AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor

Toxicological Sciences

Volumn 139, Issue 1, 2014, Pages 198-209

  Chen, Shiuan ^a   Zhou, Dujin ^a   Hsin, Li Yu ^a   Kanaya, Noriko ^a   Wong, Cynthie ^a   Yip, Richard ^a   Sakamuru, Srilatha ^b   Xia, Menghang ^b   Yuan, Yate Ching ^a   Witt, Kristine ^c   Teng, Christina ^c  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Aromatase expressing cell line; EDCs; Estrogen receptor; High throughput screening; MCF 7 cells; QHTS; Tox21

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANDROSTENEDIONE; AROMATASE; BIFONAZOLE; DIMETHYL SULFOXIDE; ENDOCRINE DISRUPTOR; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ANTAGONIST; HYGROMYCIN; LETROZOLE; LUCIFERASE; OXICONAZOLE; PAROXETINE; PRIMER DNA;

AROER TRI SCREEN ASSAY; ARTICLE; ASSAY; BINDING SITE; CELL SCREENING; CONTROLLED STUDY; DOWN REGULATION; EC50; ENZYME KINETICS; ESTROGEN RESPONSIVE ELEMENT; HIGH THROUGHPUT SCREENING; IC50; LUCIFERASE ASSAY; MATHEMATICAL PARAMETERS; MCF 7 CELL LINE; PROMOTER REGION; RECEPTOR AFFINITY; SIGNAL TO BACKGROUND RATIO; STABLE TRANSFECTION; UPREGULATION; DRUG EFFECTS; HUMAN; NUCLEOTIDE SEQUENCE; TOXICITY; VALIDATION STUDY;

AROMATASE; BASE SEQUENCE; DNA PRIMERS; ENDOCRINE DISRUPTORS; HUMANS; MCF-7 CELLS; RECEPTORS, ESTROGEN;

EID: 84922393075     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu023     Document Type: Article

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