, et al. Reported adherence as a determinant of response to highly active antiretroviral therapy in children who have human immunodeficiency virus infection. Pediatrics 2002;109:e61.
32. Martin S, Elliott-DeSorbo DK, Wolters PL, Toledo-Tamula MA, Roby G, Zeichner S, Wood LV. Patient, caregiver and regimen characteristics associated with adherence to highly active antiretroviral therapy among HIV-infected children and adolescents. Pediatr Infect Dis J 2007;26:61-67.
33. Elise A, France AM, Louise WM, Bata D, Francois R, Roger S, Philippe M. Assessment of adherence to highly active antiretroviral therapy in a cohort of African HIV-infected children in Abidjan, Cote d'lvoire. J Acquir Immune Defic Syndr 2005;40:498-500.
34. Bikaako-Kajura W, Luyirika E, Purcell DW, Downing J, Kaharuza F, Mermin J, et al. Disclosure of HIV status and adherence to daily drug regimens among HIV-infected children in Uganda. AIDS Behav 2006;10 (Suppl 4):S85-S93.
35. Republic of Uganda, Ministry of Health. National antiretroviral treatment and care guidelines for adults and children. 2003.
36. Ou CY, Yang H, Balinandi S, Sawadogo S, Shanmugam V, Tih PM, et al. Identification of HIV-1 infected infants and young children using real-time RT PCR and dried blood spots from Uganda and Cameroon. J Virol Methods 2007;144:109-114.
37. Welch SB, Gibb D. When should children with HIV infection be started on antiretroviral therapy? PLoS Med 2008;5:e73.
38. Mishra V, Arnold F, Otieno F, Cross A, Hong R. Education and nutritional status of orphans and children of HIV-infected parents in Kenya. AIDS Educ Prev 2007;19:383-395.
39. United Nations Chidren's Fund, (UNICEF). Africa's orphaned and vulnerable generations: children affected by AIDS. 2006.
40. Cherutich P, Inwani I, Nduati R, Mbori-Ngacha D. Optimizing paediatric HIV care in Kenya: challenges in early infant diagnosis. Bull World Health Organ 2008;86:155-160.