Overview of endocrine disruptor research activity in the United States

Chemosphere

Volumn 39, Issue 8, 1999, Pages 1227-1236

  Kavlock, R J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENVIRONMENTAL CHEMICAL;

CONFERENCE PAPER; ENDOCRINE SYSTEM; HEALTH HAZARD; HUMAN; LIFE CYCLE; MEDICAL RESEARCH; PRACTICE GUIDELINE; SCREENING; UNITED STATES;

ANIMALS; ENDOCRINE GLANDS; ENDOCRINOLOGY; HUMANS; RESEARCH; UNITED STATES;

EID: 0033213876     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0045-6535(99)00190-3     Document Type: Conference Paper

References (19)

1. R.J. Kavlock, G.P. Daston, C. DeRosa, P. Fenner-Crisp, L.E. Gray, S. Kaattari, G. Lucier, M. Luster, M.J. Mac, C. Maczka, R. Miller, J. Moore, R. Rolland, G. Scott, D.M. Sheehan, T. Sinks and H.A. Tilson. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the US EPA sponsored workshop. Environ. Health Perspect. 104 (Supp. 4), 715-740 (1996).
2. US EPA. Toxic substances control act test guidelines; Final rule, Federal Register 62(158): 43819-43861, August 15 (1997).
3. US EPA. Strategic Plan for the Office of Research and Development. Washington, DC, US EPA/600R-96/059, 60 pp. (1996).
4. US EPA. Office of Research and Development Strategic Research Plan for Endocrine Disruptors. Washington, DC. In press.
5. G.T. Ankley, R.D. Johnson, G. Toth, L.C. Folmar, N.E. Detenbeck and S.P. Bradbury. Development of a research strategy for assessing the ecological risk of endocrine disruptors. Rev. Toxicol. 1, 71-106 (1997).
6. US EPA. Environmental endocrine disruption: Effects assessment and analysis document. Risk Assessment Forum, December (Washington, DC) (1996).
7. L.E. Gray, Jr., J. Ostby, J. Ferrell and J. Goldman. Methoxychlor-induced alterations of estrogen-dependent running wheel activity, The reproductive tract and pituitary function in the female rat. Toxicol. Appl. Pharmacol. 96, 525-540 (1988).
8. L.E. Gray, Jr., J.S. Ostby and W.R. Kelce. Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rats. Toxicol. Appl. Pharmacol. 129, 46-52 (1994).
9. L.E. Gray, Jr., W.R. Kelce, E. Monosson, J.S. Ostby and L.S. Birnbaum. Exposure to TCDD during development permanently alters reproductive function in male LE rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol. Appl. Pharmacol. 131, 108-118 (1995).
10. L.E. Gray, Jr., W.R. Kelce, T. Wiese, R. Tyl, K. Gaido, J. Cook, G. Klinefelter, D. Deaulniers, E. Wilson, T. Zacharewski, C. Waller, P. Faoster, J. Laskey, J. Reel, J. Geisy, S. Laws, J. McLachlan, W. Breslin, R. Cooper, R. DiGuilio, R. Johnson, R. Purdy, E. Mihaich, S. Safe, C. Sonneschein, W. Welshons, R. Miller, S. McMaster and T. Colborn. Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. Reprod. Toxicol. 11, 719-750 (1997).
11. G.T. Ankley, et al. (30 coauthors), Overview of a workshop on screening methods for detecting (anti-)estrogenic/androgenic chemicals in wildlife, Environ. Toxicol. Chem. 17, 68-87 (1998).
12. CENR. The Health and Ecological Effects of Endocrine Disrupting Chemicals: A Framework for Planning. Committee on Environment and Natural Resources, National Science and Technology Council, Office of Science and Technology Policy. November 22 (Washington, DC) (1996).
13. L.W. Reiter, C. DeRosa, R.J. Kavlock, G. Lucier, M.J. Mac, J. Melillo, R.L. Melnick, T. Sinks and B. Walton, The US federal framework for research on endocrine disruptors and an analysis of research programs supported during fiscal year 1996, Environ. Health Perspect. 106 (1998).
14. L.E. Gray, Jr., J. Ostby, R. Sigmon, J. Ferrell, G. Rehnberg, R. Linder, R. Cooper, J. Goldman and J. Laskey, The development of a protocol to assess reproductive effects of toxicants in the rat, Reprod. Toxicol. 2, 281-287 (1988).
15. L.E. Gray, Jr., J. Ferrell, J. Ostby, G. Rehnberg, R. Linder, R. Cooper, J. Goldman and V. Slott, A dose-response analysis of methoxychlor-induced alterations of reproductive function in the rat using a new protocol developed, Fundam. Appl. Toxicol. 12, 92-108 (1989).
16. Ostby J, LE Gray, WR Kelce, CJ Wolf, and OP Huey, Sexual differentiation in male rats exposed to low doses of the antiandrogen Vinclozolin, Biol. Reprod. 56 (Suppl. 1), p. 99 (abstract) (1997).
17. L.E. Gray, Jr., J.S. Ostby and W.R. Kelce, A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8 tetrachloro-p-dioxin (TCDD) in male Long Evans Hooded rat offspring, Toxicol. Appl. Pharmacol. 146, 11-20 (1997).
18. L.E. Gray, Jr., C. Wolf, P. Mann, and J.S. Ostby, In utero exposure to low doses of 2,3,7,8 Tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive development of female Long Evans Hooded rat offspring, Toxicol. Appl. Pharmacol. 146, 237-244 (1997).
19. L.E. Gray, Jr., and J.S. Ostby, In utero 2,3,7,8 Tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology and function in female rat offspring, Toxicol. Appl. Pharmacol. 133, 285-294 (1995).